ES2091768T3 - Factor neurotrofico ciliar purificado. - Google Patents

Factor neurotrofico ciliar purificado.

Info

Publication number
ES2091768T3
ES2091768T3 ES90100226T ES90100226T ES2091768T3 ES 2091768 T3 ES2091768 T3 ES 2091768T3 ES 90100226 T ES90100226 T ES 90100226T ES 90100226 T ES90100226 T ES 90100226T ES 2091768 T3 ES2091768 T3 ES 2091768T3
Authority
ES
Spain
Prior art keywords
cntf
neurotrophic factor
supplied
data
purified
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90100226T
Other languages
English (en)
Inventor
Franklin D Collins
Leu-Fen Lin
Drzislav Mismer
Christine Ko
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Boulder Inc
Original Assignee
Amgen Boulder Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/293,851 external-priority patent/US5011914A/en
Priority claimed from US07/404,533 external-priority patent/US4997929A/en
Application filed by Amgen Boulder Inc filed Critical Amgen Boulder Inc
Application granted granted Critical
Publication of ES2091768T3 publication Critical patent/ES2091768T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

SE PRESENTA UN FACTOR NEUROTROFICO CILIAR (CNTF), PARTICULARMENTE UN NERVIO CIATICO CNTF (SN-CNTF). EL SN-CNTF DESCRITO AQUI ES UNA ESPECIA DE PROTEINA SIMPLE Y TIENE UNA ACTIVIDAD ESPECIFICA INCREMENTADA MAS ALLA DE 25.000 PLIEGUES A PARTIR DEL EXTRACTO CRUDO. TAMBIEN SE SUMINISTRAN DATOS DE UN ACIDO AMINO PARA ESTE SN-CNTF. ADEMAS TAMBIEN SE SUMINISTRAN METODOS PARA USAR ESTOS DATOS SUMINISTRANDO ENSAYOS DE SN-CNTF Y ASI MISMO SE SUMINISTRAN BIBLIOTECAS GENOMICAS. SE DESCRIBEN METODOS DE DNA RECOMBINANTE PARA LA PRODUCCION DEL SN-CNTF. SE SUMINISTRAN SECUENCIAS DE ACIDO NUCLEICO QUE CODIFICAN CNTF HUMANO Y DE CONEJO. TAMBIEN SE SUMINISTRA UN SISTEMA DE EXPRESION RECOMBINANTE PARA PRODUCIR CNTF BIOLOGICAMENTE ACTIVO.
ES90100226T 1989-01-05 1990-01-05 Factor neurotrofico ciliar purificado. Expired - Lifetime ES2091768T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/293,851 US5011914A (en) 1989-01-05 1989-01-05 Purified ciliary neurotrophic factor
US07/404,533 US4997929A (en) 1989-01-05 1989-09-08 Purified ciliary neurotrophic factor
US07/458,564 US5141856A (en) 1989-01-05 1989-12-28 Expression of purified ciliary neurotrophic factor

Publications (1)

Publication Number Publication Date
ES2091768T3 true ES2091768T3 (es) 1996-11-16

Family

ID=27404236

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90100226T Expired - Lifetime ES2091768T3 (es) 1989-01-05 1990-01-05 Factor neurotrofico ciliar purificado.

Country Status (21)

