ES2093699T3 - Metodo y composiciones para inhibir la angiogenesis. - Google Patents

Metodo y composiciones para inhibir la angiogenesis.

Info

Publication number
ES2093699T3
ES2093699T3 ES91904851T ES91904851T ES2093699T3 ES 2093699 T3 ES2093699 T3 ES 2093699T3 ES 91904851 T ES91904851 T ES 91904851T ES 91904851 T ES91904851 T ES 91904851T ES 2093699 T3 ES2093699 T3 ES 2093699T3
Authority
ES
Spain
Prior art keywords
collagenase
inhibitor
compositions
specific
inhibit angiogenesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91904851T
Other languages
English (en)
Inventor
Marsha A Moses
Judith Sudhalter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cincinnati Childrens Hospital Medical Center
Boston Childrens Hospital
Original Assignee
Cincinnati Childrens Hospital Medical Center
Boston Childrens Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cincinnati Childrens Hospital Medical Center, Boston Childrens Hospital filed Critical Cincinnati Childrens Hospital Medical Center
Application granted granted Critical
Publication of ES2093699T3 publication Critical patent/ES2093699T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/8146—Metalloprotease (E.C. 3.4.24) inhibitors, e.g. tissue inhibitor of metallo proteinase, TIMP
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

SE PRESENTAN COMPUESTOS FARMACEUTICOS PARA LIBERAR UNA DOSIS EFECTIVA DE UN INHIBIDOR DE LA ANGIOGENESIS QUE CONSTAN DE UN INHIBIDOR ESPECIFICO DE LA COLAGENASA, PARA INHIBIR EL CRECIMIENTO INTERNO DE LOS VASOS SANGUINEOS Y LA FORMACION DE CONDUCTOS "IN VIVO" Y LA PROLIFERACION DE CELULAS ENDOTELIALES CAPILARES Y LA MIGRACION "IN VITRO", EL INHIBIDOR NO ES CITOTOXICO PARA LAS CELULAS NORMALES. EL COMPUESTO SE LIBERA TOPICA O LOCALMENTE USANDO IMPLANTES O INYECCIONES. EJEMPLOS DE INHIBIDORES ESPECIFICOS DE LA COLAGENASA INCLUYEN EL INHIBIDOR PURIFICADO QUE SE DERIVA DEL CARTILAGO, LOS PEPTIDOS QUE SE UNEN A LA COLAGENASA Y LOS ANTICUERPOS QUE BLOQUEAN LA ZONA ACTIVA O LAS ZONAS PARA LA UNION DE METALES DE LA COLAGENASA, Y COMPUESTOS QUE INHIBEN LAS ENZIMAS QUE ACTIVAN LA COLAGENASA.
ES91904851T 1990-01-25 1991-01-25 Metodo y composiciones para inhibir la angiogenesis. Expired - Lifetime ES2093699T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47006790A 1990-01-25 1990-01-25
US59155990A 1990-10-02 1990-10-02

Publications (1)

Publication Number Publication Date
ES2093699T3 true ES2093699T3 (es) 1997-01-01

Family

ID=27042958

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91904851T Expired - Lifetime ES2093699T3 (es) 1990-01-25 1991-01-25 Metodo y composiciones para inhibir la angiogenesis.

Country Status (10)

