ES2081966T3 - Derivados heterociclicos benzocondensados que contienen n. - Google Patents

Derivados heterociclicos benzocondensados que contienen n.

Info

Publication number
ES2081966T3
ES2081966T3 ES90830040T ES90830040T ES2081966T3 ES 2081966 T3 ES2081966 T3 ES 2081966T3 ES 90830040 T ES90830040 T ES 90830040T ES 90830040 T ES90830040 T ES 90830040T ES 2081966 T3 ES2081966 T3 ES 2081966T3
Authority
ES
Spain
Prior art keywords
alkyl
rent
link
present
arylalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90830040T
Other languages
English (en)
Inventor
Rosamaria Micheletti
Henri Nico Doods
Marco Turconi
Angelo Sagrada
Arturo Donetti
Battista Giovanni Schiavi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Italia SpA
Original Assignee
Boehringer Ingelheim Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Italia SpA filed Critical Boehringer Ingelheim Italia SpA
Application granted granted Critical
Publication of ES2081966T3 publication Critical patent/ES2081966T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/12—Oxygen atoms acylated by aromatic or heteroaromatic carboxylic acids, e.g. cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Indole Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

SE DESCRIBEN DERIVADOS HETEROCICLICOS CONTENIENDO BENCENO ENLAZADO EN LA POSICION N, FARMACOLOGICAMENTE ACTIVOS COMO AGENTES DE BLOQUEO DE RECEPTORES MUSCARINICOS, USADOS PARA EL TRATAMIENTO DE DESORDENES GASTROINTESTINALES Y DEL TRACTO RESPIRATORIO, DE LA SIGUIENTE FORMULA: EN DONDE R REPRESENTA H O C1-6 ALQUILO; R1 Y R2 REPRESENTAN H, HALOGENO, C1-6 ALQUILO, C1-6 ALCOXILO, C1-6 ALQUILTIO, C1-6 ALCOXICARBONILO, CARBOXILO, HIDROXILO, NITROGENO, CIANO, CARBAMOIL OPCIONALMENTE MONO- O ALQUILO C1-4 DISUBSTITUIDO, AMINO OPCIONALMENTE MONO- O C1-4 ALQUILO DISUBSTITUIDO, ACILAMINO C1-6, C1-4 ALCOXI CARBONILAMINO, C1-6 ALQUILSULFINILO, C1-6 ALQUILSULFONILO, C1-6 ACILO; R3 REPRESENTA H, C1-6 ALQUILO, ARILO, ARILALQUILO O PUEDE NO ESTAR PRESENTE; A REPRESENTA CO,C = S, S-, O O B REPRESENTA NITROGENO CUANDO R3 NO ESTA PRESENTE Y EL ENLACE B-D ES UNICO, O ES CARBONO; D REPRESENTA CO, CH2-CH2, CUANDO EL ENLACE B-D ES UNICO, O D ES C-R CUANDO EL ENLACE D-B ES DOBLE, EN LA CUAL R4 REPRESENTA H, ALQUILOC1-6, ARILO, ARILALQUILO, HIDROXILO, ALCOXILO C1-4 Y R5 REPRESENTA H; X REPRESENTA OXIGENO, N-R O NO ESTA PRESENTE; Y REPRESENTA UN GRUPO BASICO SELECCIONADO ENTRE: EN DONDE N ES 2 O 3; P ES 0 O 1 A LA VEZ, O NO, EN SUS DOS OCURRENCIAS; Q ES 0,2 O 3; R6 Y R7 PUEDEN SER A LA VEZ, O NO, H, ALQUILO C1-4, ARILALQUILO O, CUANDO R7 ES H O ALQUILO C1-4, R6 PUEDE SER EN DONDE R8 REPRESENTA H, ALQUILO C1-4 O AMINO. TAMBIEN SE DESCRIBEN LOS PROCESOS PARA LA PREPARACION DE LOS COMPUESTOS DE LA FORMULA (I), AL IGUAL QUE, COMPOSICIONES FARMACEUTICAS CONTENIENDOLOS.
ES90830040T 1989-02-06 1990-02-05 Derivados heterociclicos benzocondensados que contienen n. Expired - Lifetime ES2081966T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8919316A IT1228293B (it) 1989-02-06 1989-02-06 Benzoderivati di composti eterociclici contenenti azoto.

