ES2090963T3 - Higado biologico artificial. - Google Patents

Higado biologico artificial.

Info

Publication number
ES2090963T3
ES2090963T3 ES93902996T ES93902996T ES2090963T3 ES 2090963 T3 ES2090963 T3 ES 2090963T3 ES 93902996 T ES93902996 T ES 93902996T ES 93902996 T ES93902996 T ES 93902996T ES 2090963 T3 ES2090963 T3 ES 2090963T3
Authority
ES
Spain
Prior art keywords
artificial biological
container
biological liver
liver
perfusion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93902996T
Other languages
English (en)
Inventor
George Edward Barker
Dale Joseph Beck
Albert Pak-Hung Li
Timothy Daniel Whitehead
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monsanto Co
Original Assignee
Monsanto Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Co filed Critical Monsanto Co
Application granted granted Critical
Publication of ES2090963T3 publication Critical patent/ES2090963T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0671—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • A61M1/3486—Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents
    • A61M1/3489—Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents by biological cells, e.g. bioreactor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/16—Particles; Beads; Granular material; Encapsulation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2531/00—Microcarriers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/10—Mineral substrates
    • C12N2533/12—Glass

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Vascular Medicine (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Sustainable Development (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • External Artificial Organs (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Prostheses (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

SE DESCRIBE UN HIGADO BIO-ARTIFICIAL O BIOREACTOR HEPATOCITA QUE COMPRENDE UN RECIPIENTE CONTENEDOR CON UNOS MEDIOS DE ENTRADA DE PERFUSION Y UNOS MEDIOS DE SALIDA DE PERFUSION; UNA MATRIZ DENTRO DEL RECIPIENTE PERMITE LA ENTRADA DE LOS AGREGADOS HEPATOCITOS DENTRO DEL MISMO MIENTRAS PERMITE LA TRANSFUSION DE LA MATRIZ. LA INVENCION ES UTIL COMO HIGADO ARTIFICIAL
ES93902996T 1992-02-07 1993-01-06 Higado biologico artificial. Expired - Lifetime ES2090963T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US83246192A 1992-02-07 1992-02-07

Publications (1)

Publication Number Publication Date
ES2090963T3 true ES2090963T3 (es) 1996-10-16

Family

ID=25261723

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93902996T Expired - Lifetime ES2090963T3 (es) 1992-02-07 1993-01-06 Higado biologico artificial.

Country Status (12)

Country Link
EP (1) EP0579804B1 (es)
JP (1) JP3339685B2 (es)
KR (1) KR100250630B1 (es)
AT (1) ATE140726T1 (es)
AU (1) AU661561B2 (es)
CA (1) CA2107582A1 (es)
DE (1) DE69303779T2 (es)
DK (1) DK0579804T3 (es)
ES (1) ES2090963T3 (es)
GR (1) GR3020619T3 (es)
MX (1) MX9300674A (es)
WO (1) WO1993016171A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5712154A (en) * 1995-06-07 1998-01-27 W.R. Grace & Co.-Conn. Dual fiber bioreactor
DE19540487A1 (de) * 1995-10-20 1997-04-24 Olaf Schultz Zellinteraktionssystem zur Induktion künstlicher Gewebe
US5827729A (en) * 1996-04-23 1998-10-27 Advanced Tissue Sciences Diffusion gradient bioreactor and extracorporeal liver device using a three-dimensional liver tissue
AUPP108597A0 (en) * 1997-12-22 1998-01-22 Sheil, A G R Prof. Liver support system
JP4222658B2 (ja) * 1998-06-23 2009-02-12 テルモ株式会社 細胞支持基材、培養装置および液体処理装置
DE19831873A1 (de) 1998-07-16 2000-03-30 Jens Altrichter Verfahren und Einrichtung zur therapeutischen Immunmodulation
WO2001051068A1 (de) * 2000-01-14 2001-07-19 Teraklin Aktiengesellschaft Verfahren und vorrichtung zur erhöhung und/oder verringerung der konzentration immunmodulatorisch wirksamer stoffe in stoffgemischen
RU2163148C1 (ru) * 2000-01-19 2001-02-20 Соловьев Валерий Владимирович Биологическая искусственная печень
WO2001070302A1 (fr) * 2000-03-22 2001-09-27 Katsutoshi Naruse Nouveau systeme d'organe artificiel
JP4672511B2 (ja) * 2005-10-05 2011-04-20 学校法人早稲田大学 マイクロ反応装置
GB2450761B (en) 2007-07-06 2010-08-04 Univ London Multi-functional chamber for housing a biological component
DE102008023545A1 (de) * 2008-05-14 2009-11-19 Roderfeld Und Bora Gmbh & Co.Kg Vorrichtung zur Herstellung einer biologisch aktiven Substanz
WO2009151514A1 (en) 2008-06-11 2009-12-17 Millipore Corporation Stirred tank bioreactor
EP2508607A1 (en) * 2011-04-07 2012-10-10 Helmholtz-Zentrum für Infektionsforschung GmbH Medicament for liver regeneration and for treatment of liver failure
JP2020074698A (ja) * 2018-11-06 2020-05-21 国立大学法人 東京大学 灌流培養システム及び培養方法
JP2023546661A (ja) * 2020-10-22 2023-11-07 アイオバンス バイオセラピューティクス，インコーポレイテッド 細胞培養システム及びその使用方法
WO2025125314A1 (fr) * 2023-12-11 2025-06-19 Commissariat A L'energie Atomique Et Aux Energies Alternatives Dispositif et procédé de culture cellulaire

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1213404A (en) * 1981-11-13 1986-11-04 Theodore E. Spielberg Ultrafiltering hybrid artificial organ
SU1113131A1 (ru) * 1982-05-31 1984-09-15 Рижский Медицинский Институт Способ лечени печеночной недостаточности
US5043260A (en) * 1987-11-02 1991-08-27 Rhode Island Hospital Perfusion device with hepatocytes

Also Published As

Publication number Publication date
WO1993016171A1 (en) 1993-08-19
EP0579804B1 (en) 1996-07-24
KR100250630B1 (ko) 2000-04-01
AU3437393A (en) 1993-09-03
EP0579804A1 (en) 1994-01-26
ATE140726T1 (de) 1996-08-15
DE69303779D1 (de) 1996-08-29
AU661561B2 (en) 1995-07-27
CA2107582A1 (en) 1993-08-08
JP3339685B2 (ja) 2002-10-28
DK0579804T3 (da) 1996-08-26
MX9300674A (es) 1993-10-01
DE69303779T2 (de) 1997-01-16
GR3020619T3 (en) 1996-10-31
JPH06509476A (ja) 1994-10-27

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