ES2101867T3 - Aplicaciones diagnosticas de la formacion de lazos d dobles. - Google Patents

Aplicaciones diagnosticas de la formacion de lazos d dobles.

Info

Publication number
ES2101867T3
ES2101867T3 ES92918877T ES92918877T ES2101867T3 ES 2101867 T3 ES2101867 T3 ES 2101867T3 ES 92918877 T ES92918877 T ES 92918877T ES 92918877 T ES92918877 T ES 92918877T ES 2101867 T3 ES2101867 T3 ES 2101867T3
Authority
ES
Spain
Prior art keywords
double
formation
dna
diagnostic applications
ties
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92918877T
Other languages
English (en)
Inventor
Elissa P Sena
Cornelia J Calhoun
David A Zarling
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daikin Industries Ltd
Original Assignee
Daikin Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/520,321 external-priority patent/US5223414A/en
Priority claimed from US07/755,462 external-priority patent/US5273881A/en
Application filed by Daikin Industries Ltd filed Critical Daikin Industries Ltd
Application granted granted Critical
Publication of ES2101867T3 publication Critical patent/ES2101867T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/682—Signal amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C12Q1/683—Hybridisation assays for detection of mutation or polymorphism involving restriction enzymes, e.g. restriction fragment length polymorphism [RFLP]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Stabilization Of Oscillater, Synchronisation, Frequency Synthesizers (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

EN LA PRESENTE INVENCION SE DESCRIBE LA FORMACION DE COMPLEJOS DE SONDA DE TRENZADO DOBLE CATALIZADA CON UNA PROTEINA RECA:ADN OBJETIVO LINEAL DUPLEX QUE SON ESTABLES A LA DESPROTEINIZACION. SE PRESENTAN LOS USOS DE ESTE COMPLEJO DE SONDA:OBJETIVO ESTABLE EN SISTEMAS DE DIAGNOSTICO/DETECCION DEL ADN EN REACCIONES DE HIBRIDACION DEL ADN IN VITRO E IN SITU. LOS COMPLEJOS SONDA:OBJETIVO SON UTILES TAMBIEN PARA APLICACIONES DE DIAGNOSTICO EN REACCIONES DE AMPLIFICACION DEL ADN FACILITADAS POR LA PROTEINA RECA.
ES92918877T 1990-05-07 1992-09-04 Aplicaciones diagnosticas de la formacion de lazos d dobles. Expired - Lifetime ES2101867T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/520,321 US5223414A (en) 1990-05-07 1990-05-07 Process for nucleic acid hybridization and amplification
US07/755,462 US5273881A (en) 1990-05-07 1991-09-04 Diagnostic applications of double D-loop formation
US91079192A 1992-07-09 1992-07-09

Publications (1)

Publication Number Publication Date
ES2101867T3 true ES2101867T3 (es) 1997-07-16

Family

ID=27414753

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92918877T Expired - Lifetime ES2101867T3 (es) 1990-05-07 1992-09-04 Aplicaciones diagnosticas de la formacion de lazos d dobles.

Country Status (13)

