ES2075894T3 - Metodo para la formacion de vesiculas. - Google Patents

Metodo para la formacion de vesiculas.

Info

Publication number
ES2075894T3
ES2075894T3 ES90903531T ES90903531T ES2075894T3 ES 2075894 T3 ES2075894 T3 ES 2075894T3 ES 90903531 T ES90903531 T ES 90903531T ES 90903531 T ES90903531 T ES 90903531T ES 2075894 T3 ES2075894 T3 ES 2075894T3
Authority
ES
Spain
Prior art keywords
film
vesicles
formation
agitation
homogeneous
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90903531T
Other languages
English (en)
Inventor
Kevin R Bracken
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nexstar Pharmaceuticals Inc
Original Assignee
Vestar Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vestar Inc filed Critical Vestar Inc
Application granted granted Critical
Publication of ES2075894T3 publication Critical patent/ES2075894T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D1/00—Evaporating
    • B01D1/22—Evaporating by bringing a thin layer of the liquid into contact with a heated surface
    • B01D1/222—In rotating vessels; vessels with movable parts
    • B01D1/223—In rotating vessels; vessels with movable parts containing a rotor
    • B01D1/225—In rotating vessels; vessels with movable parts containing a rotor with blades or scrapers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/829—Liposomes, e.g. encapsulation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

SE PRESENTA UN METODO DE RECIPIENTE UNICO PARA PREPARAR LIPOSOMAS EN CANTIDADES COMERCIALES FORMANDO UNA PELICULA DE LIPIDOS HOMOGENEA Y UNIFORME EN UN EVAPORADOR DE PELICULA DELGADA (10, 70) MEDIANTE LA EVAPORACION DEL SOLVENTE ORGANICO, SEGUIDA DE LA HIDRATACION IN SITU DE LA PELICULA EN UNA FASE ACUOSA POR AGITACION CON EL ROTOR (30, 80).
ES90903531T 1989-01-27 1990-01-22 Metodo para la formacion de vesiculas. Expired - Lifetime ES2075894T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/303,473 US4935171A (en) 1989-01-27 1989-01-27 Method for vesicle formation

Publications (1)

Publication Number Publication Date
ES2075894T3 true ES2075894T3 (es) 1995-10-16

Family

ID=23172272

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90903531T Expired - Lifetime ES2075894T3 (es) 1989-01-27 1990-01-22 Metodo para la formacion de vesiculas.

Country Status (9)

Country Link
US (1) US4935171A (es)
EP (1) EP0457833B1 (es)
JP (1) JPH04504527A (es)
AT (1) ATE127014T1 (es)
AU (1) AU5103990A (es)
DE (1) DE69022034T2 (es)
DK (1) DK0457833T3 (es)
ES (1) ES2075894T3 (es)
WO (1) WO1990008535A1 (es)

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US5143661A (en) * 1987-05-26 1992-09-01 American Cyanamid Company Silicone-hardened pharmaceutical microcapsules
US5178875A (en) * 1991-01-14 1993-01-12 The Board Of Regents, The University Of Texas System Liposomal-polyene preliposomal powder and method for its preparation
US5830498A (en) * 1987-10-16 1998-11-03 Board Of Regents, The University Of Texas System Liposomal-polyene preliposomal powder and method for its preparation
US5096629A (en) * 1988-08-29 1992-03-17 501 Nippon Fine Chemical Co., Ltd. Method for preparing lipid powder for use in preparing liposomes and method for preparing liposomes
US5236355A (en) * 1988-12-22 1993-08-17 American Cyanamid Company Apparatus for the treatment of periodontal disease
EP0374531B1 (en) * 1988-12-22 1994-05-04 American Cyanamid Company Method for the treatment of periodontal disease by sustained delivery of a therapeutic agent to the periodontal pocket, composition of matter therefor and apparatus for the administration thereof
WO1995003035A1 (en) * 1993-07-23 1995-02-02 Massachusetts Institute Of Technology Polymerized liposomes with enhanced stability for oral delivery
US6004534A (en) * 1993-07-23 1999-12-21 Massachusetts Institute Of Technology Targeted polymerized liposomes for improved drug delivery
ES2336857T3 (es) 1995-05-04 2010-04-16 Gilead Sciences, Inc. Complejos de ligandos de acido nucleico.
WO1997035559A2 (en) * 1996-03-27 1997-10-02 Ortho Pharmaceutical Corporation Manufacture of liposomes and lipid-protein complexes by ethanolic injection and thin film evaporation
US6060082A (en) * 1997-04-18 2000-05-09 Massachusetts Institute Of Technology Polymerized liposomes targeted to M cells and useful for oral or mucosal drug delivery
JP4808842B2 (ja) * 1997-08-18 2011-11-02 ジーイー・ヘルスケア・アクスイェ・セルスカプ 小胞の調製方法
US6855296B1 (en) 1998-11-13 2005-02-15 Optime Therapeutics, Inc. Method and apparatus for liposome production
ATE397488T1 (de) * 1998-11-13 2008-06-15 Heriot William A Vorrichtung zur herstellung von liposomen
US6160143A (en) * 2000-02-18 2000-12-12 Artisan Industries Inc. Method for the concentration and separation of sterols
JP2004505700A (ja) * 2000-08-09 2004-02-26 ラツィオナル　アクチエンゲゼルシャフト 特に調理機器のための蒸気を発生する方法と装置
US20110142922A1 (en) * 2002-04-30 2011-06-16 Ferndale Ip, Inc. Stabilized composition and method for dermatological treatment
AU2003298738A1 (en) * 2002-11-26 2004-06-18 Su-Ming Chiang Liposomal formulations
US7192989B2 (en) * 2002-12-20 2007-03-20 Akzo Nobel N.V. Method and expansion device for preparing expanded thermoplastic microspheres
DE102005002469B3 (de) * 2005-01-18 2006-05-11 Abnoba Heilmittel Gmbh Verfahren und Vorrichtungen zur Einkapselung von Stoffen in Liposomen mit frei einstellbarem Membranaufbau
US20070166386A1 (en) * 2006-01-13 2007-07-19 Chinea Vanessa I Nanoparticle formation of pharmaceutical ingredients
US20080069857A1 (en) * 2006-04-12 2008-03-20 Yoon Yeo Compositions And Methods For Inhibiting Adhesions
EP2196194B1 (en) * 2007-09-10 2017-08-09 M Technique Co., Ltd. Process for producing biological ingesta and biological ingesta obtained thereby
SG190562A1 (en) 2008-04-18 2013-06-28 Vaxinnate Corp Deletion mutants of flagellin and methods of use
CN103635180B (zh) * 2011-04-04 2016-08-03 学校法人早稻田大学 囊泡的制造方法
CA2830372A1 (en) 2011-04-07 2012-10-11 Sheau Yu Hsu Long-acting peptide analogs
GB201204384D0 (en) 2012-03-13 2012-04-25 Univ Dundee Anti-flammatory agents
US9931298B2 (en) 2015-05-26 2018-04-03 Comfort Care For Animals Llc Liposome loading
CN115551626A (zh) * 2020-04-07 2022-12-30 V·E·麦克卢尔 用于聚合物的液相催化热解的反应容器
WO2024216279A2 (en) * 2023-04-13 2024-10-17 University Of Connecticut Analgesic compounds comprising charged particles and method of manufacture thereof