Country Link
US (2) US5141856A (es)
EP (1) EP0385060B1 (es)
JP (2) JPH0768270B2 (es)
KR (1) KR930012105B1 (es)
AU (1) AU7032496A (es)
BR (1) BR9006996A (es)
CH (1) CH681426A5 (es)
DD (1) DD299318A5 (es)
DE (1) DE4090006C2 (es)
DK (1) DK131391A (es)
ES (1) ES2091768T3 (es)
FI (1) FI104375B (es)
GB (1) GB2246132B (es)
GR (1) GR3021705T3 (es)
HU (2) HUT58792A (es)
IE (1) IE81151B1 (es)
IL (1) IL92958A (es)
NL (1) NL9020024A (es)
NZ (1) NZ231985A (es)
SE (1) SE513358C2 (es)
WO (1) WO1990007341A1 (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5328988A (en) * 1987-10-26 1994-07-12 Immunex Corporation Interleukin-7
US5714585A (en) * 1987-10-26 1998-02-03 Sterling Winthrop, Inc. Antibodies that are immunoreactive with interleukin-7
US5141856A (en) * 1989-01-05 1992-08-25 Synergen, Inc. Expression of purified ciliary neurotrophic factor
IE903130A1 (en) * 1989-09-15 1991-03-27 Regeneron Pharma Ciliary neurotrophic factor
EP0446931A1 (en) * 1990-03-14 1991-09-18 FIDIA S.p.A. Human ciliary neuronotrophic factor, DNA sequence encoding the factor, and production of the factor by recombinant technology
US6511823B1 (en) * 1990-08-20 2003-01-28 American Cyanamid Corporation Heparin binding neurotrophic factor gene sequence
IT1247150B (it) * 1991-01-21 1994-12-12 Fidia Spa Processo per la sintesi e la purificazione del fattore neuronotroficociliare umano (cntf) da escherichia coli.
US5593857A (en) * 1991-08-23 1997-01-14 Scios Inc. Production of homogeneous truncated CNTF
WO1993010233A1 (en) * 1991-11-11 1993-05-27 Fidia S.P.A. Synthesis and purification of truncated and mutein forms of human ciliary neuronotrophic factor
US5360740A (en) * 1992-07-02 1994-11-01 Regeneron Pharmaceuticals, Inc. Assay system for degenerative muscle disease
AU6130094A (en) * 1993-01-29 1994-08-15 Regeneron Pharmaceuticals, Inc. Methods of treatment using ciliary neurotrophic factor
EP0632008B1 (en) * 1993-06-01 1998-02-04 Ono Pharmaceutical Co., Ltd. Pentanoic acid derivatives
AU1847695A (en) * 1994-02-22 1995-09-04 Syntex-Synergen Neuroscience Joint Venture, The Pharmaceutical formulations of cntf
US7258983B2 (en) * 1994-04-25 2007-08-21 Genentech, Inc. Cardiotrophin-1 compositions and methods for the treatment of tumor
US6472585B1 (en) 1994-04-25 2002-10-29 Genentech, Inc. Cardiotrophin-1 defective mouse
DK0755446T3 (da) * 1994-04-25 2007-01-29 Genentech Inc Cardiotrophin og anvendelser deraf
US5534615A (en) * 1994-04-25 1996-07-09 Genentech, Inc. Cardiac hypertrophy factor and uses therefor
US6743628B1 (en) 1995-08-28 2004-06-01 Washington University Method of cell culture using neurturin
US5739307A (en) * 1995-08-28 1998-04-14 Washington University Polynucleotide encoding neurturin neurotrophic factor
DE69732350T2 (de) 1996-03-14 2005-12-22 Washington University Persephin und verwandte wachstumsfaktoren
US6222022B1 (en) 1996-03-14 2001-04-24 Washington University Persephin and related growth factors
US7015316B1 (en) 1996-03-14 2006-03-21 Washington University Polynucleotides encoding human persephin and related growth factors
US6299895B1 (en) 1997-03-24 2001-10-09 Neurotech S.A. Device and method for treating ophthalmic diseases
IT1288388B1 (it) 1996-11-19 1998-09-22 Angeletti P Ist Richerche Bio Uso di sostanze che attivano il recettore del cntf ( fattore neurotrofico ciliare) per la preparazione di farmaci per la terapia
US6042579A (en) * 1997-04-30 2000-03-28 Medtronic, Inc. Techniques for treating neurodegenerative disorders by infusion of nerve growth factors into the brain
US6689573B1 (en) * 1999-05-24 2004-02-10 New England Biolabs, Inc. Method for screening restriction endonucleases
IL152799A0 (en) 2000-04-14 2003-06-24 Uab Research Foundation Methods for delivering polypeptides to cells
WO2005014641A2 (en) * 2003-07-09 2005-02-17 Xencor, Inc. Ciliary neurotrophic factor variants
US20100143500A1 (en) * 2006-10-31 2010-06-10 The Ohio State University Research Foundation Methods and Compositions for Inhibiting GSK-3 In Glial Cell Related Disorders
EP2646007B1 (en) 2010-12-02 2016-12-21 Neurotech USA, Inc. Cell lines that secrete anti-angiogenic antibody-scaffolds and soluble receptors and uses thereof
JP6850734B2 (ja) 2015-05-27 2021-03-31 ニューロテック ユーエスエー， インコーポレイテッド 眼の障害の処置のためのカプセル化細胞療法の使用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US404533A (en) * 1889-06-04 Signments
US293851A (en) * 1884-02-19 de castro
US570651A (en) * 1896-11-03 Motor-driven fan
US429517A (en) * 1890-06-03 Packing-box
US458564A (en) * 1891-09-01 Ring-gage
US408172A (en) * 1889-07-30 Steam-boiler house
US4399216A (en) * 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4923696A (en) * 1987-05-04 1990-05-08 Baylor College Of Medicine Method to prepare a neurotrophic composition
US5028622A (en) * 1988-05-06 1991-07-02 Ajinomoto Company, Inc. Administration of amino acids as treatment for neurodegenerative disorders
US5141856A (en) * 1989-01-05 1992-08-25 Synergen, Inc. Expression of purified ciliary neurotrophic factor
US4997929A (en) * 1989-01-05 1991-03-05 Synergen, Inc. Purified ciliary neurotrophic factor
US5011914A (en) * 1989-01-05 1991-04-30 Collins Franklin D Purified ciliary neurotrophic factor
WO1990010647A1 (en) * 1989-03-15 1990-09-20 The Regents Of The University Of California Purified ciliary neurotrophic factor
IE903130A1 (en) * 1989-09-15 1991-03-27 Regeneron Pharma Ciliary neurotrophic factor
FI912358A7 (fi) * 1989-09-15 1991-05-15 Regeneron Pharma Silmäkuopan takaosan hermosolmun neurotrofinen tekijä
US5349056A (en) * 1992-10-09 1994-09-20 Regeneron Pharmaceuticals Modified ciliary neurotrophic factors

