ES2076219T3 - Sondas de nucleotidos. - Google Patents

Sondas de nucleotidos.

Info

Publication number
ES2076219T3
ES2076219T3 ES89313143T ES89313143T ES2076219T3 ES 2076219 T3 ES2076219 T3 ES 2076219T3 ES 89313143 T ES89313143 T ES 89313143T ES 89313143 T ES89313143 T ES 89313143T ES 2076219 T3 ES2076219 T3 ES 2076219T3
Authority
ES
Spain
Prior art keywords
nucleotide probes
moiety
moieties
producing
signal generating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89313143T
Other languages
English (en)
Inventor
Chandler Dr Bahl
Leopoldo Mendoza
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ortho Clinical Diagnostics Inc
Original Assignee
Ortho Diagnostic Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Diagnostic Systems Inc filed Critical Ortho Diagnostic Systems Inc
Application granted granted Critical
Publication of ES2076219T3 publication Critical patent/ES2076219T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

LA PRESENTE INVENCION PRESENTA UN METODO PARA PRODUCIR UNA SONDA NUCLEOTIDA MARCADA QUE UNA PARTE DE COMBINACION QUIMICA DE RECONOCIMIENTO DE ANTICATODOS QUE COMPRENDE AL MENOS 15 BASES NUCLEOTIDAS Y UNA PARTE GENERADORA DE SEÑALES PARA PROVEER FUNCIONALIDADES REACTIVAS EN LOS RESPECTIVOS EXTREMOS DE DICHAS PARTES.
ES89313143T 1988-12-16 1989-12-15 Sondas de nucleotidos. Expired - Lifetime ES2076219T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/285,274 US5324829A (en) 1988-12-16 1988-12-16 High specific activity nucleic acid probes having target recognition and signal generating moieties

Publications (1)

Publication Number Publication Date
ES2076219T3 true ES2076219T3 (es) 1995-11-01

Family

ID=23093537

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89313143T Expired - Lifetime ES2076219T3 (es) 1988-12-16 1989-12-15 Sondas de nucleotidos.

Country Status (8)

Country Link
US (3) US5324829A (es)
EP (1) EP0373956B1 (es)
JP (1) JPH02245663A (es)
AT (1) ATE125545T1 (es)
CA (1) CA2005557A1 (es)
DE (1) DE68923603T2 (es)
ES (1) ES2076219T3 (es)
GR (1) GR890100824A (es)

Families Citing this family (25)

