ES2097154T3 - Vacuna con conjugado para streptococcus de grupo b. - Google Patents

Vacuna con conjugado para streptococcus de grupo b.

Info

Publication number
ES2097154T3
ES2097154T3 ES90915038T ES90915038T ES2097154T3 ES 2097154 T3 ES2097154 T3 ES 2097154T3 ES 90915038 T ES90915038 T ES 90915038T ES 90915038 T ES90915038 T ES 90915038T ES 2097154 T3 ES2097154 T3 ES 2097154T3
Authority
ES
Spain
Prior art keywords
streptococcus
group
vaccine
conjugate
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90915038T
Other languages
English (en)
Inventor
James L Michel
Dennis L Kasper
Frederick M Ausubel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Brigham and Womens Hospital Inc
General Hospital Corp
Original Assignee
Brigham and Womens Hospital Inc
General Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brigham and Womens Hospital Inc, General Hospital Corp filed Critical Brigham and Womens Hospital Inc
Application granted granted Critical
Publication of ES2097154T3 publication Critical patent/ES2097154T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6068—Other bacterial proteins, e.g. OMP

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

UNA VACUNA CAPAZ DE PROTEGER UN RECIPIENTE DE LA INFECCION CAUSADA POR STREPTOCOCCUS DEL GRUPO B. LA VACUNA SE ELABORA CONJUGANDO (A) UN POLISACARIDO CONJUGADO CON (B) UNA PROTEINA; DONDE TANTO EL POLISACARIDO COMO LA PROTEINA SON MOLECULAS CARACTERISTICAS DE LOS STREPTOCOCCUS DEL GRUPO B.
ES90915038T 1989-09-15 1990-09-14 Vacuna con conjugado para streptococcus de grupo b. Expired - Lifetime ES2097154T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US40803689A 1989-09-15 1989-09-15

Publications (1)

Publication Number Publication Date
ES2097154T3 true ES2097154T3 (es) 1997-04-01

Family

ID=23614587

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90915038T Expired - Lifetime ES2097154T3 (es) 1989-09-15 1990-09-14 Vacuna con conjugado para streptococcus de grupo b.

Country Status (22)