Publications (1)

Publication Number Publication Date
ES2081966T3 true ES2081966T3 (es) 1996-03-16

Family

ID=11156671

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90830040T Expired - Lifetime ES2081966T3 (es) 1989-02-06 1990-02-05 Derivados heterociclicos benzocondensados que contienen n.

Country Status (23)

Country Link
US (1) US5106851A (es)
EP (1) EP0382687B1 (es)
JP (1) JPH03197462A (es)
KR (1) KR900012919A (es)
AT (1) ATE132140T1 (es)
AU (1) AU623733B2 (es)
CA (1) CA2009300A1 (es)
CZ (1) CZ277886B6 (es)
DE (1) DE69024381T2 (es)
DK (1) DK0382687T3 (es)
ES (1) ES2081966T3 (es)
FI (1) FI96686C (es)
GR (1) GR3018549T3 (es)
HU (2) HUT54118A (es)
IL (1) IL93257A (es)
IT (1) IT1228293B (es)
MX (1) MX19368A (es)
NO (1) NO173500C (es)
PL (1) PL162682B1 (es)
PT (1) PT93066B (es)
RU (1) RU2040524C1 (es)
YU (1) YU21590A (es)
ZA (1) ZA90825B (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1226389B (it) * 1988-07-12 1991-01-15 Angeli Inst Spa Nuovi derivati ammidinici e guanidinici
US5225419A (en) * 1989-10-14 1993-07-06 John Wyeth & Brother, Limited Certain 1,8-ethano or propano-1,4-dihydro-4-oxo-quinoline-3-carboxamides and derivatives thereof
GB2236751B (en) * 1989-10-14 1993-04-28 Wyeth John & Brother Ltd Heterocyclic compounds
HU211081B (en) * 1990-12-18 1995-10-30 Sandoz Ag Process for producing indole derivatives as serotonin antagonists and pharmaceutical compositions containing the same
JPH0692948A (ja) * 1992-03-04 1994-04-05 Snow Brand Milk Prod Co Ltd 新規なアセタミド誘導体及びその用途
JPH05310732A (ja) * 1992-03-12 1993-11-22 Mitsubishi Kasei Corp シンノリン−３−カルボン酸誘導体
JP2699794B2 (ja) * 1992-03-12 1998-01-19 三菱化学株式会社 チエノ〔３，２−ｂ〕ピリジン誘導体
WO1994012497A1 (fr) * 1992-11-20 1994-06-09 Taisho Pharmaceutical Co., Ltd. Compose heterocyclique
US5340826A (en) * 1993-02-04 1994-08-23 Pfizer Inc. Pharmaceutical agents for treatment of urinary incontinence
KR970701191A (ko) * 1994-02-28 1997-03-17 우에하라 아키라 복소환 화합물
JP3829879B2 (ja) * 1994-05-18 2006-10-04 大正製薬株式会社 キノリンカルボン酸誘導体
CA2196979A1 (en) * 1994-08-25 1996-02-29 T. Y. Shen 7-azabicyclo¬2.2.1|-heptane and -heptene derivatives as cholinergic receptor ligands
NO2005012I1 (no) * 1994-12-28 2005-06-06 Debio Rech Pharma Sa Triptorelin og farmasoytisk akseptable salter derav
EE9900034A (et) * 1996-07-29 1999-08-16 Pharmacia & Upjohn Ab Arüültsükloalkaankarboksüülestrid, nende kasutamine, farmatseutilised kompositsioonid ja valmistamine
CA2391498A1 (en) * 1999-11-18 2001-05-25 Antexpharma, Inc. Substituted 1-benzazepines and derivatives thereof
FR2801310B1 (fr) * 1999-11-24 2004-04-16 Adir NOUVEAUX DERIVES DE DIHYDROFURO-[3,4-b]QUINOLEIN-1-ONES, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT
US6451813B1 (en) 2001-01-26 2002-09-17 R. T. Alamo Ventures I, Llc Treatment of gastroparesis in certain patient groups
MXPA03009894A (es) * 2001-06-19 2004-02-17 Warner Lambert Co Agentes antibacterianos.
EP1500652A4 (en) * 2002-04-26 2006-05-03 Nippon Shinyaku Co Ltd DERIVATIVE AND MEDICINAL PRODUCT OF QUINAZOLINE
DE10255040A1 (de) * 2002-11-26 2004-06-03 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Carbaminsäureester mit anticholinerger Wirksamkeit
ES2338882T3 (es) * 2003-11-24 2010-05-13 Pfizer, Inc. Compuestos de acido quinolona-carboxilico que tienen actividad agonista del receptor 5-ht4.
ATE531367T1 (de) * 2004-09-17 2011-11-15 Whitehead Biomedical Inst Verbindungen, zusammensetzungen und verfahren zur verhinderung einer a-synuklein-vergiftung
DK2217597T3 (da) * 2007-10-01 2011-06-20 Comentis Inc Quinuclidin-4-ylmethyl-1h-indol-3-carboxylatderivater som alpha-7-nicotin-acetylcholin-receptor-ligander til behandling af Alzheimers sygdom
US9145396B2 (en) 2008-12-01 2015-09-29 Targacept, Inc. Synthesis and novel salt forms of (R)-5-((E)-2-pyrrolidin-3ylvinyl)pyrimidine
LT2685986T (lt) * 2011-03-18 2020-03-10 Genzyme Corporation Gliukozilceramido sintazės slopiklis
MA37975B2 (fr) 2012-09-11 2021-03-31 Genzyme Corp Inhibiteurs de synthase de glucosylcéramide
TW201617342A (zh) 2014-07-11 2016-05-16 阿法馬根公司 調節α７活性之啶類
US11377452B2 (en) 2017-01-16 2022-07-05 Drexel University Glutamate transporter activators and methods using same
PT3920912T (pt) 2019-02-04 2025-09-09 Genzyme Corp Tratamento de ciliopatias usando inibidores da glucosilceramida sintase (gcs)
IL295255A (en) 2020-02-03 2022-10-01 Genzyme Corp Methods for treating neurological symptoms associated with lysosomal storage diseases
IL300090A (en) 2020-07-24 2023-03-01 Genzyme Corp Pharmaceutical preparations containing VENGLUSTAT

