IT1274673B - Derivati dell'acido fosfonico utili nel trattamento delle malattie car.iovascolari - Google Patents

Derivati dell'acido fosfonico utili nel trattamento delle malattie car.iovascolari

Info

Publication number: IT1274673B
Authority: IT; Italy
Prior art keywords: carbon atoms; alkyl; pct; groups; alkyl moiety
Prior art date: 1994-04-14

Application number

ITMI940696A

Other languages

English (en)

Inventor

Gabriele Norcini

Gabriele Morazzoni

Francesco Santangelo

Original Assignee

Zambon Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-04-14

Filing date

1994-04-14

Publication date

1997-07-24

1994-04-14 Application filed by Zambon Spa filed Critical Zambon Spa

1994-04-14 Publication of ITMI940696A0 publication Critical patent/ITMI940696A0/it

1994-04-14 Priority to ITMI940696A priority Critical patent/IT1274673B/it

1995-04-11 Priority to DE69511689T priority patent/DE69511689T2/de

1995-04-11 Priority to AU23058/95A priority patent/AU2305895A/en

1995-04-11 Priority to EP95916625A priority patent/EP0755405B1/en

1995-04-11 Priority to US08/702,701 priority patent/US5760285A/en

1995-04-11 Priority to ES95916625T priority patent/ES2136848T3/es

1995-04-11 Priority to AT95916625T priority patent/ATE183750T1/de

1995-04-11 Priority to PCT/EP1995/001322 priority patent/WO1995028417A1/en

1995-10-14 Publication of ITMI940696A1 publication Critical patent/ITMI940696A1/it

1997-07-24 Application granted granted Critical

1997-07-24 Publication of IT1274673B publication Critical patent/IT1274673B/it

Links

229940042400 direct acting antivirals phosphonic acid derivative Drugs 0.000 title 1
201000010099 disease Diseases 0.000 title 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
150000003007 phosphonic acid derivatives Chemical class 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 abstract 6
125000000217 alkyl group Chemical group 0.000 abstract 5
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
125000003710 aryl alkyl group Chemical group 0.000 abstract 2
125000001424 substituent group Chemical group 0.000 abstract 2
125000004846 (C1-C4) allyl group Chemical group 0.000 abstract 1
208000024172 Cardiovascular disease Diseases 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
239000005864 Sulphur Substances 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
125000006267 biphenyl group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000001153 fluoro group Chemical group F* 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000004001 thioalkyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

ITMI940696A 1994-04-14 1994-04-14 Derivati dell'acido fosfonico utili nel trattamento delle malattie car.iovascolari IT1274673B (it)

Priority Applications (8)

Application Number	Priority Date	Filing Date	Title
ITMI940696A IT1274673B (it)	1994-04-14	1994-04-14	Derivati dell'acido fosfonico utili nel trattamento delle malattie car.iovascolari
US08/702,701 US5760285A (en)	1994-04-14	1995-04-11	Phosphonyldipeptides useful in the treatment of cardiovascular diseases
AU23058/95A AU2305895A (en)	1994-04-14	1995-04-11	Phosphonyldipeptides useful in the treatment of cardiovascular diseases
EP95916625A EP0755405B1 (en)	1994-04-14	1995-04-11	Phosphonyldipeptides useful in the treatment of cardiovascular diseases
DE69511689T DE69511689T2 (de)	1994-04-14	1995-04-11	Phosphonyldipeptide zur bekämpfung von kardiovasvakuläre erkrankungen
ES95916625T ES2136848T3 (es)	1994-04-14	1995-04-11	Fosfonildipeptidos utiles para el tratamiento de enfermedades cardiovasculares.
AT95916625T ATE183750T1 (de)	1994-04-14	1995-04-11	Phosphonyldipeptide zur bekämpfung von kardiovasvakuläre erkrankungen
PCT/EP1995/001322 WO1995028417A1 (en)	1994-04-14	1995-04-11	Phosphonyldipeptides useful in the treatment of cardiovascular diseases

