ES2087879T3 - Nuevos derivados de insulina, procedimiento para su preparacion, su uso y un preparado farmaceutico que los contiene. - Google Patents
Nuevos derivados de insulina, procedimiento para su preparacion, su uso y un preparado farmaceutico que los contiene.Info
- Publication number
- ES2087879T3 ES2087879T3 ES90121101T ES90121101T ES2087879T3 ES 2087879 T3 ES2087879 T3 ES 2087879T3 ES 90121101 T ES90121101 T ES 90121101T ES 90121101 T ES90121101 T ES 90121101T ES 2087879 T3 ES2087879 T3 ES 2087879T3
- Authority
- ES
- Spain
- Prior art keywords
- elevated
- well
- physiologically
- insulin derivatives
- radical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- Emergency Medicine (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
NUEVOS DERIVADOS DE LA INSULINA DE LA FORMULA III EN LA CUAL A) R ELEVADO 30 + R ELEVADO 31 JUNTOS = OH O B) R ELEVADO 30 = RADICAL DE UN AMINOACIDO-L NEUTRO Y GENETICAMENTE CODIFICABLE, Y R ELEVADO 31 = OH O UN GRUPO ORGANICO FISIOLOGICAMENTE INOFENSIVO CON CARACTER BASICO CON HASTA 50 ATOMOS-C, EN CUYA ESTRUCTURA PARTICIPAN DE 0 A 3 ALFA -AMINOACIDOS Y CUYA FUNCION CARBOXILICA FINAL, EN EL CASO DE QUE EXISTA, PUEDE PRESENTARSE LIBRE COMO FUNCION ESTER, COMO FUNCION AMIDA, COMO LACTONA O REDUCIDA A CH SUB 2 OH, Y C) R ELEVADO A-1 = RADICAL DE UN AMINOACIDO-L GENETICAMENTE CODIFICABLE O UN GRUPO ORGANICO, FISIOLOGICAMENTE INOFENSIVO, CON HASTA 50 ATOMOS-C, A EXCEPCION DE LOS CASOS EN LA QUE, AL MISMO TIEMPO, R ELEVADO 30 = ALA, R ELEVADO 31 = OH, R ELEVADO A-1 = LYS O ARG ASI COMO LA CADENA A Y B SON SECUENCIAS DE LA INSULINA DE BUEY, ASI COMO SUS SALES FISIOLOGICAMENTE COMPATIBLES. LOS COMPUESTOS SIRVEN PARA EL TRATAMIENTO DE DIABETES MELLITUS, POSEEN UN PERFIL DE EFECTO RETARDADO Y SON MUY BIEN ASIMILABLES.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3936876A DE3936876A1 (de) | 1989-11-06 | 1989-11-06 | Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2087879T3 true ES2087879T3 (es) | 1996-08-01 |
Family
ID=6392948
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES90121101T Expired - Lifetime ES2087879T3 (es) | 1989-11-06 | 1990-11-03 | Nuevos derivados de insulina, procedimiento para su preparacion, su uso y un preparado farmaceutico que los contiene. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5149716A (es) |
| EP (1) | EP0427162B1 (es) |
| JP (1) | JP3131215B2 (es) |
| KR (1) | KR910009930A (es) |
| AT (1) | ATE137765T1 (es) |
| AU (1) | AU6577290A (es) |
| CA (1) | CA2029289A1 (es) |
| DE (2) | DE3936876A1 (es) |
| DK (1) | DK0427162T3 (es) |
| ES (1) | ES2087879T3 (es) |
| FI (1) | FI905439A7 (es) |
| GR (1) | GR3020095T3 (es) |
| HU (1) | HU205773B (es) |
| IE (1) | IE903978A1 (es) |
| IL (1) | IL96239A0 (es) |
| NO (1) | NO904808L (es) |
| PT (1) | PT95788A (es) |
| ZA (1) | ZA908842B (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6875589B1 (en) * | 1988-06-23 | 2005-04-05 | Hoechst Aktiengesellschaft | Mini-proinsulin, its preparation and use |
| TW224471B (es) * | 1991-11-26 | 1994-06-01 | Lilly Co Eli | |
| JP3406244B2 (ja) | 1999-04-30 | 2003-05-12 | 伊藤ハム株式会社 | 新規な融合蛋白質からの組み換えインスリンの製造方法 |
| PL374949A1 (en) * | 2001-12-20 | 2005-11-14 | Eli Lilly And Company | Insulin molecule having protracted time action |
| US20060217290A1 (en) * | 2003-04-29 | 2006-09-28 | Kohn Wayne D | Insulin analogs having protracted time action |
| US7833513B2 (en) | 2004-12-03 | 2010-11-16 | Rhode Island Hospital | Treatment of Alzheimer's Disease |
| WO2007081824A2 (en) * | 2006-01-06 | 2007-07-19 | Case Western Reserve University | Fibrillation resistant proteins |
| EP2074140B8 (en) * | 2006-10-04 | 2015-10-28 | Case Western Reserve University | Fibrillation-resistant insulin and insulin analogues |
