ATE159720T1 - Saccharinderivate zur verwendung als proteolytische enzyminhibitoren sowie verfahren zur herstellung - Google Patents
Saccharinderivate zur verwendung als proteolytische enzyminhibitoren sowie verfahren zur herstellungInfo
- Publication number
- ATE159720T1 ATE159720T1 AT90907695T AT90907695T ATE159720T1 AT E159720 T1 ATE159720 T1 AT E159720T1 AT 90907695 T AT90907695 T AT 90907695T AT 90907695 T AT90907695 T AT 90907695T AT E159720 T1 ATE159720 T1 AT E159720T1
- Authority
- AT
- Austria
- Prior art keywords
- proteolytic
- enzymin
- hibitors
- production
- saccharine derivatives
- Prior art date
Links
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical class C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 title abstract 2
- 230000002797 proteolythic effect Effects 0.000 title 1
- 102000035195 Peptidases Human genes 0.000 abstract 1
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 239000002532 enzyme inhibitor Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Pyrrole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34712689A | 1989-05-04 | 1989-05-04 | |
| US34712589A | 1989-05-04 | 1989-05-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE159720T1 true ATE159720T1 (de) | 1997-11-15 |
Family
ID=26995139
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90907695T ATE159720T1 (de) | 1989-05-04 | 1990-05-01 | Saccharinderivate zur verwendung als proteolytische enzyminhibitoren sowie verfahren zur herstellung |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0471756B1 (de) |
| JP (1) | JPH04507095A (de) |
| KR (1) | KR0183397B1 (de) |
| AT (1) | ATE159720T1 (de) |
| AU (1) | AU637614B2 (de) |
| DE (1) | DE69031656T2 (de) |
| DK (1) | DK0471756T3 (de) |
| ES (1) | ES2110414T3 (de) |
| FI (1) | FI103111B (de) |
| GR (1) | GR1000965B (de) |
| IL (1) | IL94278A (de) |
| MY (1) | MY106202A (de) |
| NO (1) | NO300808B1 (de) |
| NZ (1) | NZ233521A (de) |
| PT (1) | PT93959B (de) |
| SG (1) | SG48298A1 (de) |
| WO (1) | WO1990013549A1 (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6204261B1 (en) | 1995-12-20 | 2001-03-20 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β Converting enzyme inhibitors |
| US5874424A (en) * | 1995-12-20 | 1999-02-23 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
| US6008217A (en) * | 1995-12-20 | 1999-12-28 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
| US5236917A (en) * | 1989-05-04 | 1993-08-17 | Sterling Winthrop Inc. | Saccharin derivatives useful as proteolytic enzyme inhibitors and compositions and method of use thereof |
| US5380737A (en) * | 1989-05-04 | 1995-01-10 | Sterling Winthrop Inc. | Saccharin derivative proteolytic enzyme inhibitors |
| US5512589A (en) * | 1990-11-01 | 1996-04-30 | Sterling Winthrop Inc. | 2-saccharinylmethyl aryl carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof |
| US5250696A (en) * | 1990-11-01 | 1993-10-05 | Sterling Winthrop Inc. | 2-saccharinylmethyl aryl carboxylate |
| US5306818A (en) * | 1990-11-01 | 1994-04-26 | Sterling Winthrop Inc. | Tetrahydro 2-saccharinylmerthyl aryl carboxylates |
| AU642537B2 (en) * | 1990-11-01 | 1993-10-21 | Sanofi | 2-saccharinylmethyl aryl carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof |
| TW282463B (de) * | 1991-11-15 | 1996-08-01 | Sterling Winthrop Inc | |
| US5378720A (en) * | 1991-12-19 | 1995-01-03 | Sterling Winthrop Inc. | Saccharin derivative proteolytic enzyme inhibitors |
| AU668694B2 (en) * | 1991-12-19 | 1996-05-16 | Sanofi-Synthelabo | Saccharin derivative proteolytic enzyme inhibitors |
| US5187173A (en) * | 1991-12-27 | 1993-02-16 | Sterling Winthrop Inc. | 2-saccharinylmethyl and 4,5,6,7-tetrahydro-2-saccharinylmethyl phosphates, phosphonates and phosphinates useful as proteolytic enzyme inhibitors and compositions and method of use thereof |
| US5296496A (en) * | 1991-12-27 | 1994-03-22 | Sterling Winthrop Inc. | 2-saccharinylmethyl phosphates, phosphonates and phosphinates useful as proteolytic enzyme inhibitors and compositions and method of use thereof |
| TW226016B (de) * | 1991-12-30 | 1994-07-01 | Sterling Winthrop Inc | |
| AU653279B2 (en) * | 1991-12-30 | 1994-09-22 | Sanofi | Novel 2-saccharinylmethyl heterocyclic carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof |
| DE4413951C1 (de) * | 1994-04-21 | 1995-08-03 | Cpc Maizena Gmbh | Verfahren zur Herstellung einer Würzsoße |
| US6420522B1 (en) | 1995-06-05 | 2002-07-16 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
