ES2090193T3 - Analogos nucleosidicos carbociclicos como inmunosupresores. - Google Patents

Analogos nucleosidicos carbociclicos como inmunosupresores.

Info

Publication number
ES2090193T3
ES2090193T3 ES91115487T ES91115487T ES2090193T3 ES 2090193 T3 ES2090193 T3 ES 2090193T3 ES 91115487 T ES91115487 T ES 91115487T ES 91115487 T ES91115487 T ES 91115487T ES 2090193 T3 ES2090193 T3 ES 2090193T3
Authority
ES
Spain
Prior art keywords
carbociclic
immunosuppressants
halogen
hydrogen
nucleosidic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91115487T
Other languages
English (en)
Inventor
David R Borcherding
Ronald E Esser
Iii Carl K Edwards
Douglas L Cole
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Application granted granted Critical
Publication of ES2090193T3 publication Critical patent/ES2090193T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

LA INVENCION SE REFIERE A UN METODO PARA EFECTUAR UNA INMUNOSUPRESION EN UN PACIENTE QUE NECESITA LA MISMA, EL CUAL CONSISTE EN ADMINISTRAR UNA CANTIDAD EFICAZ DEL COMPUESTO QUE TIENE LA FORMULA (1) EN DONDE EL SUSTITUYENTE DE HIDROXI DEL ANILLO DE CICLOPENTENILO ESTA EN LA CONFIGURACION CIS RELATIVA AL SUSTITUYENTE BICICLICO, Y SUB 3, Y SUB 7, Y SUB 8 E Y SUB 9 SON CADA UNO INDEPENDIENTEMENTE NITROGENO O UN GRUPO DE CH, Q ES NH SUB 2, HALOGENO O HIDROGENO, Y Z ES HIDROGENO, HALOGENO O NH SUB 2; O UNA SAL FARMACEUTICAMENTE ACEPTABLE DEL MISMO.
ES91115487T 1990-09-14 1991-09-12 Analogos nucleosidicos carbociclicos como inmunosupresores. Expired - Lifetime ES2090193T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58226590A 1990-09-14 1990-09-14
US74817391A 1991-08-23 1991-08-23

Publications (1)

Publication Number Publication Date
ES2090193T3 true ES2090193T3 (es) 1996-10-16

Family

ID=27078521

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91115487T Expired - Lifetime ES2090193T3 (es) 1990-09-14 1991-09-12 Analogos nucleosidicos carbociclicos como inmunosupresores.

Country Status (10)

Country Link
EP (1) EP0475413B1 (es)
JP (1) JPH0543578A (es)
KR (1) KR0175313B1 (es)
AT (1) ATE139444T1 (es)
AU (1) AU642526B2 (es)
DE (1) DE69120357T2 (es)
DK (1) DK0475413T3 (es)
ES (1) ES2090193T3 (es)
GR (1) GR3020794T3 (es)
IE (1) IE74172B1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0521463A3 (en) * 1991-07-04 1993-04-14 Hoechst Aktiengesellschaft Substituted cyclic cycloalkyltriols, process, intermediates for their preparation and their use as antiviral and antiparasitic agents
AU677851B2 (en) 1993-06-21 1997-05-08 Merrell Pharmaceuticals Inc. Novel carbocyclic nucleoside agents useful as selective inhibitors of proinflammatory cytokines
US6395733B1 (en) 1995-06-07 2002-05-28 Pfizer Inc Heterocyclic ring-fused pyrimidine derivatives
CN1871240B (zh) * 2003-08-26 2012-11-07 帝人制药株式会社 吡咯并嘧啶酮衍生物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2001715C (en) * 1988-11-14 1999-12-28 Muzammil M. Mansuri Carbocyclic nucleosides and nucleotides
CA2051012C (en) * 1990-09-14 2002-04-02 David R. Borcherding Carbocyclic adenosine analogs useful as immunosupressants

