ES2101185T3 - Composiciones micronutrientes. - Google Patents

Composiciones micronutrientes.

Info

Publication number
ES2101185T3
ES2101185T3 ES93115055T ES93115055T ES2101185T3 ES 2101185 T3 ES2101185 T3 ES 2101185T3 ES 93115055 T ES93115055 T ES 93115055T ES 93115055 T ES93115055 T ES 93115055T ES 2101185 T3 ES2101185 T3 ES 2101185T3
Authority
ES
Spain
Prior art keywords
micronutrient
compositions
binder
densifying
amount
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93115055T
Other languages
English (en)
Inventor
William Joseph Mergens
Joseph Edward Raymond
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2101185T3 publication Critical patent/ES2101185T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Nutrition Science (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Grain Derivatives (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Jellies, Jams, And Syrups (AREA)
  • Fertilizers (AREA)
  • Fodder In General (AREA)

Abstract

SE PRESENTAN COMPOSICIONES MICRONUTRIENTES SUBSTANCIALMENTE SECAS QUE COMPRENDEN HASTA UN 15% DE UN MICRONUTRIENTE, UNA CANTIDAD SUFICIENTE DE UN AMALGAMADOR Y UNA CANTIDAD SUFICIENTE DE UN AGENTE DENSIFICADOR CON UN TAMAÑO DE PARTICULA DE ENTRE APROXIMADAMENTE 40 MESH Y APROXIMADAMENTE 325 MESH, Y QUE TIENE UNA DENSIDAD DE ENTRE 0.7 G/CM3 Y 1.2 G/CM3, MEDIANTE LO CUAL EL AGENTE DENSIFICADOR SE ENCUENTRA SUBSTANCIALMENTE RECUBIERTO CON EL MICRONUTRIENTE Y EL AMALGAMADOR. EL PROCESO PARA PRODUCIR LA COMPOSICION INCLUYE LOS PASOS DE DISOLVER O DISPERSAR CANTIDADES APROPIADAS DEL MICRONUTRIENTE Y DEL AMALGAMADOR EN AGUA, SUSPENDER UNA CANTIDAD APROPIADA DEL AGENTE DENSIFICADOR EN LA SOLUCION ASI OBTENIDA Y SECAR MEDIANTE ROCIADO LA SUSPENSION RESULTANTE, OPCIONALMENTE EN LA PRESENCIA DE DIOXIDO DE SILICIO, PARA PRODUCIR LA COMPOSICION MICRONUTRIENTE DESEADA. LA INVENCION TAMBIEN COMPRENDE LA SUSPENSION. LAS COMPOSICIONES DE MICRONUTRIENTE SUBSTANCIALMENTE SECAS DE LA INVENCION PRESENTAN UNA DENSIDAD CONSIDERABLEMENTE MAYOR QUE LAS COMPOSICIONES MICRONUTRIENTES CONVENCIONALES.
ES93115055T 1992-09-23 1993-09-18 Composiciones micronutrientes. Expired - Lifetime ES2101185T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US95038192A 1992-09-23 1992-09-23

Publications (1)

Publication Number Publication Date
ES2101185T3 true ES2101185T3 (es) 1997-07-01

Family

ID=25490365

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93115055T Expired - Lifetime ES2101185T3 (es) 1992-09-23 1993-09-18 Composiciones micronutrientes.

Country Status (7)