| US8993516B2 (en) * | 2008-04-14 | 2015-03-31 | Case Western Reserve University | Meal-time insulin analogues of enhanced stability |
| RU2010147076A (ru) * | 2008-04-22 | 2012-05-27 | Кейз Вестерн Ризев Юнивесити (Us) | Аналоги инсулина специфичные к изоформам |
| KR20120129875A (ko) | 2008-07-31 | 2012-11-28 | 케이스 웨스턴 리저브 유니버시티 | 염소화 아미노산을 갖는 인슐린 유사체 |
| US9200053B2 (en) | 2008-07-31 | 2015-12-01 | Case Western Reserve University | Insulin analogues containing penta-fluoro-Phenylalanine at position B24 |
| PL2451437T3 (pl) | 2009-07-06 | 2017-05-31 | Sanofi-Aventis Deutschland Gmbh | Wodne preparaty insuliny zawierające metioninę |
| US8399407B2 (en) * | 2009-09-17 | 2013-03-19 | Case Western Reserve University | Non-standard insulin analogues |
| EA201200717A1 (ru) | 2009-12-11 | 2013-03-29 | Кейз Вестерн Ризев Юнивесити | Аналоги инсулина, содержащие хлорированные аминокислоты |
| RU2447149C1 (ru) * | 2011-03-24 | 2012-04-10 | Винсорт Менеджемент Инк | РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК pMSIN4, КОДИРУЮЩАЯ ГИБРИДНЫЙ ПОЛИПЕПТИД - ПРЕДШЕСТВЕННИК ИНСУЛИНА ЧЕЛОВЕКА, ШТАММ BL21(DE3)/pMSIN4-ПРОДУЦЕНТ РЕКОМБИНАНТНОГО ИНСУЛИНА ЧЕЛОВЕКА, СПОСОБ ПОЛУЧЕНИЯ РЕКОМБИНАНТНОГО ИНСУЛИНА ЧЕЛОВЕКА |
| EP2983697B1 (en) | 2013-04-03 | 2018-10-31 | Sanofi | Treatment of diabetes mellitus by long acting formulations of insulins |
| AU2015328222B9 (en) | 2014-10-06 | 2020-12-24 | Case Western Reserve University | Biphasic single-chain insulin analogues |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3326473A1 (de) * | 1983-07-22 | 1985-01-31 | Hoechst Ag, 6230 Frankfurt | Pharmazeutisches mittel zur behandlung des diabetes mellitus |
| DE3326472A1 (de) * | 1983-07-22 | 1985-02-14 | Hoechst Ag, 6230 Frankfurt | Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus |
| DE3327928A1 (de) * | 1983-08-03 | 1985-02-21 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung von insulin-derivaten |
| DE3333640A1 (de) * | 1983-09-17 | 1985-04-25 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung von insulin-derivaten, deren b-kette c-terminal verlaengert ist, neue basisch modifizierte insulin-derivate diese enthaltende mittel und ihre verwendung |
| DK113585D0 (da) * | 1985-03-12 | 1985-03-12 | Novo Industri As | Nye peptider |
| DK347086D0 (da) * | 1986-07-21 | 1986-07-21 | Novo Industri As | Novel peptides |
| DE3837273A1 (de) * | 1987-05-05 | 1990-05-10 | Hoechst Ag | Verfahren zur herstellung eines insulin-vorprodukts in streptomyceten |
| DE3714866A1 (de) * | 1987-05-05 | 1988-11-24 | Hoechst Ag | Verfahren zur herstellung von fremdproteinen in streptomyceten |
| DE3844211A1 (de) * | 1988-12-29 | 1990-07-05 | Hoechst Ag | Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung |
-
1989
- 1989-11-06 DE DE3936876A patent/DE3936876A1/de not_active Withdrawn
-
1990
- 1990-10-26 US US07/603,835 patent/US5149716A/en not_active Expired - Lifetime
- 1990-11-02 FI FI905439A patent/FI905439A7/fi not_active Application Discontinuation
- 1990-11-03 DK DK90121101.1T patent/DK0427162T3/da active
- 1990-11-03 ES ES90121101T patent/ES2087879T3/es not_active Expired - Lifetime
- 1990-11-03 EP EP90121101A patent/EP0427162B1/de not_active Expired - Lifetime
- 1990-11-03 AT AT90121101T patent/ATE137765T1/de not_active IP Right Cessation
- 1990-11-03 DE DE59010316T patent/DE59010316D1/de not_active Expired - Lifetime
- 1990-11-05 ZA ZA908842A patent/ZA908842B/xx unknown
- 1990-11-05 IE IE397890A patent/IE903978A1/en unknown
- 1990-11-05 PT PT95788A patent/PT95788A/pt not_active Application Discontinuation
- 1990-11-05 HU HU907026A patent/HU205773B/hu not_active IP Right Cessation
- 1990-11-05 JP JP02297376A patent/JP3131215B2/ja not_active Expired - Lifetime
- 1990-11-05 AU AU65772/90A patent/AU6577290A/en not_active Abandoned
- 1990-11-05 NO NO90904808A patent/NO904808L/no unknown
