ES2103374T3 - Derivados de carboxamido-(1,2n)-carbociclo-2-aminotetralina. - Google Patents

Derivados de carboxamido-(1,2n)-carbociclo-2-aminotetralina.

Info

Publication number
ES2103374T3
ES2103374T3 ES92912273T ES92912273T ES2103374T3 ES 2103374 T3 ES2103374 T3 ES 2103374T3 ES 92912273 T ES92912273 T ES 92912273T ES 92912273 T ES92912273 T ES 92912273T ES 2103374 T3 ES2103374 T3 ES 2103374T3
Authority
ES
Spain
Prior art keywords
carbociclo
aminotetralina
carboxamido
derivatives
alkynyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92912273T
Other languages
English (en)
Inventor
Chiu-Hong Lin
Susanne R Haadsma-Svensson
Robert B Mccall
Arthur G Romero
William Harold Darlington
Michael D Ennis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Pharmacia and Upjohn Co
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co, Upjohn Co filed Critical Pharmacia and Upjohn Co
Application granted granted Critical
Publication of ES2103374T3 publication Critical patent/ES2103374T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/10—Aza-phenanthrenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

ESTA INVENCION USA TERAPEUTICAMENTE TETRALINAS Y SALES DE ADICION ACIDA FARMACEUTICAMENTE ACEPTABLES DE ELLAS DE FORMULA (I), EN DONDE X ES -(CH2)NY R1 Y R2 SON LO MISMO O DIFERENTE Y SE SELECCIONAN DEL GRUPO COMPUESTO DE HIDROGENO, ALQUILO C1-C8, ALQUENILO C2-C8, ALQUINILO C2-C8, ARILO O BENCILO. ESTOS COMPUESTOS SE USAN PARA TRATAR DESORDENES DEL SISTEMA NERVIOSO CENTRAL Y SON INESPERADAMENTE RESISTENTES AL METABOLISMO POR EL HIGADO Y TIENEN BIODISPONIBILIDAD DE PLASMA ORAL SUPERIOR.
ES92912273T 1991-05-20 1992-05-13 Derivados de carboxamido-(1,2n)-carbociclo-2-aminotetralina. Expired - Lifetime ES2103374T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70281491A 1991-05-20 1991-05-20
US9201651 1992-03-11

Publications (1)

Publication Number Publication Date
ES2103374T3 true ES2103374T3 (es) 1997-09-16

Family

ID=26784656

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92912273T Expired - Lifetime ES2103374T3 (es) 1991-05-20 1992-05-13 Derivados de carboxamido-(1,2n)-carbociclo-2-aminotetralina.

Country Status (5)

Country Link
EP (1) EP0586525B1 (es)
JP (1) JP3155276B2 (es)
AU (1) AU1928792A (es)
ES (1) ES2103374T3 (es)
WO (1) WO1992020655A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7490496A (en) * 1995-11-10 1997-05-29 Novo Nordisk A/S Enantiomers of cis-benz{e}indole compounds, their preparation and utility as dopamine-d3 receptor selective agents
WO1997041101A1 (en) * 1996-05-01 1997-11-06 Novo Nordisk A/S Enantiomers of trans-benz[e]indole compounds, their preparation and utility as dopamine-d3 receptor selective agents
GB9612153D0 (en) * 1996-06-11 1996-08-14 Smithkline Beecham Plc Compounds
TWI274750B (en) 1999-01-12 2007-03-01 Abbott Gmbh & Co Kg Triazole compounds showing high affinity to dopamine D3 receptor and pharmaceutical composition comprising the same
US7053092B2 (en) 2001-01-29 2006-05-30 Otsuka Pharmaceutical Co., Ltd. 5-HT1a receptor subtype agonist
AR032641A1 (es) * 2001-01-29 2003-11-19 Otsuka Pharma Co Ltd Agonista de subtipo de receptor 5-ht 1a.
AR033485A1 (es) 2001-09-25 2003-12-26 Otsuka Pharma Co Ltd Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma
US8703772B2 (en) 2001-09-25 2014-04-22 Otsuka Pharmaceutical Co., Ltd. Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
EP2792678A1 (en) * 2009-12-22 2014-10-22 Cephalon, Inc. Tricyclic derivatives and their pharmaceutical use and compositions
WO2013025664A1 (en) * 2011-08-17 2013-02-21 Boehringer Ingelheim International Gmbh Indenopyridine derivatives
US10941153B2 (en) * 2018-05-31 2021-03-09 Regents Of The University Of Minnesota Substituted phenethylamine derivatives

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8302361D0 (sv) * 1983-04-27 1983-04-27 Astra Laekemedel Ab New tricyclic amines
DE3719924A1 (de) * 1986-12-22 1988-06-30 Bayer Ag 8-substituierte 2-aminotetraline
KR100195656B1 (ko) * 1989-05-31 1999-06-15 로버트 에이.아미테이지 치료학적으로 유용한 2-아미노테트랄린 유도체
AU648032B2 (en) * 1989-07-13 1994-04-14 Pharmacia & Upjohn Company (1,2N) and (3,2N)-carbocyclic-2-amino tetralin derivatives
WO1991013872A1 (en) * 1990-03-15 1991-09-19 The Upjohn Company Therapeutically useful heterocyclic indole compounds

Also Published As

Publication number Publication date
EP0586525A1 (en) 1994-03-16
JP3155276B2 (ja) 2001-04-09
JPH06511476A (ja) 1994-12-22
WO1992020655A1 (en) 1992-11-26
AU1928792A (en) 1992-12-30
EP0586525B1 (en) 1997-04-16

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