ES2095833T3 - Derivados de benzodiazepinas. - Google Patents

Derivados de benzodiazepinas.

Info

Publication number
ES2095833T3
ES2095833T3 ES89112084T ES89112084T ES2095833T3 ES 2095833 T3 ES2095833 T3 ES 2095833T3 ES 89112084 T ES89112084 T ES 89112084T ES 89112084 T ES89112084 T ES 89112084T ES 2095833 T3 ES2095833 T3 ES 2095833T3
Authority
ES
Spain
Prior art keywords
alkyl
rent
hydrogen
carboxyl
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89112084T
Other languages
English (en)
Inventor
Yoshinari Sato
Teruaki Matuo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888816207A external-priority patent/GB8816207D0/en
Priority claimed from GB888820560A external-priority patent/GB8820560D0/en
Priority claimed from GB888823660A external-priority patent/GB8823660D0/en
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2095833T3 publication Critical patent/ES2095833T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Otolaryngology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

UN COMPUESTO DE LA FORMULA: EN DONDE R1 ES UN HALOGENO, GRUPO HETEROCICLICO EL CUAL PUEDE TENER UNO O MAS SUSTITUYENTE(S) ADECUADOS, ARILO EL CUAL PUEDE TENER UNO O MAS SUSTITUYENTE(S) ADECUADOS, -NH-R5 (EN EL CUAL R5 ES HIDROGENO, ALCANILO INFERIOR O HIDROXILO (INFERIOR) ALQUILO)), -S-R6 (EN EL CUAL R6 ES ALQUILO INFERIOR, ALQUILO INFERIOR SUBSTITUIDO CON CARBOXILO Y AMINO, ALQUILO INFERIOR SUBSTITUIDO CON CARBOXILO PROTEGIDO Y AMINO PROTEGIDO, O PIRIDILO), -O-R7 (EN EL CUAL R7 ES HIDROGENO, GRUPO HIDROXILO PROTECTOR, ALQUILO INFERIOR, ALQUENILO INFERIOR, ARI(INFERIOR)ALQUILO, HALO(INFERIOR)ALQUILO, AMINO(INFERIOR)ALQUILO, AMINO(INFERIOR)ALQUILO PROTEGIDO, O PIPERACINILO (INFERIOR) ALQUILO EL CUAL PUEDE TENER ALQUILO INFERIOR), -CONH-R8 (EN LA CUAL R8 ES CIANO, CARBAMOIL(INFERIOR) ALQUILO, CARBOXILO (INFERIOR) ALQUILO, O ALQUILO INFERIOR SUBSTITUIDO CON CARBAMOIL Y ARILO), O -Z-R9[EN LA CUAL R9 ES HIDROGENO O ALQUILO INFERIOR, Y Z ES (EN DONDE R10 ES HIDROXILO, ALCOXILO INFERIOR O AMINO)O (EN DONDE R11 ES CARBOXILO O CARBOXILO PROTEGIDO Y R12 ES HIDROGENO; O R11 ES HALOGENO Y R12 ES HALOGENO)], R (AL CUADRADO) ES ARILO EL CUAL PUEDE TENER UNO O MAS SUSTITUYENTE(S) APROPIADOS R3 ES HIDROGENO O HALOGENO, R4 ES HIDROGENO, HALOGENO O ALCOXILO INFERIOR Y A ES ALQUILENO INFERIOR, Y UNA SAL FARMACEUTICAMENTE ACEPTABLE DE ELLA, PROCESOS PARA LA PREPARACION Y COMPOSICIONES FARMACEUTICAS COMPRENDIENDOLO COMO UN INGREDIENTE ACTIVO.
ES89112084T 1988-07-07 1989-07-01 Derivados de benzodiazepinas. Expired - Lifetime ES2095833T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB888816207A GB8816207D0 (en) 1988-07-07 1988-07-07 Benzodiazepine derivatives
GB888820560A GB8820560D0 (en) 1988-08-31 1988-08-31 Benzodiazepine derivatives
GB888823660A GB8823660D0 (en) 1988-10-07 1988-10-07 Benzodiazepine derivatives

Publications (1)

Publication Number Publication Date
ES2095833T3 true ES2095833T3 (es) 1997-03-01

Family

ID=27263983

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89112084T Expired - Lifetime ES2095833T3 (es) 1988-07-07 1989-07-01 Derivados de benzodiazepinas.

