ES2087729T3 - Derivados de 2-amino-1,2,3,4-tetrahidronaftaleno activos sobre el sistema cardiovascular, procedimientos para su preparacion y composiciones farmaceuticas que los contienen. - Google Patents

Derivados de 2-amino-1,2,3,4-tetrahidronaftaleno activos sobre el sistema cardiovascular, procedimientos para su preparacion y composiciones farmaceuticas que los contienen.

Info

Publication number
ES2087729T3
ES2087729T3 ES93906515T ES93906515T ES2087729T3 ES 2087729 T3 ES2087729 T3 ES 2087729T3 ES 93906515 T ES93906515 T ES 93906515T ES 93906515 T ES93906515 T ES 93906515T ES 2087729 T3 ES2087729 T3 ES 2087729T3
Authority
ES
Spain
Prior art keywords
amino
derivatives
tetrahidronaftaleno
procedures
contain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93906515T
Other languages
English (en)
Inventor
Francesco Santangelo
Giorgio Bertolini
Cesare Casagrande
Francesco Marchini
Stefania Montanari
Claudio Semeraro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zambon Group SpA
Zambon SpA
Original Assignee
Zambon Group SpA
Zambon SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Group SpA, Zambon SpA filed Critical Zambon Group SpA
Application granted granted Critical
Publication of ES2087729T3 publication Critical patent/ES2087729T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C07C217/20—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by halogen atoms, by trihalomethyl, nitro or nitroso groups, or by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/44—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)

Abstract

SE DESCRIBEN DERIVADOS DE 2-AMINO-1,2,3,4-TETRAHIDRONAFTALENO DE FORMULA (I) EN LA QUE R1 Y R2, DIFERENTES UNOS DE OTROS, SON UN ATOMO DE HIDROGENO O UN GRUPO OY''; Y E Y'' SON UN ATOMO DE HIDROGENO O UN GRUPO ACILO O UN FENILO; M ES 1 Y 2; N ES UN NUMERO ENTERO DE 3 A 7; R3 ES HIDROALQUILO DE HIDROGENO; R4 Y R5, SON ALKILO DE HIDROGENO O HALOALQUILO O ALCOXI; Y SUS USOS EN EL CAMPO TERAPEUTICO. LOS COMPUESTOS SON PARTICULARMENTE UTILES EN EL TRATAMIENTO DE LA HIPERTENSION ARTERIAL, LA DESCOMPENSACION CARDIACA Y LOS FALLOS RENALES, EN EL TRATAMIENTO DE ARTERIOPATIAS PERIFERICAS Y EN LA INSUFICIENCIA CEREBROVASCULAR.
ES93906515T 1992-03-17 1993-03-13 Derivados de 2-amino-1,2,3,4-tetrahidronaftaleno activos sobre el sistema cardiovascular, procedimientos para su preparacion y composiciones farmaceuticas que los contienen. Expired - Lifetime ES2087729T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI920608A IT1254521B (it) 1992-03-17 1992-03-17 Derivati della 2-ammino-tetralina attivi sul sistema cardiovascolare

Publications (1)

Publication Number Publication Date
ES2087729T3 true ES2087729T3 (es) 1996-07-16

Family

ID=11362451

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93906515T Expired - Lifetime ES2087729T3 (es) 1992-03-17 1993-03-13 Derivados de 2-amino-1,2,3,4-tetrahidronaftaleno activos sobre el sistema cardiovascular, procedimientos para su preparacion y composiciones farmaceuticas que los contienen.

