ATE130039T1 - Selektive enzymatische acylierung von einem der enantiomere einer racemischen 3-aminoazetidinone. - Google Patents

Selektive enzymatische acylierung von einem der enantiomere einer racemischen 3-aminoazetidinone.

Info

Publication number
ATE130039T1
ATE130039T1 AT91305110T AT91305110T ATE130039T1 AT E130039 T1 ATE130039 T1 AT E130039T1 AT 91305110 T AT91305110 T AT 91305110T AT 91305110 T AT91305110 T AT 91305110T AT E130039 T1 ATE130039 T1 AT E130039T1
Authority
AT
Austria
Prior art keywords
racemic
aminoazetidinone
enantiomers
selective enzymatic
enzymatic acylation
Prior art date
Application number
AT91305110T
Other languages
English (en)
Inventor
Jeffrey Neal Levy
Milton Joseph Zmijewski Jr
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE130039T1 publication Critical patent/ATE130039T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
    • C12P41/007—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures by reactions involving acyl derivatives of racemic amines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT91305110T 1990-06-08 1991-06-06 Selektive enzymatische acylierung von einem der enantiomere einer racemischen 3-aminoazetidinone. ATE130039T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53508690A 1990-06-08 1990-06-08
US07/591,586 US5057607A (en) 1990-06-08 1990-10-02 Enantiomerically selective biocatalyzed acylation

Publications (1)

Publication Number Publication Date
ATE130039T1 true ATE130039T1 (de) 1995-11-15

Family

ID=27064707

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91305110T ATE130039T1 (de) 1990-06-08 1991-06-06 Selektive enzymatische acylierung von einem der enantiomere einer racemischen 3-aminoazetidinone.

Country Status (13)

Country Link
US (1) US5057607A (de)
EP (1) EP0460949B1 (de)
JP (1) JP2971621B2 (de)
KR (1) KR0169995B1 (de)
AT (1) ATE130039T1 (de)
CA (1) CA2043763C (de)
DE (1) DE69114363T2 (de)
DK (1) DK0460949T3 (de)
ES (1) ES2080899T3 (de)
GR (1) GR3018170T3 (de)
HU (1) HU211034B (de)
IE (1) IE69754B1 (de)
IL (1) IL98351A (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5550231A (en) * 1993-06-15 1996-08-27 Eli Lilly And Company Loracarbef hydrochloride C1-C3 alcohol solvates and uses thereof
DE4332738A1 (de) * 1993-09-25 1995-03-30 Basf Ag Racematspaltung primärer und sekundärer Amine durch Enzym-katalysierte Acylierung
DK0801683T3 (da) 1995-02-03 2002-06-17 Basf Ag Racematspaltning af primære og sekundære heteroatomsubstituerede aminer ved enzymkatalyseret acylering
AU7359198A (en) * 1997-05-01 1998-11-27 G.D. Searle & Co. Method and apparatus for preparation of chiral beta amino acids
DE19727517A1 (de) * 1997-06-30 1999-01-07 Basf Ag Racematspaltung von Aminosäureestern durch Enzym-katalysierte Acylierung
NL1009814C2 (nl) * 1998-08-06 2000-02-08 Dsm Nv Werkwijze voor de bereiding van een N-geacyleerd aminonitril.
DE19904207A1 (de) 1999-02-03 2000-08-10 Basf Ag Verfahren zur Herstellung von Estern
US6617451B1 (en) 1999-07-23 2003-09-09 Eli Lilly And Company Enantioselective acylation of cis racemic azetidinones
DE19956786A1 (de) * 1999-11-25 2001-05-31 Basf Ag Verfahren zur Herstellung optisch aktiver Amine
KR20020087500A (ko) * 2000-12-23 2002-11-23 주식회사대웅제약 3-치환 아제티디논의 제조방법
JP4457660B2 (ja) * 2003-12-12 2010-04-28 パナソニック株式会社 画像分類装置、画像分類システム、画像分類に関するプログラム、およびそのプログラムを記録したコンピュータ読み取り可能な記録媒体

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3150059A (en) * 1962-12-26 1964-09-22 Lilly Co Eli Penicillin deacylation via actinoplanaceae fermentation
GB1369462A (en) * 1971-11-23 1974-10-09 Beecham Group Ltd Enzymic resolution of racemic n-acyl-dl-amino acids
US4316958A (en) * 1979-02-10 1982-02-23 Kyowa Hakko Kogyo Co., Ltd. Process for producing optically active cephalosporin analogs
JPS5672698A (en) * 1979-11-14 1981-06-16 Kyowa Hakko Kogyo Co Ltd Preparation of optically active cephalosporin analogue
US4332896A (en) * 1979-04-14 1982-06-01 Kyowa Hakko Kogyo Co., Ltd. Process for producing cephalosporin analogs
DE3048612C2 (de) * 1980-12-23 1982-12-02 Hoechst Ag, 6000 Frankfurt "Verfahren zur enzymatischen Trennung von L-2-Ami no-4-methylphosphinobuttersäure"
DE3435156A1 (de) * 1984-09-25 1986-04-03 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur herstellung der stereoisomeren von 1-amino-alkylphosphonsaeuren oder 1-aminoalkylphosphinsaeuren
GB8728121D0 (en) * 1987-12-01 1988-01-06 Ciba Geigy Ag Resolution process
US4931556A (en) * 1988-10-17 1990-06-05 Eli Lilly And Company Method of resolving cis 3-amino-4-(2-(2-furyl)eth-1-yl)-methoxycarbonylmethyl-azetidin-2-one and malic acid salts thereof

Also Published As

Publication number Publication date
EP0460949A2 (de) 1991-12-11
EP0460949B1 (de) 1995-11-08
IL98351A0 (en) 1992-07-15
DK0460949T3 (da) 1995-12-11
DE69114363T2 (de) 1996-04-25
IE911958A1 (en) 1991-12-18
US5057607A (en) 1991-10-15
IE69754B1 (en) 1996-10-02
HUT61604A (en) 1993-01-28
CA2043763A1 (en) 1991-12-09
ES2080899T3 (es) 1996-02-16
EP0460949A3 (en) 1992-10-21
HU211034B (en) 1995-09-28
HU911918D0 (en) 1991-12-30
JPH04341196A (ja) 1992-11-27
KR920000942A (ko) 1992-01-29
IL98351A (en) 1996-07-23
GR3018170T3 (en) 1996-02-29
DE69114363D1 (de) 1995-12-14
CA2043763C (en) 2001-05-15
KR0169995B1 (ko) 1999-02-01
JP2971621B2 (ja) 1999-11-08

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee