ES2085021T3 - Procedimiento para la obtencion de diacetilreina. - Google Patents

Procedimiento para la obtencion de diacetilreina.

Info

Publication number
ES2085021T3
ES2085021T3 ES92913299T ES92913299T ES2085021T3 ES 2085021 T3 ES2085021 T3 ES 2085021T3 ES 92913299 T ES92913299 T ES 92913299T ES 92913299 T ES92913299 T ES 92913299T ES 2085021 T3 ES2085021 T3 ES 2085021T3
Authority
ES
Spain
Prior art keywords
rhein
obtaining
diacetilreine
aloe emodin
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92913299T
Other languages
English (en)
Inventor
Alfons Carcasona
Wolf Grimminger
Pentti Hietala
Helga Zaeske
Klaus Witthohn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Madaus Holding GmbH
Original Assignee
Madaus AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Madaus AG filed Critical Madaus AG
Application granted granted Critical
Publication of ES2085021T3 publication Critical patent/ES2085021T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/24—Anthracenes; Hydrogenated anthracenes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A UN PROCESO PARA LA PREPARACION DE DIACETIL RHEIN EN UN NIVEL DE PUREZA QUE PUEDA SER UTILIZADO FARMACEUTICAMENTE, CON UN CONTENIDO RESIDUAL TOTAL DE DERIVADOS ALOE EMODIN NO DESEADOS DE MENOS DE 20 PPM. EL METODO COMPRENDE LAS SIGUIENTES ETAPAS: EL RHEIN SIDO CONTENIENDO COMPONENTES ALOE EMODIN ES SOMETIDO A UN PROCESO DE EXTRACCION LIQUIDO-LIQUIDO, 1,8 OSIDOS SON OXIDIZADOS HASTA CONSEGUIR 1,8 ONA GLUCOSIDA, SE SEPARA LA UNIDAD GLUCOSA, EL COMPUESTO RESULTANTE 1,8 DIHIDROXIANTRAQUINONA ACETILATADA, Y EL PRODUCTO CRISTALIZADO OBTENIDO SON ENTONCES SECADOS BAJO CONDICIONES SUAVES EXTREMAS. LA INVENCION SE REFIERE TAMBIEN A LA OBTENCION DE DIACETIL RHEIN POR MEDIO DE ESTE METODO, ASI COMO A LOS AGENTES FARMACEUTICOS QUE CONTIENEN ESTOS COMPUESTOS.
ES92913299T 1991-06-25 1992-06-24 Procedimiento para la obtencion de diacetilreina. Expired - Lifetime ES2085021T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4120990A DE4120990C2 (de) 1991-06-25 1991-06-25 Verfahren zur Herstellung von Diacetylrhein

Publications (1)

Publication Number Publication Date
ES2085021T3 true ES2085021T3 (es) 1996-05-16

Family

ID=6434718

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92913299T Expired - Lifetime ES2085021T3 (es) 1991-06-25 1992-06-24 Procedimiento para la obtencion de diacetilreina.

Country Status (20)

Country Link
US (1) US6596764B1 (es)
EP (1) EP0544880B1 (es)
JP (2) JP2650237B2 (es)
AT (1) ATE135342T1 (es)
AU (1) AU658910B2 (es)
CA (1) CA2090423C (es)
CZ (1) CZ281686B6 (es)
DE (2) DE4120990C2 (es)
DK (1) DK0544880T3 (es)
ES (1) ES2085021T3 (es)
FI (1) FI104893B (es)
GR (1) GR3019320T3 (es)
HU (1) HU210144B (es)
IE (1) IE72525B1 (es)
PL (1) PL168446B1 (es)
RU (1) RU2125875C1 (es)
SK (1) SK23593A3 (es)
TW (1) TW364902B (es)
WO (1) WO1993000322A1 (es)
ZA (1) ZA924645B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH689279A5 (fr) * 1995-02-07 1999-01-29 Steba Beheer Bv Procédé de purification de la diacétylrhéine.
US5652265A (en) * 1995-03-29 1997-07-29 Wisconsin Alumni Research Foundation Production of rhein and rhein derivatives
ITMI20040347A1 (it) * 2004-02-26 2004-05-26 Pharma Medical Ltd Nuovo farmaco di associazione
CN1748675A (zh) * 2005-07-11 2006-03-22 丛晓东 大黄酸类化合物的复合物及制备方法与治疗糖尿病的应用
RU2293720C1 (ru) * 2005-12-06 2007-02-20 Ооо "Эстеркем" Способ восстановления ненасыщенных кетонов в насыщенные кетоны
EP2060562A1 (en) 2007-11-16 2009-05-20 Laboratoire Medidom S.A. Dioxoanthracene sulphonate derivatives
EP2218707A1 (en) 2009-02-16 2010-08-18 Evultis S.A. Process for the preparation of non-genotoxic Diacetylrhein (Diacerein)
CN110286177B (zh) * 2019-08-05 2022-08-30 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 一种检测芦荟苷的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3998966A (en) * 1971-11-04 1976-12-21 Syntex Corporation Anti-inflammatory, analgesic, anti-pyretic and anti-pruritic 6-substituted 2-naphthyl acetic acid derivative-containing compositions and methods of use thereof
ZA761627B (en) * 1976-03-16 1978-01-25 C Friedmann Improvements in or relating to the treatment of arthritis
DE3200131A1 (de) * 1982-01-05 1983-07-14 Madaus & Co Dr "verfahren zur gewinnung von laxativen verbindungen aus sennadroge"
FR2566772B1 (fr) * 1984-06-29 1986-11-14 Cird Diacyloxy-1,8 acyl-10 anthrones, leur procede de preparation et leur utilisation en medecine humaine ou veterinaire et en cosmetique

Also Published As

Publication number Publication date
CZ36993A3 (en) 1996-12-11
TW364902B (en) 1999-07-21
FI930789A0 (fi) 1993-02-23
SK23593A3 (en) 1993-07-07
HU9300505D0 (en) 1993-05-28
US6596764B1 (en) 2003-07-22
IE922047A1 (en) 1992-12-30
FI930789L (fi) 1993-02-23
PL168446B1 (en) 1996-02-29
GR3019320T3 (en) 1996-06-30
JPH06502190A (ja) 1994-03-10
DK0544880T3 (da) 1996-04-01
AU2165392A (en) 1993-01-25
DE4120990C2 (de) 1995-07-27
CA2090423C (en) 1997-10-14
JP2948161B2 (ja) 1999-09-13
DE4120990A1 (de) 1993-01-07
WO1993000322A1 (de) 1993-01-07
IE72525B1 (en) 1997-04-23
DE59205680D1 (de) 1996-04-18
HUT63604A (en) 1993-09-28
RU2125875C1 (ru) 1999-02-10
CZ281686B6 (cs) 1996-12-11
ATE135342T1 (de) 1996-03-15
JP2650237B2 (ja) 1997-09-03
PL298139A1 (en) 1993-11-02
AU658910B2 (en) 1995-05-04
EP0544880A1 (de) 1993-06-09
CA2090423A1 (en) 1992-12-26
ZA924645B (en) 1993-02-24
EP0544880B1 (de) 1996-03-13
FI104893B (fi) 2000-04-28
JPH09202729A (ja) 1997-08-05
HU210144B (en) 1995-02-28

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