ES2078337T3 - Derivado de sulfonamida y composicion farmaceutica que lo contiene. - Google Patents

Derivado de sulfonamida y composicion farmaceutica que lo contiene.

Info

Publication number
ES2078337T3
ES2078337T3 ES90904424T ES90904424T ES2078337T3 ES 2078337 T3 ES2078337 T3 ES 2078337T3 ES 90904424 T ES90904424 T ES 90904424T ES 90904424 T ES90904424 T ES 90904424T ES 2078337 T3 ES2078337 T3 ES 2078337T3
Authority
ES
Spain
Prior art keywords
group
substituted
diazacycloalkyl
residue
lower alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90904424T
Other languages
English (en)
Inventor
Akiro Kajihara
Shiro Miyoshi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Kasei Corp
Asahi Chemical Industry Co Ltd
Original Assignee
Asahi Chemical Industry Co Ltd
Asahi Kasei Kogyo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Chemical Industry Co Ltd, Asahi Kasei Kogyo KK filed Critical Asahi Chemical Industry Co Ltd
Application granted granted Critical
Publication of ES2078337T3 publication Critical patent/ES2078337T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

ESTA INVENCION DESCRIBE UN DERIVADO DE SULFONAMIDA DE LA FORMULA GENERAL (I) Y UN ANTIASMATICO CON UNA ACTIVIDAD BRONCODILATADORA Y CONTENIENDO DICHO DERIVADO COMO EL INGREDIENTE ACTIVO (I), DONDE X REPRESENTA UN RESIDUO DE QUINOLINA DE LA FORMULA (II) O UN RESIDUO DE ISOQUINOLINA DE LA FORMULA (III) (DONDE R ELEVADO 1 REPRESENTA UN HIDROGENO O ATOMO HALOGENO, O UN ALQUILO INFERIOR O GRUPO ALCOXI INFERIOR, Y R (AL CUADRADO) REPRESENTA UN ATOMO DE HIDROGENO O GRUPO HIDROXI); Y CUANDO X ES UN RESIDUO DE QUINOLINA (II), N ES 0 O 1 SIEMPRE QUE CUANDO N ES 0, R ELEVADO 4 REPRESENTE UN GRUPO DIAZACICLOALQUILO SUSTITUIDO O NO, MIENTRAS QUE CUANDO N ES 1, R ELEVADO 3 REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO INFERIOR Y R ELEVADO 4 REPRESENTA UN GRUPO ARALQUILAMINO SUSTITUIDO O NO, O UN GRUPO DIAZACICLOALQUILO SUSTITUIDO O NO, CUANDO X ES UN RESIDUO ISOQUINOLINO (III), N ES 1, R ELEVADO 3 REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO INFERIOR, Y R ELEVADO 4 REPRESENTE UN GRUPO 3, 4 METILENO-DIOXIFENELTILAMINO, UN GRUPO 3, 4-METILENODIOXI-BENZILAMINO O UN GRUPO DIAZACICLOALQUILO SUSTITUIDO O NO, SIEMPRE QUE CUANDO R ELEVADO 4 ES UN GRUPO DIAZACICLOALQUILO SUSTITUIDO O NO, DICHO GRUPO DIAZACICLOALQUILO ESTE UNIDO A LA CADENA PRINCIPAL EN EL CITOMO DE NITROGENO DE DICHO GRUPO.
ES90904424T 1990-03-08 1990-03-08 Derivado de sulfonamida y composicion farmaceutica que lo contiene. Expired - Lifetime ES2078337T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP1990/000303 WO1991013875A1 (en) 1990-03-08 1990-03-08 Sulfonamide derivative and pharmaceutical composition containing the same

Publications (1)

Publication Number Publication Date
ES2078337T3 true ES2078337T3 (es) 1995-12-16

Family

ID=13986411

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90904424T Expired - Lifetime ES2078337T3 (es) 1990-03-08 1990-03-08 Derivado de sulfonamida y composicion farmaceutica que lo contiene.

