ES2089875T3 - Metodo para purificar interleuquina-4. - Google Patents

Metodo para purificar interleuquina-4.

Info

Publication number
ES2089875T3
ES2089875T3 ES94105833T ES94105833T ES2089875T3 ES 2089875 T3 ES2089875 T3 ES 2089875T3 ES 94105833 T ES94105833 T ES 94105833T ES 94105833 T ES94105833 T ES 94105833T ES 2089875 T3 ES2089875 T3 ES 2089875T3
Authority
ES
Spain
Prior art keywords
interleuquine
purify
chromatography
following
interlequine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94105833T
Other languages
English (en)
Inventor
Eric Bonnem
Lee Sullivan
Michael Grace
Loretta Bober
John Chu-Tay Tang
David Naveh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ES2089875T3 publication Critical patent/ES2089875T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5406—IL-4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Manufacture Of Alloys Or Alloy Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

SE PRESENTA UN METODO PARA LA PURIFICACION DE INTERLEQUINA-4 QUE CONSISTE EN LOS PASOS SUCESIVOS SIGUIENTES: UNA CROMATOGRAFIA EN UN GEL DE AGAROSA QUELANTE DE METALES, UNA CROMATOGRAFIA EN UN INTERCAMBIADOR DE CATIONES, UNA CONCENTRACION EN UNA MEMBRANA DE CELULAS EXCITADAS Y UNA CROMATOGRAFIA DE EXCLUSION DEL APRESTO.
ES94105833T 1989-07-28 1990-07-26 Metodo para purificar interleuquina-4. Expired - Lifetime ES2089875T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US38693789A 1989-07-28 1989-07-28

Publications (1)

Publication Number Publication Date
ES2089875T3 true ES2089875T3 (es) 1996-10-01

Family

ID=23527716

Family Applications (2)

Application Number Title Priority Date Filing Date
ES94105833T Expired - Lifetime ES2089875T3 (es) 1989-07-28 1990-07-26 Metodo para purificar interleuquina-4.
ES90308198T Expired - Lifetime ES2072395T3 (es) 1989-07-28 1990-07-26 Uso de interleuquina-4 para aumentar el numero de neutrofilos y para tratar la leucemia mieloide y monocitoide.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES90308198T Expired - Lifetime ES2072395T3 (es) 1989-07-28 1990-07-26 Uso de interleuquina-4 para aumentar el numero de neutrofilos y para tratar la leucemia mieloide y monocitoide.

Country Status (20)

Country Link
EP (3) EP0484380A1 (es)
JP (2) JP2580391B2 (es)
KR (1) KR100191223B1 (es)
AT (2) ATE135366T1 (es)
AU (2) AU645514B2 (es)
CA (1) CA2064753A1 (es)
DE (2) DE69025961T2 (es)
DK (2) DK0618220T3 (es)
ES (2) ES2089875T3 (es)
FI (2) FI981585L (es)
GR (1) GR3019707T3 (es)
HK (1) HK185196A (es)
HU (1) HU215257B (es)
IL (2) IL95201A0 (es)
NO (1) NO304555B1 (es)
OA (1) OA09649A (es)
RU (1) RU2082756C1 (es)
SG (1) SG44544A1 (es)
WO (1) WO1991001744A2 (es)
ZA (1) ZA905896B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5723119A (en) * 1989-07-28 1998-03-03 Schering Corporation Method for enhancing wound healing/repair with IL-4
US5077388A (en) * 1990-05-31 1991-12-31 Schering Corporation Purification of human interleukin-4 from a secreted escherichia coli mutant
US5827670A (en) * 1990-08-02 1998-10-27 Fred Hutchinson Cancer Research Center Methods of isolating and detecting bone marrow stromal cells with VCAM-1-specific antibodies
US7449186B1 (en) 1990-08-02 2008-11-11 Fred Hutchinson Cancer Research Center Methods of blocking the interaction between stromal cells and hemopoietic cells with anti-VCAM-1 antibodies
AU660942B2 (en) * 1990-09-13 1995-07-13 Commonwealth Scientific And Industrial Research Organisation Ovine cytokine genes
DK0566661T3 (da) * 1991-01-10 1996-07-01 Schering Corp Anvendelse af IL-4 til forstærkning af den reparative fase af sårheling og -reparation og til forstærkning af helingen af inficerede sår og sår hos diabetiske pattedyr
JPH07165602A (ja) * 1993-12-16 1995-06-27 Kirin Brewery Co Ltd 放射線障害防護剤
US5716612A (en) * 1994-09-07 1998-02-10 Schering Corporation Use of IL-4 for potentiation of chemotherapeutic agents
US6132737A (en) * 1997-09-29 2000-10-17 Revlon Consumer Products Corporation Method for reducing sunburn cell formation with cosmetic compositions containing ascorbic acid
EP1131093A4 (en) * 1998-11-09 2002-05-02 Idec Pharma Corp TREATMENT OF HEMATOLOGICAL VILTIES ASSOCIATED WITH CIRCULATING TUMOR CELLS USING CHIMERIC ANTI-CD20 ANTIBODIES
EP2421952B1 (en) * 2009-04-20 2016-03-30 Galen Bio, Inc. Compositions for transfection of biomolecules into cells
JP5784416B2 (ja) * 2011-08-26 2015-09-24 出光興産株式会社 菌類の回収方法
EP3995196B1 (en) * 2020-11-04 2023-08-09 Sartorius BIA Separations d.o.o. Purification process for lipid-membrane-enclosed complex assemblages

