ES2079982T3 - Procedimiento para la preparacion de derivados del taxano. - Google Patents

Procedimiento para la preparacion de derivados del taxano.

Info

Publication number
ES2079982T3
ES2079982T3 ES93918756T ES93918756T ES2079982T3 ES 2079982 T3 ES2079982 T3 ES 2079982T3 ES 93918756 T ES93918756 T ES 93918756T ES 93918756 T ES93918756 T ES 93918756T ES 2079982 T3 ES2079982 T3 ES 2079982T3
Authority
ES
Spain
Prior art keywords
general formula
radical
procedure
preparation
taxane derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93918756T
Other languages
English (en)
Inventor
Dominique Deprez
Jean-Pierre Pulicani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Rhone Poulenc Rorer SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer SA filed Critical Rhone Poulenc Rorer SA
Application granted granted Critical
Publication of ES2079982T3 publication Critical patent/ES2079982T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
    • C25B11/00—Electrodes; Manufacture thereof not otherwise provided for
    • C25B11/04—Electrodes; Manufacture thereof not otherwise provided for characterised by the material
    • C25B11/042—Electrodes formed of a single material
    • C25B11/043—Carbon, e.g. diamond or graphene
    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
    • C25B11/00—Electrodes; Manufacture thereof not otherwise provided for
    • C25B11/04—Electrodes; Manufacture thereof not otherwise provided for characterised by the material
    • C25B11/042—Electrodes formed of a single material
    • C25B11/046—Alloys
    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
    • C25B3/00—Electrolytic production of organic compounds
    • C25B3/01—Products
    • C25B3/05—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
    • C25B3/00—Electrolytic production of organic compounds
    • C25B3/01—Products
    • C25B3/07—Oxygen containing compounds
    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
    • C25B3/00—Electrolytic production of organic compounds
    • C25B3/01—Products
    • C25B3/09—Nitrogen containing compounds
    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
    • C25B3/00—Electrolytic production of organic compounds
    • C25B3/20—Processes
    • C25B3/25—Reduction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Materials Engineering (AREA)
  • Metallurgy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Electrolytic Production Of Non-Metals, Compounds, Apparatuses Therefor (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION POR VIA ELECTROQUIMICA DE DERIVADOS DEL TAXANO DE FORMULA GENERAL (I) A PARTIR DE UN PRODUCTO DE LA FORMULA GENERAL (II). EN LA FORMULA GENERAL (I), AR REPRESENTA UN RADICAL ARILO, R1 REPRESENTA UN RADICAL BENZOILO O UN RADICAL R2 ALQUILO, ALQUENILO, ALQUINILO, CICLOALQUILO, CICLOALQUENILO, BICICLOALQUILO, FENILO O HETEROCICLILO Y R2 REPRESENTA UN ATOMO DE HIDROGENO O EL RADICAL ACETILO. EN LA FORMULA GENERAL (II), AR Y R SE DEFINEN COMO EN LA FORMULA GENERAL (I), R'' REPRESENTA UN RADICAL ACETILO O TRICLORO RESENTA UN RADICAL TRICLORO ENTA UN ATOMO DE HIDROGENO. LOS PRODUCTOS DE FORMULA GENERAL (I) PRESENTAN IMPORTANTES PROPIEDADES ANTITUMORALES.
ES93918756T 1992-03-13 1993-03-11 Procedimiento para la preparacion de derivados del taxano. Expired - Lifetime ES2079982T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9203000A FR2688518B1 (fr) 1992-03-13 1992-03-13 Procede de preparation de derives du taxane.

Publications (1)

Publication Number Publication Date
ES2079982T3 true ES2079982T3 (es) 1996-01-16

Family

ID=9427641

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93918756T Expired - Lifetime ES2079982T3 (es) 1992-03-13 1993-03-11 Procedimiento para la preparacion de derivados del taxano.