Country Status (20)

Country Link
US (2) US5407956A (es)
EP (1) EP0585440B1 (es)
JP (1) JP3231775B2 (es)
KR (1) KR100283945B1 (es)
AT (1) ATE137737T1 (es)
CA (1) CA2102490C (es)
DE (1) DE69302544T2 (es)
DK (1) DK0585440T3 (es)
ES (1) ES2087729T3 (es)
FI (1) FI935066A7 (es)
GR (1) GR3020419T3 (es)
HU (2) HUT68936A (es)
IT (1) IT1254521B (es)
MD (1) MD1449G2 (es)
NO (1) NO180230C (es)
NZ (1) NZ249845A (es)
OA (1) OA09843A (es)
PL (2) PL172056B1 (es)
RU (1) RU2120435C1 (es)
WO (1) WO1993019036A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1271411B (it) * 1993-09-14 1997-05-28 Zambon Spa Derivati del 2-ammino-1,2,3,4-tetraidro-naftalene attivi sul sistema cardiovascolare
IT1274673B (it) * 1994-04-14 1997-07-24 Zambon Spa Derivati dell'acido fosfonico utili nel trattamento delle malattie car.iovascolari
IT1270260B (it) * 1994-06-21 1997-04-29 Zambon Spa Derivati dell'acido fosfonico ad attivita' inibitrice delle metallopeptidasi
IT1271008B (it) * 1994-09-13 1997-05-26 Zambon Spa Derivati del 2-ammino-1,2,3,4-tetraidro-naftalene attivi sul sistema cardiovascolare
IT1271007B (it) * 1994-09-13 1997-05-26 Zambon Spa Derivati del 2-ammino-1,2,3,4-tetraidronaftalene attivi sul sistema cardiovascolare
IT1271009B (it) * 1994-09-13 1997-05-26 Zambon Spa Derivati del benzopirano e del benzotiopirano attivi sul sistema cardiovascolare
IT1273455B (it) * 1995-01-27 1997-07-08 Zambon Spa Derivati tiolici ad attivita' inibitrice delle metallopeptidasi
IT1276710B1 (it) * 1995-06-14 1997-11-03 Zambon Spa Derivati dell'acido fosfinico ad attivita' inibitrice delle metallopeptidasi
GB9625455D0 (en) * 1996-12-07 1997-01-22 Glaxo Group Ltd Process for resolving mixtures of carbocyclic steroisomers
IT1289980B1 (it) * 1997-02-26 1998-10-19 Zambon Spa Derivati idrossimetilici del 2-ammino-1,2,3,4-tetraidronaftalene attivi in campo cardiovascolare
KR101774598B1 (ko) 2008-12-09 2017-09-04 인터퀴임, 에스.에이. （6ｓ）­（­）­５，６，７，８­테트라하이드로-６-［프로필­（２­티에닐）에틸］아미노­１­나프톨（로티고틴）의 제조를 위한 공정

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0072061B1 (en) * 1981-08-05 1985-05-15 FISONS plc Amine derivatives, processes for their production and pharmaceutical compositions containing them
EP0142283B1 (en) * 1983-10-25 1991-01-30 FISONS plc Phenylethylamines, process for their preparation and compositions containing them
IT1224405B (it) * 1987-12-23 1990-10-04 Simes Composti attivi sul sistema cardiovascolare

Also Published As

Publication number Publication date
PL171844B1 (pl) 1997-06-30
IT1254521B (it) 1995-09-25
HUT68936A (en) 1995-08-28
US5451608A (en) 1995-09-19
RU2120435C1 (ru) 1998-10-20
PL172056B1 (pl) 1997-07-31
GR3020419T3 (en) 1996-10-31
AU650201B2 (en) 1994-06-09
JPH06507920A (ja) 1994-09-08
NO934160D0 (no) 1993-11-17
DE69302544D1 (de) 1996-06-13
ITMI920608A0 (it) 1992-03-17
KR100283945B1 (ko) 2001-03-02
HU211517A9 (en) 1995-11-28
NZ249845A (en) 1996-03-26
OA09843A (en) 1994-08-15
US5407956A (en) 1995-04-18
CA2102490C (en) 2004-06-08
AU3747893A (en) 1993-10-21
FI935066L (fi) 1993-11-16
EP0585440B1 (en) 1996-05-08
DE69302544T2 (de) 1996-09-19
NO180230B (no) 1996-12-02
CA2102490A1 (en) 1993-09-18
ATE137737T1 (de) 1996-05-15
JP3231775B2 (ja) 2001-11-26
EP0585440A1 (en) 1994-03-09
FI935066A0 (fi) 1993-11-16
FI935066A7 (fi) 1993-11-16
NO934160L (no) 1993-11-17
ITMI920608A1 (it) 1993-09-17
MD960271A (en) 1997-09-30
MD1449F1 (en) 2000-04-30
WO1993019036A1 (en) 1993-09-30
NO180230C (no) 1997-03-12
MD1449G2 (ro) 2000-12-31
DK0585440T3 (da) 1996-06-10

