ES2080137T3 - Composicion oftalmica. - Google Patents
Composicion oftalmica.Info
- Publication number
- ES2080137T3 ES2080137T3 ES90870103T ES90870103T ES2080137T3 ES 2080137 T3 ES2080137 T3 ES 2080137T3 ES 90870103 T ES90870103 T ES 90870103T ES 90870103 T ES90870103 T ES 90870103T ES 2080137 T3 ES2080137 T3 ES 2080137T3
- Authority
- ES
- Spain
- Prior art keywords
- ophthalmic composition
- gmp
- monophosphate
- bromoguanosine
- phosphodiesterases
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- RQFCJASXJCIDSX-UUOKFMHZSA-N guanosine 5'-monophosphate Chemical compound C1=2NC(N)=NC(=O)C=2N=CN1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O RQFCJASXJCIDSX-UUOKFMHZSA-N 0.000 abstract 2
- 235000013928 guanylic acid Nutrition 0.000 abstract 2
- DESCTCWKDLHEJQ-YEOHUATISA-N 2-amino-8-bromo-9-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3h-purin-6-one;phosphoric acid Chemical compound OP(O)(O)=O.C1=2NC(N)=NC(=O)C=2N=C(Br)N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O DESCTCWKDLHEJQ-YEOHUATISA-N 0.000 abstract 1
- ZOOGRGPOEVQQDX-UUOKFMHZSA-N 3',5'-cyclic GMP Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=C(NC2=O)N)=C2N=C1 ZOOGRGPOEVQQDX-UUOKFMHZSA-N 0.000 abstract 1
- 102000004861 Phosphoric Diester Hydrolases Human genes 0.000 abstract 1
- 108090001050 Phosphoric Diester Hydrolases Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 230000004410 intraocular pressure Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Ophthalmology & Optometry (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
SE PRESENTA UN NUEVO COMPUESTO OFATALMOLOGICO PARA HACER DESCENDER LA PRESION INTRAOCULAR QUE COMPRENDE UN ANALOGO DEL MONOFOSFATO DE GUANOSINA CICLICA (GMP) EL CUAL ES MAS RESISTENTE A LA HIDROLISIS MEDIANTE LAS FOSFODIESTERASAS QUE EL GMP CICLICO. EL ANALOGO MAS ADECUADO DEL GMP CICLICO ES EL MONOFOSFATO 3,5''- CICLICO DE 8-BROMOGUANOSINA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37372589A | 1989-06-29 | 1989-06-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2080137T3 true ES2080137T3 (es) | 1996-02-01 |
Family
ID=23473611
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES90870103T Expired - Lifetime ES2080137T3 (es) | 1989-06-29 | 1990-06-26 | Composicion oftalmica. |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0406210B1 (es) |
| JP (1) | JPH0338526A (es) |
| AT (1) | ATE128357T1 (es) |
| CA (1) | CA2020085A1 (es) |
| DE (1) | DE69022638T2 (es) |
| DK (1) | DK0406210T3 (es) |
| ES (1) | ES2080137T3 (es) |
| GR (1) | GR3018267T3 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT409967B (de) | 2000-10-17 | 2002-12-27 | Solutia Austria Gmbh | Zweikomponentensysteme auf basis von wasserlöslichen polyestern und verkappten isocyanaten zur formulierung von wasserverdünnbaren einbrennlacken |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4753945A (en) * | 1986-02-19 | 1988-06-28 | Eye Research Institute Of Retina Foundation | Stimulation of tear secretion with phosphodiesterase inhibitors |
| ATE191145T1 (de) * | 1987-01-23 | 2000-04-15 | Gen Hospital Corp | Hydralazin zur topischen behandlung von glaukom |
-
1990
- 1990-06-26 DE DE69022638T patent/DE69022638T2/de not_active Expired - Fee Related
- 1990-06-26 DK DK90870103.0T patent/DK0406210T3/da active
- 1990-06-26 EP EP90870103A patent/EP0406210B1/en not_active Expired - Lifetime
- 1990-06-26 AT AT90870103T patent/ATE128357T1/de not_active IP Right Cessation
- 1990-06-26 ES ES90870103T patent/ES2080137T3/es not_active Expired - Lifetime
- 1990-06-28 CA CA002020085A patent/CA2020085A1/en not_active Abandoned
- 1990-06-28 JP JP2168629A patent/JPH0338526A/ja active Pending
-
1995
- 1995-11-30 GR GR950403384T patent/GR3018267T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK0406210T3 (da) | 1995-12-04 |
| JPH0338526A (ja) | 1991-02-19 |
| EP0406210B1 (en) | 1995-09-27 |
| EP0406210A2 (en) | 1991-01-02 |
| ATE128357T1 (de) | 1995-10-15 |
| DE69022638T2 (de) | 1996-04-18 |
| EP0406210A3 (en) | 1991-10-09 |
| GR3018267T3 (en) | 1996-02-29 |
| DE69022638D1 (de) | 1995-11-02 |
| CA2020085A1 (en) | 1990-12-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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