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ITMI940696A IT1274673B (it)	1994-04-14	1994-04-14	Derivati dell'acido fosfonico utili nel trattamento delle malattie car.iovascolari

Publications (3)

Publication Number	Publication Date
ITMI940696A0 ITMI940696A0 (it)	1994-04-14
ITMI940696A1 ITMI940696A1 (it)	1995-10-14
IT1274673B true IT1274673B (it)	1997-07-24

Family

ID=11368561

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ITMI940696A IT1274673B (it)	1994-04-14	1994-04-14	Derivati dell'acido fosfonico utili nel trattamento delle malattie car.iovascolari

Country Status (8)

Country	Link
US (1)	US5760285A (it)
EP (1)	EP0755405B1 (it)
AT (1)	ATE183750T1 (it)
AU (1)	AU2305895A (it)
DE (1)	DE69511689T2 (it)
ES (1)	ES2136848T3 (it)
IT (1)	IT1274673B (it)
WO (1)	WO1995028417A1 (it)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1276161B1 (it) *	1995-11-23	1997-10-27	Zambon Spa	Derivati dell'acido fosfonico ad attivita' inibitrice delle metallopeptidasi
US6166052A (en) *	1998-03-11	2000-12-26	Warner-Lambert Company	Heteroaryl alkyl alpha substituted peptidylamine calcium channel blockers

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4379146A (en) *	1981-02-17	1983-04-05	Merck & Co., Inc.	Substituted phosphonamides as antihypertensives
US4432972A (en) *	1981-08-03	1984-02-21	E. R. Squibb & Sons, Inc.	Phosphonamidate compounds
IT1224405B (it) *	1987-12-23	1990-10-04	Simes	Composti attivi sul sistema cardiovascolare
FR2652087B1 (fr) *	1989-09-15	1993-10-15	Bioprojet Ste Civile	Derives d'amino-acides, leur procede de preparation et leurs applications therapeutiques.
US5155100A (en) *	1991-05-01	1992-10-13	Ciba-Geigy Corporation	Phosphono/biaryl substituted dipeptide derivatives
US5294632A (en) *	1991-05-01	1994-03-15	Ciba-Geigy Corporation	Phosphono/biaryl substituted dipetide derivatives
JPH05105698A (ja) *	1991-06-13	1993-04-27	Takeda Chem Ind Ltd	ホスホン酸誘導体、その製造法および用途
IT1254521B (it) *	1992-03-17	1995-09-25	Zambon Spa	Derivati della 2-ammino-tetralina attivi sul sistema cardiovascolare

1994
- 1994-04-14 IT ITMI940696A patent/IT1274673B/it active IP Right Grant
1995
- 1995-04-11 AT AT95916625T patent/ATE183750T1/de not_active IP Right Cessation
- 1995-04-11 AU AU23058/95A patent/AU2305895A/en not_active Abandoned
- 1995-04-11 ES ES95916625T patent/ES2136848T3/es not_active Expired - Lifetime
- 1995-04-11 WO PCT/EP1995/001322 patent/WO1995028417A1/en not_active Ceased
- 1995-04-11 US US08/702,701 patent/US5760285A/en not_active Expired - Fee Related
- 1995-04-11 EP EP95916625A patent/EP0755405B1/en not_active Expired - Lifetime
- 1995-04-11 DE DE69511689T patent/DE69511689T2/de not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0755405A1 (en)	1997-01-29
ITMI940696A1 (it)	1995-10-14
AU2305895A (en)	1995-11-10
ES2136848T3 (es)	1999-12-01
EP0755405B1 (en)	1999-08-25
US5760285A (en)	1998-06-02
ITMI940696A0 (it)	1994-04-14
WO1995028417A1 (en)	1995-10-26
DE69511689D1 (de)	1999-09-30
DE69511689T2 (de)	2000-04-27
ATE183750T1 (de)	1999-09-15

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Legal Events

Date	Code	Title	Description
1997-07-24	0001	Granted
1999-10-27	TA	Fee payment date (situation as of event date), data collected since 19931001	Effective date: 19971020