Country Link
EP (1) EP0491865B1 (es)
JP (2) JPH05500455A (es)
KR (1) KR0180559B1 (es)
AT (1) ATE146081T1 (es)
AU (1) AU641439B2 (es)
CA (2) CA2066221C (es)
DE (1) DE69029396T2 (es)
DK (1) DK0491865T3 (es)
ES (1) ES2097154T3 (es)
FI (1) FI105154B (es)
GR (1) GR1002294B (es)
HU (1) HU219327B (es)
IE (1) IE903349A1 (es)
IL (1) IL95578A (es)
NO (1) NO313908B1 (es)
NZ (1) NZ235316A (es)
PL (3) PL168587B1 (es)
PT (1) PT95316A (es)
RU (1) RU2113234C1 (es)
WO (1) WO1991004049A1 (es)
YU (1) YU176490A (es)
ZA (1) ZA907297B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5648241A (en) * 1989-09-15 1997-07-15 The General Hospital Corporation Conjugate vaccine against group B streptococcus
IL107103A (en) * 1992-09-24 2001-03-19 Brigham & Womens Hospital Multivalent vaccine based on conjugated molecule comprising a capsular polysaccharide linked to a protein and a method for the preparation thereof
ZA937034B (en) * 1992-09-24 1995-06-23 Brigham & Womens Hospital Group B streptococcus type II and type V polysaccharide-protein conjugate vaccines
IL107458A0 (en) * 1992-11-02 1994-02-27 Gen Hospital Corp Conjugate vaccine against group b streptococcus
AU722078B2 (en) * 1992-11-02 2000-07-20 Brigham And Women's Hospital Conjugate vaccine against group B Streptococcus
US6015889A (en) * 1993-03-19 2000-01-18 Gunnar Lindahl Protein rib, a cell surface protein that confers immunity to many strains of the group B streptococcus: process for purification of the protein, reagent kit and pharmaceutical composition
PT656014E (pt) * 1993-03-19 2003-09-30 Gunnar Lindahl Proteina rib, uma proteina da superficie celular que confere imunidade a muitas estirpes de estreptococos do grupo b: processo para purificacao da proteina, estojo de reagentes e composicao farmaceutica
US5439808A (en) * 1993-07-23 1995-08-08 North American Vaccine, Inc. Method for the high level expression, purification and refolding of the outer membrane group B porin proteins from Neisseria meningitidis
US5565204A (en) * 1994-08-24 1996-10-15 American Cyanamid Company Pneumococcal polysaccharide-recombinant pneumolysin conjugate vaccines for immunization against pneumococcal infections
US5747287A (en) * 1995-04-28 1998-05-05 North American Vaccine, Inc. Method for the high level expression, purification and refolding of the outer membrane group B porin proteins from Neisseria meningitidis
US6284884B1 (en) 1995-06-07 2001-09-04 North American Vaccine, Inc. Antigenic group B streptococcus type II and type III polysaccharide fragments having a 2,5-anhydro-D-mannose terminal structure and conjugate vaccine thereof
WO1999033969A1 (en) * 1997-12-31 1999-07-08 Pincus Seth H A method of isolating a peptide which immunologically mimics microbial carbohydrates including group b streptococcal carbohydrates and the use thereof in a vaccine
RU2186389C1 (ru) * 2001-01-09 2002-07-27 Государственное федеральное учреждение науки Уральский научно-исследовательский институт травматологии и ортопедии Способ культивирования h. influenzae из носоглоточной слизи (варианты)
RU2261109C1 (ru) * 2004-01-05 2005-09-27 ГНУ Научно-исследовательский институт пушного звероводства и кролиководства им. В.А. Афанасьева Штамм бактерий streptococcus agalactiae №71 для изготовления вакцин против стрептококкоза пушных зверей
WO2006069200A2 (en) * 2004-12-22 2006-06-29 Novartis Vaccines And Diagnostics Inc. Group b streptococcus
RU2378374C2 (ru) * 2008-03-21 2010-01-10 Учреждение Российской академии медицинских наук Научно-исследовательский институт экспериментальной медицины Северо-Западного отделения РАМН Рекомбинантная днк, обеспечивающая получение рекомбинантного белка pb1, обладающего протективными свойствами в отношении streptococcus pyogenes и streptococcus agalactiae
RU2387715C2 (ru) * 2008-06-18 2010-04-27 Учреждение Российской Академии Медицинских Наук Научно-исследовательский институт экспериментальной медицины Северо-западного отделения РАМН (НИИЭМ СЗО РАМН) РЕКОМБИНАНТНЫЕ ДНК, ОБЕСПЕЧИВАЮЩИЕ ПОЛУЧЕНИЕ ПОЛИПЕПТИДОВ Р6, Р7, Р8, ОБЛАДАЮЩИХ ПРОТЕКТИВНЫМИ СВОЙСТВАМИ В ОТНОШЕНИИ STREPTOCOCCUS AGALACTIAE И СЕЛЕКТИВНО-СВЯЗЫВАЮЩИХ IgA

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4367222A (en) * 1980-06-09 1983-01-04 President And Fellows Of Harvard College Immune globulin specific to Group B streptococci
US4367223A (en) * 1980-06-09 1983-01-04 President And Fellows Of Harvard College Vaccine against Group B streptococci
US4356170A (en) * 1981-05-27 1982-10-26 Canadian Patents & Development Ltd. Immunogenic polysaccharide-protein conjugates
NZ214503A (en) * 1984-12-20 1990-02-26 Merck & Co Inc Covalently-modified neutral bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins, and methods of preparing such polysaccharides and conjugates
EP0302887B1 (en) * 1986-04-16 1994-06-22 The Brigham And Women's Hospital, Inc. Bacterial antigens, antibodies, vaccines, and methods of manufacture
EP0419462A4 (en) * 1987-07-17 1991-07-17 Xoma Corporation Improved immunotoxin therapies utilizing purified ricin a-chain species

