ES2092191T3 - Metodo para purificar derivados nucleosidos. - Google Patents

Metodo para purificar derivados nucleosidos.

Info

Publication number
ES2092191T3
ES2092191T3 ES93111859T ES93111859T ES2092191T3 ES 2092191 T3 ES2092191 T3 ES 2092191T3 ES 93111859 T ES93111859 T ES 93111859T ES 93111859 T ES93111859 T ES 93111859T ES 2092191 T3 ES2092191 T3 ES 2092191T3
Authority
ES
Spain
Prior art keywords
dideoxinucleoside
derivative
crude
absorbed
purified
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93111859T
Other languages
English (en)
Inventor
Hiroshi Shiragami
Masayuki Arai
Kunisuke Izawa
Yutaka Honda
Yasuhiro Tanaka
Toshihide Yukawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP04199964A external-priority patent/JP3123238B2/ja
Priority claimed from JP04199965A external-priority patent/JP3123239B2/ja
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Application granted granted Critical
Publication of ES2092191T3 publication Critical patent/ES2092191T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)

Abstract

UN COMPUESTO DE 2'',3''-DIDEOXINUCLEOSIDO CRUDO SE PURIFICA EXTRAYENDO CON UN SOLVENTE ORGANICO, O CRISTALIZANDO, EL COMPUESTO DE 2'',3''-DIDEOXINUCLEOSIDO DE UNA SOLUCION ACUOSA BASICA QUE TENGA UN PH NO INFERIOR A 12 QUE CONTENGA EL MISMO. EN OTRA CONFORMACION DE LA PURIFICACION, UNA SOLUCION ACUOSA BASICA QUE TENGA UN PH NO INFERIOR A 11 DE UN DERIVADO DEL 2'',3''-DIDEOXINUCLEOSIDO CRUDO SE PONE EN CONTACTO CON UNA RESINA POROSA NO POLAR, MEDIANTE LO CUAL EL DERIVADO ES ABSORBIDO EN LA RESINA, Y POSTERIORMENTE EL DERIVADO ASI OBTENIDO SE DESABSORBE CON UNA SOLUCION ALCOHOLICA ACUOSA. LOS COMPUESTOS DE 2'',3''-DIDEOXINUCLEOSIDO QUE TIENEN UTILIDAD COMO DROGAS ANTI SIDA O DROGAS ANTIVIRALES PUEDEN SER AISLADAS Y PURIFICADAS CON UNA GRAN PUREZA Y UN ALTO RENDIMIENTO A PARTIR DE SUS PRODUCTOS CRUDOS QUE CONTENGAN IMPUREZAS.
ES93111859T 1992-07-27 1993-07-23 Metodo para purificar derivados nucleosidos. Expired - Lifetime ES2092191T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP04199964A JP3123238B2 (ja) 1992-07-27 1992-07-27 ヌクレオシド誘導体の精製法
JP04199965A JP3123239B2 (ja) 1992-07-27 1992-07-27 ヌクレオシド誘導体の樹脂精製法

Publications (1)

Publication Number Publication Date
ES2092191T3 true ES2092191T3 (es) 1996-11-16

Family

ID=26511865

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93111859T Expired - Lifetime ES2092191T3 (es) 1992-07-27 1993-07-23 Metodo para purificar derivados nucleosidos.

Country Status (5)

Country Link
US (1) US5451671A (es)
EP (1) EP0582157B1 (es)
CA (1) CA2101281C (es)
DE (1) DE69304839T2 (es)
ES (1) ES2092191T3 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6090937A (en) 1998-03-17 2000-07-18 Ajinomoto Co., Inc. Methods for producing nucleoside derivatives and intermediates therefor
EP1910393A2 (en) * 2005-07-05 2008-04-16 Hetero Drugs Limited A novel process for the preparation of didanosine using novel intermediates
EP2123653A4 (en) * 2007-01-19 2012-02-01 Ajinomoto Kk PROCESS FOR PREPARING A CRYSTAL OF A PURIN NUCLEOSIDE COMPOUND

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3817982A (en) * 1971-12-29 1974-06-18 Syntex Inc 2{40 ,3{40 -unsaturated nucleosides and method of making
ATE135011T1 (de) * 1985-03-16 1996-03-15 Wellcome Found Therapeutische nukleoside
ATE190064T1 (de) * 1985-09-17 2000-03-15 Wellcome Found Kombination therapeutische nukleoside mit weiteren therapeutisch wirksamen komponenten.
JPH0710236B2 (ja) * 1987-10-12 1995-02-08 味の素株式会社 ジデオキシアデノシンの精製方法
US4835104A (en) * 1987-06-16 1989-05-30 Ajinomoto Co., Inc., Patent & Licensing Department Process for producing and purifying 2',3'-dideoxynucleosides, and process for producing 2',3'-dideoxy-2',3'-didehydronucleosides
JPH0691830B2 (ja) * 1987-12-22 1994-11-16 味の素株式会社 ジデオキシイノシンの精製法
JPH01102095A (ja) * 1987-10-14 1989-04-19 Ajinomoto Co Inc ジデオキシウリジンの精製方法
US4833924A (en) * 1987-10-30 1989-05-30 Robertshaw Controls Company Differential pressure transmitter, a square root extractor device therefor and methods of making the same
US4997926A (en) * 1987-11-18 1991-03-05 Scripps Clinic And Research Foundation Deaminase-stable anti-retroviral 2-halo-2',3'-dideoxy
JPH0826020B2 (ja) * 1987-12-29 1996-03-13 味の素株式会社 ジデオキシイノシンの精製方法
JPH0717670B2 (ja) * 1988-03-01 1995-03-01 味の素株式会社 ヌクレオシド誘導体の製造方法
JPH02204489A (ja) * 1989-02-02 1990-08-14 Ajinomoto Co Inc 易溶性２’，３’―ジデオキシイノシン、その製造法及び２’，３’―ジデオキシイノシン水性溶液の製造法
JPH02243690A (ja) * 1989-03-15 1990-09-27 Daicel Chem Ind Ltd ヌクレオシド誘導体の製造法

Also Published As

Publication number Publication date
CA2101281A1 (en) 1994-01-28
CA2101281C (en) 2003-11-04
EP0582157A1 (en) 1994-02-09
DE69304839D1 (de) 1996-10-24
DE69304839T2 (de) 1997-04-30
US5451671A (en) 1995-09-19
EP0582157B1 (en) 1996-09-18

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