Similar Documents

Publication Publication Date Title
ES2083123T3 (es) Nuevos derivados de aril-etil-aminas, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.
DK0447285T3 (da) Nephtalenderivater, fremgangsmåde til fremstilling heraf og farmaceutiske midler indeholdende dem
AR033594A1 (es) Un compuesto derivado de 3-aroilindol, su utilizacion, procedimientos para prepararlo, una composicion farmaceutica que lo contiene, un medicamento constituido por dicho compuesto, y compuestos intermediarios
ES2190396T3 (es) Nuevos compuestos amino-triazoles, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
ES2142798T3 (es) Derivados de 3-amido pirazol, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
ES2071621T3 (es) Enantiomero dextrogiro del alfa-(tetrahidro-4,5,6,7-tieno-(3,2-c)-piridil-5)(cloro-2-fenil) acetato de metilo, su procedimiento de preparacion y las composiciones farmaceuticas que lo contienen.
ES2097859T3 (es) Derivados de dihidropiridina, su preparacion y su utilizacion.
AR045040A1 (es) Derivados de compuestos espiroazabiciclicos, composiciones farmaceuticas que los contienen y su uso en la preparacion de medicamentos
AR048567A1 (es) Derivados de benzoxazinona, su preparacion y composiciones farmaceuticas.
ES8107201A1 (es) Un procedimiento para la preparacion de derivados de morfo- lina
ES2118203T3 (es) Nuevos derivados benzopiranicos, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.
ES2149777T3 (es) Derivados de triazol que tienen actividad antifungica.
ES2038172T3 (es) Procedimiento para preparar carboxamidas heterociclicas.
GB1087243A (en) Improvements in or relating to naphthalene derivatives and the manufacture thereof
DK60981A (da) Fremgangsmaade til fremstilling af aromatiske aminoethanolforbindelser
SE8406302L (sv) Nya aminoguanidinderivat och ett forfarande for deras framstellning
AR021068A1 (es) Benzoilpiridazinas y procedimientos para elaborarlas; preparados farmaceuticos que las contienen y procedimiento para elaborarlos, y utilizacion de dichasbenzoilpiridazinas
NO912298L (no) Fremgangsmaate for fremstilling av terapeutisk aktive 1,3-dioksanderivater.
ES2183492T3 (es) Nuevos derivados de nitrono,su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
AR016416A1 (es) Fenil-alquil-imidazoles, composiciones farmaceuticas que los comprenden y el uso de los mismos para la manufactura de un medicamento
ES2153457T3 (es) Amino-alquil-benzoxazolinonas y benzotiazolinonas, su procedimiento de preparacion y las composiciones farmaceuticas que las contienen.
MD1449G2 (ro) Derivaţi ai 2-amino-1,2,3,4-tetrahidronaftalinei cu acţiune asupra sistemului cardiovascular, procedeu de obţinere a acestora şi compoziţii farmaceutice care îi conţin
ES2032217T3 (es) Nuevos derivados n-(23-vinblastinoil del acido 1-amino-metilfosfonico, sus procedimientos de preparacion y las composiciones farmaceuticas que los contienen.
ES2125963T3 (es) Nuevos derivados espiranicos del 3-amino-cromano, sus procedimientos de preparacion y las composiciones farmaceuticas que los contienen.
ES2130548T3 (es) Nuevos derivados alquil-amino-indanos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 0585440

Country of ref document: ES