Country Link
EP (1) EP0512071B1 (es)
JP (1) JPH06509791A (es)
AT (1) ATE144710T1 (es)
AU (1) AU652744B2 (es)
CA (1) CA2074725A1 (es)
DE (1) DE69122956T2 (es)
DK (1) DK0512071T3 (es)
ES (1) ES2093699T3 (es)
GR (1) GR3021925T3 (es)
WO (1) WO1991011193A1 (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5268384A (en) * 1990-11-21 1993-12-07 Galardy Richard E Inhibition of angiogenesis by synthetic matrix metalloprotease inhibitors
US5853746A (en) * 1991-01-31 1998-12-29 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone using functional barrier
DE4106570A1 (de) * 1991-03-01 1992-09-03 Max Planck Gesellschaft Neue inhibitoren der endothelzell-proliferation
US5716981A (en) * 1993-07-19 1998-02-10 Angiogenesis Technologies, Inc. Anti-angiogenic compositions and methods of use
AU728873B2 (en) * 1993-07-19 2001-01-18 Angiotech Pharmaceuticals, Inc. Anti-angiogenic compositions and methods of use
CN1502331A (zh) * 1993-07-19 2004-06-09 Ѫ�ܼ���ҩ�﹫˾ 抗血管生长组合物及使用方法
US20030203976A1 (en) 1993-07-19 2003-10-30 William L. Hunter Anti-angiogenic compositions and methods of use
AU771815B2 (en) * 1993-07-19 2004-04-01 Angiotech Pharmaceuticals, Inc. Anti-angiogenic compositions and methods of use
US6562596B1 (en) * 1993-10-06 2003-05-13 Amgen Inc. Tissue inhibitor of metalloproteinase type three (TIMP-3) composition and methods
US5837680A (en) * 1996-02-16 1998-11-17 Children's Medical Center Corporation Pharmaceutical compositions comprising troponin subunits, fragments and analogs thereof and methods of their use to inhibit angiogenesis
US6515016B2 (en) 1996-12-02 2003-02-04 Angiotech Pharmaceuticals, Inc. Composition and methods of paclitaxel for treating psoriasis
US6495579B1 (en) 1996-12-02 2002-12-17 Angiotech Pharmaceuticals, Inc. Method for treating multiple sclerosis
ATE241993T1 (de) * 1997-03-11 2003-06-15 Aeterna Lab Inc Zubereitungen zur tumorbehandlung enthaltend hai- knorpelextrakte und antineoplastische mittel
US7208010B2 (en) 2000-10-16 2007-04-24 Conor Medsystems, Inc. Expandable medical device for delivery of beneficial agent
US20040254635A1 (en) 1998-03-30 2004-12-16 Shanley John F. Expandable medical device for delivery of beneficial agent
US6241762B1 (en) 1998-03-30 2001-06-05 Conor Medsystems, Inc. Expandable medical device with ductile hinges
US7208011B2 (en) 2001-08-20 2007-04-24 Conor Medsystems, Inc. Implantable medical device with drug filled holes
AU760408B2 (en) 1998-04-27 2003-05-15 Surmodics, Inc. Bioactive agent release coating
US6120847A (en) * 1999-01-08 2000-09-19 Scimed Life Systems, Inc. Surface treatment method for stent coating
US6419692B1 (en) 1999-02-03 2002-07-16 Scimed Life Systems, Inc. Surface protection method for stents and balloon catheters for drug delivery
US6156373A (en) 1999-05-03 2000-12-05 Scimed Life Systems, Inc. Medical device coating methods and devices
US6290673B1 (en) 1999-05-20 2001-09-18 Conor Medsystems, Inc. Expandable medical device delivery system and method
PT1328213E (pt) 2000-10-16 2005-10-31 Conor Medsystems Inc Dispositivo medico expansivel para a administracao de um agente benefico
US6964680B2 (en) 2001-02-05 2005-11-15 Conor Medsystems, Inc. Expandable medical device with tapered hinge
US20040073294A1 (en) 2002-09-20 2004-04-15 Conor Medsystems, Inc. Method and apparatus for loading a beneficial agent into an expandable medical device
US7056338B2 (en) 2003-03-28 2006-06-06 Conor Medsystems, Inc. Therapeutic agent delivery device with controlled therapeutic agent release rates
US7479270B2 (en) 2002-07-23 2009-01-20 Vegenics Limited Methods and compositions for activating VEGF-D and VEGF-C
AU2004226327A1 (en) 2003-03-28 2004-10-14 Innovational Holdings, Llc Implantable medical device with beneficial agent concentration gradient
US7169179B2 (en) 2003-06-05 2007-01-30 Conor Medsystems, Inc. Drug delivery device and method for bi-directional drug delivery
US7785653B2 (en) 2003-09-22 2010-08-31 Innovational Holdings Llc Method and apparatus for loading a beneficial agent into an expandable medical device
CN1964748A (zh) 2004-04-06 2007-05-16 苏莫迪克斯公司 用于生物活性剂的涂料组合物
KR101539700B1 (ko) * 2012-09-05 2015-07-28 아주대학교산학협력단 연골세포 유래 세포외 기질막을 이용한 신생혈관질환 치료용 조성물 및 각막 또는 결막 이식재
WO2014038866A1 (ko) * 2012-09-05 2014-03-13 아주대학교산학협력단 연골세포 유래 세포외 기질막을 이용한 신생혈관질환 치료용 조성물 및 각막 또는 결막 이식재

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4743587A (en) * 1985-09-10 1988-05-10 G. D. Searle & Co. Hydroxamic acid based collagenase inhibitors
US4766111A (en) * 1985-10-31 1988-08-23 Trustees Of Boston University Lipids with plasmin inhibitory properties
US5260059A (en) * 1989-04-14 1993-11-09 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon Health Sciences University Treatment of open-angle glaucoma by modulation matrix metalloproteinases and their inhibitor

Also Published As

Publication number Publication date
ATE144710T1 (de) 1996-11-15
DK0512071T3 (da) 1996-11-25
DE69122956D1 (de) 1996-12-05
GR3021925T3 (en) 1997-03-31
EP0512071B1 (en) 1996-10-30
WO1991011193A1 (en) 1991-08-08
DE69122956T2 (de) 1997-05-22
CA2074725A1 (en) 1991-07-26
EP0512071A4 (en) 1993-05-05
EP0512071A1 (en) 1992-11-11
AU652744B2 (en) 1994-09-08
AU7335191A (en) 1991-08-21
JPH06509791A (ja) 1994-11-02

Similar Documents

Publication Publication Date Title
GR3021925T3 (en) Method and compositions for inhibiting angiogenesis
ATE556705T1 (de) Darreichungsform enthaltend taxol in kristalliner form
ATE278397T1 (de) Verwendung von cytoskelettinhibitoren zur vorbeugung der restenose
CY1107438T1 (el) Παραγωγα καρβοξυλικου οξεος, τα οποια παρεμποδιζουν την συνδεσιν ιντεγκρινων εις τους υποδοχεις των
TR200102648T2 (tr) Büyümeyi destekleyen bileşimler
DE69942610D1 (de) Die bindung von integrinen zu deren rezeptoren verhindernde verbindungen
DE60014369D1 (de) Propansäurederivate, die die bindung von integrinen an ihre rezeptoren behindern
ATE232748T1 (de) Hemmung von gefässverengungen nach eingriffen an den gefässen
TR200103179A2 (tr) Integrinlerin reseptörlerine bağlanmasını engelleyen karboksilik asit türevleri
BR9811099A (pt) Inibidores de urocinase
HUP9900979A2 (hu) Endoteliális sejtek proliferációját gátló inhibitor és eljárás alkalmazására
DK0817646T3 (da) Fremgangsmåder til behandling af inflammation og præparater derfor
ATE240100T1 (de) Verwendung von fc101 als hemmstoff der angiogenese zur behandlung von krebs und anderen angiogenen krankheiten
DK0644768T3 (da) Fremgangsmåder og præparater til inhibering af endotelcelle- og fibrinogenfremkaldt inflammation
KR920700642A (ko) 치료제

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 512071

Country of ref document: ES