ES2098543T3 - Un proceso para la purificacion de extractos acuosos que contienen proteinas alergenicamente activas, extractos obtenibles de acuerdo con este proceso, asi como su uso. - Google Patents

Un proceso para la purificacion de extractos acuosos que contienen proteinas alergenicamente activas, extractos obtenibles de acuerdo con este proceso, asi como su uso.

Info

Publication number
ES2098543T3
ES2098543T3 ES92920684T ES92920684T ES2098543T3 ES 2098543 T3 ES2098543 T3 ES 2098543T3 ES 92920684 T ES92920684 T ES 92920684T ES 92920684 T ES92920684 T ES 92920684T ES 2098543 T3 ES2098543 T3 ES 2098543T3
Authority
ES
Spain
Prior art keywords
pct
allergenic
molecular weight
proteins
low
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92920684T
Other languages
English (en)
Inventor
Lubertus Berrens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Leti SA
CBF Leti SA
Original Assignee
Laboratorios Leti SA
CBF Leti SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Leti SA, CBF Leti SA filed Critical Laboratorios Leti SA
Priority claimed from CA002145169A external-priority patent/CA2145169C/en
Application granted granted Critical
Publication of ES2098543T3 publication Critical patent/ES2098543T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/35—Allergens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/35—Allergens
    • A61K39/36—Allergens from pollen

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compounds Of Unknown Constitution (AREA)

Abstract

EL INVENTO SE REFIERE A LA ELIMINACION DE DIVERSOS COMPONENTES DE BAJO PESO MOLECULAR ALERGOLOGICAMENTE IRRELEVANTES DE LOS EXTRACTOS ACUOSOS USUALES EN PROTEINAS ALERGENICAMENTE ACTIVAS DE POLEN DE PLANTAS. SE DESCRIBE LA DESORCION Y ELIMINACION SUBSECUENTE, DESDE EXTRACTOS DE PROTEINAS DE POLEN ALERGENICO PREPARADOS TRADICIONALMENTE, DE PIGMENTOS DE BAJO PESO MOLECULAR Y OTROS COMPUESTOS QUE NORMALMENTE SE RETIENEN POR PODEROSAS FUERZAS ELECTROSTATICA Y/O HIDROFOBICA. LA PREPARACION DE TALES PROTEINAS DE POLEN DEPIGMENTADO NO DISMINUYE SU POTENCIA ALERGENICA O SU ESPECIFICIDAD INMUNOLOGICA. EL INVENTO POSIBILITA LA PRODUCCION DE PROTEINAS DE POLEN ALERGENICO TOTALMENTE ACTIVO DESPROVISTAS DE ADHESION DE SUBSTANCIAS DE BAJO PESO MOLECULAR QUE INTERFIEREN CON SU SEGURIDAD, PRECISION DIAGNOSTICA Y EFICACIA CLINICA. LAS PROTEINAS DE POLEN PURIFICADO REPRESENTAN MATERIALES DE INICIO MEJORADOS POR DERIVACION QUIMICA, ES DECIR, LA PREPARACION DE VACUNAS ATENUADAS DE INMUNOTERAPIA. EL INVENTO TAMBIEN PROPORCIONA PRODUCTOS APROPIADOS PARA LA INVESTIGACION DE LA ESTRUCTURA MOLECULAR DE EPITOPES ALERGENICOS.
ES92920684T 1992-09-21 1992-09-21 Un proceso para la purificacion de extractos acuosos que contienen proteinas alergenicamente activas, extractos obtenibles de acuerdo con este proceso, asi como su uso. Expired - Lifetime ES2098543T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA002145169A CA2145169C (en) 1992-09-21 1992-09-21 A process for the purification of aqueous extracts containing allergenically active proteins, extracts obtainable according to this process as well as their use
PCT/NL1992/000160 WO1994006821A1 (en) 1992-09-21 1992-09-21 A process for the purification of aqueous extracts containing allergenically active proteins, extracts obtainable according to this process as well as their use

Publications (1)

Publication Number Publication Date
ES2098543T3 true ES2098543T3 (es) 1997-05-01

Family

ID=4155482

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92920684T Expired - Lifetime ES2098543T3 (es) 1992-09-21 1992-09-21 Un proceso para la purificacion de extractos acuosos que contienen proteinas alergenicamente activas, extractos obtenibles de acuerdo con este proceso, asi como su uso.

