ES2095825T3 - Activadores del plasminogeno hibridos. - Google Patents

Activadores del plasminogeno hibridos.

Info

Publication number
ES2095825T3
ES2095825T3 ES87117892T ES87117892T ES2095825T3 ES 2095825 T3 ES2095825 T3 ES 2095825T3 ES 87117892 T ES87117892 T ES 87117892T ES 87117892 T ES87117892 T ES 87117892T ES 2095825 T3 ES2095825 T3 ES 2095825T3
Authority
ES
Spain
Prior art keywords
plasminogen activators
activators
glycosilation
human
points
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87117892T
Other languages
English (en)
Inventor
Bhanu Dr Rajput
Bhabatosh Dr Chaudhuri
Fredericus Alphonsu Asselbergs
Bernd Dr Meyhack
Jutta Dr Heim
Oostrum Jan Dr Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB868629153A external-priority patent/GB8629153D0/en
Priority claimed from GB878709656A external-priority patent/GB8709656D0/en
Priority claimed from GB878715890A external-priority patent/GB8715890D0/en
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Application granted granted Critical
Publication of ES2095825T3 publication Critical patent/ES2095825T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Amplifiers (AREA)
  • Adhesives Or Adhesive Processes (AREA)

Abstract

LOS NUEVOS ACTIVADORES HIBRIDOS DE PLASMINOGENOS DE CADENA SENCILLA, QUE TIENEN UNA SECUENCIA DE AMINOACIDO COMPUESTA POR AL MENOS DOS SUBSECUENCIAS QUE CORRESPONDEN EN NUMERO E IDENTIDAD DE AMINOACIDOS A SUBSECUENCIAS DE T-PA HUMANO Y DE U-PA HUMANO, Y SUS MUTANTES EN LOS QUE AL MENOS UNO DE LOS PUNTOS DE N-GLICOSILACION SE MODIFICAN DE MANERA QUE LA GLICOSILACION NO PUEDE OCURRIR EN ESTOS PUNTOS, MUESTRAN PROPIEDADES FARMACOLOGICAS VALIOSAS, LOS ACTIVADORES HIBRIDOS DE PLASMINOGENO ESTAN PRODUCIDOS POR TECNOLOGIA DE ADN RECOMBINANTE.
ES87117892T 1986-12-05 1987-12-03 Activadores del plasminogeno hibridos. Expired - Lifetime ES2095825T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB868629153A GB8629153D0 (en) 1986-12-05 1986-12-05 Hybrid proteins
GB878701160A GB8701160D0 (en) 1986-12-05 1987-01-20 Hybrid proteins
GB878709656A GB8709656D0 (en) 1986-12-05 1987-04-23 Hybrid proteins
GB878715890A GB8715890D0 (en) 1986-12-05 1987-07-06 Hybrid proteins

Publications (1)

Publication Number Publication Date
ES2095825T3 true ES2095825T3 (es) 1997-03-01

Family

ID=27449853

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87117892T Expired - Lifetime ES2095825T3 (es) 1986-12-05 1987-12-03 Activadores del plasminogeno hibridos.

Country Status (16)

