ES2116315T3 - Proinsulina a-c-b, procedimiento de preparacion y de utilizacion e intermediarios en la produccion de insulina. - Google Patents

Proinsulina a-c-b, procedimiento de preparacion y de utilizacion e intermediarios en la produccion de insulina.

Info

Publication number
ES2116315T3
ES2116315T3 ES92305222T ES92305222T ES2116315T3 ES 2116315 T3 ES2116315 T3 ES 2116315T3 ES 92305222 T ES92305222 T ES 92305222T ES 92305222 T ES92305222 T ES 92305222T ES 2116315 T3 ES2116315 T3 ES 2116315T3
Authority
ES
Spain
Prior art keywords
insulin
molecules
proinsulin
production
species
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92305222T
Other languages
English (en)
Inventor
Rama M Belagaje
Richard Dennis Dimarchi
William Francis Heath Jr
Harlan Beall Long
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of ES2116315T3 publication Critical patent/ES2116315T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

LA INVENCION SUMINISTRA NUEVAS MOLECULAS DERIVADAS DE LOS COMPONENTES DE LA PROINSULINA QUE USA TECNOLOGIA DE DNA RECOMBINANTE. LA INVENCION SUMINISTRA MOLECULAS DE LA FORMULA AC-B EN LA QUE A ES LA CADENA A DE UNA ESPECIE DE INSULINA, B ES LA CADENA B DE UNA ESPECIE DE INSULINA Y C ES UN PEPTIDO DE CONEXION. ESTAS MOLECULAS POSEEN ACTIVIDAD SIMILAR A LA INSULINA Y SON UTILES PARA EL TRATAMIENTO DE LA DIABETES, PARTICULARMENTE DE LA DIABETES NO DEPENDIENTE DE LA INSULINA. ESTAS MOLECULAS SON TAMBIEN UTILES PARA LA PRODUCCION DE INSULINA Y CONSTITUYEN UNA NUEVA LINEA DE PRODUCCION RECOMBINANTE DE ESPECIES DE INSULINA. LA INVENCION SUMINISTRA UN METODO PARA FABRICAR INSULINA A PARTIR DE LOS COMPUESTOS DE LA INVENCION USADOS COMO PRODUCTOS INTERMEDIOS. LA INVENCION SUMINISTRA ADEMAS COMPUESTOS DE DNA RECOMBINANTE QUE CODIFICA LOS COMPUESTOS DE LA INVENCION.
ES92305222T 1991-06-11 1992-06-08 Proinsulina a-c-b, procedimiento de preparacion y de utilizacion e intermediarios en la produccion de insulina. Expired - Lifetime ES2116315T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/715,183 US5304473A (en) 1991-06-11 1991-06-11 A-C-B proinsulin, method of manufacturing and using same, and intermediates in insulin production

Publications (1)

Publication Number Publication Date
ES2116315T3 true ES2116315T3 (es) 1998-07-16

Family

ID=24872995

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92305222T Expired - Lifetime ES2116315T3 (es) 1991-06-11 1992-06-08 Proinsulina a-c-b, procedimiento de preparacion y de utilizacion e intermediarios en la produccion de insulina.

Country Status (23)

Country Link
US (1) US5304473A (es)
EP (1) EP0518587B1 (es)
JP (1) JPH05255392A (es)
KR (1) KR930000536A (es)
CN (1) CN1068501A (es)
AT (1) ATE166106T1 (es)
AU (1) AU648670B2 (es)
BR (1) BR9202180A (es)
CA (1) CA2070503C (es)
CZ (1) CZ171492A3 (es)
DE (1) DE69225432T2 (es)
DK (1) DK0518587T3 (es)
ES (1) ES2116315T3 (es)
FI (1) FI922645L (es)
HU (1) HUT63193A (es)
IE (1) IE921862A1 (es)
IL (1) IL102107A0 (es)
MX (1) MX9202726A (es)
NO (1) NO922224L (es)
NZ (1) NZ243089A (es)
SK (1) SK171492A3 (es)
YU (1) YU59392A (es)
ZA (1) ZA924080B (es)

