ES2078277T3 - Una nueva arginina desiminasa, su metodo de fabricacion y un agente anti-cancer que contiene esta enzima como un ingrediente eficaz. - Google Patents

Una nueva arginina desiminasa, su metodo de fabricacion y un agente anti-cancer que contiene esta enzima como un ingrediente eficaz.

Info

Publication number
ES2078277T3
ES2078277T3 ES90114846T ES90114846T ES2078277T3 ES 2078277 T3 ES2078277 T3 ES 2078277T3 ES 90114846 T ES90114846 T ES 90114846T ES 90114846 T ES90114846 T ES 90114846T ES 2078277 T3 ES2078277 T3 ES 2078277T3
Authority
ES
Spain
Prior art keywords
enzyme
manufacturing
cancer agent
desiminase
effective ingredient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90114846T
Other languages
English (en)
Inventor
Haruo Takaku
Kaoru Miyazaki
Miho Aoshima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eneos Corp
Original Assignee
Japan Energy Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Energy Corp filed Critical Japan Energy Corp
Application granted granted Critical
Publication of ES2078277T3 publication Critical patent/ES2078277T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

DICHO COMPUESTO, DE APROXIMADAMENTE 45.000 DE PESO MOLELCULAR, DERIVADO DE MICROPLASMA, TIENE CAPACIDAD EN LA DESCOMPOSICION DE ARGININA. SE DESCRIBE TAMBIEN, EL METODO DE FABRICAR ESTE NUEVO ENZIMA DE MICROPLASMA. ESTE ENZIMA ES UN AGENTE ANTICANCERIGENO MUY EFECTIVO, TANTO IN VITRO COMO EN VIVO.
ES90114846T 1989-08-02 1990-08-02 Una nueva arginina desiminasa, su metodo de fabricacion y un agente anti-cancer que contiene esta enzima como un ingrediente eficaz. Expired - Lifetime ES2078277T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP20090289 1989-08-02

Publications (1)

Publication Number Publication Date
ES2078277T3 true ES2078277T3 (es) 1995-12-16

Family

ID=16432163

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90114846T Expired - Lifetime ES2078277T3 (es) 1989-08-02 1990-08-02 Una nueva arginina desiminasa, su metodo de fabricacion y un agente anti-cancer que contiene esta enzima como un ingrediente eficaz.

Country Status (12)

Country Link
US (1) US5474928A (es)
EP (1) EP0414007B1 (es)
JP (1) JP2900279B2 (es)
AT (1) ATE125295T1 (es)
CA (1) CA2022177C (es)
DE (1) DE69020979T2 (es)
DK (1) DK0414007T3 (es)
ES (1) ES2078277T3 (es)
FI (1) FI903826A7 (es)
IE (1) IE62120B1 (es)
NO (1) NO178734C (es)
PT (1) PT94882B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0956864A1 (en) * 1996-12-03 1999-11-17 Kyowa Hakko Kogyo Co., Ltd. Tissue fibrosis inhibitor
US5804183A (en) * 1997-01-31 1998-09-08 Enzon, Inc. Arginine deminase derived from mycoplasma arthritidis and polymer conjugates containing the same
US6635462B1 (en) 1997-05-12 2003-10-21 Phoenix Pharmacologies, Inc. Mutated form of arginine deiminase
US6183738B1 (en) 1997-05-12 2001-02-06 Phoenix Pharamacologics, Inc. Modified arginine deiminase
US6180387B1 (en) * 1997-08-11 2001-01-30 Smithkline Beecham Corporation Arginine deiminase
IT1298918B1 (it) * 1998-02-20 2000-02-07 Mendes Srl Uso di batteri dotati di arginina deiminasi per indurre apoptosi e/o ridurre una reazione infiammatoria e composizioni farmaceutiche
WO2002009741A1 (en) * 2000-07-27 2002-02-07 Angiolab, Inc. The pharmaceutical composition comprising arginine deiminase for inhibiting angiogenesis
ES2477118T3 (es) * 2002-11-18 2014-07-15 Polaris Group Método para inhibir la replicaci�n viral in vivo
FR2884717B1 (fr) 2005-04-25 2009-07-03 Erytech Pharma Soc Par Actions Erythrocytes renfermant de l'arginine deiminase
CN101002945B (zh) 2006-01-20 2012-09-05 清华大学 一种用于肿瘤治疗的新型复合物
FR2919804B1 (fr) 2007-08-08 2010-08-27 Erytech Pharma Composition et vaccin therapeutique anti-tumoral
EP2295560A1 (en) 2009-09-14 2011-03-16 RWTH Aachen University Directed evolution of arginine deiminase for increased activity at physiological pH
USRE48805E1 (en) 2013-03-06 2021-11-02 Vision Global Holdings Ltd. Method for cancer targeting treatment and detection of arginine using albumin-binding arginine deiminase fusion protein
US9255262B2 (en) 2013-03-06 2016-02-09 Vision Global Holdings Ltd. Albumin-binding arginine deminase and the use thereof
WO2014151982A2 (en) 2013-03-15 2014-09-25 Polaris Group Arginine deiminase with reduced cross-reactivity toward adi – peg 20 antibodies for cancer treatment
WO2015143006A1 (en) 2014-03-18 2015-09-24 Tdw Group Engineered chimeric pegylated adi and methods of use
US11613759B2 (en) 2015-09-04 2023-03-28 Sqz Biotechnologies Company Intracellular delivery of biomolecules to cells comprising a cell wall
CN109415741A (zh) 2016-05-03 2019-03-01 Sqz生物技术公司 细胞内递送生物分子以诱导耐受性
EP3534963B1 (en) 2016-11-02 2024-04-17 Polaris Group Formulations of pegylated arginine deiminase
WO2019042628A1 (en) 2017-08-31 2019-03-07 Erytech Pharma ARGININE DEIMINASE ENCAPSULATED WITHIN ERYTHROCYTES AND THEIR USE IN THE TREATMENT OF CANCER AND ARGINASE-1 DEFICIENCY
EP3449935A1 (en) 2017-08-31 2019-03-06 Erytech Pharma Arginine deiminase encapsulated inside erythrocytes and their use in treating cancer and arginase-1 deficiency

Also Published As

Publication number Publication date
CA2022177A1 (en) 1991-02-03
EP0414007A2 (en) 1991-02-27
EP0414007A3 (en) 1991-03-20
EP0414007B1 (en) 1995-07-19
US5474928A (en) 1995-12-12
JP2900279B2 (ja) 1999-06-02
DE69020979T2 (de) 1996-01-04
FI903826A0 (fi) 1990-08-01
NO903398D0 (no) 1990-08-01
NO903398L (no) 1991-02-04
NO178734C (no) 1996-05-22
IE62120B1 (en) 1994-12-14
NO178734B (no) 1996-02-12
ATE125295T1 (de) 1995-08-15
CA2022177C (en) 2001-02-27
IE902771A1 (en) 1991-02-27
JPH03164173A (ja) 1991-07-16
PT94882B (pt) 1997-07-31
FI903826A7 (fi) 1991-02-03
DK0414007T3 (da) 1995-09-04
DE69020979D1 (de) 1995-08-24
PT94882A (pt) 1991-05-22

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