| US5684195A (en) * | 1994-07-14 | 1997-11-04 | G. D. Searle & Co. | Method of preparing sulfmonamides from sulfones |
| DE4427996A1 (de) * | 1994-08-08 | 1996-02-15 | Basf Ag | Verfahren zur Herstellung von Saccharincarbonsäuren und -carbonsäureestern |
| US5494925A (en) * | 1994-12-02 | 1996-02-27 | Sterling Winthrop Inc. | 2-heterocyclyloxymethyl and 2-heterocyclylthiomethyl-1,2,5-thiadiazolidin-3-one 1,1-dioxides and compositions and method of use thereof |
| US5843904A (en) * | 1995-12-20 | 1998-12-01 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1βconverting enzyme |
| WO2009052319A1 (en) * | 2007-10-16 | 2009-04-23 | Northeastern University | Monoacylglycerol lipase inhibitors for modulation of cannabinoid activity |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1302858B (de) * | 1962-09-21 | 1972-05-04 | ||
| JPS47419B1 (de) * | 1969-12-22 | 1972-01-07 | ||
| US4195023A (en) * | 1975-08-20 | 1980-03-25 | Merck & Co., Inc. | 2-(2-Furoyl)1,2-benzisothiazole-3-one, 2-(2-furoyl) saccharin, and 2-(2-thenoyl) saccharin |
| DE2800019A1 (de) * | 1978-01-02 | 1979-07-12 | Dynamit Nobel Ag | N-halobenzyl-saccharine, ihre herstellung und verwendung |
| US4276298A (en) * | 1978-03-24 | 1981-06-30 | Merck & Co., Inc. | 2-Aryl-1,2-benzisothiazolinone-1,1-dioxides and their use as selective protease inhibitors |
| US4350752A (en) * | 1980-12-29 | 1982-09-21 | Eastman Kodak Company | Photographic elements and film units containing imidomethyl blocked photographic reagents |
| US4410618A (en) * | 1982-06-11 | 1983-10-18 | Eastman Kodak Company | Blocked photographic reagents |
| CS241932B1 (cs) * | 1984-05-25 | 1986-04-17 | Jiri Svoboda | Způsob výroby substituovaných benzisothiazolin- -3-on-l,1-dioxidů |
| US4748182A (en) * | 1986-03-05 | 1988-05-31 | Merrell Dow Pharmaceuticals Inc. | Aromatic 2-aminoalkyl-1,2-benzoisothiazol-3(2H)one-1,1-dioxide derivatives and their use as anti-hypertensive and anxiolytic agents |
| AU642537B2 (en) * | 1990-11-01 | 1993-10-21 | Sanofi | 2-saccharinylmethyl aryl carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof |
| JPH07200419A (ja) * | 1993-12-28 | 1995-08-04 | Nec Corp | バスインタフェース装置 |
-
1990
- 1990-05-01 AT AT90907695T patent/ATE159720T1/de not_active IP Right Cessation
- 1990-05-01 WO PCT/US1990/002434 patent/WO1990013549A1/en not_active Ceased
- 1990-05-01 DE DE69031656T patent/DE69031656T2/de not_active Expired - Fee Related
- 1990-05-01 EP EP90907695A patent/EP0471756B1/de not_active Expired - Lifetime
- 1990-05-01 SG SG1996008764A patent/SG48298A1/en unknown
- 1990-05-01 JP JP2507810A patent/JPH04507095A/ja active Pending
- 1990-05-01 ES ES90907695T patent/ES2110414T3/es not_active Expired - Lifetime
- 1990-05-01 AU AU56649/90A patent/AU637614B2/en not_active Ceased
- 1990-05-01 DK DK90907695.2T patent/DK0471756T3/da active
- 1990-05-01 KR KR1019910701489A patent/KR0183397B1/ko not_active Expired - Fee Related
- 1990-05-01 NZ NZ233521A patent/NZ233521A/en unknown
- 1990-05-02 GR GR900100326A patent/GR1000965B/el unknown
- 1990-05-03 IL IL9427890A patent/IL94278A/en not_active IP Right Cessation
- 1990-05-04 PT PT93959A patent/PT93959B/pt not_active IP Right Cessation
- 1990-05-04 MY MYPI90000721A patent/MY106202A/en unknown
-
1991
- 1991-10-28 NO NO914217A patent/NO300808B1/no not_active IP Right Cessation
- 1991-10-29 FI FI915093A patent/FI103111B/fi active
Also Published As
| Publication number | Publication date |
|---|---|
| IL94278A (en) | 1995-03-30 |
| GR1000965B (el) | 1993-03-16 |
| ES2110414T3 (es) | 1998-02-16 |
| MY106202A (en) | 1995-03-31 |
| NO914217L (no) | 1991-10-28 |
| DE69031656D1 (de) | 1997-12-04 |
| EP0471756A1 (de) | 1992-02-26 |
| AU5664990A (en) | 1990-11-29 |
| WO1990013549A1 (en) | 1990-11-15 |
| DE69031656T2 (de) | 1998-04-09 |
| AU637614B2 (en) | 1993-06-03 |
| NO300808B1 (no) | 1997-07-28 |
| JPH04507095A (ja) | 1992-12-10 |
| EP0471756A4 (en) | 1992-04-08 |
| GR900100326A (en) | 1991-10-10 |
| FI915093A0 (fi) | 1991-10-29 |
| IL94278A0 (en) | 1991-03-10 |
| FI103111B1 (fi) | 1999-04-30 |
| PT93959B (pt) | 1996-11-29 |
| FI103111B (fi) | 1999-04-30 |
| PT93959A (pt) | 1991-01-08 |
| KR920701203A (ko) | 1992-08-11 |
| NO914217D0 (no) | 1991-10-28 |
| DK0471756T3 (da) | 1998-05-18 |
| KR0183397B1 (ko) | 1999-05-01 |
| SG48298A1 (en) | 1998-04-17 |
| EP0471756B1 (de) | 1997-10-29 |
| NZ233521A (en) | 1992-05-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |