ES2101053T3 - Procedimiento para la preparacion de 2-cloro-2'-desoxiadenosina. - Google Patents

Procedimiento para la preparacion de 2-cloro-2'-desoxiadenosina.

Info

Publication number
ES2101053T3
ES2101053T3 ES92311564T ES92311564T ES2101053T3 ES 2101053 T3 ES2101053 T3 ES 2101053T3 ES 92311564 T ES92311564 T ES 92311564T ES 92311564 T ES92311564 T ES 92311564T ES 2101053 T3 ES2101053 T3 ES 2101053T3
Authority
ES
Spain
Prior art keywords
chloro
deoxiadenosine
procedure
preparation
cda
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92311564T
Other languages
English (en)
Inventor
Robert H K Chen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ortho Pharmaceutical Corp
Original Assignee
Ortho Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Pharmaceutical Corp filed Critical Ortho Pharmaceutical Corp
Application granted granted Critical
Publication of ES2101053T3 publication Critical patent/ES2101053T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

ESTA INVENCION SE REFIERE A UN NUEVO PROCESO PARA LA PREPARACION DE 2-CLORO-2''-DESOXIADENOSINA (2-CDA) QUE TIENE LA FORMULA SIGUIENTE A PARTIR DE UN COMPUESTO DE LA FORMULA SIGUIENTE ESTA INVENCION SE REFIERE TAMBIEN A LOS INTERMEDIOS UTILES PARA LA PREPARACION DE 2-CDA. EL COMPUESTO 2-CDA ES UTIL COMO AGENTE ANTILEUCEMICO, A SABER, PARA EL TRATAMIENTO DE LEUCEMIAS, TAL COMO LA LEUCEMIA POR CELULAS PELUDAS.
ES92311564T 1991-12-18 1992-12-17 Procedimiento para la preparacion de 2-cloro-2'-desoxiadenosina. Expired - Lifetime ES2101053T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81099291A 1991-12-18 1991-12-18
US07/869,689 US5208327A (en) 1991-12-18 1992-04-16 Intermediates useful in a synthesis of 2-chloro-2'-deoxyadenosine

Publications (1)

Publication Number Publication Date
ES2101053T3 true ES2101053T3 (es) 1997-07-01

Family

ID=27123419

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92311564T Expired - Lifetime ES2101053T3 (es) 1991-12-18 1992-12-17 Procedimiento para la preparacion de 2-cloro-2'-desoxiadenosina.

Country Status (11)

