ES2081996T3 - Nuevos compuestos de diamina y agentes protectores del cerebro que contienen los mismos. - Google Patents

Nuevos compuestos de diamina y agentes protectores del cerebro que contienen los mismos.

Info

Publication number
ES2081996T3
ES2081996T3 ES90910895T ES90910895T ES2081996T3 ES 2081996 T3 ES2081996 T3 ES 2081996T3 ES 90910895 T ES90910895 T ES 90910895T ES 90910895 T ES90910895 T ES 90910895T ES 2081996 T3 ES2081996 T3 ES 2081996T3
Authority
ES
Spain
Prior art keywords
grupo
group
represent
brain
different
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90910895T
Other languages
English (en)
Inventor
Seiichi Sato
Kiyoshi Kawamura
Yoshio Takahashi
Koichiro Watanabe
Sadahiro Shimizu
Tomio Ohta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kowa Co Ltd
Original Assignee
Kowa Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kowa Co Ltd filed Critical Kowa Co Ltd
Application granted granted Critical
Publication of ES2081996T3 publication Critical patent/ES2081996T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C211/44—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring
    • C07C211/49—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring having at least two amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/30—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms, not being part of nitro or nitroso groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

EL PRESENTE INVENTO OFRECE UN COMPUESTO DE DIAMINA DE FORMULA (I) O UNA SAL DE ADICION ACIDA CONSIGUIENTE: DONDE R1,R2,R3,R4,R5 Y R6 SON IGUALES O DIFERENTES ENTRE SI Y REPRESENTAN INDIVIDUALMENTE UN ATOMO DE HIDROGENO, UN ATOMO HALOGENO, GRUPO HIDROXILO, GRUPO ALQUILO INFERIOR, GRUPO ALQUILO SUPERIOR, GRUPO ACILOXI INFERIOR, GRUPO ALCOXICARBONILOXI SUPERIOR, GRUPO ALQUILSULFONILOXI INFERIOR O GRUPO AMINO, ENTRE LOS CUALES EL GRUPO ALQUILO INFERIOR Y EL GRUPO ALCOXI INFERIOR PUEDEN ESTAR SUSTITUIDOS POR UN ATOMO HALOGENO O UN GRUPO FENOL; R7 Y R8 SON IGUALES O DIFERENTES ENTRE SI Y REPRESENTAN INDIVIDUALMENTE UN GRUPO ALQUILO INFERIOR O AMBOS SE UNEN PARA REPRESENTAR UN GRUPO ALQUILENO CON 1 A 4 ATOMOS DE CARBONO; A Y A'' SON IGUALES O DIFERENTES ENTE SI Y REPRESENTAN INDIVIDUALMENTE UN ENLACE UNICO, O2NH, O Y'' SON IGUALES O DIFERENTES ENTRE SI Y REPRESENTAN UN GRUPO ALQUILENO INFERIOR O UN GRUPO ALQUENILENO INFERIOR; Y MEDICAMENTOS PROTECTORES DEL CEREBRO QUE CONTIENEN DICHOS COMPUESTOS. LOS COMPUESTOS DE DIAMINA (I) O SUS SALES DE ADICION ACIDAS POSEEN UNA EXCELENTE ACCION DE PROTECTOR DEL CEREBRO, SON MUY SEGUROS, Y MUESTRAN UNA ACCION FUERTE CUANDO SE ADMINISTRAN ORALMENTE, Y POR TANTO LAS MEDICINAS QUE CONTIENEN DICHOS COMPUESTOS SON EFICACES EN EL TRATAMIENTO DE DESORDENES CAUSADOS POR HEMORRAGIAS CEREBRALES, INFARTO CEREBRAL, HEMORRAGIA SUBARACNOIDE, ATAQUE ISQUEMICO, DESORDENES CEREBROVASCULARES Y SIMILARES, O LA PREVENCION DEL PROGRESO DE DICHOS DESORDENES.
ES90910895T 1989-05-30 1990-07-30 Nuevos compuestos de diamina y agentes protectores del cerebro que contienen los mismos. Expired - Lifetime ES2081996T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP1136652A JP2722250B2 (ja) 1989-05-30 1989-05-30 新規なジアミン化合物及びこれを含有する脳機能障害改善剤
PCT/JP1990/000970 WO1992002487A1 (en) 1989-05-30 1990-07-30 New diamine compound and brain protecting agent containing the same

Publications (1)

Publication Number Publication Date
ES2081996T3 true ES2081996T3 (es) 1996-03-16

Family

ID=15180337

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90910895T Expired - Lifetime ES2081996T3 (es) 1989-05-30 1990-07-30 Nuevos compuestos de diamina y agentes protectores del cerebro que contienen los mismos.