Country Link
US (1) US5397576A (es)
EP (1) EP0589375B1 (es)
JP (1) JP3556689B2 (es)
AT (1) ATE150962T1 (es)
DE (1) DE69309377T2 (es)
DK (1) DK0589375T3 (es)
ES (1) ES2101185T3 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0995448A (ja) * 1995-09-29 1997-04-08 Calpis Food Ind Co Ltd:The 血中ビオチン濃度の増加方法およびビオチン含有飲食品
DE19651734C2 (de) * 1996-12-12 1999-05-12 Dds Drug Delivery Service Ges Zubereitung in Form eines Polymer-Hilfsstoff-Compounds und/oder eines Polymer-Wirkstoff-Compounds und Verfahren zu dessen Herstellung sowie dessen Verwendung zur Herstellung von Tabletten und/oder anderen größeren Matrixeinheiten
WO2000033673A1 (en) * 1998-12-08 2000-06-15 Csir Microparticles and process for making microparticles
GB9922271D0 (en) * 1999-09-21 1999-11-17 Zeneca Ltd Formulation
JP2001181211A (ja) * 1999-12-24 2001-07-03 Sumitomo Chem Co Ltd 水溶性ビタミン粉剤
GB0003782D0 (en) * 2000-02-17 2000-04-05 Dumex Ltd As Process
US6773733B2 (en) 2001-03-26 2004-08-10 Loders Croklaan Usa Llc Structured particulate systems
EP1399132A1 (en) * 2001-06-08 2004-03-24 Powderject Vaccines, Inc. Production of hard, dense particles
JP6211521B2 (ja) * 2011-09-08 2017-10-11 マイクロニュートリエンツ ユー・エス・エー エル・エル・シーＭｉｃｒｏｎｕｔｒｉｅｎｔｓ ＵＳＡ ＬＬＣ 微量栄養素補助食品
EP3982936A1 (en) 2019-06-17 2022-04-20 DSM IP Assets B.V. Solid pharmaceutical dosage form comprising spray dried vitamin b12
EP3982935A1 (en) 2019-06-17 2022-04-20 DSM IP Assets B.V. Composition comprising metformin hci, vitamin b12 and at least one flow additive
CN113180244A (zh) * 2021-05-31 2021-07-30 临汾市力圣生物科技开发有限公司 一种叶酸干燥工艺

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3175948A (en) * 1963-01-10 1965-03-30 Hoffmann La Roche Multivitamin tablets and premixes
US3293132A (en) * 1963-03-25 1966-12-20 Merck & Co Inc Spray dried vitamin compositions and method of preparation
US3396226A (en) * 1965-01-06 1968-08-06 Hoffmann La Roche Nongranulated compressed tablets of ascorbic acid with microcrystalline cellulose
US3914430A (en) * 1972-04-10 1975-10-21 Hoffmann La Roche Free-flowing, high density, agglomerated vitamin E powder compositions
US4489026A (en) * 1982-09-07 1984-12-18 The Upjohn Company Process for preparing solid unit dosage forms of ultra-low dose drugs
US4486435A (en) * 1983-05-16 1984-12-04 Basf Wyandotte Corporation Spray-dried vitamin powders using hydrophobic silica
WO1985001877A1 (en) * 1983-10-24 1985-05-09 Basf Wyandotte Corporation A process for preparation spray-dried powders containing a water-soluble vitamin and powders prepared thereby
US4533674A (en) * 1983-10-24 1985-08-06 Basf Wyandotte Corporation Process for preparing a sugar and starch free spray-dried vitamin C powder containing 90 percent ascorbic acid
CA1279574C (en) * 1985-04-17 1991-01-29 Jeffrey L. Finnan Process for lubricating water-soluble vitamin powders
IT1229930B (it) * 1988-10-14 1991-09-16 Dox Al Italia Spa Procedimento per la preparazione di miscele per uso alimentare e mangimistico comprendenti sostanze attive distribuite in modo uniforme
ES2054259T3 (es) * 1989-08-31 1994-08-01 Takeda Chemical Industries Ltd Composicion de vitamina b12.
US4994458A (en) * 1990-04-30 1991-02-19 Basf Corporation Process for rotary fluid bed granulation of riboflavin
US5000888A (en) * 1990-05-23 1991-03-19 Basf Corporation Process for spray drying riboflavin to produce a granulate product having low binder content

Also Published As

Publication number Publication date
JP3556689B2 (ja) 2004-08-18
EP0589375A1 (en) 1994-03-30
ATE150962T1 (de) 1997-04-15
JPH06197733A (ja) 1994-07-19
DE69309377T2 (de) 1997-09-18
DK0589375T3 (da) 1997-09-22
EP0589375B1 (en) 1997-04-02
DE69309377D1 (de) 1997-05-07
US5397576A (en) 1995-03-14

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