ES2088000T3 - Procedimiento para la obtencion de (2s,3s)-3-etilasparaginatos de dialquilo n-protegidos. - Google Patents

Procedimiento para la obtencion de (2s,3s)-3-etilasparaginatos de dialquilo n-protegidos.

Info

Publication number
ES2088000T3
ES2088000T3 ES91904470T ES91904470T ES2088000T3 ES 2088000 T3 ES2088000 T3 ES 2088000T3 ES 91904470 T ES91904470 T ES 91904470T ES 91904470 T ES91904470 T ES 91904470T ES 2088000 T3 ES2088000 T3 ES 2088000T3
Authority
ES
Spain
Prior art keywords
pct
dialkyl
protected
ethylasparaginates
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91904470T
Other languages
English (en)
Inventor
Ulrich Heywang
Harry Schwartz
Michael Casutt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Application granted granted Critical
Publication of ES2088000T3 publication Critical patent/ES2088000T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

LA INVENCION SE REFIERE A UN METODO PARA PREPARAR DIALQUILESTERES DE ACIDO (2S-3S)-3-ETILASPARTICO N-PROTEGIDOS O SUS SALES A PARTIR DE ACIDO (2S-3S)-ETILASPARTICO NO PURIFICADO OBTENIDO POR AMINACION ENZIMATICA DE ACIDO ETILFUMARICO.
ES91904470T 1990-03-07 1991-02-22 Procedimiento para la obtencion de (2s,3s)-3-etilasparaginatos de dialquilo n-protegidos. Expired - Lifetime ES2088000T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4007038A DE4007038A1 (de) 1990-03-07 1990-03-07 Verfahren zur herstellung von n-geschuetzten (2s,3s)-3-ethylasparaginsaeuredialkylestern

Publications (1)

Publication Number Publication Date
ES2088000T3 true ES2088000T3 (es) 1996-08-01

Family

ID=6401540

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91904470T Expired - Lifetime ES2088000T3 (es) 1990-03-07 1991-02-22 Procedimiento para la obtencion de (2s,3s)-3-etilasparaginatos de dialquilo n-protegidos.

Country Status (11)

Country Link
US (1) US5275941A (es)
EP (1) EP0471809B1 (es)
JP (1) JP2968586B2 (es)
KR (1) KR0178960B1 (es)
AT (1) ATE138640T1 (es)
AU (1) AU646844B2 (es)
CA (1) CA2054715C (es)
DE (2) DE4007038A1 (es)
ES (1) ES2088000T3 (es)
HU (1) HU210953B (es)
WO (1) WO1991013861A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102381999A (zh) * 2011-09-14 2012-03-21 杭州澳赛诺化工有限公司 一种l-天冬氨酸-4-甲酯-1-苄酯的合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4552846A (en) * 1984-01-19 1985-11-12 Uop Inc. Aspartase from a Bacillus subtilis
US4569911A (en) * 1984-01-19 1986-02-11 Uop Inc. Method of making aspartic acid and purifying aspartase

Also Published As

Publication number Publication date
CA2054715C (en) 2002-05-28
HU210953B (en) 1995-09-28
EP0471809B1 (de) 1996-05-29
KR0178960B1 (ko) 1999-05-15
HU913486D0 (en) 1992-01-28
WO1991013861A1 (de) 1991-09-19
JPH04505467A (ja) 1992-09-24
KR920701126A (ko) 1992-08-11
DE4007038A1 (de) 1991-09-12
AU646844B2 (en) 1994-03-10
DE59107855D1 (de) 1996-07-04
US5275941A (en) 1994-01-04
JP2968586B2 (ja) 1999-10-25
AU7301491A (en) 1991-10-10
ATE138640T1 (de) 1996-06-15
EP0471809A1 (de) 1992-02-26
CA2054715A1 (en) 1991-09-08
HUT60461A (en) 1992-09-28

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