Country Status (8)

Country Link
EP (1) EP0471841B1 (es)
AT (1) ATE129702T1 (es)
CA (1) CA2020027C (es)
DE (1) DE69023335T2 (es)
DK (1) DK0471841T3 (es)
ES (1) ES2078337T3 (es)
NO (1) NO177532C (es)
WO (1) WO1991013875A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5340811A (en) * 1990-03-08 1994-08-23 Asahi Kasei Kogyo Kabushiki Kaisha Isoquinoline-or quinoline-sulfonamide derivative and a pharmaceutical composition comprising the same
US5707985A (en) * 1995-06-07 1998-01-13 Tanabe Seiyaku Co. Ltd. Naphthyl-, quinolyl- and isoquinolyl- sulfonamide derivatives as cell adhesion modulators

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58121278A (ja) * 1982-01-12 1983-07-19 Asahi Chem Ind Co Ltd イソキノリンスルホン酸アミド誘導体
US4456757A (en) * 1981-03-20 1984-06-26 Asahi Kasei Kogyo Kabushiki Kaisha Isoquinolinesulfonyl derivatives and process for the preparation thereof
JPH0667926B2 (ja) * 1985-11-12 1994-08-31 旭化成工業株式会社 環状のイソキノリンスルホンアミド誘導体
US4857301A (en) * 1987-09-25 1989-08-15 Schering Corporation Sulfonamide compounds, compositions and method of use
JPH0273068A (ja) * 1988-09-09 1990-03-13 Asahi Chem Ind Co Ltd 新規なフェネチルアミン誘導体及びその酸付加塩
JP2681493B2 (ja) * 1988-09-09 1997-11-26 旭化成工業株式会社 新規なエチレンジアミン誘導体及びその酸付加塩

Also Published As

Publication number Publication date
DK0471841T3 (da) 1995-12-04
EP0471841A4 (en) 1992-08-19
EP0471841B1 (en) 1995-11-02
NO177532C (no) 1995-10-04
DE69023335T2 (de) 1996-07-11
DE69023335D1 (de) 1995-12-07
CA2020027C (en) 1996-10-15
CA2020027A1 (en) 1991-09-09
NO177532B (no) 1995-06-26
ATE129702T1 (de) 1995-11-15
EP0471841A1 (en) 1992-02-26
NO902741L (no) 1990-08-17
NO902741D0 (no) 1990-06-20
WO1991013875A1 (en) 1991-09-19

Similar Documents

Publication Publication Date Title
EA200200374A1 (ru) Производные хинолилпропилпиперидина, их получение и содержащие их композиции
CO5050332A1 (es) Composiciones fungicidas que comprenden 2-metoxibenzofenonas
FI931067A0 (fi) Antitumoera foereningar
EP0787726A4 (es)
MX9306425A (es) Compuestos benzoheterociclicos, procedimiento parasu preparacion y composiciones antagonistas de la vasopresina y la oxitocina, que contienen dichos compuestos.
BR9900788A (pt) Compostos ésteres.
FI914187A0 (fi) Menetelmä valmistaa kaavan /I/ mukaista 1-metyylikarbapeneemijohdosta
AU5504694A (en) Substituted amic acid derivatives
ATE204272T1 (de) Neue pyridon carbonsäure-derivate
NZ222185A (en) N-substituted methanesulphonamide derivatives, and anticancer compositions containing such
DK0420121T3 (da) Antitumormiddel
MY101862A (en) Dry pesticidal compositions
DK0471841T3 (da) Sulfonamidderivat og en farmaceutisk sammensætning indeholdende samme
EP0245902A3 (en) Benzothiazinone derivatives
DK35387D0 (da) Quinolinderivater og fremgangsmaade til fremstilling deraf samt midler indeholdende derivaterne
GR3015604T3 (en) Novel organo-tin compounds having anti-tumour activity and anti-tumour compositions.
DE3781986D1 (de) Substituierte chinoxaline.
ATE189813T1 (de) Prostaglandin-i-analoga
AU5977980A (en) Aminodeoxyclavulanic acids
ATE206699T1 (de) Uch-15-verbindungen
ES2184311T3 (es) Polioxaalcanocarboxilatos de estaño y composiciones que los contienen.
ATE74604T1 (de) Substituierte pyrimidochinoxaline.
SE8206378D0 (sv) Nya kelatbildande kinolinforeningar

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 471841

Country of ref document: ES