Country Link
US (1) US5670316A (es)
EP (1) EP0612352B1 (es)
JP (1) JP2745816B2 (es)
KR (1) KR100245284B1 (es)
AT (1) ATE153707T1 (es)
AU (1) AU661505B2 (es)
CA (1) CA2116215C (es)
DE (1) DE69220084T2 (es)
DK (1) DK0612352T3 (es)
ES (1) ES2101867T3 (es)
FI (1) FI941016A7 (es)
NO (1) NO313557B1 (es)
WO (1) WO1993005178A1 (es)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5506098A (en) * 1991-09-04 1996-04-09 Daikin Industries, Ltd. In situ hybridization method
AU4115693A (en) * 1992-04-24 1993-11-29 Sri International In vivo homologous sequence targeting in eukaryotic cells
US5929043A (en) * 1995-01-31 1999-07-27 Pangene Corporation Recombinase mediated DNA therapies
FR2737502B1 (fr) * 1995-07-31 1997-10-24 Genset Sa Procede de detection d'acides nucleiques utilisant des sondes nucleotidiques permettant a la fois une capture specifique et une detection
DE69730145T2 (de) 1996-08-29 2005-07-14 Tapestry Pharmaceuticals, Inc., Boulder VERFAHREN ZUM AUFFINDEN, NACHWEISEN, ANREICHERN UND/ODER ISOLIEREN VON ZIEL-NUcLEINSÄURESEQUENZEN UNTER VERWENDUNG VON VON RECA ÄHNLICHER REKOMBINASE
JP3891620B2 (ja) * 1996-11-14 2007-03-14 株式会社アイシン・コスモス研究所 ヘアピン型構造の核酸プローブ分子、及び該核酸プローブ分子を利用した核酸検出方法
US5948653A (en) * 1997-03-21 1999-09-07 Pati; Sushma Sequence alterations using homologous recombination
US6342350B1 (en) * 1997-09-05 2002-01-29 The General Hospital Corporation Alpha-2-macroglobulin diagnostic test
WO1999037755A2 (en) * 1997-12-11 1999-07-29 Pangene Corporation The use of consensus sequences for targeted homologous gene isolation and recombination in gene families
DE59906298D1 (de) * 1998-04-01 2003-08-21 Atto Tec Gmbh Verfahren und vorrichtung zur quantifizierung von dna und rna
US6287772B1 (en) 1998-04-29 2001-09-11 Boston Probes, Inc. Methods, kits and compositions for detecting and quantitating target sequences
US6541227B1 (en) * 1998-10-12 2003-04-01 Aisin Seiki Kabushiki Kaisha Preparation of labeled DNA
JP4265028B2 (ja) * 1999-04-14 2009-05-20 アイシン精機株式会社 二本鎖ｄｎａの特異的切断方法およびそのためのキット
AU4657500A (en) * 1999-04-21 2000-11-02 Pangene Corporation Locked nucleic acid hybrids and methods of use
EP1242626B1 (en) * 1999-12-21 2009-06-10 Ortho-Clinical Diagnostics, Inc. Detection of nucleic acids
EP1246938A2 (en) * 1999-12-28 2002-10-09 Pangene Corporation Recombinase mediated gene chip detection
WO2002077286A1 (en) * 2001-02-21 2002-10-03 Gene Check, Inc. Mutation detection using muts and reca
EP1414840A4 (en) * 2001-03-27 2005-04-13 Univ Delaware GENOMICS APPLICATIONS FOR MODIFIED OLIGONUCLEOTIDES
US6929915B2 (en) 2001-04-20 2005-08-16 The Penn State Research Foundation Methods for nucleic acid manipulation
US7468244B2 (en) 2001-09-27 2008-12-23 University Of Delaware Polymorphism detection and separation
EP1446502A4 (en) * 2001-09-28 2005-02-09 Univ Delaware DETECTION AND SEPARATION OF POLYMORPHISMS
US7244562B2 (en) * 2001-11-01 2007-07-17 Gene Check, Inc. RecA assisted detection of mutations, single nucleotide polymorphisms and specific sequences
WO2005118853A2 (en) * 2004-06-01 2005-12-15 Asm Scientific, Inc. Recombinase polymerase amplification
DK1499738T3 (da) * 2002-02-21 2008-11-17 Asm Scient Inc Recombinase-polymerease-amplifikation
US7399590B2 (en) 2002-02-21 2008-07-15 Asm Scientific, Inc. Recombinase polymerase amplification
US8030000B2 (en) 2002-02-21 2011-10-04 Alere San Diego, Inc. Recombinase polymerase amplification
AU2003235894A1 (en) * 2002-05-08 2003-12-12 Arkray, Inc. Method of detecting target nucleic acid
JP2005533256A (ja) * 2002-07-17 2005-11-04 ユー．エス． ジェノミクス， インコーポレイテッド キメラタグを用いるポリマーを分析するための方法と組成物
US20040224336A1 (en) * 2003-03-11 2004-11-11 Gene Check, Inc. RecA-assisted specific oligonucleotide extension method for detecting mutations, SNPs and specific sequences
US20050123944A1 (en) * 2003-08-01 2005-06-09 U.S. Genomics, Inc. Methods and compositions related to the use of sequence-specific endonucleases for analyzing nucleic acids under non-cleaving conditions
WO2005017205A2 (en) * 2003-08-04 2005-02-24 U. S. Genomics, Inc. Nucleic acid mapping using linear analysis
JP2006055065A (ja) * 2004-08-19 2006-03-02 Toyo Kohan Co Ltd 非対称ｐｃｒを用いた核酸の検出方法、ポリヌクレオチドプローブ、それを固定するプローブ固定化担体およびキット
WO2006051988A1 (ja) * 2004-11-15 2006-05-18 Riken 核酸の増幅方法
