DK0576915T3 - Cyclopentanperhydrophenanthren-17beta-(3-furyl)-3-derivater og farmaceutiske præparater indeholdende samme til behandling af cardiovaskulære lidelser. - Google Patents

Cyclopentanperhydrophenanthren-17beta-(3-furyl)-3-derivater og farmaceutiske præparater indeholdende samme til behandling af cardiovaskulære lidelser.

Info

Publication number
DK0576915T3
DK0576915T3 DK93109612.7T DK93109612T DK0576915T3 DK 0576915 T3 DK0576915 T3 DK 0576915T3 DK 93109612 T DK93109612 T DK 93109612T DK 0576915 T3 DK0576915 T3 DK 0576915T3
Authority
DK
Denmark
Prior art keywords
furyl
derivatives
treatment
pharmaceutical compositions
compositions containing
Prior art date
Application number
DK93109612.7T
Other languages
English (en)
Inventor
Luisa Quadri
Luigi Bernardi
Patrizia Ferrari
Mauro Gobbini
Piero Melloni
Loredana Valentino
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Application granted granted Critical
Publication of DK0576915T3 publication Critical patent/DK0576915T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/003—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring the S atom directly linked to a ring carbon atom of the cyclopenta(a)hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0021—Oxiranes at position 14(15)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Furan Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK93109612.7T 1992-07-01 1993-06-16 Cyclopentanperhydrophenanthren-17beta-(3-furyl)-3-derivater og farmaceutiske præparater indeholdende samme til behandling af cardiovaskulære lidelser. DK0576915T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4221636A DE4221636C1 (de) 1992-07-01 1992-07-01 Cyclopentanperhydrophenanthren-17beta-(3-furyl)-3-Derivate

Publications (1)

Publication Number Publication Date
DK0576915T3 true DK0576915T3 (da) 1997-09-01

Family

ID=6462265

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93109612.7T DK0576915T3 (da) 1992-07-01 1993-06-16 Cyclopentanperhydrophenanthren-17beta-(3-furyl)-3-derivater og farmaceutiske præparater indeholdende samme til behandling af cardiovaskulære lidelser.

Country Status (8)

Country Link
US (2) US5432169A (da)
EP (1) EP0576915B1 (da)
JP (1) JPH0665284A (da)
AT (1) ATE151774T1 (da)
DE (2) DE4221636C1 (da)
DK (1) DK0576915T3 (da)
ES (1) ES2099865T3 (da)
GR (1) GR3023310T3 (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4221636C1 (de) * 1992-07-01 1994-03-31 Sigma Tau Ind Farmaceuti Cyclopentanperhydrophenanthren-17beta-(3-furyl)-3-Derivate
DE4227616C2 (de) * 1992-08-20 1995-04-13 Sigma Tau Ind Farmaceuti 17-(3-Furyl)-und 17-(4-Pyridazinyl)-5beta, 14beta-androstanderivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammemsetzungen
DE4232656C2 (de) * 1992-09-29 1995-01-12 Sigma Tau Ind Farmaceuti Cyclopentanperhydrophenanthren-17-furyl-3ß-derivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutischen Zusammensetzungen
ATE177751T1 (de) * 1993-10-27 1999-04-15 Merrell Pharma Inc Delta 16 ungesättigtes c17 heterocyclische steroide zur verwendung als steroid c17-20 lyase inhibitoren
IT1282286B1 (it) * 1995-05-11 1998-03-16 Sigma Tau Ind Farmaceuti Seco-d steroidi sul sistema cardiovascolare, processi per la loro preparazione e composizioni farmaceutiche che li contengono.
IT1282289B1 (it) * 1995-06-23 1998-03-16 Sigma Tau Ind Farmaceuti 17-idrossiimminoalchil e 17-idrossiimminometilalchenil ciclopentaperidrofenantreni attivi sul sistema cardiovascolare,
JP3875125B2 (ja) * 2001-04-11 2007-01-31 シャープ株式会社 液晶表示装置
US20040064050A1 (en) * 2002-09-20 2004-04-01 Jun Liu System and method for screening tissue
ES2380491T3 (es) * 2005-11-25 2012-05-14 Rostaquo S.P.A. Formas cristalinas adicionales de la Rostafuroxina
EP3599243B1 (en) 2018-07-26 2023-04-12 CVIE Therapeutics Limited 17beta-heterocyclyl-digitalis like compounds for the treatment of heart failure
FI3805243T3 (fi) 2019-10-09 2024-02-07 Windtree Therapeutics Inc Androstaanijohdannaisia, joilla on aktiivisuus puhtaina tai pääasiallisesti puhtaina SERCA2a:n stimulaattoreina, sydämen vajaatoiminnan hoitoon

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1227015B (de) * 1963-01-23 1966-10-20 Bayer Ag Verfahren zur Herstellung von 3beta-Hydroxy-(bzw.-Acyloxy)-steroid-20-amidylhydrazonen der Pregnanreihe
GB1081647A (en) * 1965-04-01 1967-08-31 Shionogi & Co Furan compounds
US3436390A (en) * 1966-05-24 1969-04-01 American Home Prod 4,4-dihydroxy-2-butenoic acid lactones
DE1807585C3 (de) * 1968-11-04 1974-11-07 Schering Ag, 1000 Berlin Und 4619 Bergkamen 14,15beta-Epoxycardenolide, Verfahren zu deren Herstellung und diese enthaltende Mittel
DE1812946C3 (de) * 1968-12-05 1978-11-02 Hoechst Ag, 6000 Frankfurt Herzwirksame 14beta, lSbeta Oxidobutatrienolide und Verfahren zu ihrer Herstellung
US4259240A (en) * 1979-09-28 1981-03-31 Advance Biofactures Corporation Synthesis of furyl intermediates, and cardenolides and their isomers prepared therefrom
GB8916636D0 (en) * 1989-07-20 1989-09-06 Erba Carlo Spa Steroid ethers
DE4221636C1 (de) * 1992-07-01 1994-03-31 Sigma Tau Ind Farmaceuti Cyclopentanperhydrophenanthren-17beta-(3-furyl)-3-Derivate

Also Published As

Publication number Publication date
HK1005877A1 (en) 1999-01-29
ATE151774T1 (de) 1997-05-15
US5593982A (en) 1997-01-14
US5432169A (en) 1995-07-11
DE69309790T2 (de) 1997-09-11
JPH0665284A (ja) 1994-03-08
EP0576915A3 (en) 1994-07-06
EP0576915A2 (en) 1994-01-05
EP0576915B1 (en) 1997-04-16
DE69309790D1 (de) 1997-05-22
ES2099865T3 (es) 1997-06-01
DE4221636C1 (de) 1994-03-31
GR3023310T3 (en) 1997-08-29

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