ES2106480T3 - Un compuesto perteneciente a la familia de los analogos de la 15-deoxi-espergualina, su procedimiento de preparacion y su utilizacion en terapeutica. - Google Patents

Un compuesto perteneciente a la familia de los analogos de la 15-deoxi-espergualina, su procedimiento de preparacion y su utilizacion en terapeutica.

Info

Publication number
ES2106480T3
ES2106480T3 ES94403019T ES94403019T ES2106480T3 ES 2106480 T3 ES2106480 T3 ES 2106480T3 ES 94403019 T ES94403019 T ES 94403019T ES 94403019 T ES94403019 T ES 94403019T ES 2106480 T3 ES2106480 T3 ES 2106480T3
Authority
ES
Spain
Prior art keywords
group
espergualina
deoxi
therapeutics
analogs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94403019T
Other languages
English (en)
Inventor
Patrice Renaut
Luc Lebreton
Patrick Dutartre
Philippe Derrepas
Soth Samreth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fournier Industrie et Sante SAS
Original Assignee
Fournier Industrie et Sante SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9402125A external-priority patent/FR2716451B1/fr
Application filed by Fournier Industrie et Sante SAS filed Critical Fournier Industrie et Sante SAS
Application granted granted Critical
Publication of ES2106480T3 publication Critical patent/ES2106480T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/24—Y being a hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/12—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Transplantation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Peptides Or Proteins (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE COMO PRODUCTOS INDUSTRIALES NUEVOS, A COMPUESTOS DE ESTRUCTURA EMPARENTADA CON LA DE LA 15DESOXISPERGUALINA DE FORMULA (I): DONDE A REPRESENTA UN ENLACE SENCILLO, UN GRUPO -CH2-, UN GRUPO -CH2O-, UN GRUPO -CH2NH-, UN GRUPO -CH- (OH)-, UN GRUPO -CHT- O UN GRUPO -CH(OCH3)- Y N ES IGUAL A 6 O 8, Y SUS SALES DE ADICION. ESTOS COMPUESTOS SON PARTICULARMENTE UTILES COMO AGENTES INMUNOSUPRESORES. LA INVENCION SE REFIERE TAMBIEN AL PROCESO DE PREPARACION DE DICHOS COMPUESTOS.
ES94403019T 1994-02-24 1994-12-26 Un compuesto perteneciente a la familia de los analogos de la 15-deoxi-espergualina, su procedimiento de preparacion y su utilizacion en terapeutica. Expired - Lifetime ES2106480T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9402125A FR2716451B1 (fr) 1994-02-24 1994-02-24 Analogues de la 15-déoxyspergualine, leur procédé de préparation et leur utilisation en thérapeutique.
FR9406706A FR2716452B1 (fr) 1994-02-24 1994-06-01 Analogues de la 15-déoxyspergualine, leur procédé de préparation et leur utilisation en thérapeutique.

Publications (1)

Publication Number Publication Date
ES2106480T3 true ES2106480T3 (es) 1997-11-01

Family

ID=26230971

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94403019T Expired - Lifetime ES2106480T3 (es) 1994-02-24 1994-12-26 Un compuesto perteneciente a la familia de los analogos de la 15-deoxi-espergualina, su procedimiento de preparacion y su utilizacion en terapeutica.

Country Status (22)

Country Link
US (1) US5637613A (es)
EP (1) EP0669316B1 (es)
JP (1) JP2874839B2 (es)
KR (1) KR100188991B1 (es)
CN (1) CN1148378C (es)
AT (1) ATE156117T1 (es)
AU (1) AU691847B2 (es)
CA (1) CA2143216C (es)
CZ (1) CZ287985B6 (es)
DE (1) DE69404624T2 (es)
DK (1) DK0669316T3 (es)
ES (1) ES2106480T3 (es)
FI (1) FI950728A7 (es)
FR (1) FR2716452B1 (es)
GR (1) GR3025164T3 (es)
HU (1) HUT70958A (es)
NO (1) NO302816B1 (es)
NZ (1) NZ270449A (es)
RU (1) RU2113431C1 (es)
SK (1) SK281058B6 (es)
TW (1) TW317562B (es)
UA (1) UA37217C2 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2734263B1 (fr) * 1995-05-17 1997-06-20 Fournier Ind & Sante Analogues de la 15-deoxyspergualine, leur procede de preparation et leur utilisation en therapeutique
US5985824A (en) * 1997-02-27 1999-11-16 Genzyme Corporation Methods and compositions for treating cystic fibrosis
US5834421A (en) * 1997-02-27 1998-11-10 Genzyme Corporation Methods and compositions for treating cystic fibrosis
US20020142000A1 (en) * 1999-01-15 2002-10-03 Digan Mary Ellen Anti-CD3 immunotoxins and therapeutic uses therefor
DE19923961A1 (de) * 1999-05-25 2000-11-30 Euro Nippon Kayaku Gmbh Verwendung von 15-Deoxyspergualin zur Behandlung von hyperreaktiven entzündlichen Erkrankungen und Autoimmunerkrankungen
US20130190278A1 (en) * 2010-07-29 2013-07-25 Laboratoires Fournier Sa Compounds for the Treatment/Prevention of Ocular Inflammatory Diseases
FR2963238B1 (fr) * 2010-07-29 2012-12-28 Fournier Lab Sa Derives de 15-desoxyspergualine pour le traitement et/ou la prevention des maladies inflammatoires oculaires

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5942356A (ja) * 1982-09-02 1984-03-08 Microbial Chem Res Found スパガリン関連化合物およびその製造法
JPS61129119A (ja) * 1984-11-13 1986-06-17 Microbial Chem Res Found 新規免疫抑制剤

Also Published As

Publication number Publication date
RU2113431C1 (ru) 1998-06-20
AU1028895A (en) 1995-08-31
US5637613A (en) 1997-06-10
HUT70958A (en) 1995-11-28
HK1000489A1 (en) 1998-03-27
SK24795A3 (en) 1995-09-13
DK0669316T3 (da) 1998-03-09
JPH0841007A (ja) 1996-02-13
NO302816B1 (no) 1998-04-27
KR950032097A (ko) 1995-12-20
CA2143216A1 (en) 1995-08-25
SK281058B6 (sk) 2000-11-07
HU9500556D0 (en) 1995-04-28
FR2716452A1 (fr) 1995-08-25
RU95102479A (ru) 1997-05-10
NO950664D0 (no) 1995-02-22
NZ270449A (en) 1996-08-27
CN1148378C (zh) 2004-05-05
AU691847B2 (en) 1998-05-28
KR100188991B1 (ko) 1999-06-01
DE69404624T2 (de) 1998-02-05
DE69404624D1 (de) 1997-09-04
TW317562B (es) 1997-10-11
CA2143216C (en) 1999-04-13
FI950728L (fi) 1995-08-25
EP0669316B1 (fr) 1997-07-30
CZ50295A3 (en) 1995-10-18
FR2716452B1 (fr) 1996-05-10
JP2874839B2 (ja) 1999-03-24
CN1119191A (zh) 1996-03-27
UA37217C2 (uk) 2001-05-15
FI950728A0 (fi) 1995-02-17
NO950664L (no) 1995-08-25
GR3025164T3 (en) 1998-02-27
EP0669316A1 (fr) 1995-08-30
FI950728A7 (fi) 1995-08-25
ATE156117T1 (de) 1997-08-15
CZ287985B6 (cs) 2001-03-14

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