ES2092263T3 - Analogos de la 15-deoxispergualina, su metodo de preparacion y su utilizacion en terapeutica como agentes inmunosupresores. - Google Patents

Analogos de la 15-deoxispergualina, su metodo de preparacion y su utilizacion en terapeutica como agentes inmunosupresores.

Info

Publication number
ES2092263T3
ES2092263T3 ES93402795T ES93402795T ES2092263T3 ES 2092263 T3 ES2092263 T3 ES 2092263T3 ES 93402795 T ES93402795 T ES 93402795T ES 93402795 T ES93402795 T ES 93402795T ES 2092263 T3 ES2092263 T3 ES 2092263T3
Authority
ES
Spain
Prior art keywords
immunosuppressive agents
deoxispergualine
therapeutics
analogs
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93402795T
Other languages
English (en)
Inventor
Patrice Renaut
Luc Lebreton
Patrick Dutartre
Philippe Derrepas
Soth Samreth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fournier Industrie et Sante SAS
Original Assignee
Fournier Industrie et Sante SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fournier Industrie et Sante SAS filed Critical Fournier Industrie et Sante SAS
Application granted granted Critical
Publication of ES2092263T3 publication Critical patent/ES2092263T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/12—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/24—Y being a hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Soil Conditioners And Soil-Stabilizing Materials (AREA)
  • Curing Cements, Concrete, And Artificial Stone (AREA)

Abstract

LA PRESENTE INVENCION CONCIERNE, COMO PRODUCTOS INDUSTRIALES NUEVOS, A COMPUESTOS DE ESTRUCTURA PARECIDA A LA DE LA 15DEOXIESPERGUALINA. ESTOS NUEVOS COMPUESTOS RESPONDEN A LA FORMULA (I), EN LA CUAL: MPLE ENLACE, CH2, CHF, CH(OH), CH(OCH3), CH2NH O CH2O, Y SUS SALES DE ADICION. ESTOS NUEVOS COMPUESTOS SON UTILES COMO AGENTES INMUNOSUPRESORES.
ES93402795T 1992-12-02 1993-11-17 Analogos de la 15-deoxispergualina, su metodo de preparacion y su utilizacion en terapeutica como agentes inmunosupresores. Expired - Lifetime ES2092263T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9214517A FR2698628B1 (fr) 1992-12-02 1992-12-02 Analogues de 15-déoxyspergualine, leur procédé de préparation et leur utilisation en thérapeutique.

Publications (1)

Publication Number Publication Date
ES2092263T3 true ES2092263T3 (es) 1996-11-16

Family

ID=9436147

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93402795T Expired - Lifetime ES2092263T3 (es) 1992-12-02 1993-11-17 Analogos de la 15-deoxispergualina, su metodo de preparacion y su utilizacion en terapeutica como agentes inmunosupresores.

Country Status (24)

Country Link
US (1) US5476870A (es)
EP (1) EP0600762B1 (es)
JP (1) JP2945261B2 (es)
KR (1) KR100187328B1 (es)
CN (1) CN1045431C (es)
AT (1) ATE140215T1 (es)
AU (1) AU664124B2 (es)
CA (1) CA2110437C (es)
CZ (1) CZ284958B6 (es)
DE (1) DE69303583T2 (es)
DK (1) DK0600762T3 (es)
ES (1) ES2092263T3 (es)
FI (1) FI112211B (es)
FR (1) FR2698628B1 (es)
GR (1) GR3021269T3 (es)
HK (1) HK1000467A1 (es)
HU (1) HU218908B (es)
NO (1) NO180483C (es)
NZ (1) NZ250330A (es)
RU (1) RU2114823C1 (es)
SK (1) SK280286B6 (es)
TW (1) TW311132B (es)
UA (1) UA39920C2 (es)
ZA (1) ZA938821B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0755380T3 (da) * 1995-02-10 1999-06-23 Fournier Ind & Sante 15-deoxyspergualin-analoge, deres terapeutiske anvendelse og fremgangsmåde til fremstilling deraf
FR2734263B1 (fr) * 1995-05-17 1997-06-20 Fournier Ind & Sante Analogues de la 15-deoxyspergualine, leur procede de preparation et leur utilisation en therapeutique
IL127148A (en) * 1996-12-20 2002-11-10 Sueddeutsche Kalkstickstoff Keratin pyruvates, a method of their production and the physiologically appropriate compositions that contain them
DE19728436A1 (de) * 1997-07-03 1999-01-07 Niels Franke Niedrigdosierte 15-Desoxyspergualin-Präparate
DE69914611T2 (de) * 1998-08-28 2004-12-23 Gryphon Therapeutics, Inc., South San Francisco Verfahren zur herstellung von polyamidketten von genauer länge und deren konjugate mit proteinen
DE19923961A1 (de) * 1999-05-25 2000-11-30 Euro Nippon Kayaku Gmbh Verwendung von 15-Deoxyspergualin zur Behandlung von hyperreaktiven entzündlichen Erkrankungen und Autoimmunerkrankungen
DK1771206T3 (en) * 2004-05-05 2018-05-22 Silence Therapeutics Gmbh LIPIDS, LIPID COMPLEXES AND USE THEREOF
BRPI0519468A2 (pt) 2004-12-27 2009-01-27 Silence Therapeutics Ag complexos de lipÍdeos revestido e seu uso
WO2010074591A1 (ru) 2008-12-24 2010-07-01 Закрытое Акционерное Общество "Beptekc" Амиды креатина, способ их получения, средство, обладающее нейропротекторным действием
RU2428414C2 (ru) 2009-11-03 2011-09-10 Закрытое Акционерное Общество "Вертекс" Способ получения амидов креатина
EP2598131A1 (fr) * 2010-07-29 2013-06-05 Laboratoires Fournier S.A. Composes pour le traitement/la prevention des maladies inflammatoires oculaires
FR2963238B1 (fr) * 2010-07-29 2012-12-28 Fournier Lab Sa Derives de 15-desoxyspergualine pour le traitement et/ou la prevention des maladies inflammatoires oculaires
KR101695730B1 (ko) 2015-03-10 2017-01-12 하경훈 마늘꼭지 절단기의 절단장치
FR3050455B1 (fr) * 2016-04-26 2019-06-14 Temisis Derives amides des acides polycafeoylquiniques, procede de preparation et utilisations