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4284768A (en) * 1980-07-02 1981-08-18 American Home Products Corporation 1,2-Dihydro-4-amino-2-oxo-3-quinoline-carboxylic acid derivatives
IE52670B1 (en) * 1981-03-03 1988-01-20 Leo Ab Heterocyclic carboxamides,compositions containing such compounds,and processes for their preparation
WO1984001151A1 (en) * 1982-09-24 1984-03-29 Beecham Group Plc Amino-azabicycloalkyl derivatives as dopamine antagonists
US4599336A (en) * 1983-08-08 1986-07-08 Hoffmann-La Roche Inc. Derivatives of (E)-3-(4-oxo-4H-quinazolin-3-yl)-2-propenamide
DE3429830A1 (de) * 1983-08-26 1985-03-07 Sandoz-Patent-GmbH, 7850 Lörrach Automatische carbonsaeure- und sulfonsaeureester oder -amide
US4849513A (en) * 1983-12-20 1989-07-18 California Institute Of Technology Deoxyribonucleoside phosphoramidites in which an aliphatic amino group is attached to the sugar ring and their use for the preparation of oligonucleotides containing aliphatic amino groups
GB8623142D0 (en) * 1986-09-26 1986-10-29 Beecham Group Plc Compounds
DK623586A (da) * 1985-12-27 1987-06-28 Eisai Co Ltd Piperidinderivater eller salte deraf og farmaceutiske kompositioner indeholdende forbindelserne