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US5324829A (en) * 1988-12-16 1994-06-28 Ortho Diagnostic Systems, Inc. High specific activity nucleic acid probes having target recognition and signal generating moieties
US5258507A (en) * 1990-11-08 1993-11-02 Amoco Corporation Labeling reagents useful for the chemical attachment of nitrophenyl derivative ligands to DNA probes
KR930702373A (ko) * 1990-11-08 1993-09-08 안토니 제이. 페이네 합성 올리고누클레오티드에 대한 다중 리포터(Reporter)그룹의 첨합
EP0599337B1 (en) * 1992-11-27 2006-03-08 Canon Kabushiki Kaisha Method for detection of nucleic acid and probe therefor
FR2710075B1 (fr) * 1993-09-15 1995-10-27 Bio Merieux Réactif et procédé pour la détection d'une séquence nucléotidique avec amplification de signal.
DE69532255D1 (de) * 1994-05-26 2004-01-22 Canon Kk Verfahren zum Nachweis von einer Zielsubstanz in einer Probe mit Hilfe von Pyryliumverbindung
US5871902A (en) * 1994-12-09 1999-02-16 The Gene Pool, Inc. Sequence-specific detection of nucleic acid hybrids using a DNA-binding molecule or assembly capable of discriminating perfect hybrids from non-perfect hybrids
US20030104361A1 (en) * 1997-09-29 2003-06-05 Susan Weininger Method of detection of nucleic acids with a specific sequence composition
FR2733765B1 (fr) * 1995-05-02 1997-07-25 Genset Sa Methode de couplage specifique de la coiffe de l'extremite 5' d'un fragment d'arnm
FR2733762B1 (fr) * 1995-05-02 1997-08-01 Genset Sa Methode de couplage specifique de la coiffe de l'extremite 5' d'un fragment d'arnm et preparation d'arnm et d'adnc complet
FR2746413B1 (fr) * 1996-03-19 1998-04-24 Bio Merieux Detection d'une sequence nucleotidique avec amplification de signal
US5853993A (en) * 1996-10-21 1998-12-29 Hewlett-Packard Company Signal enhancement method and kit
WO2000079009A2 (en) * 1999-06-22 2000-12-28 Invitrogen Corporation Improved primers and methods for the detection and discrimination of nucleic acids
US7838655B2 (en) * 2000-09-15 2010-11-23 Ventana Medical Systems, Inc. Oligonucleotide sequence formula for labeling oligonucleotide probes and proteins for in-situ analysis
EP1401850A1 (en) 2001-06-20 2004-03-31 Nuevolution A/S Nucleoside derivatives for library preparation
DE60223821T2 (de) * 2001-09-12 2008-11-27 Pusan National University Industry-University Cooperation Foundation Neue terthiophen-3-carbonsäure verbindung und verfahren zu deren herstellung, funktionalisierter leitender terthiophenpolymer mit der verbindung als monomer und verfahren zum nachweis von dna-hybridisierung unter anwendung des polymers
DE10228260A1 (de) * 2002-06-25 2004-01-22 Bayer Ag Methode und Vorrichtung zum impedimetrischen Nachweis eines oder mehrerer Analyten in einer Probe
EP1539980B1 (en) 2002-08-01 2016-02-17 Nuevolution A/S Library of complexes comprising small non-peptide molecules and double-stranded oligonucleotides identifying the molecules
EP2348124B1 (en) * 2002-10-30 2013-12-11 Nuevolution A/S Synthesis of a bifunctional complex
WO2004056994A2 (en) * 2002-12-19 2004-07-08 Nuevolution A/S Quasirandom structure and function guided synthesis methods
US20070026397A1 (en) 2003-02-21 2007-02-01 Nuevolution A/S Method for producing second-generation library
US11118215B2 (en) 2003-09-18 2021-09-14 Nuevolution A/S Method for obtaining structural information concerning an encoded molecule and method for selecting compounds
PT3305900T (pt) 2005-12-01 2021-10-27 Nuevolution As Métodos de codificação enzimática para síntese eficaz de bibliotecas grandes
DE102006028101B4 (de) * 2006-06-19 2014-02-13 Siemens Aktiengesellschaft Verfahren zur Analyse von amplifizierten Nukleinsäuren
US8150101B2 (en) 2006-11-13 2012-04-03 Cybernet Systems Corporation Orientation invariant object identification using model-based image processing

Family Cites Families (40)