Country Status (17)

Country Link
US (1) US4970207A (es)
EP (1) EP0349949B1 (es)
JP (2) JP2536160B2 (es)
KR (1) KR900001688A (es)
CN (1) CN1041941A (es)
AT (1) ATE147403T1 (es)
AU (1) AU3785989A (es)
CA (1) CA1334589C (es)
DE (1) DE68927620T2 (es)
DK (1) DK336589A (es)
ES (1) ES2095833T3 (es)
FI (1) FI95699C (es)
GR (1) GR3022239T3 (es)
HU (1) HUT50331A (es)
IL (1) IL90830A (es)
NO (1) NO173014C (es)
PT (1) PT91092B (es)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01211939A (ja) * 1988-02-18 1989-08-25 Nec Kyushu Ltd イオン注入装置
US5264433A (en) * 1988-07-07 1993-11-23 Fujisawa Pharmaceutical Co., Ltd. Benzodiazepine derivatives
US4994258A (en) * 1990-03-05 1991-02-19 Merck & Co., Inc. Gamma emitting, CCK-A antagonists for pancreatic imaging
GB9015879D0 (en) * 1990-07-19 1990-09-05 Fujisawa Pharmaceutical Co Benzodiazepine derivatives
AU654140B2 (en) * 1990-07-31 1994-10-27 Lilly Industries Limited N-benzyl indoles, processes for their preparation or pharmaceutical compositions containing them
US5206238A (en) * 1990-11-13 1993-04-27 Merck & Co., Inc. Cholecystokinin antagonists
US5206235A (en) * 1991-03-20 1993-04-27 Merck & Co., Inc. Benzo-fused lactams that promote the release of growth hormone
US5218114A (en) * 1991-04-10 1993-06-08 Merck & Co., Inc. Cholecystokinin antagonists
EP0523845A3 (en) * 1991-06-14 1993-11-18 Merck & Co Inc New benzodiazepine analogs
US5283241A (en) * 1992-08-28 1994-02-01 Merck & Co., Inc. Benzo-fused lactams promote release of growth hormone
US5583130A (en) * 1992-09-25 1996-12-10 Merck & Co., Inc. Benzo-fused lactams promote release of growth hormone
US5317017A (en) * 1992-09-30 1994-05-31 Merck & Co., Inc. N-biphenyl-3-amido substituted benzolactams stimulate growth hormone release
WO1994018229A1 (en) * 1993-02-03 1994-08-18 Fisons Corporation 1,2,4-triazinone derivatives and their use in therapy
US5284841A (en) * 1993-02-04 1994-02-08 Merck & Co., Inc. Benzo-fused lactams promote release of growth hormone
JPH10504545A (ja) * 1994-07-29 1998-05-06 藤沢薬品工業株式会社 ベンゾジアゼピン誘導体
US7048906B2 (en) * 1995-05-17 2006-05-23 Cedars-Sinai Medical Center Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions
US6861053B1 (en) * 1999-08-11 2005-03-01 Cedars-Sinai Medical Center Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth
US6562629B1 (en) * 1999-08-11 2003-05-13 Cedars-Sinai Medical Center Method of diagnosing irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth by detecting the presence of anti-saccharomyces cerivisiae antibodies (asca) in human serum
EP0907644A4 (en) * 1996-06-28 2003-02-05 Merck & Co Inc PHARMACEUTICAL PREPARATION
US5776930A (en) * 1996-06-28 1998-07-07 Merck & Company, Inc. Pharmaceutical preparation
AU3591697A (en) * 1996-07-02 1998-01-21 Merck & Co., Inc. Method for the treatment of preterm labor
US5929071A (en) * 1996-07-02 1999-07-27 Merck & Co., Inc. Method for the treatment of preterm labor
AUPO284396A0 (en) 1996-10-08 1996-10-31 Fujisawa Pharmaceutical Co., Ltd. Benzodiazepine derivatives
ATE290545T1 (de) * 1996-12-06 2005-03-15 Vertex Pharma Inhibitoren des interleukin-1beta konvertierenden enzyms
US6635632B1 (en) 1996-12-23 2003-10-21 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6683075B1 (en) 1996-12-23 2004-01-27 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use
US6509331B1 (en) 1998-06-22 2003-01-21 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6528505B1 (en) 1998-06-22 2003-03-04 Elan Pharmaceuticals, Inc. Cyclic amino acid compounds pharmaceutical compositions comprising same and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6958330B1 (en) 1998-06-22 2005-10-25 Elan Pharmaceuticals, Inc. Polycyclic α-amino-ε-caprolactams and related compounds
US6774125B2 (en) 1998-06-22 2004-08-10 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6552013B1 (en) 1998-06-22 2003-04-22 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6569851B1 (en) 1998-06-22 2003-05-27 Elan Pharmaceutials, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US20060025388A1 (en) 1999-04-30 2006-02-02 Glick Gary D Compositions and methods relating to novel compounds and targets thereof
EP2359831A3 (en) * 1999-04-30 2012-02-01 The Regents of the University of Michigan Therapeutic applications of pro-apoptotic benzodiazepines
US7276348B2 (en) 1999-04-30 2007-10-02 Regents Of The University Of Michigan Compositions and methods relating to F1F0-ATPase inhibitors and targets thereof
US7144880B2 (en) 1999-04-30 2006-12-05 Regents Of The University Of Michigan Compositions relating to novel compounds and targets thereof
US6207638B1 (en) 2000-02-23 2001-03-27 Pacifichealth Laboratories, Inc. Nutritional intervention composition for enhancing and extending satiety
AU2002232575A1 (en) 2000-12-15 2002-06-24 Pacifichealth Laboratories, Inc. Nutritional composition for improving the efficacy of a lipase inhibitor
US6429190B1 (en) 2000-12-15 2002-08-06 Pacifichealth Laboratories, Inc. Method for extending the satiety of food by adding a nutritional composition designed to stimulate cholecystokinin(CCK)
US6458795B1 (en) * 2001-11-15 2002-10-01 University Of Florida Method and composition for treatment of irritable bowel disease
GB0221923D0 (en) * 2002-09-20 2002-10-30 Arrow Therapeutics Ltd Chemical compounds
WO2005000807A2 (en) * 2003-06-26 2005-01-06 Merck & Co., Inc. Benzodiazepine cgrp receptor antagonists
JP2008528448A (ja) * 2005-01-03 2008-07-31 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 新規化合物に関連する組成物および方法、ならびにその標的
WO2007053193A2 (en) 2005-06-01 2007-05-10 The Regents Of The University Of Michigan Unsolvated benzodiazepine compositions and methods
EP1948191B1 (en) 2005-11-01 2013-01-16 The Regents of the University of Michigan Novel 1,4-benzodiazepine-2,5-diones with therapeutic properties
US7759338B2 (en) 2006-04-27 2010-07-20 The Regents Of The University Of Michigan Soluble 1,4 benzodiazepine compounds and stable salts thereof
EP2418206A3 (en) 2006-06-09 2012-06-27 The Regents of the University of Michigan Benzodiazepine derivatives useful in the treatment of autoimmune disorders
CA2680017C (en) 2007-03-09 2013-11-12 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
EP2200977B1 (en) 2007-09-14 2016-11-09 The Regents of the University of Michigan F1f0-atpase inhibitors and related methods
MX2010004857A (es) 2007-11-06 2010-07-28 Univ Michigan Compuestos de benzodiazepinona utiles en el tratamiento de afecciones de la piel.
EP2352724B1 (en) 2008-09-11 2015-04-22 The Regents of the University of Michigan Aryl guanidine f1f0-atpase inhibitors and their medical use
WO2010121164A2 (en) 2009-04-17 2010-10-21 The Regents Of The University Of Michigan 1,4-benzodiazepinone compounds and their use in treating cancer
US8673897B2 (en) 2009-09-18 2014-03-18 The Regents Of The University Of Michigan Benzodiazepinone compounds and methods of treatment using same
CU20090172A6 (es) 2009-10-09 2011-10-05 Facultad De Quimica Universidad De La Habana Sistemas tricíclicos y tetracíclicos con actividad sobre el sistema nervioso central y vascular
CN102753544A (zh) 2009-11-17 2012-10-24 密执安大学评议会 具有治疗性能的1，4-苯并二氮杂*-2，5-二酮和相关化合物
WO2011062765A2 (en) 2009-11-17 2011-05-26 The Regents Of The University Of Michigan 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties
US20150374763A1 (en) 2013-02-05 2015-12-31 Ludwig Stocker Hofpfisterei Gmbh Use of microorganisms for the prevention and treatment of intestinal diseases

