ES2082232T3 - Derivados de pirrolidina diona. - Google Patents

Derivados de pirrolidina diona.

Info

Publication number
ES2082232T3
ES2082232T3 ES91917487T ES91917487T ES2082232T3 ES 2082232 T3 ES2082232 T3 ES 2082232T3 ES 91917487 T ES91917487 T ES 91917487T ES 91917487 T ES91917487 T ES 91917487T ES 2082232 T3 ES2082232 T3 ES 2082232T3
Authority
ES
Spain
Prior art keywords
pirrolidine
diona
derivatives
complications
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91917487T
Other languages
English (en)
Inventor
Banavara L Mylari
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PFIZER
Pfizer Inc
Original Assignee
PFIZER
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PFIZER, Pfizer Inc filed Critical PFIZER
Application granted granted Critical
Publication of ES2082232T3 publication Critical patent/ES2082232T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)

Abstract

LA INVENCION SE REFIERE A DERIVADOS PIRROLIDINA DIONA DE LA FORMULA (I), (II) O (III), DONDE R, R1, R3, R4, R5 Y X TIENEN EL SIGNIFICADO DEFINIDO. ESTOS COMPUESTOS SON INHIBIDORES DE LA REDUCTASA ALDOSA Y SON UTILIZADOS EN EL TRATAMIENTO DE LA DIABETES ASOCIADA CON COMPLICACIONES TALES COMO NEUROPATIAS, NEFROPATIAS, RETINOPATIAS Y CATARATAS. LA INVENCION SE REFIERE TAMBIEN A COMPOSICIONES QUE COMPRENDEN LOS COMPUESTOS MENCIONADOS Y METODOS PARA LA UTILIZACION DE ESTAS COMPOSICIONES EN EL TRATAMIENTO DE LA DIABETES MENCIONADA ASOCIADA CON COMPLICACIONES.
ES91917487T 1990-10-15 1991-09-13 Derivados de pirrolidina diona. Expired - Lifetime ES2082232T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US59761490A 1990-10-15 1990-10-15

Publications (1)

Publication Number Publication Date
ES2082232T3 true ES2082232T3 (es) 1996-03-16

Family

ID=24392236

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91917487T Expired - Lifetime ES2082232T3 (es) 1990-10-15 1991-09-13 Derivados de pirrolidina diona.

Country Status (12)

Country Link
EP (1) EP0553130B1 (es)
JP (1) JPH0692367B2 (es)
AT (1) ATE132486T1 (es)
CA (1) CA2091566A1 (es)
DE (1) DE69116162T2 (es)
DK (1) DK0553130T3 (es)
ES (1) ES2082232T3 (es)
FI (1) FI931666L (es)
GR (1) GR3018920T3 (es)
IE (1) IE913554A1 (es)
PT (1) PT99224A (es)
WO (1) WO1992006954A2 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3048067B2 (ja) * 1995-12-15 2000-06-05 ノボ ノルディスク アクティーゼルスカブ 新規方法
AU8181701A (en) * 2000-06-21 2002-01-02 Hoffmann La Roche Benzothiazole derivatives
BR0211750A (pt) 2001-08-10 2004-10-13 Shionogi & Co Agente antiviral
CN104001078A (zh) * 2014-06-05 2014-08-27 青岛市城阳区人民医院 一种治疗糖尿病肾病的中药药剂及制备方法
CN107892666B (zh) * 2017-12-12 2021-10-15 吉林医药学院 一种5-苯基吡咯衍生物及其制备方法和用途

Also Published As

Publication number Publication date
FI931666A7 (fi) 1993-04-14
GR3018920T3 (en) 1996-05-31
CA2091566A1 (en) 1992-04-16
EP0553130A1 (en) 1993-08-04
IE913554A1 (en) 1992-04-22
PT99224A (pt) 1992-09-30
JPH0692367B2 (ja) 1994-11-16
FI931666A0 (fi) 1993-04-14
DE69116162T2 (de) 1996-05-02
DE69116162D1 (de) 1996-02-15
FI931666L (fi) 1993-04-14
DK0553130T3 (da) 1996-02-05
EP0553130B1 (en) 1996-01-03
ATE132486T1 (de) 1996-01-15
WO1992006954A3 (en) 1992-08-06
WO1992006954A2 (en) 1992-04-30
JPH05507284A (ja) 1993-10-21

Similar Documents

Publication Publication Date Title
ES2007318T3 (es) Compuestos de imidazol y composiciones biocidas que los comprenden.
AR029383A1 (es) Moleculas pequenas, los intermediarios para su sintesis, las composiciones farmaceuticas que las contienen y su uso para preparar un medicamento destinado al tratamiento o la profilaxis de enfermedades inflamatorias o mediadas por celulas inmunes
ES2039278T3 (es) Procedimiento para preparar inhibidores de 5-alfa-reductasa de esteroides.
ES2140961T3 (es) Nuevos derivados de 19-nor-pregneno.
MX9300498A (es) Derivados de n-sulfonil-2-oxo-indol, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
BG92804A (bg) 4-бензоилизоксазолови производни
ES2053609T3 (es) Derivados de urea inhibidores de lipoxigenasa.
ES2032899T3 (es) Agente cosmetico para aplicacion externa y su uso.
ECSP045004A (es) Inhibidores de la 17beta-hidroxiesteroide deshidrogenasa tipo 3 para el tratamiento de enfermedades andrógeno dependientes
AR034858A1 (es) Compuestos elevadores de abca-1,composicion farmaceutica y el uso de los mismos para la manufactura de un medicamento
ES2043625T3 (es) Derivados de acido ariloxicarboxilico, su preparacion y empleo.
ES2039269T3 (es) Derivados de azolilmetil-ciclopropilo.
ES2093732T3 (es) Nuevos derivados de erucilo, brasidilo y nervonilo.
ES2136037A1 (es) Inhibidores de sulfamida-metaloproteasa
ES2045180T3 (es) Nuevo procedimiento para la obtencion de 4-aciloxi-3-hidroxietil-azetidinonas.
MX9202996A (es) Diazabiciclo-(3-3-1)nonanos.
IT1173374B (it) Derivati pirido-benzotiazinici ad elevata attivita' antimicrobica
ES2160602T3 (es) Derivados de quinolona y acridinona para el tratamiento de la incontinencia urinaria.
DE69006398D1 (de) N-substituierte Lauramide, ihre Herstellung und sie enthaltende Zusammensetzungen.
AR020563A1 (es) Compuestos (poli)tia-alquinoicos y sus derivados, composiciones que los incluyen y su utilizacion
ES2148458T3 (es) Derivados de fenil-4-tiazoles sustituidos, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
ES2116612T3 (es) Nuevas bis-naftalimidas para el tratamiento del cancer.
ES2082232T3 (es) Derivados de pirrolidina diona.
DE69208016D1 (de) Inhibierte 141b
DK260180A (da) Pseudotrisaccharider deres fremstilling og anvendelse som antibakterielle midler

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 553130

Country of ref document: ES