Country Status (14)

Country Link
US (1) US5389630A (es)
EP (1) EP0541798B1 (es)
JP (1) JP2722250B2 (es)
KR (1) KR0171569B1 (es)
AT (1) ATE130842T1 (es)
CA (1) CA2087604C (es)
DE (1) DE69023928T2 (es)
DK (1) DK0541798T3 (es)
ES (1) ES2081996T3 (es)
FI (1) FI112649B (es)
HU (1) HU220592B1 (es)
NO (1) NO179322C (es)
RU (1) RU2045522C1 (es)
WO (1) WO1992002487A1 (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0647137T3 (da) * 1992-06-22 2008-12-08 State Of Oregon Through Oregon Glycinreceptorantagonister og anvendelse deraf
DE4314962A1 (de) * 1993-05-06 1994-11-10 Bayer Ag Substituierte Piperazine
WO1995004050A1 (en) * 1993-07-28 1995-02-09 Santen Pharmaceutical Co., Ltd. Novel 1,4-di(phenylalkyl)piperazine derivative
US6017953A (en) * 1993-12-28 2000-01-25 Allergan Sales, Inc. Thromboxane ligands
EP0690051B1 (en) * 1994-01-14 2001-07-18 Azwell Inc. Diazacycloalkanealkylsulfonamide derivative
US5602123A (en) 1994-11-02 1997-02-11 Kowa Co., Ltd. Therapeutic agent for myocardial ischemic damages or reperfusion
US5849737A (en) * 1995-04-14 1998-12-15 The Regents Of The University Of California Compositions and methods for treating pain
US5944021A (en) * 1995-06-07 1999-08-31 Rodriguez; Victorio C. Therapeutic use of a carbonic anhydrase enzyme inhibitor for the treatment of brain edema
US5755237A (en) * 1995-06-07 1998-05-26 Rodriguez; Victorio C. Therapeutic use of acetazolamide for the treatment of brain edema
JP3808921B2 (ja) * 1995-11-20 2006-08-16 興和株式会社 細胞接着阻害剤
US6462034B1 (en) 1998-04-03 2002-10-08 Theravance, Inc. Local anesthetic compounds and uses
CO5040088A1 (es) 1998-04-03 2001-05-29 Advanced Medicine Inc Nuevos compuestos y usos anestesicos locales
SG83735A1 (en) * 1999-07-03 2001-10-16 Advanced Medicine Inc Novel local anesthetic compounds and uses
AU7734700A (en) 1999-10-01 2001-05-10 Advanced Medicine, Inc. Macrocyclic quinazolinones and their use as local anesthetics
US7985751B2 (en) 2005-08-09 2011-07-26 M's Science Corporation Piperazine derivatives
HUP0500886A2 (en) * 2005-09-23 2007-05-29 Sanofi Aventis Amide derivatives as ccr3 receptor ligands, process for producing them, pharmaceutical compositions containing them and their use
HUP0500879A2 (en) 2005-09-22 2007-05-29 Sanofi Aventis Amide derivatives as ccr3 receptor ligands, process for producing them, pharmaceutical compositions containing them and their use and intermediates
RU2008115499A (ru) * 2005-09-22 2009-10-27 Санофи-Авентис (Fr) Новые производные аминокиламидов в качестве антагонистов лигандов рецепторов ccr3
HUP0500877A2 (en) * 2005-09-22 2007-05-29 Sanofi Aventis Amide derivatives as ccr3 receptor ligands, process for producing them, pharmaceutical compositions containing them and their use and intermediates
JP2009519300A (ja) * 2005-12-16 2009-05-14 ノスシラ、ソシエダッド、アノニマ カルシウムチャネルブロッカーとしてのジベンゼン誘導体
CN101448503B (zh) 2006-01-27 2011-04-13 株式会社爱慕知科学 哌啶和哌嗪衍生物
JP5138612B2 (ja) 2006-02-14 2013-02-06 イースタン バージニア メディカル スクール メトキシポリエチレングリコールチオエステルキレートおよびその使用
JP6026413B2 (ja) * 2011-06-23 2016-11-16 学校法人自治医科大学 プロテアソーム阻害剤

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5732255A (en) * 1980-08-05 1982-02-20 Kowa Co Trimethoxyphenyl derivative
CS244821B2 (en) * 1983-06-16 1986-08-14 Boehringer Ingelheim Ltd Production method of new substituted phenylalkyl(piperazinyl or homopiperazinyle)-prpylureas or thioureas
US4661481A (en) * 1983-06-16 1987-04-28 Boehringer Ingelheim Pharmaceuticals, Inc Substituted phenylalkylhomopiperazinylpropyl(ureas or thioureas) useful for treatment of immulogical, inflammatory and allergic disorders
DE3403778A1 (de) * 1984-02-03 1985-08-08 Degussa Ag, 6000 Frankfurt Cyanomethyl-(2-cyano-ethyl)-(3-hydroxy-propyl)-amin seine verwendung zur herstellung von 1-(3-hydroxy-propyl)-1,4-diazepan und 1,4-bis(3-(3,4,5-trimethoxybenzoyloxy)-propyl)-diazepan
JP2556722B2 (ja) * 1988-02-18 1996-11-20 興和株式会社 新規なスルホンアミド化合物