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5942356A (ja) * 1982-09-02 1984-03-08 Microbial Chem Res Found スパガリン関連化合物およびその製造法
EP0241797B1 (en) * 1986-04-04 1991-06-12 Microbial Chemistry Research Foundation Novel spergualin-related compounds and process for producing the same
US5061787A (en) * 1988-06-24 1991-10-29 Nippon Kayaku Kabushiki Kaisha Novel spergualin-related compounds and compositions

Also Published As

Publication number Publication date
ZA938821B (en) 1994-06-30
EP0600762B1 (fr) 1996-07-10
CA2110437A1 (en) 1994-06-03
SK135793A3 (en) 1994-06-08
AU664124B2 (en) 1995-11-02
CZ284958B6 (cs) 1999-04-14
CN1045431C (zh) 1999-10-06
FI112211B (fi) 2003-11-14
CZ262293A3 (en) 1994-06-15
FR2698628B1 (fr) 1995-02-17
HU9303406D0 (en) 1994-03-28
AU5188393A (en) 1994-06-16
CN1095709A (zh) 1994-11-30
GR3021269T3 (en) 1997-01-31
DE69303583D1 (de) 1996-08-14
FR2698628A1 (fr) 1994-06-03
KR940014435A (ko) 1994-07-18
JPH06293728A (ja) 1994-10-21
KR100187328B1 (ko) 1999-05-15
NO180483C (no) 1997-04-30
NZ250330A (en) 1995-06-27
SK280286B6 (sk) 1999-11-08
HU218908B (hu) 2000-12-28
NO934338L (no) 1994-06-03
RU2114823C1 (ru) 1998-07-10
NO180483B (no) 1997-01-20
HK1000467A1 (en) 1998-03-27
EP0600762A1 (fr) 1994-06-08
NO934338D0 (no) 1993-11-30
US5476870A (en) 1995-12-19
TW311132B (es) 1997-07-21
FI935318A0 (fi) 1993-11-29
JP2945261B2 (ja) 1999-09-06
DE69303583T2 (de) 1996-11-21
DK0600762T3 (da) 1996-11-11
UA39920C2 (uk) 2001-07-16
FI935318L (fi) 1994-06-03
ATE140215T1 (de) 1996-07-15
HUT65782A (en) 1994-07-28
CA2110437C (en) 1999-04-13

Similar Documents

Publication Publication Date Title
ES2081005T3 (es) 9-amino-7-sustituido-6-demetil-6-deoxitetraciclinas.
ES2168254T3 (es) Nuevas 7-sustituidas-9-(amino sustituido)-6-desmetil-6-desoxitetraciclinas.
ES2183473T3 (es) Derivados de acido piridonacarboxilico como agentes antibacterianos.
HN1997000118A (es) 1,3, oxa thiolane nucleoside compuestos y composiciones
AR038428A2 (es) Compuestos fluorados de marcfortina
ES2068403T3 (es) Productos herbicidas.
ES2093981T3 (es) Productos cosmeticos desodorantes que contienen acidos grasos.
ES2052881T3 (es) Agentes reductores de la presion sanguinea.
IT1244643B (it) Composizioni di calcestruzzo da spruzzare
ES2138622T3 (es) Derivados de mercaptoacetilamido piridazo(1,2-a)(1,2)diazepina utilizados como inhibidores de encefalinasa y eca.
MX9301129A (es) Nuevas ciclosporinas y composiciones farmaceuticas que las contienen.
ES2058346T3 (es) Compuestos piperidinilicos 1,4-disustituidos.
ES2130312T3 (es) Nuevos derivados de tetrazina con actividad acaricida.
ES8900048A1 (es) Procedimiento para la obtencion de quinoloncarboxilatos
ES2151168T3 (es) N-(2,4-dioxo-2,3,4,5-tetrahidro-1h-1,5-benzodiazepin-3-il)-3-amidas.
ES2055867T3 (es) Derivados de dibenzotiazepina utiles como agentes antiespasmodicos.
ES2123949T3 (es) Procedimiento para la preparacion de intermediarios para la sintesis de agentes antifungicos.
ES2060127T3 (es) Halogenoalquilfenil-alcoholes-cetonas y sus hidratos.
SE9604582D0 (sv) Novel compounds
ES2054881T3 (es) Pantetina como agente inhibidor de la fibrosis hepatica.
ES2106480T3 (es) Un compuesto perteneciente a la familia de los analogos de la 15-deoxi-espergualina, su procedimiento de preparacion y su utilizacion en terapeutica.
ES2103131T3 (es) Nuevos agentes de nucleosido carbociclico utiles como inhibidores selectivos de citoquinas proinflamatorias.
ES2058264T3 (es) Sulfonildecahidro-8h-isoquino(2,1-g)(1,6)naftiridinas, isomeros opticos de las mismas y compuestos afines.
AR031658A1 (es) Procedimiento para la preparacion de 4-haloalquilnicotinonitrilos
MX166685B (es) Proceso para la preparacion de alcanosulfonamidas y arenosulfonamidas

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 600762

Country of ref document: ES