EP2829615B1 (en) 2005-07-25 2018-05-09 Alere San Diego, Inc. Kit for multiplexing recombinase polymerase amplification
EP1929036A1 (en) * 2005-09-29 2008-06-11 Keygene N.V. Method and means for targeted nucleotide exchange
US20080003600A1 (en) * 2006-02-27 2008-01-03 Salinas Frank G Isothermal screening of breast cancer related nucleic acid
US20090061413A1 (en) * 2006-02-27 2009-03-05 Salinas Frank G Isothermal screening of hiv-1 related nucleic acids
US20070202522A1 (en) * 2006-02-27 2007-08-30 Salinas Frank G Isothermal screening of tumor cell related nucleic acids
US20080220421A1 (en) * 2006-02-27 2008-09-11 Salinas Frank G Isothermal screening for nucleic acids associated with diseases and conditions of the gi tract
EP2029782B1 (en) 2006-05-04 2014-11-26 Alere San Diego, Inc. Recombinase polymerase amplification
JP5847076B2 (ja) * 2009-05-20 2016-01-20 バイオサイト インコーポレイテッド Ｄｎａグリコシラーゼ／リアーゼおよびａｐエンドヌクレアーゼ基質
WO2010141940A1 (en) 2009-06-05 2010-12-09 Alere San Diego, Inc. Recombinase polymerase amplification reagents and kits
KR101550489B1 (ko) 2010-03-08 2015-09-07 다나-파버 캔서 인스티튜트 인크. 기준 차단 서열을 이용한 완전 ｃｏｌｄ－ｐｃｒ 풍부화
EP3333269B1 (en) 2011-03-31 2021-05-05 Dana-Farber Cancer Institute, Inc. Methods to enable multiplex cold-pcr
EP3978620A1 (en) 2011-04-07 2022-04-06 Abbott Diagnostics Scarborough, Inc. Monitoring recombinase polymerase amplification mixtures
EP3095879B1 (en) 2012-04-19 2018-09-19 Life Technologies Corporation Nucleic acid amplification
SG10201802883UA (en) 2012-04-19 2018-05-30 Life Technologies Corp Nucleic acid amplification
EP2880182B1 (en) * 2012-08-02 2017-07-26 Qiagen GmbH Recombinase mediated targeted dna enrichment for next generation sequencing
EP3257952B1 (en) 2012-09-11 2020-02-12 Life Technologies Corporation Nucleic acid amplification
WO2014043143A1 (en) 2012-09-11 2014-03-20 Life Technologies Corporation Nucleic acid amplification
WO2015113725A1 (en) 2014-02-03 2015-08-06 Thermo Fisher Scientific Baltics Uab Method for controlled dna fragmentation
EP3155127B1 (en) 2014-06-13 2020-07-22 Life Technologies Corporation Multiplex nucleic acid amplification
WO2016201142A1 (en) 2015-06-09 2016-12-15 Life Technologies Corporation Methods, systems, compositions, kits, apparatus and computer-readable media for molecular tagging
JP6941568B2 (ja) * 2015-06-24 2021-09-29 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド ヌクレアーゼを使用する野生型ｄｎａの選択的分解および突然変異体対立遺伝子の濃縮
HK1258716A1 (zh) 2015-12-09 2019-11-15 Life Technologies Corporation 与表面结合的核酸分子的检测和量化
LT3402880T (lt) 2016-01-15 2024-03-12 Thermo Fisher Scientific Baltics Uab Termofiliniai dnr polimerazės mutantai
EP3469078B1 (en) 2016-06-10 2024-03-27 Life Technologies Corporation Methods and compositions for nucleic acid amplification
WO2018071522A1 (en) 2016-10-11 2018-04-19 Life Technologies Corporation Rapid amplification of nucleic acids
WO2018111835A1 (en) 2016-12-12 2018-06-21 Dana-Farber Cancer Institute, Inc. Compositions and methods for molecular barcoding of dna molecules prior to mutation enrichment and/or mutation detection
US11542540B2 (en) 2017-06-16 2023-01-03 Life Technologies Corporation Control nucleic acids, and compositions, kits, and uses thereof
US11618891B2 (en) 2017-06-26 2023-04-04 Thermo Fisher Scientific Baltics Uab Thermophilic DNA polymerase mutants
DE102017114537A1 (de) * 2017-06-29 2019-01-03 Endress+Hauser Conducta Gmbh+Co. Kg Sensormembran, Sensorkappe und optischer Sensor
WO2019094524A1 (en) 2017-11-07 2019-05-16 Life Technologies Corporation Methods and compositions for manipulating nucleic acids
US12226745B2 (en) 2017-11-07 2025-02-18 Life Technologies Corporation Methods and compositions for manipulating nucleic acids
CN113906148B (zh) 2019-05-03 2024-12-31 生命技术公司 用于操纵核酸的方法和组合物
CN114514328A (zh) 2019-08-21 2022-05-17 生命技术公司 用于测序的系统和方法
EP4243986A1 (en) 2020-11-16 2023-09-20 Life Technologies Corporation System and method for sequencing
US12668836B2 (en) 2021-05-21 2026-06-30 Tetracore, Inc. Detection of recombinase polymerase amplification (RPA) amplicons via FEN1 cleavage
NL2033124B1 (en) 2022-09-23 2024-03-29 Rapidemic B V Methods and device for multiple-label nucleic acid amplification and detection
WO2025144744A1 (en) 2023-12-29 2025-07-03 Life Technologies Corporation Enrichment of clonal substrates