Country Status (21)

Country Link
EP (1) EP0630428B1 (es)
JP (1) JPH07504461A (es)
KR (1) KR950700439A (es)
AT (1) ATE130053T1 (es)
AU (1) AU3756393A (es)
CA (1) CA2117552A1 (es)
CZ (1) CZ218694A3 (es)
DE (1) DE69300766T2 (es)
DK (1) DK0630428T3 (es)
ES (1) ES2079982T3 (es)
FI (1) FI944190A7 (es)
FR (1) FR2688518B1 (es)
GR (1) GR3018036T3 (es)
HU (1) HUT68282A (es)
MX (1) MX9301345A (es)
NO (1) NO943371D0 (es)
RU (1) RU94041682A (es)
SK (1) SK108494A3 (es)
TW (1) TW235961B (es)
WO (1) WO1993018210A1 (es)
ZA (1) ZA931800B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6794523B2 (en) 1991-09-23 2004-09-21 Florida State University Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them
DK0690867T3 (da) * 1993-03-22 2003-06-10 Univ Florida State Taxaner med furyl- eller thienylsubstitueret sidekæde
US5760251A (en) * 1995-08-11 1998-06-02 Sepracor, Inc. Taxol process and compounds
US6103698A (en) 1997-03-13 2000-08-15 Basf Aktiengesellschaft Dolastatin-15 derivatives in combination with taxanes
SI2264172T1 (sl) 2002-04-05 2017-12-29 Roche Innovation Center Copenhagen A/S Oligomerne spojine za modulacijo izražanja HIF-1alfa
US7713738B2 (en) 2003-02-10 2010-05-11 Enzon Pharmaceuticals, Inc. Oligomeric compounds for the modulation of survivin expression
JP4642775B2 (ja) 2003-12-23 2011-03-02 サンタリス ファーマ アー／エス Ｂｃｌ−２のモデュレーションのためのオリゴマー化合物
US9447138B2 (en) 2004-11-09 2016-09-20 Roche Innovation Center Copenhagen A/S Potent LNA oligonucleotides for the inhibition of HIF-1a expression
MX2007005558A (es) 2004-11-09 2008-01-31 Santaris Pharma As Oligonucleotidos de lna potentes para la inhibicion dela expresion de hif-1a.
CA2586701C (en) 2004-11-09 2014-06-03 Santaris Pharma A/S Lna oligonucleotides and the treatment of cancer
WO2026090323A1 (en) 2024-10-23 2026-04-30 Incyte Corporation Combination therapy using a kras g12d inhibitor, and a nucleoside analog, and/or a microtubule inhibitor and its use in the treatment of cancer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60187689A (ja) * 1984-03-06 1985-09-25 Otsuka Chem Co Ltd ３−エキソメチレンセフアム誘導体の製造法
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2629818B1 (fr) * 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
FR2664894A1 (fr) * 1990-07-19 1992-01-24 Rhone Poulenc Sante Nouveaux derives de streptogramines et leur preparation.

Also Published As

Publication number Publication date
FI944190A0 (fi) 1994-09-12
EP0630428B1 (fr) 1995-11-08
FI944190A7 (fi) 1994-09-12
NO943371L (no) 1994-09-12
CZ218694A3 (en) 1995-02-15
ZA931800B (en) 1993-09-30
GR3018036T3 (en) 1996-02-29
AU3756393A (en) 1993-10-05
RU94041682A (ru) 1996-07-20
KR950700439A (ko) 1995-01-16
FR2688518A1 (fr) 1993-09-17
ATE130053T1 (de) 1995-11-15
CA2117552A1 (fr) 1993-09-16
DE69300766T2 (de) 1996-04-18
SK108494A3 (en) 1995-02-08
FR2688518B1 (fr) 1994-05-06
JPH07504461A (ja) 1995-05-18
DE69300766D1 (de) 1995-12-14
WO1993018210A1 (fr) 1993-09-16
DK0630428T3 (da) 1995-12-27
MX9301345A (es) 1993-09-01
NO943371D0 (no) 1994-09-12
EP0630428A1 (fr) 1994-12-28
HUT68282A (en) 1995-04-03
HU9402614D0 (en) 1994-11-28
TW235961B (es) 1994-12-11

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