ES2077985T3 - Inhibidores de la acil-coa: colesterol-acil transferasa, a base de 5-bis-aminometilen-1,3-dioxano-4,6-diona n,n',n'-trisubstituida. - Google Patents
Inhibidores de la acil-coa: colesterol-acil transferasa, a base de 5-bis-aminometilen-1,3-dioxano-4,6-diona n,n',n'-trisubstituida.Info
- Publication number
- ES2077985T3 ES2077985T3 ES92307981T ES92307981T ES2077985T3 ES 2077985 T3 ES2077985 T3 ES 2077985T3 ES 92307981 T ES92307981 T ES 92307981T ES 92307981 T ES92307981 T ES 92307981T ES 2077985 T3 ES2077985 T3 ES 2077985T3
- Authority
- ES
- Spain
- Prior art keywords
- acil
- trisubstituida
- aminometilen
- diona
- transferase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 102000004357 Transferases Human genes 0.000 title 1
- 108090000992 Transferases Proteins 0.000 title 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- -1 cyano, carboxyl Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Steroid Compounds (AREA)
Abstract
UN COMPUESTO DE LA FORMULA: EN DONDE X, Y Y Z SON ,INDEPENDIENTEMENTE, HIDROGENO, HALOGENO, HIDROXI, NITRO, CIANO, CARBOXILO, TRIFLUORMETILO, FENILO, AMINO, ALQUILAMINO, DIALQUILAMINO, ALQUILO O ALCOXI; R1 ES ALQUILO, ALQUENILO, CICLOALQUILO, FENILO, BENZILO O BENZILO O FENILO SUSTITUIDO, R2 ES O UNA SAL FARMACEUTICAMENTE ACEPTABLE CONSIGUIENTE, SON INHIBIDORES ACAT.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/755,918 US5136039A (en) | 1991-09-06 | 1991-09-06 | N,N',N'-trisubstituted-5-bis-aminomethylene-1,3-dioxane-4,6-dione inhibitors of acyl-CoA:cholesterol-acyl transferase |
| US07/847,127 US5177219A (en) | 1992-03-06 | 1992-03-06 | N-phenyl-N'-thienylmethyl-bis-diamino-5-methylene-1,3-dioxane-4,6-dione compounds |
| US07/879,494 US5164505A (en) | 1992-05-07 | 1992-05-07 | N-phenyl-N'-alkyl-N'-pyridylmethyl-bis-diamino-5-methylene-1,3-dioxane-4,6-diones |
| US07/914,886 US5187284A (en) | 1992-07-22 | 1992-07-22 | N-phenyl-N'-benzothienylmethyl-bis-diamino-5-methylene-1,3-dioxane-4,6-dione derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2077985T3 true ES2077985T3 (es) | 1995-12-01 |
Family
ID=27505672
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES92307981T Expired - Lifetime ES2077985T3 (es) | 1991-09-06 | 1992-09-03 | Inhibidores de la acil-coa: colesterol-acil transferasa, a base de 5-bis-aminometilen-1,3-dioxano-4,6-diona n,n',n'-trisubstituida. |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0531119B1 (es) |
| JP (1) | JPH05194502A (es) |
| KR (1) | KR930006000A (es) |
| AT (1) | ATE128978T1 (es) |
| AU (1) | AU652852B2 (es) |
| DE (1) | DE69205383T2 (es) |
| DK (1) | DK0531119T3 (es) |
| ES (1) | ES2077985T3 (es) |
| GR (1) | GR3018392T3 (es) |
| HU (1) | HUT65376A (es) |
| MX (1) | MX9204939A (es) |
| NZ (1) | NZ244210A (es) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017190714A1 (es) | 2016-05-04 | 2017-11-09 | Universidad De La Habana | Compuesto fenólico y combinación del mismo con una benzodiazepina fusionada a 1,4-dihidropiridina para el tratamiento de afecciones del sistema nervioso central y vascular |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE68911203T2 (de) * | 1988-03-30 | 1994-04-14 | Warner Lambert Co | N-[[(2,6-disubstituierte)phenyl]N'- arylalkyl] Harnstoffe als antihypercholesterolemische und antiatherosclerotische Mittel. |
| US5179216A (en) * | 1990-08-16 | 1993-01-12 | American Home Products Corporation | N,n', n'-trisubstituted-5-bisaminomethylene-1,3-dioxane-4,6-dione inhibitors of acyl-coa:cholesterol-acyl transferase |
-
1992
- 1992-08-27 MX MX9204939A patent/MX9204939A/es unknown
- 1992-09-03 DE DE69205383T patent/DE69205383T2/de not_active Expired - Fee Related
- 1992-09-03 EP EP92307981A patent/EP0531119B1/en not_active Expired - Lifetime
- 1992-09-03 AT AT92307981T patent/ATE128978T1/de active
- 1992-09-03 ES ES92307981T patent/ES2077985T3/es not_active Expired - Lifetime
- 1992-09-03 KR KR1019920015983A patent/KR930006000A/ko not_active Abandoned
- 1992-09-03 DK DK92307981.8T patent/DK0531119T3/da active
- 1992-09-03 JP JP4235808A patent/JPH05194502A/ja active Pending
- 1992-09-04 HU HU9202849A patent/HUT65376A/hu unknown
- 1992-09-04 AU AU22126/92A patent/AU652852B2/en not_active Ceased
- 1992-09-04 NZ NZ244210A patent/NZ244210A/en unknown
-
1995
- 1995-12-13 GR GR950403529T patent/GR3018392T3/el unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017190714A1 (es) | 2016-05-04 | 2017-11-09 | Universidad De La Habana | Compuesto fenólico y combinación del mismo con una benzodiazepina fusionada a 1,4-dihidropiridina para el tratamiento de afecciones del sistema nervioso central y vascular |
Also Published As
| Publication number | Publication date |
|---|---|
| DE69205383D1 (de) | 1995-11-16 |
| AU2212692A (en) | 1993-03-11 |
| EP0531119A1 (en) | 1993-03-10 |
| GR3018392T3 (en) | 1996-03-31 |
| HU9202849D0 (en) | 1992-11-30 |
| DE69205383T2 (de) | 1996-03-21 |
| DK0531119T3 (da) | 1995-11-27 |
| JPH05194502A (ja) | 1993-08-03 |
| MX9204939A (es) | 1993-03-01 |
| ATE128978T1 (de) | 1995-10-15 |
| NZ244210A (en) | 1994-08-26 |
| EP0531119B1 (en) | 1995-10-11 |
| HUT65376A (en) | 1994-05-02 |
| AU652852B2 (en) | 1994-09-08 |
| KR930006000A (ko) | 1993-04-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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