- 1990-11-05 IL IL96239A patent/IL96239A0/xx unknown
- 1990-11-05 CA CA002029289A patent/CA2029289A1/en not_active Abandoned
- 1990-11-06 KR KR1019900017864A patent/KR910009930A/ko not_active Withdrawn
-
1996
- 1996-05-30 GR GR960401457T patent/GR3020095T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE59010316D1 (de) | 1996-06-13 |
| ATE137765T1 (de) | 1996-05-15 |
| KR910009930A (ko) | 1991-06-28 |
| HUT55804A (en) | 1991-06-28 |
| DK0427162T3 (da) | 1996-09-16 |
| IL96239A0 (en) | 1991-08-16 |
| CA2029289A1 (en) | 1991-05-07 |
| ZA908842B (en) | 1991-08-28 |
| HU907026D0 (en) | 1991-05-28 |
| HU205773B (en) | 1992-06-29 |
| JPH03169895A (ja) | 1991-07-23 |
| EP0427162B1 (de) | 1996-05-08 |
| JP3131215B2 (ja) | 2001-01-31 |
| NO904808D0 (no) | 1990-11-05 |
| AU6577290A (en) | 1991-05-09 |
| FI905439A0 (fi) | 1990-11-02 |
| IE903978A1 (en) | 1991-05-08 |
| EP0427162A1 (de) | 1991-05-15 |
| FI905439A7 (fi) | 1991-05-07 |
| GR3020095T3 (en) | 1996-08-31 |
| PT95788A (pt) | 1991-09-13 |
| DE3936876A1 (de) | 1991-05-23 |
| NO904808L (no) | 1991-05-07 |
| US5149716A (en) | 1992-09-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2087879T3 (es) | Nuevos derivados de insulina, procedimiento para su preparacion, su uso y un preparado farmaceutico que los contiene. | |
| FI842915A0 (fi) | Farmaceutiskt medel foer behandling av diabetes. | |
| DE58909633D1 (de) | Neue Insulinderivate, Verfahren zu deren Herstellung, ihre Verwendung und eine sie enthaltende pharmazeutische Zubereitung | |
| ES2116315T3 (es) | Proinsulina a-c-b, procedimiento de preparacion y de utilizacion e intermediarios en la produccion de insulina. | |
| ES8504678A1 (es) | Procedimiento para la preparacion de un derivado de insulina | |
| MX168494B (es) | Nuevos derivados de pirazolina su preparacion y su uso como plaguisidas | |
| GR1000908B (el) | Ηπατοειδικά ανάλογα ινσουλίνης. | |
| ES2161697T3 (es) | Peptidos agonistas de amilina y usos de los mismos. | |
| AR018501A1 (es) | Derivados de la dolastatina 15 | |
| DE68922405D1 (de) | Deletionsanaloga von magaininpeptiden. | |
| ES8602716A1 (es) | Procedimiento para la preparacion de derivados de tiazolidina. | |
| AR004497A1 (es) | Un análogo hexapéptido cíclico de somatostatina, procedimiento para prepararlos y las composiciones farmacéuticas que los contienen y el uso de dicho hexapéptido para la preparación de una composición farmacéutica. | |
| AR044852A1 (es) | Una composicion farmaceutica para la administracion parenteral que comprende un analogo de somatostatina | |
| AR034853A1 (es) | Secuencia de acido nucleico sintetico que codifica una alfa-galactosidasa, vector y celula que la comprenden, metodo para producir alfa-galactosidasa, metodo para prepararla, composicion farmaceutica que comprende dicha secuencia y su uso para preparar esta ultima | |
| ES2105194T3 (es) | Derivados de sales internas de fosfiniloxipropanaminio, procedimiento para su preparacion y composiciones farmaceuticas que los contienen. | |
| MX9703407A (es) | Uso de esteres 3-arilacrilicos como estabilizadores, particularmente contra la accion de la luz, para material organico no vivo. | |
| DK0454367T3 (da) | Væksthormon-releasing faktor-analoger | |
| ES2063014T3 (es) | Derivados de 2-oxa-isocefemo, composiciones que los contienen y procedimientos de preparacion. | |
| ES2040993T3 (es) | Un metodo para producir una formulacion promotora del crecimiento animal. | |
| ES2013431A6 (es) | Procedimiento para preparar peptidos de somatostatina. | |
| MX9204116A (es) | 2-amino-5-mercaptotiadizoles, aminoalquilsustituidos su preparacion y su empleo. | |
| ES8704185A1 (es) | Procedimiento para preparar derivados de aminoacidos |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
Ref document number: 427162 Country of ref document: ES |