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US6348327B1 (en) * 1991-12-06 2002-02-19 Genentech, Inc. Non-endocrine animal host cells capable of expressing variant proinsulin and processing the same to form active, mature insulin and methods of culturing such cells
FR2686899B1 (fr) * 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
EP0707650B1 (en) * 1993-06-21 2003-05-21 Genentech, Inc. Process for producing human relaxin
US5646242A (en) 1994-11-17 1997-07-08 Eli Lilly And Company Selective acylation of epsilon-amino groups
US5665591A (en) * 1994-12-06 1997-09-09 Trustees Of Boston University Regulation of smooth muscle cell proliferation
KR0150565B1 (ko) * 1995-02-15 1998-08-17 김정재 유전자 조환에 의한 사람 인슐린 전구체의 제조 및 이를 이용한 인슐린의 제조방법
US5576197A (en) * 1995-04-07 1996-11-19 Molecular Bio-Products Polymerase chain reaction container and methods of using the same
EP0741188A3 (en) * 1995-05-05 1999-07-14 Eli Lilly And Company Single chain insulin with high bioactivity
US5631347A (en) * 1995-06-07 1997-05-20 Eli Lilly And Company Reducing gelation of a fatty acid-acylated protein
US5700904A (en) * 1995-06-07 1997-12-23 Eli Lilly And Company Preparation of an acylated protein powder
GB9513967D0 (en) * 1995-07-08 1995-09-06 Univ Leicester Insulin
US5905140A (en) * 1996-07-11 1999-05-18 Novo Nordisk A/S, Novo Alle Selective acylation method
US7169889B1 (en) * 1999-06-19 2007-01-30 Biocon Limited Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin
US7378390B2 (en) * 1999-12-29 2008-05-27 Novo Nordisk A/S Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast
EP2206720A1 (en) * 2000-04-12 2010-07-14 Human Genome Sciences, Inc. Albumin fusion proteins
US20050100991A1 (en) * 2001-04-12 2005-05-12 Human Genome Sciences, Inc. Albumin fusion proteins
US7790690B2 (en) 2000-10-11 2010-09-07 U.S. Department Of Veterans Affairs Glucose sensitive regulator of insulin transcription
US20030054015A1 (en) * 2000-12-25 2003-03-20 Shinichiro Haze Sympathetic-activating perfume composition
US7067148B2 (en) 2001-02-15 2006-06-27 King Pharmaceutical Research & Development, Inc. Stabilized pharmaceutical and thyroid hormone compositions and method of preparation
US6867183B2 (en) * 2001-02-15 2005-03-15 Nobex Corporation Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US7060675B2 (en) * 2001-02-15 2006-06-13 Nobex Corporation Methods of treating diabetes mellitus
US7105314B2 (en) * 2001-04-02 2006-09-12 Novo Nordisk A/S Method for making human insulin precursors
WO2002097038A2 (en) * 2001-05-25 2002-12-05 Human Genome Sciences, Inc. Chemokine beta-1 fusion proteins
US6835802B2 (en) * 2001-06-04 2004-12-28 Nobex Corporation Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
US7713932B2 (en) 2001-06-04 2010-05-11 Biocon Limited Calcitonin drug-oligomer conjugates, and uses thereof
US6828297B2 (en) * 2001-06-04 2004-12-07 Nobex Corporation Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6858580B2 (en) * 2001-06-04 2005-02-22 Nobex Corporation Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6713452B2 (en) 2001-06-04 2004-03-30 Nobex Corporation Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6828305B2 (en) * 2001-06-04 2004-12-07 Nobex Corporation Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US7101569B2 (en) 2001-08-14 2006-09-05 Franz G Andrew Methods of administering levothyroxine pharmaceutical compositions
US6913903B2 (en) * 2001-09-07 2005-07-05 Nobex Corporation Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7312192B2 (en) * 2001-09-07 2007-12-25 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7166571B2 (en) * 2001-09-07 2007-01-23 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7196059B2 (en) * 2001-09-07 2007-03-27 Biocon Limited Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
AU2002364587A1 (en) * 2001-12-21 2003-07-30 Human Genome Sciences, Inc. Albumin fusion proteins
EP2261250B1 (en) * 2001-12-21 2015-07-01 Human Genome Sciences, Inc. GCSF-Albumin fusion proteins
AU2003236521A1 (en) * 2002-06-13 2003-12-31 Nobex Corporation Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
US20050026826A1 (en) * 2003-01-17 2005-02-03 Margarethe Hoenig Feline proinsulin, insulin and constituent peptides
CA2513213C (en) 2003-01-22 2013-07-30 Human Genome Sciences, Inc. Albumin fusion proteins
CN1902226A (zh) 2003-12-03 2007-01-24 诺和诺德公司 单链胰岛素
BRPI0513508B1 (pt) 2004-07-19 2021-06-01 Biocon Limited Conjugados de insulina-oligômero, formulações e usos desses
US20090099095A1 (en) * 2007-05-16 2009-04-16 Peter Eriksson Novel neuroprotective peptide
JP5868594B2 (ja) * 2007-10-16 2016-02-24 バイオコン・リミテッドＢｉｏｃｏｎ Ｌｉｍｉｔｅｄ 経口投与可能な固形医薬組成物及びそのプロセス
EP2726502A1 (en) * 2011-07-01 2014-05-07 Bayer Intellectual Property GmbH Relaxin fusion polypeptides and uses thereof
US9707276B2 (en) 2012-12-03 2017-07-18 Merck Sharp & Dohme Corp. O-glycosylated carboxy terminal portion (CTP) peptide-based insulin and insulin analogues
TW201605470A (zh) 2013-10-04 2016-02-16 默沙東藥廠 葡萄糖反應性胰島素結合物
EA036714B1 (ru) 2014-11-21 2020-12-10 Мерк Шарп И Доум Корп. Частичные агонисты инсулинового рецептора
US10745457B2 (en) 2015-09-02 2020-08-18 Merck Sharp & Dohme Corp. Process for obtaining insulin with correctly formed disulfide bonds
EP3448417B1 (en) 2016-04-26 2025-11-12 Merck Sharp & Dohme LLC Insulin dimer-incretin conjugates
EP3463429A4 (en) 2016-05-24 2020-07-22 Merck Sharp & Dohme Corp. PARTIAL INSULIN RECEPTOR AGONISTS AND GLP-1 ANALOGUES
US10689430B2 (en) 2016-05-25 2020-06-23 Merck Sharp & Dohme Corp. Insulin receptor partial agonists
JP2019520837A (ja) 2016-07-18 2019-07-25 イーティーエイチ・チューリッヒ Β細胞ミメティック細胞
EP3272877A1 (en) 2016-07-18 2018-01-24 ETH Zurich B-cell-mimetic cells
AU2017322552B2 (en) * 2016-09-06 2021-12-02 Chemical & Biopharmaceutical Laboratories Of Patras S.A. Proinsulin derivatives
WO2018175272A1 (en) 2017-03-23 2018-09-27 Merck Sharp & Dohme Corp. Glucose responsive insulin comprising a tri-valent sugar cluster for treatment of diabetes
EP3980052A4 (en) 2019-06-06 2023-08-23 Merck Sharp & Dohme LLC GLUCOSE-RESPONDING INSULIN CONJUGATES

