ES2148758T3 - Nuevos taxoides, su preparacion y las composiciones farmaceuticas que les contienen. - Google Patents

Nuevos taxoides, su preparacion y las composiciones farmaceuticas que les contienen.

Info

Publication number
ES2148758T3
ES2148758T3 ES96913578T ES96913578T ES2148758T3 ES 2148758 T3 ES2148758 T3 ES 2148758T3 ES 96913578 T ES96913578 T ES 96913578T ES 96913578 T ES96913578 T ES 96913578T ES 2148758 T3 ES2148758 T3 ES 2148758T3
Authority
ES
Spain
Prior art keywords
radical
general formula
contain
preparation
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96913578T
Other languages
English (en)
Inventor
Herve Bouchard
Alain Commercon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Aventis Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma SA filed Critical Aventis Pharma SA
Application granted granted Critical
Publication of ES2148758T3 publication Critical patent/ES2148758T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NUEVOS TAXOIDES DE FORMULA GENERAL (I), SU PREPARACION Y LAS COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN. EN LA FORMULA GENERAL (I), Z REPRESENTA UN ATOMO DE HIDROGENO O UN RADICAL DE FORMULA GENERAL (II) EN LA QUE R SUB,1} REPRESENTA UN RADICAL BENZOILO EVENTUALMENTE SUSTITUIDO O UN RADICAL R SUB,2} O ENILO, ALCINILO, CICLOALCOILO, CICLOALCENILO, BICICLOALCOILO, FENILO EVENTUALMENTE SUSTITUIDO O HETEROCICLILO, R SUB,3} REPRESENTA UN RADICAL ALCOILO, ALCENILO, ALCINILO, CICLOALCOILO, FENILO, NAFTILO O HETEROCICLICO AROMATICO, R SUB,4} REPRESENTA UN RADICAL ALCOXI, ALCENILOXI, ALCINILOXY, CICLOALCILOXI O CICLOALCENILOXI, EVENTUALMENTE SUSTITUIDO. LOS NUEVOS PRODUCTOS DE FORMULA GENERAL (I) EN LA QUE Z REPRESENTA UN RADICAL DE FORMULA GENERAL (II) PRESENTAN PROPIEDADES ANTITUMORALES Y ANTILEUCEMICAS NOTABLES.
ES96913578T 1995-04-14 1996-04-12 Nuevos taxoides, su preparacion y las composiciones farmaceuticas que les contienen. Expired - Lifetime ES2148758T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9504559A FR2732968B1 (fr) 1995-04-14 1995-04-14 Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
ES2148758T3 true ES2148758T3 (es) 2000-10-16

Family

ID=9478163

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96913578T Expired - Lifetime ES2148758T3 (es) 1995-04-14 1996-04-12 Nuevos taxoides, su preparacion y las composiciones farmaceuticas que les contienen.

Country Status (16)

