ES2103785T3 - Ciclo(hetero)acetales de benzaldehidos sustituidos con nitro que tienen actividad anticancerosa. - Google Patents

Ciclo(hetero)acetales de benzaldehidos sustituidos con nitro que tienen actividad anticancerosa.

Info

Publication number
ES2103785T3
ES2103785T3 ES91310790T ES91310790T ES2103785T3 ES 2103785 T3 ES2103785 T3 ES 2103785T3 ES 91310790 T ES91310790 T ES 91310790T ES 91310790 T ES91310790 T ES 91310790T ES 2103785 T3 ES2103785 T3 ES 2103785T3
Authority
ES
Spain
Prior art keywords
nitro
hetero
cycle
replaced
cancer activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91310790T
Other languages
English (en)
Inventor
Erik Olai Petterson
Rolf Olav Larsen
Bernt Borretzen
John Michael Dornish
Reidar Oftebro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Norsk Hydro ASA
Original Assignee
Norsk Hydro ASA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Norsk Hydro ASA filed Critical Norsk Hydro ASA
Application granted granted Critical
Publication of ES2103785T3 publication Critical patent/ES2103785T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
    • C07H9/04—Cyclic acetals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

NUEVOS COMPUESTOS QUE TIENEN 1 FORMULA GENERAL I: DONDE Y PUEDE SER H O D; Y A ES H, D, ALQUILO CON 1-4 ATOMOS DE CARBONO, HALOGENO, NITRO, AMINO, AMINO MONOALQUILO O AMINO DIALQUILO, DONDE LOS GRUPOS ALQUILO TIENE DE 1 A 4 ATOMOS DE CARBONO O OR DONDE R ES H O ALQUILO DE 1 A 4 ATOMOS DE CARBONO: X SUB 1 Y X SUB 2 PUEDEN FORMAR, CONJUNTAMENTE CON EL ATOMO DE CARBONO AL QUE ESTAN LIGADOS, UN ACETAL CICLICO, TIOACETAL, DITIANE AMINAL, OXAZOLIDINE O TIAZOLIDINE; O LAS SALES FARMACEUTICAMENTE ACEPTABLES DE LO ANTERIOR. LOS COMPUESTOS SON UTILES COMO AGENTES ANTI-CANCERIGENOS.
ES91310790T 1990-11-30 1991-11-22 Ciclo(hetero)acetales de benzaldehidos sustituidos con nitro que tienen actividad anticancerosa. Expired - Lifetime ES2103785T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909026114A GB9026114D0 (en) 1990-11-30 1990-11-30 New compounds

Publications (1)

Publication Number Publication Date
ES2103785T3 true ES2103785T3 (es) 1997-10-01

Family

ID=10686289

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91310790T Expired - Lifetime ES2103785T3 (es) 1990-11-30 1991-11-22 Ciclo(hetero)acetales de benzaldehidos sustituidos con nitro que tienen actividad anticancerosa.

Country Status (11)

