ATE149509T1 - Verfahren zur herstellung von 2-chlor-2'- desoxyadenosin - Google Patents

Verfahren zur herstellung von 2-chlor-2'- desoxyadenosin

Info

Publication number
ATE149509T1
ATE149509T1 AT92311564T AT92311564T ATE149509T1 AT E149509 T1 ATE149509 T1 AT E149509T1 AT 92311564 T AT92311564 T AT 92311564T AT 92311564 T AT92311564 T AT 92311564T AT E149509 T1 ATE149509 T1 AT E149509T1
Authority
AT
Austria
Prior art keywords
deoxyadenosine
cda
chlorine
producing
chem
Prior art date
Application number
AT92311564T
Other languages
English (en)
Inventor
Robert H K Chen
Original Assignee
Ortho Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Pharma Corp filed Critical Ortho Pharma Corp
Application granted granted Critical
Publication of ATE149509T1 publication Critical patent/ATE149509T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT92311564T 1991-12-18 1992-12-17 Verfahren zur herstellung von 2-chlor-2'- desoxyadenosin ATE149509T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81099291A 1991-12-18 1991-12-18
US07/869,689 US5208327A (en) 1991-12-18 1992-04-16 Intermediates useful in a synthesis of 2-chloro-2'-deoxyadenosine

Publications (1)

Publication Number Publication Date
ATE149509T1 true ATE149509T1 (de) 1997-03-15

Family

ID=27123419

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92311564T ATE149509T1 (de) 1991-12-18 1992-12-17 Verfahren zur herstellung von 2-chlor-2'- desoxyadenosin

Country Status (11)

Country Link
US (1) US5208327A (de)
EP (1) EP0547910B1 (de)
JP (1) JPH05255378A (de)
AT (1) ATE149509T1 (de)
AU (1) AU653457B2 (de)
CA (1) CA2085503C (de)
DE (1) DE69217873T2 (de)
DK (1) DK0547910T3 (de)
ES (1) ES2101053T3 (de)
GR (1) GR3023317T3 (de)
ZA (1) ZA929792B (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5641757A (en) * 1994-12-21 1997-06-24 Ortho Pharmaceutical Corporation Stable 2-chloro-2'-deoxyadenosine formulations
EP0801571B1 (de) * 1994-12-22 2002-09-04 Ortho Pharmaceutical Corporation Lösliche arzneizusammensetzungen enthaltend 2-chloro-2'-deoxyadenosine
US6252061B1 (en) * 1998-03-23 2001-06-26 Reliable Biopharmaceutical, Inc. Process for the production of 2-halo-6-aminopurine derivatives
US6274725B1 (en) * 1998-06-02 2001-08-14 Isis Pharmaceuticals, Inc. Activators for oligonucleotide synthesis
WO2000064918A1 (en) * 1999-04-28 2000-11-02 Sterrenbeld Biotechnologie North America, Inc. METHOD FOR THE PRODUCTION OF 2-CHLORO-2'-DEOXYADENOSINE (CLADRIBINE) AND ITS 3,5-DI-O-p-TOLUOYL DERIVATIVE
JP2002193967A (ja) * 2000-07-10 2002-07-10 Sumika Fine Chemicals Co Ltd ２，６−ジクロロプリンの製造方法
EP1556400B1 (de) * 2002-09-25 2013-05-01 Brigham Young University Verfahren zur herstellung von 2-halogen-2-desoxyadenosinverbindungen aus 2-desoxyguanosin
CN1890520A (zh) * 2003-10-28 2007-01-03 3M创新有限公司 器具内水过滤系统的改进设计
ATE431740T1 (de) * 2004-12-22 2009-06-15 Merck Serono Sa Kombinationstherapie gegen multiple sklerose
EP2275110B1 (de) 2004-12-22 2013-07-10 Merck Serono SA Cladribin Dosierschema zur Behandlung von multipler Sklerose
WO2007135172A2 (en) 2006-05-24 2007-11-29 Laboratoires Serono S.A. Cladribine regimen for treating multiple sclerosis
SI1932918T1 (sl) * 2006-12-15 2010-02-26 Explora Lab Sa Postopek izdelave kladribina
RU2324699C1 (ru) * 2007-02-05 2008-05-20 Институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Россиийской Академии Наук СПОСОБ ПОЛУЧЕНИЯ 2,6-ДИХЛОР-9-(2,3,5-ТРИ-O-АЦЕТИЛ-β-D-РИБОФУРАНОЗИЛ)ПУРИНА
RU2324698C1 (ru) * 2007-02-05 2008-05-20 Институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук Способ получения 2-хлораденозина
EP2343074A1 (de) 2009-12-23 2011-07-13 Merck Serono S.A. Verwendung von Purinanaloga zur Behandlung von Atemwegserkrankungen
WO2011113476A2 (en) 2010-03-16 2011-09-22 Cilag Ag Method for producing 2'-deoxyadenosine compounds
GB201401465D0 (en) 2014-01-29 2014-03-12 Roach Arthur H Use of cladribine for treating autoimmune inflammatory disease
CN106397516B (zh) * 2016-08-30 2019-09-27 北京沣瑞医药科技有限公司 坎格雷洛中间体及其制备方法和应用
EP3510040A4 (de) 2016-09-09 2020-06-03 Calithera Biosciences, Inc. Ektonukleotidasehemmer und verfahren zur verwendung davon
GB2564717A (en) 2017-07-21 2019-01-23 Chord Therapeutics S A R L Use of cladribine for treating autoimmune neuromuscular disease
AR113906A1 (es) 2017-11-24 2020-06-24 Merck Patent Ges Mit Beschraenkter Haftung Régimen con cladribina para tratar formas progresivas de la esclerosis múltiple
BR112023003432A2 (pt) 2020-09-10 2023-03-21 Merck Patent Gmbh Regime de tratamento para o tratamento de doenças autoimunes
GB2601786A (en) 2020-12-10 2022-06-15 Chord Therapeutics S A R L Use of cladribine for treating immune brain disease
IL305567A (en) 2021-03-03 2023-10-01 Ares Trading Sa Method for predicting the response of a patient treated with cladribine
TW202541818A (zh) 2023-12-14 2025-11-01 瑞士商亞利斯貿易公司 用於治療重症肌無力之克拉屈濱(cladribine)療程

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4760137A (en) * 1984-08-06 1988-07-26 Brigham Young University Method for the production of 2'-deoxyadenosine compounds
CA1269659A (en) * 1984-08-06 1990-05-29 Brigham Young University Method for the production of 2'-deoxyadenosine compounds
KR927003044A (ko) * 1990-01-11 1992-12-17 크리스토퍼 케이. 미라벨리 Rna 활성과 유전자 발현을 검출하고 조절하는 조성물 및 그 방법

Also Published As

Publication number Publication date
DE69217873T2 (de) 1997-06-12
GR3023317T3 (en) 1997-08-29
DE69217873D1 (de) 1997-04-10
ES2101053T3 (es) 1997-07-01
AU3012292A (en) 1993-07-01
CA2085503C (en) 1997-08-19
EP0547910B1 (de) 1997-03-05
ZA929792B (en) 1994-06-17
AU653457B2 (en) 1994-09-29
DK0547910T3 (da) 1997-03-24
US5208327A (en) 1993-05-04
JPH05255378A (ja) 1993-10-05
EP0547910A1 (de) 1993-06-23
CA2085503A1 (en) 1993-06-19

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UEP Publication of translation of european patent specification