Country Link
US (1) US5906990A (es)
EP (1) EP0820448B1 (es)
JP (1) JP4308905B2 (es)
AR (1) AR002041A1 (es)
AT (1) ATE193533T1 (es)
AU (1) AU5652296A (es)
DE (1) DE69608680T2 (es)
DK (1) DK0820448T3 (es)
ES (1) ES2148758T3 (es)
FR (1) FR2732968B1 (es)
GR (1) GR3033591T3 (es)
IL (1) IL117878A (es)
PT (1) PT820448E (es)
TW (1) TW349095B (es)
WO (1) WO1996032387A1 (es)
ZA (1) ZA962900B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2240468A1 (en) 1995-09-11 1997-03-20 Peter C. Michels Biocatalytic methods for synthesizing and identifying biologically active compounds
US6156789A (en) * 1998-03-17 2000-12-05 Rhone-Poulenc Rorer S.A. Method for treating abnormal cell proliferation in the brain
KR20010079665A (ko) * 1998-08-20 2001-08-22 추후제출 탁소이드 유도체의 신규 용도
EP0982028A1 (en) * 1998-08-20 2000-03-01 Aventis Pharma S.A. New use of taxoid derivatives
CA2365776A1 (en) * 1999-05-03 2000-11-09 Alain Renard Method for treating abnormal cell proliferation in the brain
MXPA01009921A (es) 2000-02-02 2003-08-01 Univ Florida State Res Found Taxanos sustituidos como carbamoiloxilo en c10 como agentes antitumorales.
PL350028A1 (en) * 2000-02-02 2002-10-21 Univ Florida State Res Found C10 carbonate substituted taxanes as antitumor agents
US6649632B2 (en) 2000-02-02 2003-11-18 Fsu Research Foundation, Inc. C10 ester substituted taxanes
WO2002066448A1 (en) * 2001-02-20 2002-08-29 Dabur India Limited Method of preparation of paclitaxel (taxol) using 3-(alk-2-ynyloxy) carbonyl-5-oxazolidine carboxylic acid
FR2853651B1 (fr) * 2003-04-14 2005-05-20 Aventis Pharma Sa Procede de preparation du 4,10 beta-diacetoxy-2 alpha- benzoyloxy-5 beta, 20-epoxy-1, 13 alpha-dihydroxy-9-oxo-19- norcyclopropa[g]tax-11-ene
US6956124B2 (en) 2003-04-14 2005-10-18 Aventis Pharma S.A. Process for the preparation of 4,10β-diacetoxy-2α-benzoyloxy-5β,20-epoxy-1,13α-dihydroxy-9-oxo-19-norcyclopropa[g]tax-11-ene
EP1663153A4 (en) * 2003-05-20 2011-01-05 Aronex Pharmaceuticals Inc COMBINATION SCHEMOTHERAPY WITH A LIPOSOMAL PLATINUM COMPLEX
US7064980B2 (en) * 2003-09-17 2006-06-20 Sandisk Corporation Non-volatile memory and method with bit line coupled compensation
SV2006002010A (es) * 2004-02-13 2006-08-23 Univ Florida State Res Found Taxanos sustituidos con esteres de ciclopentilo en c10
MX2007009748A (es) * 2005-02-14 2007-09-26 Univ Florida State Res Found Composiciones de taxano sustituidas con esteres ciclopropilicos en c10.
US20090076127A1 (en) * 2007-09-19 2009-03-19 Protia, Llc Deuterium-enriched larotaxel
EP2276755A4 (en) * 2008-03-31 2011-05-04 Univ Florida State Res Found C (10) -ETHYESTER- AND C (10) -CYCLOPROPYLESTER-SUBSTITUTED TAXANES
EP2177630A1 (en) * 2008-10-02 2010-04-21 Institut Gustave Roussy Methods for predicting or monitoring whether a patient affected by a cancer is responsive to a treatment with a molecule of the taxoid family

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5254580A (en) * 1993-01-19 1993-10-19 Bristol-Myers Squibb Company 7,8-cyclopropataxanes
US5294637A (en) * 1992-07-01 1994-03-15 Bristol-Myers Squibb Company Fluoro taxols
FR2698871B1 (fr) * 1992-12-09 1995-02-24 Rhone Poulenc Rorer Sa Nouveau taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
FR2710642B1 (fr) * 1993-09-29 1995-11-17 Rhone Poulenc Rorer Sa Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
US5395850A (en) * 1994-03-10 1995-03-07 Bristol-Myers Squibb Company 6,7-epoxy paclitaxels
FR2718135B1 (fr) * 1994-04-05 1996-04-26 Rhone Poulenc Rorer Sa Procédé de préparation d'hydroxy-7 taxanes.

Also Published As

Publication number Publication date
GR3033591T3 (en) 2000-09-29
EP0820448A1 (fr) 1998-01-28
JP4308905B2 (ja) 2009-08-05
JPH11503443A (ja) 1999-03-26
IL117878A (en) 2001-03-19
AR002041A1 (es) 1998-01-07
IL117878A0 (en) 1996-08-04
WO1996032387A1 (fr) 1996-10-17
AU5652296A (en) 1996-10-30
ZA962900B (en) 1996-07-30
FR2732968A1 (fr) 1996-10-18
DK0820448T3 (da) 2000-08-21
TW349095B (en) 1999-01-01
FR2732968B1 (fr) 1997-05-16
DE69608680D1 (de) 2000-07-06
DE69608680T2 (de) 2000-10-19
PT820448E (pt) 2000-09-29
ATE193533T1 (de) 2000-06-15
US5906990A (en) 1999-05-25
EP0820448B1 (fr) 2000-05-31

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