Also Published As

Publication number Publication date
EP0491865A1 (en) 1992-07-01
EP0491865A4 (en) 1993-05-05
PL167882B1 (pl) 1995-11-30
EP0491865B1 (en) 1996-12-11
GR900100692A (el) 1992-01-20
CA2383393A1 (en) 1991-04-04
FI921111A0 (fi) 1992-03-13
ATE146081T1 (de) 1996-12-15
YU176490A (sh) 1992-12-21
PL286898A1 (en) 1991-06-03
ZA907297B (en) 1993-06-01
NO920942L (no) 1992-05-12
KR0180559B1 (ko) 1999-03-20
HU219327B (en) 2001-03-28
IL95578A (en) 1998-08-16
CA2066221A1 (en) 1991-03-16
CA2066221C (en) 2002-07-23
KR920703097A (ko) 1992-12-17
AU641439B2 (en) 1993-09-23
PL167444B1 (pl) 1995-09-30
PL168587B1 (pl) 1996-03-29
DK0491865T3 (da) 1997-06-02
GR1002294B (el) 1996-05-03
IL95578A0 (en) 1991-06-30
WO1991004049A1 (en) 1991-04-04
IE903349A1 (en) 1991-04-10
NZ235316A (en) 1992-11-25
FI105154B (fi) 2000-06-30
DE69029396T2 (de) 1997-06-05
AU6519090A (en) 1991-04-18
JPH05500455A (ja) 1993-02-04
PT95316A (pt) 1991-06-25
JP3447713B2 (ja) 2003-09-16
NO920942D0 (no) 1992-03-11
RU2113234C1 (ru) 1998-06-20
DE69029396D1 (de) 1997-01-23
HUT63770A (en) 1993-10-28
JP2001309795A (ja) 2001-11-06
NO313908B1 (no) 2002-12-23

Similar Documents

Publication Publication Date Title
DK0491865T3 (da) Konjugatvaccine for gruppe B-Streptococcus
DK614987A (da) Syntetiske htlv-iii peptider, praeparater og anvendelser deraf
DK93584A (da) Haemophilus-b-influenza polysaccharid exotoxoid-konjugatvaccine
BR9007917A (pt) Vacina aperfeicoada de conjugado polissacaridico meningogocico
YU153291A (sh) Poboljšani vakcinski preparati
DE69627149D1 (de) Antigene polysaccharidfragmente mit einer terminalen 2,5-anhydro-d-mannosegruppevon gruppe b-streptococcus, typ ii und typ iii, und daraus hergestellte konjugatimpfstoffe
DK205585A (da) Polysaccharidproteinkonjugat, fremgangsmaade til fremstilling deraf ogpraeparat omfattende et polysaccharidproteinkonjugat
DE69132055D1 (de) Ortsgenaue konjugatbildung zwischen immunglobulinen und nachweisbaren markierungsstoffen
SE8600998D0 (sv) Parenterala fenytoinpreparat
ES2137310T3 (es) Vacuna contra una infeccion por streptococcus suis.
SE8202439L (sv) 4'-jodderivat av antracyklinglykosider
WO1994010317A3 (en) Conjugate vaccine against group b streptococcus
PT95625A (pt) Processo para a preparacao de arilsulfatase
NO911174D0 (no) Kermesbaer antiviralt protein (pap)-monoklonalt antistoffkonjugat.
DK0502100T3 (da) Vaccine mod svinedysemteri med formindsket indhold af proteinsubunit
FR2693723B1 (fr) Dérivés de la N-(phényléthyl-beta-ol) amine ainsi que leur procédé de préparation.
ATE47863T1 (de) Makrolide derivate.
NO920160D0 (no) Cytokin- og hormonbaerere for konjugatvaksiner
SU1739559A1 (ru) Штамм вируса aphtae epizooticae типа o, используемый для изготовления диагностических сывороток и антигенных препаратов

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 491865

Country of ref document: ES