Also Published As

Publication number Publication date
JPH032144A (ja) 1991-01-08
FI112649B (fi) 2003-12-31
JP2722250B2 (ja) 1998-03-04
WO1992002487A1 (en) 1992-02-20
HU9300228D0 (en) 1993-04-28
AU647034B2 (en) 1994-03-17
NO930328L (no) 1993-01-29
EP0541798A4 (es) 1994-04-13
KR0171569B1 (ko) 1999-05-01
CA2087604C (en) 2000-04-18
NO179322B (no) 1996-06-10
DE69023928D1 (de) 1996-01-11
HUT63143A (en) 1993-07-28
DE69023928T2 (de) 1996-04-18
RU2045522C1 (ru) 1995-10-10
EP0541798B1 (en) 1995-11-29
EP0541798A1 (en) 1993-05-19
ATE130842T1 (de) 1995-12-15
FI930360A7 (fi) 1993-01-28
HU220592B1 (hu) 2002-03-28
DK0541798T3 (da) 1995-12-27
NO179322C (no) 1996-09-18
AU6056590A (en) 1992-03-02
US5389630A (en) 1995-02-14
NO930328D0 (no) 1993-01-29
FI930360A0 (fi) 1993-01-28

Similar Documents

Publication Publication Date Title
ES8106134A1 (es) Un procedimiento para la preparacion de carboxialquil-dipep-tidos
ES2153491T3 (es) Derivados de quinazolina.
ES8103751A1 (es) Procedimiento para la preparacion de acidos 3-cefem-4-carbo-xilicos sustituidos en la posicion 7
ES8706673A1 (es) Un procedimiento para la preparacion de derivados de 1,4-dihidro-4-oxonaftiridina y sus sales
SV1994000028A (es) Nuevas sulfonilamino pirimidinas, ref. 10916 sv.
ES2040234T3 (es) Derivados del tetrahidronaftaleno y medicamentos que los contienen.
HU9300228D0 (en) New diamine derivatives and pharmaceutical preparatives of brain protecting effect containing them as active substance
ES2043781T3 (es) Un procedimiento para la preparacion de nuevos derivados de 2beta-morfolino-androstano.
ES2117155T3 (es) Nuevas 3,3-difenilpropilaminas, su uso y su preparacion.
AR029151A1 (es) Una sal cuaternaria de piperidina, su uso, un proceso para su preparacion, y una composicion farmaceutica que la contiene
ES2165485T3 (es) Compuestos de o-carbamoil-(d)-fenilalaninol y procedimiento para preparar los mismos.
RU93005056A (ru) Новое диаминовое соединение и церебральное защитное лекарственное средство на его основе
ES2065975T3 (es) Derivados de benceno condensados.
ES2118203T3 (es) Nuevos derivados benzopiranicos, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.
NO932992L (no) Nye polyjoderte forbindelser, fremgangsmaate for deres fremstilling og kontrastmidler inneholdende dem
MX9306311A (es) Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen
ES2029879T3 (es) Procedimiento para producir derivados de aminas sustituidas.
DK0553016T3 (da) Hidtil ukendte naphtalenamider og -sulfonamider, fremgangsmåder til deres fremstilling samt farmaceutiske midler indeholdende dem
HU205856B (en) Process for producing pharmaceutical compositions containing pyrimidinyl-piperazine derivative against blood insufficiency inthe brain
ES2189956T3 (es) Derivados de quinolina, procedimientos para su preparacion y su uso como medicamentos.
ES2075976T3 (es) Derivados de aminoacido y su empleo como agentes antiviricos.
ES2064361T3 (es) Nuevos compuestos.
ES2063266T3 (es) 4,5,6,11-tetrahidrobenzo(6,7)cicloocta(1,2-b)tiofen-6,11-iminas y 6,11-dihidrobenzo(6,7)cicloocta(1,2-b)tiofen-6,11-iminas.
ES2157248T3 (es) Uso de macrolidos para el tratamiento de isquemia cerebral.
AR001998A1 (es) Derivados de 6-metoxi-1h-benzotriazol-5-carboxamida, las composiciones farmaceuticas que los contienen y procedimientos para su preparacion

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 541798

Country of ref document: ES