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI63596C (fi) * 1981-10-16 1983-07-11 Orion Yhtymae Oy Mikrobdiagnostiskt foerfarande som grundar sig pao skiktshybridisering av nukleinsyror och vid foerfarandet anvaenda kombinationer av reagenser
CA1254114A (en) * 1984-05-07 1989-05-16 Allied Corporation Displacement polynucleotide assay employing recombination protein and diagnostic kit
US4766062A (en) * 1984-05-07 1988-08-23 Allied Corporation Displacement polynucleotide assay method and polynucleotide complex reagent therefor
WO1985005685A1 (en) * 1984-06-01 1985-12-19 National Biomedical Research Foundation Catalyzed nucleic acid hybridization using enzymatic reagent
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4888274A (en) * 1985-09-18 1989-12-19 Yale University RecA nucleoprotein filament and methods
WO1987001730A1 (en) * 1985-09-18 1987-03-26 Yale University RecA NUCLEOPROTEIN FILAMENT AND METHODS
EP0322311B1 (en) * 1987-12-21 1994-03-23 Applied Biosystems, Inc. Method and kit for detecting a nucleic acid sequence
AU2735988A (en) * 1987-12-21 1989-07-13 Amoco Corporation Target and background capture methods with amplification for affinity assays
US5273881A (en) * 1990-05-07 1993-12-28 Daikin Industries, Ltd. Diagnostic applications of double D-loop formation
US5223414A (en) * 1990-05-07 1993-06-29 Sri International Process for nucleic acid hybridization and amplification
US5506098A (en) * 1991-09-04 1996-04-09 Daikin Industries, Ltd. In situ hybridization method

