ES2094157T3 - Receptor de acido gamma-retinoico. - Google Patents

Receptor de acido gamma-retinoico.

Info

Publication number
ES2094157T3
ES2094157T3 ES90911356T ES90911356T ES2094157T3 ES 2094157 T3 ES2094157 T3 ES 2094157T3 ES 90911356 T ES90911356 T ES 90911356T ES 90911356 T ES90911356 T ES 90911356T ES 2094157 T3 ES2094157 T3 ES 2094157T3
Authority
ES
Spain
Prior art keywords
retinoic acid
gamma
receptor
disclosed
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90911356T
Other languages
English (en)
Inventor
Fumimaro Takaku
Michio Imawari
Takashi Ishikawa
Ronald Mark Evans
Kazuhiko Umesono
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Salk Institute for Biological Studies
Memorial Sloan Kettering Cancer Center
Original Assignee
Salk Institute for Biological Studies
Memorial Sloan Kettering Cancer Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Salk Institute for Biological Studies, Memorial Sloan Kettering Cancer Center filed Critical Salk Institute for Biological Studies
Application granted granted Critical
Publication of ES2094157T3 publication Critical patent/ES2094157T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/71—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16
    • C07K2319/715—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16 containing a domain for ligand dependent transcriptional activation, e.g. containing a steroid receptor domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/826—Viruses
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/843—Digestive system
    • Y10S530/846—Liver

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Physics & Mathematics (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

SE PRESENTA UN NUEVO RECEPTOR DE ACIDO RETINOICO GAMMA. EL NUEVO RECEPTOR ES CODIFICADO POR UN PORTADOR DE CADN EN PGEM-HRARJ PLASMICO, QUE HA SIDO DEPOSITADO EN LA AMERICAN TYPE CULTURE COLLECTION CON EL FIN DE PATENTARLO. TAMBIEN SE PRESENTAN LAS PROTEINAS RECEPTORAS QUIMERICAS. LA QUIMERA CONTIENE AL MENOS UN DOMINIO FUNCIONAL DEL NUEVO RECEPTOR DE ACIDO RETINOICO GAMMA.
ES90911356T 1989-06-22 1990-06-22 Receptor de acido gamma-retinoico. Expired - Lifetime ES2094157T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/370,407 US5260432A (en) 1989-06-22 1989-06-22 Human gamma retinoic acid receptor DNA

Publications (1)

Publication Number Publication Date
ES2094157T3 true ES2094157T3 (es) 1997-01-16

Family

ID=23459521

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90911356T Expired - Lifetime ES2094157T3 (es) 1989-06-22 1990-06-22 Receptor de acido gamma-retinoico.

Country Status (10)

Country Link
US (4) US5260432A (es)
EP (1) EP0479916B1 (es)
JP (1) JP3240056B2 (es)
KR (1) KR0159106B1 (es)
AT (1) ATE145406T1 (es)
AU (1) AU640940B2 (es)
CA (1) CA2066692A1 (es)
DE (1) DE69029197T2 (es)
ES (1) ES2094157T3 (es)
WO (1) WO1990015815A1 (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5571692A (en) * 1987-12-02 1996-11-05 The Salk Institute For Biological Studies Retinoic acid receptor α, vectors and cells comprising the same DNA encoding
US5260432A (en) * 1989-06-22 1993-11-09 Sloan-Kettering Institute For Cancer Research Human gamma retinoic acid receptor DNA
EP0411323A3 (en) * 1989-06-30 1991-08-21 Institut National De La Sante Et De La Recherche Medicale (Inserm) Human and mouse retinoic acid receptors and genes encoding for them
ES2152920T3 (es) * 1990-02-09 2001-02-16 Salk Inst For Biological Studi Composiciones receptoras de retinoides y metodos.
US5861274A (en) * 1990-03-22 1999-01-19 The Salk Institute For Biological Studies Nucleic acids encoding peroxisome proliferator-activated receptor
US5641652A (en) * 1990-03-22 1997-06-24 The Salk Institute For Biological Studies Insect retinoid-like receptor compositions and methods
US5922596A (en) * 1990-12-10 1999-07-13 Bristol-Myers Squibb Co. Promoter of the retinoic acid receptor gene for directing gene expression
US6989242B1 (en) 1992-02-26 2006-01-24 The General Hospital Coporation Car receptors and related molecules and methods
US5756448A (en) * 1992-02-26 1998-05-26 The General Hospital Corporation Constitute activator of retinoid (CAR) receptor polypeptides
HUT73101A (en) * 1993-02-12 1996-06-28 Harvard College Method for regulating transcription of targeted genes and other biological events
US6891021B2 (en) 1993-02-12 2005-05-10 Board Of Trustees Of The Leland Stanford Junior University Regulated apoptosis
US6030794A (en) * 1993-05-18 2000-02-29 Institut National De La Sante Et De La Recherche Medicale Genetically engineered mice and cell lines containing alterations in the genes encoding retinoic acid receptor and retinoid X receptor proteins
US6031149A (en) 1993-05-18 2000-02-29 Institut National De La Sante Et De La Recherche Medicale Genetically engineered mice containing alterations in the genes encoding retinoic acid receptor proteins
WO1996000242A1 (en) * 1994-06-24 1996-01-04 Human Genome Sciences, Inc. Retinoic acid receptor epsilon
AU2952695A (en) * 1994-07-01 1996-01-25 Salk Institute For Biological Studies, The Mammalian peroxisome proliferator-activated receptors and uses thereof
US6489441B1 (en) 1995-09-01 2002-12-03 The Salk Institute For Biological Studies Transcriptional co-repressor that interacts with nuclear hormone receptors
US5939264A (en) * 1996-07-19 1999-08-17 Iowa State University Research Foundation, Inc. Genes and genetic markers for improved reproductive traits in animals
WO1998048055A1 (en) 1997-04-24 1998-10-29 Institut National De La Sante Et De La Recherche Medicale Methods and compositions for use in modulating expression of matrix metalloproteinase genes
AUPP012097A0 (en) 1997-10-30 1997-11-27 Commonwealth Scientific And Industrial Research Organisation Assessing lipid metabolism
US6521814B1 (en) 1997-12-22 2003-02-18 Institut National De La Santa Et De La Recherche Medicale Use of ligands for treatment of diseases responsive to retinoids
US6665594B1 (en) * 2001-12-13 2003-12-16 The United States Of America As Represented By The Secretary Of The Navy Plug and play modular mission payloads
EP2272946B9 (en) 2002-02-25 2015-06-24 Vaxiion Therapeutics, LLC Minicell compositions and methods
US8309687B2 (en) * 2007-03-15 2012-11-13 Reverse Proteomics Research Institute Co., Ltd. Biomarker specific for cancer
US10155929B2 (en) 2012-05-13 2018-12-18 Allele Biotechnology & Pharmaceuticals, Inc. Feeder-free derivation of human-induced pluripotent stem cells with synthetic messenger RNA
US10119150B2 (en) 2012-05-13 2018-11-06 Allele Biotechnology & Pharmaceuticals, Inc. Feeder-free Derivation of human-induced pluripotent stem cells with synthetic messenger RNA
CN104520424B (zh) * 2012-05-13 2019-06-28 美国绿阳生物技术及医药公司 使用合成的信使rna无饲养细胞地衍生人类诱导性多能干细胞

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5171671A (en) * 1987-12-02 1992-12-15 The Salk Institute For Biological Studies Retinoic acid receptor composition
US4981784A (en) * 1987-12-02 1991-01-01 The Salk Institute For Biological Studies Retinoic acid receptor method
CA1320161C (en) * 1987-12-16 1993-07-13 Hugues Blaudin De The Steroid/thyroid hormone receptor-related gene, which is inappropriately expressed in human heptocellular carcinoma, and which is a retinoic acid receptor
US5260432A (en) * 1989-06-22 1993-11-09 Sloan-Kettering Institute For Cancer Research Human gamma retinoic acid receptor DNA
US5091518A (en) * 1989-11-16 1992-02-25 The Salk Institute For Biological Studies Beta retinoic acid response elements compositions and assays

Also Published As

Publication number Publication date
CA2066692A1 (en) 1990-12-23
WO1990015815A1 (en) 1990-12-27
US20040171800A9 (en) 2004-09-02
EP0479916B1 (en) 1996-11-20
US5530094A (en) 1996-06-25
ATE145406T1 (de) 1996-12-15
US7033828B2 (en) 2006-04-25
EP0479916A4 (en) 1992-10-07
EP0479916A1 (en) 1992-04-15
DE69029197T2 (de) 1997-04-10
AU6051990A (en) 1991-01-08
US5260432A (en) 1993-11-09
US20020077457A1 (en) 2002-06-20
AU640940B2 (en) 1993-09-09
US6284870B1 (en) 2001-09-04
JP3240056B2 (ja) 2001-12-17
KR0159106B1 (ko) 1998-11-16
JPH05501349A (ja) 1993-03-18
DE69029197D1 (de) 1997-01-02

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