Also Published As

Publication number Publication date
DE69120357D1 (de) 1996-07-25
EP0475413B1 (en) 1996-06-19
GR3020794T3 (en) 1996-11-30
DK0475413T3 (da) 1996-07-15
KR920005985A (ko) 1992-04-27
EP0475413A3 (en) 1992-11-04
JPH0543578A (ja) 1993-02-23
IE74172B1 (en) 1997-07-02
ATE139444T1 (de) 1996-07-15
AU8372891A (en) 1992-03-19
KR0175313B1 (ko) 1999-02-18
DE69120357T2 (de) 1996-11-28
IE913248A1 (en) 1992-02-25
EP0475413A2 (en) 1992-03-18
AU642526B2 (en) 1993-10-21

Similar Documents

Publication Publication Date Title
IL99525A0 (en) Fused ring analogs of nitrogen containing nonaromatic heterocycles
FR2383171A1 (fr) Derives de thiopropanoylaminoacides utiles comme hypotenseurs
FR2442845A1 (fr) Derives amines spiranniques, leur preparation et leur utilisation comme medicaments
EP0160842A3 (en) 2-substituted ergoline derivatives, processes for their preparation, and their use as medicaments
FR2383165A1 (fr) Nouveaux derives d'acides phenoxy-a-phenoxy-alcanecarboxyliques, leur preparation et leur application comme herbicides
CA2098020A1 (en) Anti-viral compounds
FR2358406A1 (fr) Derives d'acides 5-aroyl-1,2-dihydro-3h-pyrrolo (1,2-a)pyrrole-1-carboxyliques, leur obtention et leur application a titre de medicament
ES2046641T3 (es) Composicion antitumoral.
FR2384745A1 (fr) Derives de la somatostatine et leur preparation
FR2445328A1 (fr) Derives du 14-oxo-e-homo-eburnane, leur procede de preparation et leur utilisation comme medicament
ES473754A1 (es) Procedimiento de preparacion de composiciones farmaceuticas a base de nuevas w-tiopropinamidas, y de sus sales con una base mineral y organica
GR3020794T3 (en) Carbocyclic nucleoside analogs useful as immunosuppressants
HUT62896A (en) Process for producing new trans-cyclopentanylpurine analogs having immunosuppressant activity and pharmaceutical compositions comprising same as active ingredient
FR2398736A1 (fr) Derives a-halogenomethyles d'aminoacides, leur procede de preparation et leur utilisation comme antiallergiques
FR2443457A1 (fr) Derives de 1-phenyl-2-amino-1-propanol, leur procede de preparation et leur utilisation comme medicaments
DE69007356D1 (de) Zyklisches Tetrapeptid und Verfahren zu dessen Herstellung.
FR2389631A1 (es)
FR2395995A1 (fr) Nouveaux derives d'a-vinylaminoacides, leur preparation et leur utilisation comme inhibiteurs de la decarboxylase des aminoacides aromatiques
DE3464609D1 (en) Spiro(benzofuran-azalkanes), a method for their preparation and their use as medicaments
ES2177539T3 (es) Benzoxacinas 4-oxo- y 4h-imidazo(5,1-c)(1,4) utilez como agentes de union de receptores de benzodiacepina.
FR2397836A1 (fr) Derives de l'oxo-1-dihydro-1,2-isoquinoleine utilises comme agents anti-inflammatoires analgesiques forts
BG96041A (bg) Антивирусни тетрахидроимидазо /1,4/ бензодиазепини
ES480562A1 (es) Un procedimiento para la preparacion de un nuevo vincaderi- vado dimero.
FR2376139A1 (fr) Nouveaux derives d'isoquinoleine-acetamide utiles comme medicaments
FR2401133A1 (fr) Nouveaux derives d'aminoacides a-acetyleniques, leur preparation et leur utilisation comme inhibiteurs de la decarboxylase des aminoacides aromatiques

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 475413

Country of ref document: ES

FG2A Definitive protection

Ref document number: 475413

Country of ref document: ES