Also Published As

Publication number Publication date
DE69220084D1 (de) 1997-07-03
EP0612352A1 (en) 1994-08-31
NO313557B1 (no) 2002-10-21
FI941016L (fi) 1994-05-03
DK0612352T3 (da) 1997-06-30
JP2745816B2 (ja) 1998-04-28
CA2116215A1 (en) 1993-03-05
FI941016A7 (fi) 1994-05-03
DE69220084T2 (de) 1997-09-11
EP0612352B1 (en) 1997-05-28
US5670316A (en) 1997-09-23
FI941016A0 (fi) 1994-03-03
WO1993005178A1 (en) 1993-03-18
KR100245284B1 (ko) 2000-03-02
CA2116215C (en) 1998-12-22
AU2540192A (en) 1993-04-05
NO940744L (es) 1994-05-02
AU661505B2 (en) 1995-07-27
ATE153707T1 (de) 1997-06-15
NO940744D0 (no) 1994-03-03
JPH06510201A (ja) 1994-11-17

Similar Documents

Publication Publication Date Title
DK0612352T3 (da) Diagnostiske anvendelser af dobbelt-D-sløjfedannelse
MX9701419A (es) Reduccion de hibridizacion no especifica mediante la utilizacion de esquemas novedosos de pareamiento de bases.
AT374901B (de) Verfahren zur kunststoffauskleidung von rohrleitungen, durchlaessen od.dgl.
ATE383430T1 (de) Rekombinante antikörper und immunkonjugate gezielt auf cd22-tragende zellen und tumoren
CO4600637A1 (es) Compuestos para inmunoterapia e inmunodiagnosis del cancer de prostata
ATE412432T1 (de) Internalisierende erbb2 antikörper
IT8021803A0 (it) Apparecchiatura per rinforzare e riparare tubazioni o condutture.
ES2183978T3 (es) Complejos metalicos que contienen indenilo sustituido y procedimiento de polimerizacion de olefinas.
ES2167561T3 (es) Moleculas de acido nucleico aisladas, peptidos que forman complejos con la molecula mhc hla-a2 y usos de los mismos.
ATE304709T1 (de) Substanzen mit verzweigten linkermolekülen
ES2175244T3 (es) Empleo de acido poliasparaginico y de sus sales.
ATE229073T1 (de) Protein e25a, methoden zu dessen herstellung und anwendung
ES2185218T3 (es) Un plasma sanguineo aplicable universalmente.
NL7604640A (nl) Met corpusculaire stralen werkende transmissie- microscoop, voorzien van een achter het prepa- raat gelegen afbuigstelsel.
ES2131612T3 (es) Oligomeros de union a acidos nucleicos con ramificacion en c para terapia y diagnostico.
DE69626789D1 (de) Isolierte und verkürzte nukleinsäuremoleküle kodierend für gage-tumorabstossungsantigen
ATE148503T1 (de) Sonde zusammensetzungen für chromosom identifizierung und verfahren
WO2024220380A3 (en) Pi3k assays and probe compounds therein
ES2132508T3 (es) Procedimiento para la produccion de aldehidos.
ES2186675T3 (es) Procedimiento de produccion de sondas especificas de una region cromosomica.
CY1106833T1 (el) Ενας κινητηρας πολυνουκλεοτιδιου, ενα συστημα κινητηρα, η παρασκευη και οι χρησεις τους
SU540057A1 (ru) Насос
DE60232258D1 (de) Lipid-aminoglykosid konjugate zur transfektion
ES2161698T3 (es) Anticuerpos especificos contra plaquetas activadas, su produccion y su utilizacion en la diagnosis y terapia.
SU610948A1 (ru) Гидравлическа система скрепера

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 612352

Country of ref document: ES