ES2088882T3 - Derivados de pirrol(3,2-e)pirazol(1,5-a)pirimidina y medicinas que comprenden los mismos. - Google Patents

Derivados de pirrol(3,2-e)pirazol(1,5-a)pirimidina y medicinas que comprenden los mismos.

Info

Publication number
ES2088882T3
ES2088882T3 ES89118210T ES89118210T ES2088882T3 ES 2088882 T3 ES2088882 T3 ES 2088882T3 ES 89118210 T ES89118210 T ES 89118210T ES 89118210 T ES89118210 T ES 89118210T ES 2088882 T3 ES2088882 T3 ES 2088882T3
Authority
ES
Spain
Prior art keywords
derivatives
pirrol
pirimidine
pyrazol
medicines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89118210T
Other languages
English (en)
Inventor
Michihiko Tsujitani
Kenichi Kishii
Masato Inazu
Toshihiro Morimoto
Yoshiaki Motoki
Ichiro Matsuo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pola Orbis Holdings Inc
Original Assignee
Pola Chemical Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pola Chemical Industries Inc filed Critical Pola Chemical Industries Inc
Application granted granted Critical
Publication of ES2088882T3 publication Critical patent/ES2088882T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE DESCUBREN DERIVADOS DE PIRROLO[3,2-E]PIRAZOLO[1,5-A] PIRIMIDINA. LOS COMPUESTOS SE REPRESENTAN POR LA FORMULA (I) EN DONDE R1 Y R2 REPRESENTAN INDIVIDUALMENTE UN ATOMO DE HIDROGENO, UN GRUPO ALQUILO LINEAL O RAMIFICADO EL CUAL PUEDE TENER UN SUSTITUYENTE, UN GRUPO CICLOALQUILO O FENILO EL CUAL PUEDE TENER UN SUSTITUYENTE, O UN GRUPO HETEROCICLICO EL CUAL PUEDE TENER UN SUSTITUYENTE, Y R3 ES UN ATOMO DE HIDROGENO O UN GRUPO CIANO. LOS COMPUESTOS TIENEN EXCELENTE ACTIVIDAD CURANDO ENFERMEDADES CIRCULATORIAS ASI COMO ACTIVIDAD BRONCODILATADORA.
ES89118210T 1988-10-13 1989-10-02 Derivados de pirrol(3,2-e)pirazol(1,5-a)pirimidina y medicinas que comprenden los mismos. Expired - Lifetime ES2088882T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP25808488 1988-10-13
JP1155589 1989-01-20
JP1155689 1989-01-20

Publications (1)

Publication Number Publication Date
ES2088882T3 true ES2088882T3 (es) 1996-10-01

Family

ID=27279472

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89118210T Expired - Lifetime ES2088882T3 (es) 1988-10-13 1989-10-02 Derivados de pirrol(3,2-e)pirazol(1,5-a)pirimidina y medicinas que comprenden los mismos.

Country Status (7)

Country Link
US (1) US4992442A (es)
EP (1) EP0369145B1 (es)
KR (1) KR0137766B1 (es)
CN (1) CN1041943A (es)
CA (1) CA1330079C (es)
DE (1) DE68925270T2 (es)
ES (1) ES2088882T3 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0276880A (ja) * 1988-06-16 1990-03-16 Sankyo Co Ltd 悪液質改善治療剤
JPH04307543A (ja) * 1991-04-04 1992-10-29 Konica Corp 新規な写真用カプラー
KR0146931B1 (ko) * 1992-04-30 1998-08-17 고바야시 유끼오 옥사졸리딘 유도체 및 그의 약학적으로 허용가능한 염
JPH10218881A (ja) * 1997-02-03 1998-08-18 Pola Chem Ind Inc 新規なピロロピラゾロピリミジン誘導体
US6329382B1 (en) * 1997-02-14 2001-12-11 Pola Chemical Industries, Inc. Pyrrolo[3,2-e]pyrazolo[1,5-a]pyrimidine remedies/preventives for respiratory diseases
WO2000044754A1 (en) * 1999-01-29 2000-08-03 Sumitomo Chemical Company, Limited Fat accumulation inhibitory agents
TWI271406B (en) 1999-12-13 2007-01-21 Eisai Co Ltd Tricyclic condensed heterocyclic compounds, preparation method of the same and pharmaceuticals comprising the same
US20020061897A1 (en) 2000-03-30 2002-05-23 Elliott Richard L. Neuropeptide Y antagonists
MXPA02010222A (es) 2000-04-18 2003-05-23 Agouron Pharma Pirazoles para inhibir proteina cinasa.
DK1433480T3 (da) 2001-07-13 2011-04-11 Btg Internat Ltd Company Lægemiddel indeholdende pyrimidin-derivat
US7662826B2 (en) * 2002-04-23 2010-02-16 Shionogi & Co., Ltd. Pyrazolo [1,5-a] pyrimidine derivative and nad (p) h oxidase inhibitor containing the same
US7329658B2 (en) * 2003-02-06 2008-02-12 Pfizer Inc Cannabinoid receptor ligands and uses thereof
US7176210B2 (en) * 2003-02-10 2007-02-13 Pfizer Inc. Cannabinoid receptor ligands and uses thereof
EP2266990B1 (en) 2008-04-15 2012-09-26 Eisai R&D Management Co., Ltd. 3-PHENYLPYRAZOLO[5,1-b]THIAZOLE COMPOUND
KR20150130491A (ko) * 2013-03-13 2015-11-23 제넨테크, 인크. 피라졸로 화합물 및 그것의 용도
US12479816B2 (en) 2019-02-08 2025-11-25 University of Pittsburgh—of the Commonwealth System of Higher Education 20-HETE formation inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE792533A (fr) * 1971-12-09 1973-06-08 Int Chem & Nuclear Corp Nouvelles pyrazolo (1,5a) pyrimidines et leur procede de preparation
JPH0276880A (ja) * 1988-06-16 1990-03-16 Sankyo Co Ltd 悪液質改善治療剤

Also Published As

Publication number Publication date
CN1041943A (zh) 1990-05-09
DE68925270T2 (de) 1996-06-13
KR900006330A (ko) 1990-05-07
DE68925270D1 (de) 1996-02-08
EP0369145B1 (en) 1995-12-27
EP0369145A3 (en) 1991-07-17
CA1330079C (en) 1994-06-07
US4992442A (en) 1991-02-12
KR0137766B1 (ko) 1998-05-15
EP0369145A2 (en) 1990-05-23

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