ES2087109T3 - Procedimiento para la purificacion de una proteina antigenica de 69000 daltons a partir de bordetella pertussis. - Google Patents

Procedimiento para la purificacion de una proteina antigenica de 69000 daltons a partir de bordetella pertussis.

Info

Publication number
ES2087109T3
ES2087109T3 ES90120662T ES90120662T ES2087109T3 ES 2087109 T3 ES2087109 T3 ES 2087109T3 ES 90120662 T ES90120662 T ES 90120662T ES 90120662 T ES90120662 T ES 90120662T ES 2087109 T3 ES2087109 T3 ES 2087109T3
Authority
ES
Spain
Prior art keywords
daltons
bordetella pertussis
purification
procedure
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90120662T
Other languages
English (en)
Inventor
John William Gotto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Application granted granted Critical
Publication of ES2087109T3 publication Critical patent/ES2087109T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/235—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/825—Bacteria

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE PROPORCIONA UN PROCESO PARA EXTRAER Y PURIFICAR UNA PROTEINA CON UN PESO MOLECULAR APARENTE DE ALREDEDOR DE 69000 DALTONS, DE LA MEMBRANA EXTERIOR DE LA BACTERIA BORDETELLA PERTUSSIS. EL PROCESO INCLUYE LA INACTIVACION DE LA BORDETELLA PERTUSSIS POR UN AGENTE BACTERIOSTATICO, EXTRACCION REPETIDA, Y PURIFICACION DE LA PROTEINA DE 69000 DALTONS, DE LA EXTRACCION POR CROMATOGRAFIA DE CONTRASTE, SEGUIDA DE CROMATOFIJACION. EL PROCESO NOS LLEVA A UN MEJOR RENDIMIENTO Y ESTABILIDAD DE LA PROTEINA DE 69000 DALTONS.
ES90120662T 1989-12-11 1990-10-29 Procedimiento para la purificacion de una proteina antigenica de 69000 daltons a partir de bordetella pertussis. Expired - Lifetime ES2087109T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/448,777 US5276142A (en) 1989-12-11 1989-12-11 Process for purification of a 69000 dalton antigenic protein from Bordetella pertussis

Publications (1)

Publication Number Publication Date
ES2087109T3 true ES2087109T3 (es) 1996-07-16

Family

ID=23781640

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90120662T Expired - Lifetime ES2087109T3 (es) 1989-12-11 1990-10-29 Procedimiento para la purificacion de una proteina antigenica de 69000 daltons a partir de bordetella pertussis.

Country Status (13)

Country Link
US (1) US5276142A (es)
EP (1) EP0437687B1 (es)
JP (1) JP2950970B2 (es)
KR (1) KR0180527B1 (es)
AT (1) ATE137976T1 (es)
AU (1) AU641711B2 (es)
CA (1) CA2031763A1 (es)
DE (1) DE69027013T2 (es)
DK (1) DK0437687T3 (es)
ES (1) ES2087109T3 (es)
FI (1) FI101380B1 (es)
NO (1) NO301717B1 (es)
SG (1) SG54177A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8412207D0 (en) 1984-05-12 1984-06-20 Wellcome Found Antigenic preparations
GB8910570D0 (en) * 1989-05-08 1989-06-21 Wellcome Found Acellular vaccine
US6197548B1 (en) 1990-04-02 2001-03-06 Medeva Pharma Limited Transformed Pichia expressing the pertactin antigen
GB9007657D0 (en) * 1990-04-04 1990-05-30 Connaught Lab Purification of a pertussis outer membrane protein(omp69)
EP0484621A3 (en) * 1990-07-11 1992-08-26 American Cyanamid Company Efficacious vaccines against bordetella pertussis comprising a combination of individually purified pertussis antigens
US6444211B2 (en) 1991-04-03 2002-09-03 Connaught Laboratories, Inc. Purification of a pertussis outer membrane protein
GB9304399D0 (en) * 1993-03-04 1993-04-21 Smithkline Beecham Biolog Novel process
KR100266556B1 (ko) * 1994-04-28 2000-09-15 다께다구니오 백일해균의 방어성분의 분리방법
DE19512346C1 (de) * 1995-04-01 1996-06-13 Behringwerke Ag Verfahren zur Reinigung von Filamenthämagglutinin und Pertussis-Toxin
ATE496634T1 (de) 1995-05-04 2011-02-15 Sanofi Pasteur Ltd Azelluläre pertussis-impfstoffe und verfahren zu deren herstellung
US5877298A (en) * 1995-05-04 1999-03-02 Connaught Lab Acellular pertussis vaccines and methods of preparing thereof
GB9611501D0 (en) * 1996-06-03 1996-08-07 Smithkline Beecham Biolog Vaccine compositions
DE69736709T2 (de) 1996-07-02 2007-10-04 Sanofi Pasteur Ltd., Toronto Vielwertige dtp-polio-impfstoffe
EP2430040A1 (en) * 2009-05-11 2012-03-21 Novartis AG Antigen purification process for pertactin antigen
CN102584958A (zh) * 2012-02-08 2012-07-18 北京天坛生物制品股份有限公司 百日咳杆菌69kd外膜蛋白的纯化方法
WO2014135651A1 (en) 2013-03-08 2014-09-12 Crucell Holland B.V. Acellular pertussis vaccine

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4220717A (en) * 1977-12-22 1980-09-02 American Cyanamid Company Isolation and purification of polyribosyl ribitol phosphate from Haemophilus influenzae type b.
GB8412207D0 (en) * 1984-05-12 1984-06-20 Wellcome Found Antigenic preparations
GB8512972D0 (en) * 1985-05-22 1985-06-26 Univ Glasgow Vaccine production
DE3886332T2 (de) * 1987-09-28 1994-03-31 Beecham Inc Inaktivierung von Viren und Bakterien.
US5101014A (en) * 1989-02-10 1992-03-31 United States Of America Process for the purification of a 69,000 da outer membrane protein of Bordetella pertussis

Also Published As

Publication number Publication date
AU641711B2 (en) 1993-09-30
JP2950970B2 (ja) 1999-09-20
FI906071L (fi) 1991-06-12
NO905324D0 (no) 1990-12-10
NO905324L (no) 1991-06-12
NO301717B1 (no) 1997-12-01
SG54177A1 (en) 1998-11-16
DK0437687T3 (da) 1996-06-03
DE69027013T2 (de) 1996-12-19
FI101380B (fi) 1998-06-15
FI906071A0 (fi) 1990-12-10
EP0437687A2 (en) 1991-07-24
EP0437687B1 (en) 1996-05-15
EP0437687A3 (en) 1991-07-31
KR0180527B1 (ko) 1999-04-01
FI101380B1 (fi) 1998-06-15
KR910012234A (ko) 1991-08-07
US5276142A (en) 1994-01-04
JPH03191789A (ja) 1991-08-21
AU6793390A (en) 1991-06-13
CA2031763A1 (en) 1991-06-12
ATE137976T1 (de) 1996-06-15
DE69027013D1 (de) 1996-06-20

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