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Publication number Priority date Publication date Assignee Title
US4458066A (en) * 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
US4358535A (en) * 1980-12-08 1982-11-09 Board Of Regents Of The University Of Washington Specific DNA probes in diagnostic microbiology
US4711955A (en) * 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
US4717653A (en) * 1981-09-25 1988-01-05 Webster John A Jr Method for identifying and characterizing organisms
FI63596C (fi) * 1981-10-16 1983-07-11 Orion Yhtymae Oy Mikrobdiagnostiskt foerfarande som grundar sig pao skiktshybridisering av nukleinsyror och vid foerfarandet anvaenda kombinationer av reagenser
FR2519005B1 (fr) * 1981-12-29 1985-10-25 Pasteur Institut Fragments d'adn marques a l'une au moins de leurs extremites par des ribonucleotides modifies reconnaissables par des molecules affines et procede pour realiser une analyse de tels fragments d'adn
CA1223831A (en) * 1982-06-23 1987-07-07 Dean Engelhardt Modified nucleotides, methods of preparing and utilizing and compositions containing the same
US4556643A (en) * 1982-07-26 1985-12-03 Agracetus Assay method and probe for polynucleotide sequences
JPS5984162A (ja) * 1982-11-05 1984-05-15 Toshiba Corp 免疫分析法
CA1309672C (en) * 1983-01-27 1992-11-03 Jannis G. Stavrianopoulos Methods and structures employing non-radioactive chemically-labeled polynucleotide probes
US4605735A (en) * 1983-02-14 1986-08-12 Wakunaga Seiyaku Kabushiki Kaisha Oligonucleotide derivatives
EP0135587B2 (en) * 1983-02-22 2002-12-18 Syngene, Inc. Defined sequence single strand oligonucleotides incorporating reporter groups, process for the chemical synthesis thereof, and nucleosides useful in such synthesis
GB8306426D0 (en) * 1983-03-09 1983-04-13 Malcolm A D B Detecting polynucleotide sequence
CA1254525A (en) * 1983-04-13 1989-05-23 Christine L. Brakel Kit for terminally chemically labeling dna
DK188184A (da) * 1983-04-20 1984-10-21 Enzo Biochem Inc Fremgangsmaade til dannelse af et kompleks af biologisk aktive eller funktionelle forbindelser og anvendelse af forbindelserne
US4533628A (en) * 1983-08-03 1985-08-06 New York University Colony hybridization method
US5015733A (en) * 1983-12-20 1991-05-14 California Institute Of Technology Nucleosides possessing blocked aliphatic amino groups
US4707440A (en) * 1984-01-30 1987-11-17 Enzo Biochem, Inc. Nucleic acid hybridization assay and detectable molecules useful in such assay
DE177497T1 (de) * 1984-04-05 1986-11-27 Life Technologies Inc., Gaithersburg, Md. Immobilisierung von nukleinsaeuren.
US4957858A (en) * 1986-04-16 1990-09-18 The Salk Instute For Biological Studies Replicative RNA reporter systems
FR2567541B1 (fr) * 1984-07-13 1987-02-06 Pasteur Institut Sonde d'adn et procede pour la detection de " shigelles " et des souches entero-invasives de escherichia coli
US5118605A (en) * 1984-10-16 1992-06-02 Chiron Corporation Polynucleotide determination with selectable cleavage sites
US4670379A (en) * 1984-12-19 1987-06-02 E. I. Du Pont De Nemours And Company Polynucleotide hydridization assays employing catalyzed luminescence
CA1278755C (en) * 1985-03-15 1991-01-08 William J. Knowles Labelling of oligonucleotides
CA1295559C (en) * 1985-08-13 1992-02-11 Jannis Stavrianopoulos Method for labeling polynucleotide sequences
US4806631A (en) * 1985-09-30 1989-02-21 Miles Inc. Immobilization of nucleic acids on solvolyzed nylon supports
US4806546A (en) * 1985-09-30 1989-02-21 Miles Inc. Immobilization of nucleic acids on derivatized nylon supports
EP0224126A3 (en) * 1985-11-25 1989-02-01 The University of Calgary Covalently linked complementary oligodeoxynucleotides as universal nucleic acid sequencing primer linkers
JP3293820B2 (ja) * 1985-12-13 2002-06-17 エンゾ− バイオケム インコ−ポレイテツド 標的ポリヌクレオチドにハイブリツド形成するための新規な一工程方法とポリヌクレオチド化合物
US4882269A (en) * 1985-12-13 1989-11-21 Princeton University Amplified hybridization assay
EP0286642A4 (en) * 1985-12-17 1990-06-27 Genetics Inst TEST PROCEDURE BY MEANS OF POLYNUCLEOTIDE DISPLACEMENT AND REAGENT COMPLEX.
ATE88761T1 (de) * 1986-01-10 1993-05-15 Amoco Corp Kompetitiver homogener test.
US4900659A (en) * 1986-01-30 1990-02-13 Enzo Biochem, Inc. Nucleotide sequence composition and method for detection of Neisseria gonorrhoeae and method for screening for a nucleotide sequence that is specific for a genetically distinct group
NO870613L (no) * 1986-03-05 1987-09-07 Molecular Diagnostics Inc Deteksjon av mikroorganismer i en prŸve inneholdende nukleinsyre.
US4851331A (en) * 1986-05-16 1989-07-25 Allied Corporation Method and kit for polynucleotide assay including primer-dependant DNA polymerase
WO1988001302A1 (en) * 1986-08-11 1988-02-25 Siska Diagnostics, Inc. Nucleic acid probe assay methods and compositions
US4794082A (en) * 1987-02-17 1988-12-27 Hoechst Celanese Corporation Biotinylating agents
IL86164A0 (en) * 1987-04-28 1988-11-15 Tamir Biotechnology Ltd Improved dna probes
EP0310312A3 (en) * 1987-10-02 1990-08-16 M.L. Technology Ventures, L.P. Non-nucleotide reagents for substituting termini of oligonucleotides
US5324829A (en) * 1988-12-16 1994-06-28 Ortho Diagnostic Systems, Inc. High specific activity nucleic acid probes having target recognition and signal generating moieties

Also Published As

Publication number Publication date
DE68923603D1 (de) 1995-08-31
DE68923603T2 (de) 1996-01-04
US5324829A (en) 1994-06-28
US5783685A (en) 1998-07-21
EP0373956B1 (en) 1995-07-26
ATE125545T1 (de) 1995-08-15
GR890100824A (el) 1991-03-15
EP0373956A3 (en) 1991-01-30
CA2005557A1 (en) 1990-06-16
JPH02245663A (ja) 1990-10-01
US5521298A (en) 1996-05-28
EP0373956A2 (en) 1990-06-20

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