ES2096614T3 - Derivados de acidos biliares, procedimiento para su preparacion y utilizacion de este compuesto como medicamento. - Google Patents

Derivados de acidos biliares, procedimiento para su preparacion y utilizacion de este compuesto como medicamento.

Info

Publication number
ES2096614T3
ES2096614T3 ES91120841T ES91120841T ES2096614T3 ES 2096614 T3 ES2096614 T3 ES 2096614T3 ES 91120841 T ES91120841 T ES 91120841T ES 91120841 T ES91120841 T ES 91120841T ES 2096614 T3 ES2096614 T3 ES 2096614T3
Authority
ES
Spain
Prior art keywords
galic acid
derivatives
procedure
compound
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91120841T
Other languages
English (en)
Inventor
Werner Dr Dr Kramer
Gunther Dr Wess
Stefan Dr Mullner
Horst Dr Neubauer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of ES2096614T3 publication Critical patent/ES2096614T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0016—Oximes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Train Traffic Observation, Control, And Security (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Motorcycle And Bicycle Frame (AREA)

Abstract

LA INVENCION CONCIERNE A DERIVADOS DEL ACIDO GALICO DE FORMULA GENERAL I G1 RESTOS DEL ACIDO GALICO, O RESTOS MODIFICADOS DEL ACIDO GALICO, EN FORMA DE ACIDOS LIBRES, DE ESTERES O DE AMIDAS, DE LAS FORMAS DE SALES, ASI COMO DE LAS FORMAS DERIVADAS DE LOS GRUPOS ALCOHOLICOS Y X REPRESENTA UN GRUPO PUENTE O UN ENLACE SENCILLO COVALENTE, PUDIENDO ESTAR LIGADOS G1 Y G2 A TRAVES DE X DE LA FORMA QUE SE DESEE. LOS COMPUESTOS CONFORME A LA INVENCION POSEEN UNA ELEVADA AFINIDAD CON EL SISTEMA ESPECIFICO PARA EL TRANSPORTE DEL ACIDO GALICO DEL INTESTINO DELGADO Y INHIBEN LA ABSORCION DE ACIDO GALICO DE FORMA DEPENDIENTE DE LA CONCENTRACION Y DE LA COMPETITIVIDAD.
ES91120841T 1990-12-06 1991-12-04 Derivados de acidos biliares, procedimiento para su preparacion y utilizacion de este compuesto como medicamento. Expired - Lifetime ES2096614T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4038833 1990-12-06

Publications (1)

Publication Number Publication Date
ES2096614T3 true ES2096614T3 (es) 1997-03-16

Family

ID=6419672

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91120841T Expired - Lifetime ES2096614T3 (es) 1990-12-06 1991-12-04 Derivados de acidos biliares, procedimiento para su preparacion y utilizacion de este compuesto como medicamento.

Country Status (23)

Country Link
US (1) US5250524A (es)
EP (1) EP0489423B1 (es)
JP (1) JP3237882B2 (es)
KR (1) KR100221690B1 (es)
AT (1) ATE144988T1 (es)
AU (1) AU649089B2 (es)
CA (1) CA2057099C (es)
CZ (1) CZ281075B6 (es)
DE (1) DE59108326D1 (es)
DK (1) DK0489423T3 (es)
ES (1) ES2096614T3 (es)
FI (1) FI106800B (es)
GR (1) GR3021572T3 (es)
HR (1) HRP940751B1 (es)
HU (2) HU213402B (es)
IE (1) IE914235A1 (es)
IL (1) IL100240A (es)
NO (1) NO304187B1 (es)
NZ (1) NZ240846A (es)
PT (1) PT99713B (es)
SI (1) SI9111899B (es)
YU (1) YU48636B (es)
ZA (1) ZA919605B (es)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2318927A1 (es) * 2005-08-25 2009-05-01 Universidade De Santiago De Compostela Nuevos dimeros de acidos biliares funcionalizados en la posicion 24 de la cadena alquilica de la sal biliar. procedimientos para su obtencion y aplicaciones.
ES2318922A1 (es) * 2005-05-30 2009-05-01 Universidade De Santiago De Compostela Nuevos dimeros derivados de acidos biliares funcionalizados en la posicion 3 del anillo a. metodo para la sintesis y aplicaciones.

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ES2318922B1 (es) * 2005-05-30 2010-02-12 Universidade De Santiago De Compostela Nuevos dimeros derivados de acidos biliares funcionalizados en la posicion 3 del anillo a. metodo para la sintesis y aplicaciones.
ES2318927A1 (es) * 2005-08-25 2009-05-01 Universidade De Santiago De Compostela Nuevos dimeros de acidos biliares funcionalizados en la posicion 24 de la cadena alquilica de la sal biliar. procedimientos para su obtencion y aplicaciones.
ES2318927B1 (es) * 2005-08-25 2010-02-12 Universidade De Santiago De Compostela Nuevos dimeros de acidos biliares funcionalizados en la posicion 24 de la cadena alquilica de la sal biliar. procedimientos para su obtencion y aplicaciones.

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DE59108326D1 (de) 1996-12-12
CS369791A3 (en) 1992-06-17
IL100240A0 (en) 1992-09-06
ATE144988T1 (de) 1996-11-15
CA2057099A1 (en) 1992-06-07
ZA919605B (en) 1992-08-26
EP0489423B1 (de) 1996-11-06
HRP940751B1 (en) 2000-12-31
JP3237882B2 (ja) 2001-12-10
NZ240846A (en) 1994-04-27
DK0489423T3 (da) 1997-04-14
HU213402B (en) 1997-06-30
JPH05294988A (ja) 1993-11-09
HU913817D0 (en) 1992-02-28
SI9111899B (sl) 2000-06-30
FI915719A0 (fi) 1991-12-04
CA2057099C (en) 2005-05-17
CZ281075B6 (cs) 1996-06-12
KR920012108A (ko) 1992-07-25
NO304187B1 (no) 1998-11-09
PT99713B (pt) 1999-05-31
EP0489423A1 (de) 1992-06-10
YU48636B (sh) 1999-03-04
GR3021572T3 (en) 1997-02-28
HU211900A9 (en) 1996-01-29
US5250524A (en) 1993-10-05
HRP940751A2 (en) 1997-04-30
FI915719L (fi) 1992-06-07
IL100240A (en) 1995-10-31
KR100221690B1 (ko) 1999-10-01
FI106800B (fi) 2001-04-12
HUT62599A (en) 1993-05-28
AU8884991A (en) 1992-06-11
YU189991A (sh) 1995-10-03
SI9111899A (sl) 1998-04-30
NO914792D0 (no) 1991-12-05
NO914792L (no) 1992-06-09
PT99713A (pt) 1992-10-30
IE914235A1 (en) 1992-06-17
AU649089B2 (en) 1994-05-12

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