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US2812019A (en) * 1954-09-22 1957-11-05 Rodney Hunt Machine Co Treatment of lecithin
US2863888A (en) * 1954-09-28 1958-12-09 Colgate Palmolive Co Process for the production of fatty acid hydroxy amides
US2927634A (en) * 1956-05-23 1960-03-08 Arne R Gudheim Apparatus for evaporating and otherwise treating fluid materials
US3129132A (en) * 1960-04-14 1964-04-14 Arne R Gudheim Treatment of latex
US3261391A (en) * 1964-05-20 1966-07-19 Arne R Gudheim Thin-film processing apparatus
CH487345A (de) * 1965-11-11 1970-03-15 Karl Fischer App Und Rohrleitu Verfahren zur Förderung eines dampfförmigen Stoffes und Anwendung dieses Verfahrens
US3346034A (en) * 1966-12-21 1967-10-10 Artisan Ind Thin film processing apparatus
IT1029819B (it) * 1974-02-28 1979-03-20 Feres Vaclav Vaporizzatore a strato sittile
DE2625930A1 (de) * 1975-06-18 1976-12-30 Artisan Ind Duennschichtverdampfer sowie verfahren zur behandlung von fluessigkeiten in duennen schichten
JPS5240203A (en) * 1975-09-26 1977-03-29 Kansai Kagaku Kikai Seisaku Kk Film system evaporator
US4065346A (en) * 1975-11-26 1977-12-27 Ivan Frolovich Evkin Roter thin-film evaporator
GB1578776A (en) * 1976-06-10 1980-11-12 Univ Illinois Hemoglobin liposome and method of making the same
CH643149A5 (de) * 1979-07-10 1984-05-30 Luwa Ag Verfahren und vorrichtung zum kontinuierlichen thermischen behandeln von pumpfaehigen stoffen in duenner schicht.
JPS5698696A (en) * 1980-01-10 1981-08-08 Hitachi Ltd Method of processing radioactive liquid waste
US4485054A (en) * 1982-10-04 1984-11-27 Lipoderm Pharmaceuticals Limited Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV)
JPS6036999A (ja) * 1983-08-09 1985-02-26 株式会社荏原製作所 放射性ほう酸ナトリウム廃液の減容固化物、減容固化方法及びその装置
US4761288A (en) * 1984-09-24 1988-08-02 Mezei Associates Limited Multiphase liposomal drug delivery system
US4753788A (en) * 1985-01-31 1988-06-28 Vestar Research Inc. Method for preparing small vesicles using microemulsification
DE3511981A1 (de) * 1985-04-02 1986-11-20 Fa. Fritz Genser, 8803 Rothenburg Verfahren zur vakuumrotationsverdampfung, sowie vorrichtung zur durchfuehrung des verfahrens
FR2586587B1 (fr) * 1985-08-30 1987-10-23 Adir Nouveaux surfactants artificiels, leur preparation et les compositions pharmaceutiques qui les contiennent.
US4752425A (en) * 1986-09-18 1988-06-21 Liposome Technology, Inc. High-encapsulation liposome processing method

Also Published As

Publication number Publication date
DE69022034T2 (de) 1996-04-11
JPH04504527A (ja) 1992-08-13
EP0457833B1 (en) 1995-08-30
WO1990008535A1 (en) 1990-08-09
EP0457833A1 (en) 1991-11-27
AU5103990A (en) 1990-08-24
ATE127014T1 (de) 1995-09-15
DK0457833T3 (da) 1995-09-25
DE69022034D1 (de) 1995-10-05
EP0457833A4 (en) 1992-03-11
US4935171A (en) 1990-06-19

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