Also Published As

Publication number Publication date
US5780600A (en) 1998-07-14
IE81151B1 (en) 2000-05-03
JPH1129598A (ja) 1999-02-02
AU4838190A (en) 1990-08-01
IE900020L (en) 1990-07-05
EP0385060A3 (en) 1991-04-03
FI913251A0 (fi) 1991-07-04
NL9020024A (nl) 1991-10-01
DK131391A (da) 1991-09-05
DD299318A5 (de) 1992-04-09
DE4090006C2 (de) 1996-09-19
EP0385060A2 (en) 1990-09-05
IL92958A (en) 1997-09-30
FI104375B (fi) 2000-01-14
HU211933A9 (en) 1996-01-29
NZ231985A (en) 1992-12-23
SE513358C2 (sv) 2000-08-28
GB2246132A (en) 1992-01-22
CH681426A5 (es) 1993-03-31
GR3021705T3 (en) 1997-02-28
KR910700068A (ko) 1991-03-13
JPH04502916A (ja) 1992-05-28
DK131391D0 (da) 1991-07-05
WO1990007341A1 (en) 1990-07-12
SE9102079D0 (sv) 1991-07-03
GB9113704D0 (en) 1991-08-21
US5141856A (en) 1992-08-25
GB2246132B (en) 1993-09-15
JPH0768270B2 (ja) 1995-07-26
GB2246132A8 (en) 2001-05-22
AU7032496A (en) 1997-01-16
EP0385060B1 (en) 1996-08-28
IL92958A0 (en) 1990-09-17
HUT58792A (en) 1992-03-30
AU642858B2 (en) 1993-11-04
BR9006996A (pt) 1991-11-12
KR930012105B1 (ko) 1993-12-24
SE9102079L (sv) 1991-07-03

Similar Documents

Publication Publication Date Title
DK0473724T3 (da) Et humant cytokin, interleukin-9
SE9102079D0 (sv) Purified ciliary neurotrophic factor
ES2084045T3 (es) Bacterias que albergan vectores de expresion que codifican el factor neurotrofico ciliar humano (h-cntf), su uso en la produccion de h-cntf, anticuerpos para h-cntf y el uso de h-cntf en el tratamiento medico.
NO905264D0 (no) Fremgangsmaate for fremstilling av biologisk aktivt protein
IL207348A0 (en) Circular dna molecules, processes for their preparation, pharmaceutical compositions comprising them, and use thereof in the manufacture of medicinal products for producing recombinant proteins in vivo
ES8505724A1 (es) Procedimiento para la produccion de polipetidos mediante levadura.
ES8705521A1 (es) Un metodo de producir un polipetido similar a factor de necrosis de tumores (tnf) de mamiferos.
DE3280400D1 (de) Oligonukleotides heilmittel und dessen herstellungsverfahren.
DE68910354D1 (de) Menschliches mutantes Angiogenin (Angiogenese-Faktor mit überlegener Angiogenin-Aktivität), Gene dafür und Methode zur Expression.
ATE69241T1 (de) Herstellung von polypeptiden mit humangammainterferon-aktivitaet.
ATE380867T1 (de) Lactoferrinrezeptorgen von moraxella
EP0232523A3 (en) Dna sequences which encode for proteins with the biological activity of husi-type i inhibitors, their production by gene technology and drugs containing these proteins
KR920004570A (ko) 사람 mk 단백질을 암호하는 유전자, 이를 포함하는 발현 벡터 및 숙주 세포, mk단백질의 생산 방법 및 사용방법
AUPN154295A0 (en) Nucleic acid molecule encoding a protein with avian gamma-interferon activity
IL88034A0 (en) Mutant acidic fibroblast growth factor,its preparation and pharmaceutical compositions containing it
DK595187A (da) Minactivin og fremgangsmaade til fremstilling deraf
ES2088911T3 (es) Gen de la proteasa i de achromobacter y el producto de este gen.
ATE140928T1 (de) Proteine, die die expression von vertebraten-mhc- klasse-ii-genen regulieren, dafür kodierende dna- sequenzen und pharmazeutische zusammensetzungen
DE69306273D1 (de) Mitogen für die glatte Muskulatur und dessen kodierende DNS
DE3784308D1 (de) Verwendung von somatostatin zur herstellung eines arzneimittels fuer die behandlung von rheumatoider arthritis.
PT84474B (pt) Processo para a preparacao de uma substancia proteica insecticida
DE68918197D1 (de) Methode zur Herstellung von rekombinantem menschlichem beta-Interleukin-1 in homogener Form.
MX9600765A (es) Proteina y metodos para producir la proteina.
ATE346920T1 (de) Neues immunoregulatorisches protein lst-1

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 385060

Country of ref document: ES