Also Published As

Publication number Publication date
HU900671D0 (en) 1990-04-28
AU623733B2 (en) 1992-05-21
GR3018549T3 (en) 1996-03-31
FI96686C (fi) 1996-08-12
HUT54118A (en) 1991-01-28
DE69024381T2 (de) 1996-05-15
AU4908690A (en) 1990-10-25
NO900542L (no) 1990-08-07
DE69024381D1 (de) 1996-02-08
NO173500B (no) 1993-09-13
PL162682B1 (pl) 1993-12-31
RU2040524C1 (ru) 1995-07-25
FI900553A0 (fi) 1990-02-05
HU210348A9 (en) 1995-03-28
CZ33590A3 (en) 1993-02-17
IT1228293B (it) 1991-06-07
CA2009300A1 (en) 1990-08-06
KR900012919A (ko) 1990-09-03
ATE132140T1 (de) 1996-01-15
PL283642A1 (en) 1991-02-11
IL93257A0 (en) 1990-11-29
US5106851A (en) 1992-04-21
EP0382687A3 (en) 1991-12-04
MX19368A (es) 1993-09-01
JPH03197462A (ja) 1991-08-28
FI96686B (fi) 1996-04-30
YU21590A (sh) 1993-05-28
EP0382687A2 (en) 1990-08-16
NO173500C (no) 1993-12-22
EP0382687B1 (en) 1995-12-27
CZ277886B6 (en) 1993-06-16
NO900542D0 (no) 1990-02-05
IL93257A (en) 1994-07-31
ZA90825B (en) 1991-10-30
IT8919316A0 (it) 1989-02-06
DK0382687T3 (da) 1996-02-05
PT93066A (pt) 1990-08-31
PT93066B (pt) 1997-01-31

Similar Documents

Publication Publication Date Title
AR008272A1 (es) Derivados de piperidina 1,4-disustituida que contienen fluor, composicion farmaceutica compuesta de los mismos y un proceso para su preparacion
ES2061471T5 (es) Derivados de la piridina, compuestos farmaceuticos que comprenden la misma, su utilizacion para la fabricacion de medicamentos con valor terapeutico o preventivo y procedimiento para su fabricacion.
DK0382687T3 (da) N-Holdige heterocyliske derivater, som har en ondenseret benzenring
ATE247654T1 (de) Neue heterozyklische verbindungen
ES2059327T3 (es) Derivados de tetrahidronaftaleno y de indano, obtencion de los mismos y utilizacion en preparados farmaceuticos.
SV2003000876A (es) Quinazolinas como inhibidores de mmp-13
CO5560573A2 (es) Derivados activos de amino-ftalazinona como inhibidores de quinasa, proceso para su preparacion y composiciones farmaceuticas que los contienen
ES2055056T3 (es) Derivados de pirimidopirimidina.
ATE557002T1 (de) Verbindungen mit calcimimetischer wirkung
AR037907A1 (es) Derivados de azaindolilalquilamina como ligandos de 5-hidroxitriptamina-6
ES2123652T3 (es) 7-(2-aminoetil)-benzotiazolonas.
ES2147726T3 (es) Nuevos derivados del acido metilenbisfosfonico.
ES2136291T3 (es) Derivados de pirimidina.
DE69019859D1 (de) Chinolon-Derivate und deren Salze, Verfahren zu deren Herstellung und diese enthaltende antibakterielle Wirkstoffe.
AR006719A1 (es) Derivados de bencilamina y formulacion farmaceutica que comprende a uno de dichos derivados.
PE20040750A1 (es) Derivados de n-(1-acetilpiperidin-4-il)-4-benzidril-2-isopropilpiperazin-1-carboxamida como inhibidores de 17beta-hidroxiesteroide deshidrogenasa de tipo 3
ES2061753T3 (es) (4,5-c)imidazopiridinas substituidas en 5.
FI941863A0 (fi) Oksatsolidonijohdannainen
AR041481A1 (es) Derivados de acido arilpropionico-oxazol y su uso como agonistas de ppar
ATE120452T1 (de) Entzündungshemmende verbindungen.
AR034400A1 (es) Piranoindoles, composiciones farmaceuticas que los comprenden y el uso de los mismos para la manufactura de medicamentos para el tratamiento de glaucoma
AR007299A1 (es) 1-naftoilguanidinas sustituidas, procedimiento para su preparacion, su empleo para la preparacion de un medicamento y agente curativo y terapeuticoque las contiene
ES2122982T3 (es) Derivados de tetrahidrocarbazol para la fabricacion de un medicamento para el tratamiento de una enfermedad en la que esta indicado un agonista similar a 5-ht1.
EA200400667A3 (ru) Новые соединения бензотиазина и бензотиадиазина, способ их получения и фармацевтические композиции, которые их содержат
ES2136013B1 (es) Derivados de tieno y pirazolo (1,2,4) tiadiazina-1,1-dioxido farmacologicamente activos.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 382687

Country of ref document: ES