Country Link
US (1) US5393741A (es)
EP (1) EP0493883B1 (es)
JP (1) JPH054985A (es)
AT (1) ATE152720T1 (es)
AU (1) AU635445B2 (es)
CA (1) CA2056693A1 (es)
DE (1) DE69126009T2 (es)
DK (1) DK0493883T3 (es)
ES (1) ES2103785T3 (es)
GB (1) GB9026114D0 (es)
GR (1) GR3023755T3 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9201275D0 (en) * 1992-01-21 1992-03-11 Norsk Hydro As New compounds
GB9201274D0 (en) * 1992-01-21 1992-03-11 Norsk Hydro As New compounds
CN1056082C (zh) * 1994-04-08 2000-09-06 北京市兴大科学系统公司 一种抗癌药
JP2990015B2 (ja) * 1994-06-20 1999-12-13 睦之 東風 抗ｈｉｖ剤
US6777217B1 (en) 1996-03-26 2004-08-17 President And Fellows Of Harvard College Histone deacetylases, and uses related thereto
US20030129724A1 (en) 2000-03-03 2003-07-10 Grozinger Christina M. Class II human histone deacetylases, and uses related thereto
WO2002089782A2 (en) * 2001-05-09 2002-11-14 President And Fellows Of Harvard College Dioxanes and uses thereof
US7244853B2 (en) * 2001-05-09 2007-07-17 President And Fellows Of Harvard College Dioxanes and uses thereof
CN101495116A (zh) 2005-03-22 2009-07-29 哈佛大学校长及研究员协会 蛋白降解病症的治疗
AU2007214458C1 (en) * 2006-02-14 2012-12-06 Dana-Farber Cancer Institute, Inc. Histone deacetylase inhibitors
AU2007345292B2 (en) 2006-02-14 2013-10-31 Dana-Farber Cancer Institute, Inc. Bifunctional histone deacetylase inhibitors
CA2654540C (en) * 2006-05-03 2017-01-17 President And Fellows Of Harvard College Histone deacetylase and tubulin deacetylase inhibitors
RU2515611C2 (ru) * 2008-07-23 2014-05-20 Президент Энд Феллоуз Оф Гарвард Колледж Ингибиторы деацетилазы и их применение
WO2011019393A2 (en) 2009-08-11 2011-02-17 President And Fellows Of Harvard College Class- and isoform-specific hdac inhibitors and uses thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1289966A (es) * 1968-12-24 1972-09-20
GB1561290A (en) * 1975-10-16 1980-02-20 Nyegaard & Co As Pyrimid - 2 - ones
JPS5788170A (en) * 1980-11-18 1982-06-01 Hisamitsu Pharmaceut Co Inc Thiazolidone derivative
IL67646A0 (en) * 1982-01-15 1983-05-15 Lilly Co Eli Ascorbic acid ethers and related compounds
US4552888A (en) * 1982-01-15 1985-11-12 Eli Lilly And Company Ascorbic acid ethers in angiogene
EP0085760A3 (en) * 1982-02-04 1984-07-04 American Cyanamid Company Novel 1-4-bis(substituted-amino)-5,8-dihydroxyanthraquinones and leuco bases thereof
JPS60139619A (ja) * 1983-12-27 1985-07-24 Mutsuyuki Kochi Ｏ−ベンジリデン−アスコルビン酸又はその塩よりなる抗腫瘍剤
HU200177B (en) * 1985-06-18 1990-04-28 Biogal Gyogyszergyar Process for producing thiazolidinecarboxylic acids and pharmaceutical compositions comprising such compounds
US4723986A (en) * 1986-05-19 1988-02-09 Stauffer Chemical Company Herbicidal oxazolidines and methods of use
US5149820A (en) * 1987-03-11 1992-09-22 Norsk Hydro A.S. Deuterated compounds
US4874780A (en) * 1987-03-11 1989-10-17 Norsk Hydro A.S. Anticancer compounds
GB8810173D0 (en) * 1988-04-29 1988-06-02 Norsk Hydro As Pharmaceutical compositions with anti-cancer activity & method for treatment of cancer
US5135948A (en) * 1988-11-21 1992-08-04 Norsk Hydro A.S. Pharmaceutical compositions with anti-cancer activity against carcinoma and method for the treatment of carcinoma
US5032610A (en) * 1988-11-21 1991-07-16 Norsk Hydro As Activity against carcinoma and method for the treatment of carcinoma

Also Published As

Publication number Publication date
GB9026114D0 (en) 1991-01-16
EP0493883A1 (en) 1992-07-08
CA2056693A1 (en) 1992-05-31
AU635445B2 (en) 1993-03-18
DK0493883T3 (da) 1997-10-13
EP0493883B1 (en) 1997-05-07
US5393741A (en) 1995-02-28
GR3023755T3 (en) 1997-09-30
AU8813891A (en) 1992-06-04
ATE152720T1 (de) 1997-05-15
DE69126009D1 (de) 1997-06-12
JPH054985A (ja) 1993-01-14
DE69126009T2 (de) 1997-09-18

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