Family Cites Families (4)

* Cited by examiner, † Cited by third party
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US4666884A (en) * 1984-04-10 1987-05-19 New England Deaconess Hospital Method of inhibiting binding of von Willebrand factor to human platelets and inducing interaction of platelets with vessel walls
KR910700262A (ko) * 1988-12-23 1991-03-14 안네 제케르 사람 인슐린 유사체
PT93057B (pt) * 1989-02-09 1995-12-29 Lilly Co Eli Processo para a preparacao de analogos da insulina
DK134189D0 (da) * 1989-03-20 1989-03-20 Nordisk Gentofte Insulinforbindelser

Also Published As

Publication number Publication date
SK171492A3 (en) 1995-04-12
NO922224D0 (no) 1992-06-05
FI922645A7 (fi) 1992-12-12
JPH05255392A (ja) 1993-10-05
EP0518587A2 (en) 1992-12-16
EP0518587A3 (en) 1993-12-01
CA2070503A1 (en) 1992-12-12
FI922645L (fi) 1992-12-12
FI922645A0 (fi) 1992-06-08
DE69225432T2 (de) 1998-10-01
AU1806992A (en) 1993-03-11
US5304473A (en) 1994-04-19
MX9202726A (es) 1992-12-01
NZ243089A (en) 1994-01-26
DK0518587T3 (da) 1998-10-19
AU648670B2 (en) 1994-04-28
HUT63193A (en) 1993-07-28
EP0518587B1 (en) 1998-05-13
CA2070503C (en) 1999-01-12
CZ171492A3 (en) 1993-05-12
YU59392A (sh) 1994-11-15
ZA924080B (en) 1993-12-06
BR9202180A (pt) 1993-02-02
DE69225432D1 (de) 1998-06-18
CN1068501A (zh) 1993-02-03
IE921862A1 (en) 1992-12-16
IL102107A0 (en) 1993-01-14
KR930000536A (ko) 1993-01-15
ATE166106T1 (de) 1998-05-15
HU9201915D0 (en) 1992-08-28
NO922224L (no) 1992-12-14

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