ES2081977T3 - Procedimiento de sustitucion especifica de una copia de un gen presente en el genoma receptor mediante la integracion de un gen diferente de aquel en el que se ha realizado la integracion. - Google Patents

Procedimiento de sustitucion especifica de una copia de un gen presente en el genoma receptor mediante la integracion de un gen diferente de aquel en el que se ha realizado la integracion.

Info

Publication number
ES2081977T3
ES2081977T3 ES90905207T ES90905207T ES2081977T3 ES 2081977 T3 ES2081977 T3 ES 2081977T3 ES 90905207 T ES90905207 T ES 90905207T ES 90905207 T ES90905207 T ES 90905207T ES 2081977 T3 ES2081977 T3 ES 2081977T3
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ES
Spain
Prior art keywords
gene
integration
dna
copy
genome
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90905207T
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English (en)
Inventor
Mouellic Herve Le
Philippe Brullet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut Pasteur
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Institut Pasteur
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Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9379875&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2081977(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Institut Pasteur filed Critical Institut Pasteur
Application granted granted Critical
Publication of ES2081977T3 publication Critical patent/ES2081977T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/108—Plasmid DNA episomal vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Environmental Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Husbandry (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

EL INVENTO CONSISTE EN LA INSERCION, OBJETO DE UN ADN EXTRAÑO EN UN SITIO ESCOGIDO EN EL GENOMA DE UNA CELULA EUCARYOTE. EL SITIDO DE INSERCION ESCOGIDO SE ENCUENTRA EN UN GEN. LA INSERCION OBJETO ES EFECTUADA TRANSFIRIENDO CELULAS EUCARYOTES CON UN VECTOR QUE CONTIENE EL ADN EXTRAÑO A INSERTAR FLANQUEADO POR DOS SECUENCIAS GENOMICAS QUE SON ADYACENTES AL SITIO DE INSERCION DESEADO EN EL GEN RECEPTOR. EL ADN DE INSERCION PUEDE COMPORTAR SEA UNA SECUENCIA CODIFICANTE, SEA UNA SECUENCIA REGULADORA. LAS SECUENCIAS FLANQUEANTES ESTAN ESCOGIDAS A FIN DE PERMITIR POR RECOMBINACION HOMOLOGA, SEGUN EL CASO, SEA LA EXPRESION DE LA SECUENCIA CODIFICANTE DEL ADN DE INSERCION BAJO EL CONTROL DE LAS SECUENCIAS REGULADORAS DEL GEN RECEPTOR, SEA LA EXPRESION DE UNA SECUENCIA CODIFICANTE DEL GEN RECEPTOR BAJO EL CONTROL DE SECUENCIA REGULADORA DEL ADN DE INSERCION.
ES90905207T 1989-03-20 1990-03-19 Procedimiento de sustitucion especifica de una copia de un gen presente en el genoma receptor mediante la integracion de un gen diferente de aquel en el que se ha realizado la integracion. Expired - Lifetime ES2081977T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8903630A FR2646438B1 (fr) 1989-03-20 1989-03-20 Procede de remplacement specifique d'une copie d'un gene present dans le genome receveur par l'integration d'un gene different de celui ou se fait l'integration

Publications (1)

Publication Number Publication Date
ES2081977T3 true ES2081977T3 (es) 1996-03-16

Family

ID=9379875

Family Applications (4)

Application Number Title Priority Date Filing Date
ES07007307T Expired - Lifetime ES2381039T3 (es) 1989-03-20 1990-03-19 Procedimiento para obtener la expresión, o para mejorar la tasa de expresión, de un gen
ES95107952T Expired - Lifetime ES2281897T3 (es) 1989-03-20 1990-03-19 Procedimiento para obtener la expresion, o para mejorar el nivel de expresion de un gen.
ES95107951T Expired - Lifetime ES2375345T3 (es) 1989-03-20 1990-03-19 Animal transgénico y procedimiento de cribado de productos farmacéuticos.
ES90905207T Expired - Lifetime ES2081977T3 (es) 1989-03-20 1990-03-19 Procedimiento de sustitucion especifica de una copia de un gen presente en el genoma receptor mediante la integracion de un gen diferente de aquel en el que se ha realizado la integracion.

Family Applications Before (3)

Application Number Title Priority Date Filing Date
ES07007307T Expired - Lifetime ES2381039T3 (es) 1989-03-20 1990-03-19 Procedimiento para obtener la expresión, o para mejorar la tasa de expresión, de un gen
ES95107952T Expired - Lifetime ES2281897T3 (es) 1989-03-20 1990-03-19 Procedimiento para obtener la expresion, o para mejorar el nivel de expresion de un gen.
ES95107951T Expired - Lifetime ES2375345T3 (es) 1989-03-20 1990-03-19 Animal transgénico y procedimiento de cribado de productos farmacéuticos.

Country Status (13)

Country Link
US (6) US6528313B1 (es)
EP (4) EP0682111B1 (es)
JP (3) JP3059481B2 (es)
AT (4) ATE359363T1 (es)
DE (5) DE07007307T1 (es)
DK (4) DK0682112T3 (es)
ES (4) ES2381039T3 (es)
FR (2) FR2646438B1 (es)
HK (1) HK150696A (es)
LU (1) LU91371I2 (es)
NL (1) NL300297I2 (es)
SG (2) SG49112A1 (es)
WO (1) WO1990011354A1 (es)

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