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Publication number Priority date Publication date Assignee Title
CA1332410C (en) * 1984-06-26 1994-10-11 Roger M. Freidinger Benzodiazepine analogs
US4820834A (en) * 1984-06-26 1989-04-11 Merck & Co., Inc. Benzodiazepine analogs
US4628084A (en) * 1986-01-02 1986-12-09 Merck & Co., Inc. Process for 3-acylamino benzodiazepines

Also Published As

Publication number Publication date
JPH0256481A (ja) 1990-02-26
DE68927620T2 (de) 1997-04-24
EP0349949A3 (en) 1991-09-04
EP0349949A2 (en) 1990-01-10
IL90830A (en) 1995-06-29
PT91092A (pt) 1990-02-08
FI95699B (fi) 1995-11-30
NO892799D0 (no) 1989-07-06
US4970207A (en) 1990-11-13
FI95699C (fi) 1996-03-11
PT91092B (pt) 1995-05-04
AU3785989A (en) 1990-01-11
NO892799L (no) 1990-01-08
KR900001688A (ko) 1990-02-27
FI893226A0 (fi) 1989-07-03
JPH07224060A (ja) 1995-08-22
DK336589A (da) 1990-01-08
CA1334589C (en) 1995-02-28
DE68927620D1 (de) 1997-02-20
IL90830A0 (en) 1990-01-18
DK336589D0 (da) 1989-07-06
ATE147403T1 (de) 1997-01-15
GR3022239T3 (en) 1997-04-30
JP2536160B2 (ja) 1996-09-18
EP0349949B1 (en) 1997-01-08
NO173014C (no) 1993-10-13
NO173014B (no) 1993-07-05
FI893226L (fi) 1990-01-08
CN1041941A (zh) 1990-05-09
HUT50331A (en) 1990-01-29

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