Country Status (6)

Country Link
US (1) US5770698A (es)
EP (1) EP0662080B1 (es)
AT (1) ATE148708T1 (es)
AU (1) AU675629B2 (es)
DE (3) DE122005000034I1 (es)
ES (1) ES2098543T3 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL187544B1 (pl) 1997-10-30 2004-07-30 C B F Leti Sa Wywołujące tolerancję fragmenty naturalnych alergenów
US6562630B2 (en) * 2000-10-12 2003-05-13 Thomas H. Bryant Method for preparation and use of preservative-free immunoassay reagents
IL139308A0 (en) * 2000-10-26 2001-11-25 Marikovsky Moshe Peptides from amyloid precursor protein which inhibit tumor growth and metastasis
SE0004891D0 (sv) * 2000-12-29 2000-12-29 Pharmacia Diagnostics Ab Use of a pure allergen component
US20060269576A1 (en) * 2005-05-27 2006-11-30 Curalogic, A/S Non-injection immunotherapy
EP1872792A1 (en) * 2006-06-29 2008-01-02 Biotech Tools S.A. A method for the production of hydrolyzed allergen
KR100828107B1 (ko) * 2006-09-29 2008-05-08 주식회사 코스트리 저백피 추출물을 함유하는 화장료 조성물
EP2224953A1 (en) * 2008-01-02 2010-09-08 Biotech Tools S.A. Pharmaceutical formulation for allergen preparation
EP2258391A1 (en) * 2009-06-05 2010-12-08 Stallergenes S.A. Reduction of in vitro genotoxicity of pollen extracts by removal of flavonoids
AU2011214316B2 (en) 2010-02-12 2015-07-02 Laboratorios Leti, S.L. Process for producing an allergen extract
US9175052B2 (en) 2013-05-17 2015-11-03 R.J. Reynolds Tobacco Company Tobacco-derived protein compositions
EP2974741A1 (en) * 2014-07-16 2016-01-20 Stallergenes Composition of allergen extracts having reduced toxicity and method of production thereof
FR3049866B1 (fr) 2016-04-07 2019-09-06 Nfl Biosciences Extrait de feuilles de tabac et utilisation pour le traitement de l'addiction au tabac
ES2868631T3 (es) 2016-10-05 2021-10-21 Asit Biotech S A Prevención de la alergia
US11408895B1 (en) 2018-04-09 2022-08-09 Hob Biotech Group Corp., Ltd. Allergen characterization, potent allergen product formulation, comprehensive allergen reagent, and allergy assay
US11617789B2 (en) 2018-11-09 2023-04-04 Jubilant HollisterStier LLC Process for the preparation of allergenic extracts
CA3126499A1 (en) 2019-01-17 2020-07-23 LETI Pharma S.L. Methods of purifying an allergen extract
IT202200011459A1 (it) * 2022-05-31 2023-12-01 Anallergo S P A Uso della ultrafiltrazione per la produzione di estratti allergenici purificati
KR20250105395A (ko) 2022-10-24 2025-07-08 엔에프엘 바이오사이언시스 금연을 돕기 위한 담배 잎 추출물을 포함하는 치료 방법

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8900652A (nl) * 1989-03-16 1990-10-16 Leti Lab Primair-toxische stoffen of allergenen, isoleerbaar uit plantaardig materiaal, alsmede werkwijzen ter bereiding ervan en de toepassing ervan.

Also Published As

Publication number Publication date
DE69217395T2 (de) 1997-05-22
EP0662080B1 (en) 1997-02-05
EP0662080A1 (en) 1995-07-12
ATE148708T1 (de) 1997-02-15
DE122005000035I1 (de) 2005-10-20
DE69217395D1 (de) 1997-03-20
DE122005000034I1 (de) 2005-10-20
US5770698A (en) 1998-06-23
AU675629B2 (en) 1997-02-13
DE122005000035I2 (de) 2008-03-27
AU2648692A (en) 1994-04-12

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