Country Link
US (1) US5208327A (es)
EP (1) EP0547910B1 (es)
JP (1) JPH05255378A (es)
AT (1) ATE149509T1 (es)
AU (1) AU653457B2 (es)
CA (1) CA2085503C (es)
DE (1) DE69217873T2 (es)
DK (1) DK0547910T3 (es)
ES (1) ES2101053T3 (es)
GR (1) GR3023317T3 (es)
ZA (1) ZA929792B (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5641757A (en) * 1994-12-21 1997-06-24 Ortho Pharmaceutical Corporation Stable 2-chloro-2'-deoxyadenosine formulations
ES2182920T3 (es) * 1994-12-22 2003-03-16 Ortho Pharma Corp Formulaciones solubles de 2-cloro02'-deoxiadenosina.
US6252061B1 (en) * 1998-03-23 2001-06-26 Reliable Biopharmaceutical, Inc. Process for the production of 2-halo-6-aminopurine derivatives
US6274725B1 (en) * 1998-06-02 2001-08-14 Isis Pharmaceuticals, Inc. Activators for oligonucleotide synthesis
WO2000064918A1 (en) * 1999-04-28 2000-11-02 Sterrenbeld Biotechnologie North America, Inc. METHOD FOR THE PRODUCTION OF 2-CHLORO-2'-DEOXYADENOSINE (CLADRIBINE) AND ITS 3,5-DI-O-p-TOLUOYL DERIVATIVE
JP2002193967A (ja) * 2000-07-10 2002-07-10 Sumika Fine Chemicals Co Ltd ２，６−ジクロロプリンの製造方法
ES2405825T3 (es) * 2002-09-25 2013-06-03 Brigham Young University Método para la preparación de compuestos 2-halo-2'-desoxiadenosina a partir de 2'-desoxiguanosina
AU2004288182A1 (en) * 2003-10-28 2005-05-19 3M Innovative Properties Company Improved designs for filtration systems within appliances
JP2008524310A (ja) * 2004-12-22 2008-07-10 ラボラトワール セローノ ソシエテ アノニム 多発性硬化症の組み合せ治療
EP3332789B1 (en) 2004-12-22 2022-04-06 Merck Serono SA Cladribine regimen for treating multiple sclerosis
AU2007253254B2 (en) 2006-05-24 2013-01-17 Merck Serono Sa Cladribine regimen for treating multiple sclerosis
DE602006009282D1 (de) * 2006-12-15 2009-10-29 Explora Lab Sa Verfahren zur Herstellung von Cladribin
RU2324699C1 (ru) * 2007-02-05 2008-05-20 Институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Россиийской Академии Наук СПОСОБ ПОЛУЧЕНИЯ 2,6-ДИХЛОР-9-(2,3,5-ТРИ-O-АЦЕТИЛ-β-D-РИБОФУРАНОЗИЛ)ПУРИНА
RU2324698C1 (ru) * 2007-02-05 2008-05-20 Институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук Способ получения 2-хлораденозина
EP2343074A1 (en) 2009-12-23 2011-07-13 Merck Serono S.A. Use of purine analogues for treating airway diseases
WO2011113476A2 (en) 2010-03-16 2011-09-22 Cilag Ag Method for producing 2'-deoxyadenosine compounds
GB201401465D0 (en) 2014-01-29 2014-03-12 Roach Arthur H Use of cladribine for treating autoimmune inflammatory disease
CN106397516B (zh) * 2016-08-30 2019-09-27 北京沣瑞医药科技有限公司 坎格雷洛中间体及其制备方法和应用
TWI767937B (zh) 2016-09-09 2022-06-21 美商卡利泰拉生物科技公司 外核苷酸酶抑制劑及其使用方法
GB2564717A (en) 2017-07-21 2019-01-23 Chord Therapeutics S A R L Use of cladribine for treating autoimmune neuromuscular disease
EP3713582A1 (en) 2017-11-24 2020-09-30 Merck Patent GmbH Cladribine regimen for use intreating progressive forms of multiple sclerosis
CA3194812A1 (en) 2020-09-10 2022-03-17 Merck Patent Gmbh Novel treatment regimen for the treatment of autoimmune disorders
GB2601786A (en) 2020-12-10 2022-06-15 Chord Therapeutics S A R L Use of cladribine for treating immune brain disease
US20240077481A1 (en) 2021-03-03 2024-03-07 Ares Trading S.A. Improved treatment methods using dmds for the treatment of autoimmune diseases, and biomarker for predicting and/or optimising said treatment methods
TW202541818A (zh) 2023-12-14 2025-11-01 瑞士商亞利斯貿易公司 用於治療重症肌無力之克拉屈濱(cladribine)療程

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4760137A (en) * 1984-08-06 1988-07-26 Brigham Young University Method for the production of 2'-deoxyadenosine compounds
CA1269659A (en) * 1984-08-06 1990-05-29 Brigham Young University Method for the production of 2'-deoxyadenosine compounds
AU651569B2 (en) * 1990-01-11 1994-07-28 Isis Pharmaceuticals, Inc. Compositions and methods for detecting and modulating RNA activity and gene expression

Also Published As

Publication number Publication date
AU653457B2 (en) 1994-09-29
DE69217873T2 (de) 1997-06-12
US5208327A (en) 1993-05-04
CA2085503C (en) 1997-08-19
AU3012292A (en) 1993-07-01
JPH05255378A (ja) 1993-10-05
EP0547910B1 (en) 1997-03-05
ZA929792B (en) 1994-06-17
EP0547910A1 (en) 1993-06-23
GR3023317T3 (en) 1997-08-29
DE69217873D1 (de) 1997-04-10
DK0547910T3 (da) 1997-03-24
CA2085503A1 (en) 1993-06-19
ATE149509T1 (de) 1997-03-15

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