ES2094558T3 - Particulas para formacion de imagenes de resonancia magnetica nuclear (nmr) y metodo de fabricacion. - Google Patents

Particulas para formacion de imagenes de resonancia magnetica nuclear (nmr) y metodo de fabricacion.

Info

Publication number
ES2094558T3
ES2094558T3 ES93917714T ES93917714T ES2094558T3 ES 2094558 T3 ES2094558 T3 ES 2094558T3 ES 93917714 T ES93917714 T ES 93917714T ES 93917714 T ES93917714 T ES 93917714T ES 2094558 T3 ES2094558 T3 ES 2094558T3
Authority
ES
Spain
Prior art keywords
particles
coating
glycerophospholipid
micellar
liver
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93917714T
Other languages
English (en)
Inventor
Herve Tournier
Roland Hyacinthe
Michel Schneider
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco International BV
Original Assignee
Bracco International BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco International BV filed Critical Bracco International BV
Application granted granted Critical
Publication of ES2094558T3 publication Critical patent/ES2094558T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
    • A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
    • A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
    • A61K49/1833—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with a small organic molecule
    • A61K49/1839—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with a small organic molecule the small organic molecule being a lipid, a fatty acid having 8 or more carbon atoms in the main chain, or a phospholipid
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/832—Nanostructure having specified property, e.g. lattice-constant, thermal expansion coefficient
    • Y10S977/838—Magnetic property of nanomaterial
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/905—Specially adapted for travel through blood circulatory system
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/927—Diagnostic contrast agent
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/932—Specified use of nanostructure for electronic or optoelectronic application
    • Y10S977/953—Detector using nanostructure
    • Y10S977/96—Of magnetic property
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y10T428/2998—Coated including synthetic resin or polymer
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Nanotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Hard Magnetic Materials (AREA)
  • Oxygen, Ozone, And Oxides In General (AREA)
  • Soft Magnetic Materials (AREA)
  • Manufacturing Of Micro-Capsules (AREA)

Abstract

SE DESCRIBEN UNAS PARTICULAS DE MAGNETITA ADECUADAS PARA SU INYECCION EN LA CORRIENTE SANGUINEA DE PACIENTES QUE TIENEN UNA GRAN RESISTENCIA CONTRA LA AGLOMERACION Y ENTRADA MEDIANTE EL RES DEL HIGADO Y BAZO. LAS PARTICULAS CONSTAN ESENCIALMENTE DE UN NUCLEO DE OXIDO FERRICO Y UN REVESTIMIENTO TRIDIMENSIONAL QUE LO RODEA COMPUESTO DE UN SURFACTANTE GLICEROFOSFOLIPIDO O ESTER ALQUENIL, O UN ALQUILO MONOACIDO FOSFORICO. EL NUCLEO Y EL MONOESTER O UN GLICEROFOSFOLIPIDO MICELAR FORMAN UNA ESTRUCTURA TIPO --TANTE NO IONICO PARA PRODUCIR UN REVESTIMIENTO TRIDIMENSIONAL PROTECTOR QUE CEDE PARTICULAS CASI INDETECTABLES MEDIANTE LAS MACROFASES. LAS PARTICULAS PREPARADAS DE ACUERDO CON LA INVENCION SE MANTIENEN EN LA CIRCULACION DE LA SANGRE DURANTE LARGOS PERIODOS Y REPRESENTAN EXCELENTES AGENTES MAS DURADEROS DE COAGULACION SANGUINEA. LOS COMPONENTES PRINCIPALES DEL REVESTIMIENTO SON (A) ESPECIES ORGANICO-MINERALES POLIBASICAS TALES COMO UN ACIDO GLICERO FOSFATIDICO EN FORMA MICELAR Y (B) UN COPOLIMERO BLOQUE QUE TIENE SUCESIVOS SEGMENTOS HIDROFOBICOS E HIDROFILICOS.
ES93917714T 1992-08-13 1993-07-30 Particulas para formacion de imagenes de resonancia magnetica nuclear (nmr) y metodo de fabricacion. Expired - Lifetime ES2094558T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP92810618 1992-08-13
EP93810380 1993-05-25

Publications (1)

Publication Number Publication Date
ES2094558T3 true ES2094558T3 (es) 1997-01-16

Family

ID=26132520

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93917714T Expired - Lifetime ES2094558T3 (es) 1992-08-13 1993-07-30 Particulas para formacion de imagenes de resonancia magnetica nuclear (nmr) y metodo de fabricacion.

Country Status (20)

Country Link
US (3) US5464696A (es)
EP (1) EP0607401B1 (es)
JP (1) JP2968588B2 (es)
KR (1) KR100307773B1 (es)
CN (1) CN1076205C (es)
AT (1) ATE144714T1 (es)
AU (1) AU660108B2 (es)
CA (1) CA2119654C (es)
DE (1) DE69305730T2 (es)
DK (1) DK0607401T3 (es)
ES (1) ES2094558T3 (es)
FI (1) FI941677A7 (es)
GR (1) GR3022288T3 (es)
HU (1) HU221805B1 (es)
IL (1) IL106493A (es)
IS (1) IS1648B (es)
MX (1) MX9304924A (es)
NO (1) NO307244B1 (es)
NZ (1) NZ254791A (es)
WO (1) WO1994004197A1 (es)

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NO941311D0 (no) 1994-04-12
FI941677L (fi) 1994-04-12
US5464696A (en) 1995-11-07
CN1076205C (zh) 2001-12-19
EP0607401A1 (en) 1994-07-27
US5545395A (en) 1996-08-13
HU221805B1 (hu) 2003-01-28
NO307244B1 (no) 2000-03-06
JPH07503976A (ja) 1995-04-27
WO1994004197A1 (en) 1994-03-03
NO941311L (no) 1994-04-12
DE69305730T2 (de) 1997-05-28
IL106493A (en) 1997-02-18
DE69305730D1 (de) 1996-12-05
CA2119654C (en) 2001-02-06
FI941677A0 (fi) 1994-04-12
IS1648B (is) 1997-03-25
FI941677A7 (fi) 1994-04-12
AU4705493A (en) 1994-03-15
IL106493A0 (en) 1993-11-15
JP2968588B2 (ja) 1999-10-25
IS4058A (is) 1994-02-14
ATE144714T1 (de) 1996-11-15
EP0607401B1 (en) 1996-10-30
KR100307773B1 (ko) 2001-12-28
US5587199A (en) 1996-12-24
HUT75149A (en) 1997-04-28
CN1089470A (zh) 1994-07-20
NZ254791A (en) 1996-11-26
GR3022288T3 (en) 1997-04-30
HU9401038D0 (en) 1994-07-28
CA2119654A1 (en) 1994-03-03
DK0607401T3 (da) 1996-11-25
AU660108B2 (en) 1995-06-08
MX9304924A (es) 1994-08-31

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