ES2100274T3 - Nuevos 2-sacarinilmetil y 4,5,6,7-tetrahidro-2-sacarinilmetil fosfatos, fosfonatos y fosfinatos utiles como inhibidores de enzimas proteoliticos y composiciones y metodos de empleo de los mismos. - Google Patents

Nuevos 2-sacarinilmetil y 4,5,6,7-tetrahidro-2-sacarinilmetil fosfatos, fosfonatos y fosfinatos utiles como inhibidores de enzimas proteoliticos y composiciones y metodos de empleo de los mismos.

Info

Publication number
ES2100274T3
ES2100274T3 ES92204032T ES92204032T ES2100274T3 ES 2100274 T3 ES2100274 T3 ES 2100274T3 ES 92204032 T ES92204032 T ES 92204032T ES 92204032 T ES92204032 T ES 92204032T ES 2100274 T3 ES2100274 T3 ES 2100274T3
Authority
ES
Spain
Prior art keywords
sacarinylmethyl
phosphonates
methods
phosphates
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92204032T
Other languages
English (en)
Inventor
Ranjit Chimanlal Desai
John Joseph Court
Dennis John Hlasta
Chakrapani Subramanyam
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Application granted granted Critical
Publication of ES2100274T3 publication Critical patent/ES2100274T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
    • C07F9/6539—Five-membered rings
    • C07F9/6541—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/6574—Esters of oxyacids of phosphorus
    • C07F9/65742—Esters of oxyacids of phosphorus non-condensed with carbocyclic rings or heterocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/6574—Esters of oxyacids of phosphorus
    • C07F9/65744—Esters of oxyacids of phosphorus condensed with carbocyclic or heterocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE PRESENTAN NUEVOS FOSFATOS, FOSFONATOS Y FOSFINATOS DE 4-R1R2-R3-2-SACARINILMETIL, 4-R4-4-R5-6-R6-4,5,6,7-TETRAHIDO-2SACARINILMETIL Y 4,7-C-4,5,6,7-TETRAHIDRO-2-SACARINILMETIL DE LAS FORMULAS I, II Y IIA RESPECTIVAMENTE. LOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES DEGENERATIVAS, ASIMISMO SE PRESENTAN COMPOSICIONES QUE LOS CONTIENEN, METODOS PARA USARLOS PARA TRATAR LAS ENFERMEDADES DEGENERATIVAS Y PROCESOS PARA SU PREPARACION MEDIANTE LA REACCION DE LAS CORRESPONDIENTES 2-HALOMETILSACARINAS CON UN FOSFATO, FOSFONATO O ACIDODERIVADOFOSFINICO.
ES92204032T 1991-12-27 1992-12-19 Nuevos 2-sacarinilmetil y 4,5,6,7-tetrahidro-2-sacarinilmetil fosfatos, fosfonatos y fosfinatos utiles como inhibidores de enzimas proteoliticos y composiciones y metodos de empleo de los mismos. Expired - Lifetime ES2100274T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/814,741 US5187173A (en) 1991-12-27 1991-12-27 2-saccharinylmethyl and 4,5,6,7-tetrahydro-2-saccharinylmethyl phosphates, phosphonates and phosphinates useful as proteolytic enzyme inhibitors and compositions and method of use thereof

Publications (1)

Publication Number Publication Date
ES2100274T3 true ES2100274T3 (es) 1997-06-16

Family

ID=25215883

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92204032T Expired - Lifetime ES2100274T3 (es) 1991-12-27 1992-12-19 Nuevos 2-sacarinilmetil y 4,5,6,7-tetrahidro-2-sacarinilmetil fosfatos, fosfonatos y fosfinatos utiles como inhibidores de enzimas proteoliticos y composiciones y metodos de empleo de los mismos.

Country Status (22)

Country Link
US (1) US5187173A (es)
EP (1) EP0549073B1 (es)
JP (1) JPH05271262A (es)
AT (1) ATE150755T1 (es)
AU (1) AU648938B2 (es)
CA (1) CA2085427A1 (es)
CZ (1) CZ371692A3 (es)
DE (1) DE69218568T2 (es)
DK (1) DK0549073T3 (es)
ES (1) ES2100274T3 (es)
FI (1) FI925875L (es)
GR (1) GR3023632T3 (es)
HU (1) HUT63630A (es)
IL (3) IL104229A (es)
MX (1) MX9207542A (es)
MY (1) MY106897A (es)
NO (1) NO303639B1 (es)
NZ (1) NZ245585A (es)
RU (1) RU2091377C1 (es)
SG (1) SG48310A1 (es)
SK (1) SK371692A3 (es)
TW (1) TW225538B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5236917A (en) * 1989-05-04 1993-08-17 Sterling Winthrop Inc. Saccharin derivatives useful as proteolytic enzyme inhibitors and compositions and method of use thereof
US5296496A (en) * 1991-12-27 1994-03-22 Sterling Winthrop Inc. 2-saccharinylmethyl phosphates, phosphonates and phosphinates useful as proteolytic enzyme inhibitors and compositions and method of use thereof
AU653279B2 (en) * 1991-12-30 1994-09-22 Sanofi Novel 2-saccharinylmethyl heterocyclic carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof
US5541168A (en) * 1994-12-02 1996-07-30 Sterling Winthrop Inc. Substituted 2-(phosphinyloxymethyl)-1,2,5-thiadiazolidin-3-one 1,1-dioxides and compositions and method of use thereof
JP4201716B2 (ja) * 2002-03-05 2008-12-24 メルク フロスト カナダ リミテツド カテプシンシステインプロテアーゼ阻害剤
WO2003080047A1 (en) * 2002-03-20 2003-10-02 Bristol-Myers Squibb Company Phosphate prodrugs of fluorooxindoles
WO2006102243A2 (en) * 2005-03-21 2006-09-28 Applera Corporation Alpha ketoamide compounds as cysteine protease inhibitors