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4723000A (en) * 1983-07-05 1988-02-02 Biospectrum, Inc. Human interferon gamma and interleukin-2
SE8701004D0 (sv) * 1987-03-11 1987-03-11 Astra Ab Method for therapy of leukemias and certain other malignancies
US5077388A (en) * 1990-05-31 1991-12-31 Schering Corporation Purification of human interleukin-4 from a secreted escherichia coli mutant
ZA912037B (en) * 1990-03-21 1992-03-25 Schering Corp Use of il-4 to enhance immune response to infectious antigenic challenges

Also Published As

Publication number Publication date
ES2072395T3 (es) 1995-07-16
FI102039B1 (fi) 1998-10-15
FI981585A0 (fi) 1990-07-26
DE69017547D1 (de) 1995-04-13
FI981585A7 (fi) 1998-07-10
OA09649A (en) 1993-05-15
RU2082756C1 (ru) 1997-06-27
HU215257B (hu) 1998-11-30
EP0484380A1 (en) 1992-05-13
AU6055890A (en) 1991-03-11
FI102039B (fi) 1998-10-15
AU5476194A (en) 1994-06-02
DK0410750T3 (da) 1995-07-10
HUT60146A (en) 1992-08-28
SG44544A1 (en) 1997-12-19
KR100191223B1 (ko) 1999-06-15
EP0618220A1 (en) 1994-10-05
DE69017547T2 (de) 1995-11-02
FI920367A0 (fi) 1992-01-28
ATE135366T1 (de) 1996-03-15
ZA905896B (en) 1991-04-24
AU645514B2 (en) 1994-01-20
IL121897A0 (en) 1998-03-10
EP0410750A3 (en) 1991-06-19
EP0410750A2 (en) 1991-01-30
EP0410750B1 (en) 1995-03-08
JP2580391B2 (ja) 1997-02-12
IL95201A0 (en) 1991-06-10
EP0618220B1 (en) 1996-03-13
DE69025961T2 (de) 1996-10-31
HU9200254D0 (en) 1992-04-28
HK185196A (en) 1996-10-11
ATE119395T1 (de) 1995-03-15
WO1991001744A2 (en) 1991-02-21
NO304555B1 (no) 1999-01-11
AU661221B2 (en) 1995-07-13
JPH0940575A (ja) 1997-02-10
NO920351D0 (no) 1992-01-27
CA2064753A1 (en) 1991-01-29
FI981585L (fi) 1998-07-10
JPH04506299A (ja) 1992-11-05
DK0618220T3 (da) 1996-07-22
NO920351L (no) 1992-03-27
DE69025961D1 (de) 1996-04-18
WO1991001744A3 (en) 1991-04-04
KR920700670A (ko) 1992-08-10
GR3019707T3 (en) 1996-07-31

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