Country Link
EP (1) EP0277313B1 (es)
JP (2) JP2641875B2 (es)
AT (1) ATE148167T1 (es)
AU (1) AU621281B2 (es)
CA (1) CA1341479C (es)
CY (1) CY2156B1 (es)
DE (1) DE3752008T2 (es)
DK (1) DK175483B1 (es)
ES (1) ES2095825T3 (es)
FI (1) FI100106B (es)
GR (1) GR3023047T3 (es)
IE (1) IE81116B1 (es)
IL (1) IL84700A (es)
NO (1) NO177603C (es)
NZ (1) NZ222793A (es)
PT (1) PT86276B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5204255A (en) * 1986-01-31 1993-04-20 Sagami Chemical Research Center Hybrid tissue plasminogen activator/urokinase polypeptides
MY103358A (en) * 1987-04-15 1993-06-30 Novartis Ag Process for the production of protiens.
AU1893988A (en) * 1987-07-13 1989-01-19 Collaborative Research Inc. Nonglycosylated plasminogen activator and method of preparation
FR2637600B1 (fr) * 1988-10-11 1992-03-06 Pasteur Institut Peptides et polypeptides provenant de la glande sous maxillaire du rat, anticorps monoclonaux et polyclonaux correspondants, hybridomes correspondants et applications de ces produits au diagnostic, a la detection ou a des fins therapeutiques
EP0440709B1 (en) * 1988-10-27 1995-05-24 Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno Thrombolytic agents with modified kringle domains
GB8826975D0 (en) * 1988-11-18 1988-12-21 Beecham Group Plc Novel compounds
DE3923339A1 (de) * 1989-05-31 1990-12-06 Boehringer Mannheim Gmbh Gewebs-plasminogen-aktivator-derivat
IE901849A1 (en) * 1989-07-19 1991-06-19 Gruenenthal Gmbh Plasmids, their preparation and their use in the manufacture¹of a plasminogen activator
GB8919803D0 (en) * 1989-09-01 1989-10-18 Ciba Geigy Pharmaceutical compositions
GB8927546D0 (en) * 1989-12-06 1990-02-07 Ciba Geigy Process for the production of biologically active tgf-beta
EP0462651A1 (en) * 1990-06-15 1991-12-27 Leuven Research & Development V.Z.W. Chimeric plasminogen activators
ATE157703T1 (de) * 1991-12-16 1997-09-15 Ciba Geigy Ag Endoplasmatisches retikulum-ständige rekombinante dibasische endoprotease und deren verwendungen
JPH07143877A (ja) * 1993-10-01 1995-06-06 Sumitomo Pharmaceut Co Ltd 新規なｔ−ＰＡ類似体
TW517059B (en) 1994-07-25 2003-01-11 Ciba Geigy Ag New process for the production of biologically active protein
KR101126423B1 (ko) * 2005-10-21 2012-07-11 카탈리스트 바이오사이언시즈, 인코포레이티드 보체 활성화를 억제하는 변형된 프로테아제
ES2372709T3 (es) 2006-07-05 2012-01-25 Catalyst Biosciences, Inc. Procedimientos de cribado de proteasas y proteasas identificadas por los mismos.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8334498D0 (en) * 1983-12-24 1984-02-01 Beecham Group Plc Compounds
US4916071A (en) * 1985-08-14 1990-04-10 American Home Products Corporation Poly-kringle plasminogen activator
WO1987004722A1 (en) * 1986-01-31 1987-08-13 Genetics Institute, Inc. Novel thrombolytic proteins
DE3781420T2 (de) * 1986-01-31 1993-02-25 Central Glass Co Ltd Hybrides plasminogenaktivatoraehnliches polypeptid.

Also Published As

Publication number Publication date
HK1005037A1 (en) 1998-12-18
CY2156B1 (en) 2002-08-23
JPS63160581A (ja) 1988-07-04
AU8209187A (en) 1988-06-16
IE81116B1 (en) 2000-03-22
AU621281B2 (en) 1992-03-12
NO177603C (no) 1995-10-18
DK175483B1 (da) 2004-11-08
DE3752008D1 (de) 1997-03-06
EP0277313A1 (en) 1988-08-10
PT86276A (en) 1988-06-01
GR3023047T3 (en) 1997-07-30
PT86276B (pt) 1990-11-07
DE3752008T2 (de) 1997-08-14
FI875324A0 (fi) 1987-12-02
NO875069L (no) 1988-06-06
IE873299L (en) 1988-06-05
IL84700A (en) 1992-11-15
NO875069D0 (no) 1987-12-04
NZ222793A (en) 1990-09-26
CA1341479C (en) 2005-04-12
ATE148167T1 (de) 1997-02-15
FI875324L (fi) 1988-06-06
IL84700A0 (en) 1988-05-31
DK638187A (da) 1988-06-06
FI100106B (fi) 1997-09-30
JP2645237B2 (ja) 1997-08-25
JP2641875B2 (ja) 1997-08-20
EP0277313B1 (en) 1997-01-22
NO177603B (no) 1995-07-10
DK638187D0 (da) 1987-12-04
JPH09117292A (ja) 1997-05-06

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