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3002884A (en) * 1959-04-15 1961-10-03 Rohm & Haas Horticultural process with n-halomethyl-1,2-benzisothiazolin - 3 - one-1,1-dioxides for controlling fungus diseases
US3314960A (en) * 1964-08-25 1967-04-18 American Home Prod Benzisothiazol glutarimides
FR1451417A (fr) * 1965-07-15 1966-01-07 Roussel Uclaf Nouveaux esters d'acides cycliques et leur procédé de préparation
US4195023A (en) * 1975-08-20 1980-03-25 Merck & Co., Inc. 2-(2-Furoyl)1,2-benzisothiazole-3-one, 2-(2-furoyl) saccharin, and 2-(2-thenoyl) saccharin
US4276298A (en) * 1978-03-24 1981-06-30 Merck & Co., Inc. 2-Aryl-1,2-benzisothiazolinone-1,1-dioxides and their use as selective protease inhibitors
US4263393A (en) * 1979-09-06 1981-04-21 Eastman Kodak Company Novel electron donor precursors and photographic element containing them
US4350752A (en) * 1980-12-29 1982-09-21 Eastman Kodak Company Photographic elements and film units containing imidomethyl blocked photographic reagents
US4363865A (en) * 1981-03-04 1982-12-14 Eastman Kodak Company Imido methyl blocked photographic dyes and dye releasing compounds
US4410618A (en) * 1982-06-11 1983-10-18 Eastman Kodak Company Blocked photographic reagents
US4547371A (en) * 1983-04-18 1985-10-15 Merck & Co., Inc. Substituted cephalosporin sulfones as anti-inflammatory and anti-degenerative agents
US4623645A (en) * 1983-04-18 1986-11-18 Merck & Co., Inc. Substituted cephalosporin sulfoxides as anti-inflammatory and antidegenerative agents
US4659855A (en) * 1983-05-09 1987-04-21 Georgia Tech Research Corporation Aryl sulfonyl fluoride compounds
JPH026496A (ja) * 1988-06-27 1990-01-10 Ishihara Sangyo Kaisha Ltd 有機リン酸アミド系化合物、それらの製造方法及びそれらを含有する有害動物防除剤
AU637614B2 (en) * 1989-05-04 1993-06-03 Sanofi Saccharin derivatives useful as proteolytic enzyme inhibitors and preparation thereof
US5236917A (en) * 1989-05-04 1993-08-17 Sterling Winthrop Inc. Saccharin derivatives useful as proteolytic enzyme inhibitors and compositions and method of use thereof
AU642537B2 (en) * 1990-11-01 1993-10-21 Sanofi 2-saccharinylmethyl aryl carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof

Also Published As

Publication number Publication date
IL104229A (en) 1997-02-18
FI925875A7 (fi) 1993-06-28
FI925875L (fi) 1993-06-28
MY106897A (en) 1995-08-30
US5187173A (en) 1993-02-16
IL116601A0 (en) 1996-03-31
HU9204123D0 (en) 1993-04-28
GR3023632T3 (en) 1997-08-29
NO303639B1 (no) 1998-08-10
ATE150755T1 (de) 1997-04-15
DE69218568D1 (de) 1997-04-30
CA2085427A1 (en) 1993-06-28
MX9207542A (es) 1993-06-01
EP0549073B1 (en) 1997-03-26
SK371692A3 (en) 1995-05-10
IL116601A (en) 1997-04-15
CZ371692A3 (en) 1994-04-13
HUT63630A (en) 1993-09-28
JPH05271262A (ja) 1993-10-19
NO924991L (no) 1993-06-28
EP0549073A1 (en) 1993-06-30
IL104229A0 (en) 1993-05-13
FI925875A0 (fi) 1992-12-23
AU2829492A (en) 1993-07-01
TW225538B (es) 1994-06-21
RU2091377C1 (ru) 1997-09-27
DK0549073T3 (da) 1997-10-06
SG48310A1 (en) 1998-04-17
DE69218568T2 (de) 1997-11-13
AU648938B2 (en) 1994-05-05
NZ245585A (en) 1995-05-26
NO924991D0 (no) 1992-12-23

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