ES2103820T3 - Piperazinas 1,4-disustituidas. - Google Patents

Piperazinas 1,4-disustituidas.

Info

Publication number
ES2103820T3
ES2103820T3 ES91913695T ES91913695T ES2103820T3 ES 2103820 T3 ES2103820 T3 ES 2103820T3 ES 91913695 T ES91913695 T ES 91913695T ES 91913695 T ES91913695 T ES 91913695T ES 2103820 T3 ES2103820 T3 ES 2103820T3
Authority
ES
Spain
Prior art keywords
alkyl
replaced
acid
alcoxi
ciano
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91913695T
Other languages
English (en)
Inventor
Rolf Hohlweg
Erling Guddal
Erik Bardrum Nielsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Application granted granted Critical
Publication of ES2103820T3 publication Critical patent/ES2103820T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/650952—Six-membered rings having the nitrogen atoms in the positions 1 and 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Physical Water Treatments (AREA)
  • Water Treatment By Sorption (AREA)
  • Removal Of Specific Substances (AREA)

Abstract

UN COMPUESTO DE PIPERACINA DISUSTITUIDA CON LA FORMULA (I), EN DONDE R1 ES UN HALOGENO, METOXIDO, ALQUILO DE C1-6 TRIFLUOROMETILO Y R2 ES METILO O UN ALQUILO DE C1-8 SUSTITUIDO, ALQUENILO DE C3-8 O CICLOALQUILO DE C3-8, DONDE LOS SUSTITUYENTES PUEDEN SER HIDROXIDOS, GRUPOS OXIMINO O CETO EN UNA POSICION QUE LLEVA A UNA AMINA TERCIARIA ESTABLE: O R2 ES UN ALQUILO DE C1-8 RAMIFICADO O NO, O UN ALQUENILO DE C3-8 EL CUAL EN ALGUNA POSICION PUEDE ESTAR SUSTITUIDO COMO ARRIBA, PERO ESTA SUSTITUIDO TERMINALMENTE CON UNO DE LOS SIGUIENTES GRUPOS: CIANO, UN ALCOXI C1-4 SUSTITUIDO OPCIONALMENTE POR UN ALCOXI C1-4, DIMETOXI, PHENOXI OPCIONALMENTE SUSTITUIDO, ACIDO FOSFORICO, TIENIL, FURIL, OXOZOLINO, ISOXAZOL, OXODIOZOL, DONDE LA SUSTITUCION OPCIONAL SE REPRESENTA POR UN ALQUILO C1-6 O UN FENILO, CON TAL QUE CUANDO EL CIANO SEA EL UNICO SUSTITUYENTE EN R2, R2 DEBE CONTENER AL MENOS CUATRO ATOMOS DE CARBONO Y UNA FARMACEUTICAMENTE ACEPTABLE SUMA DE SALES DEL ACIDO DE ESTA. LOS COMPUESTOS SON MUY UTILESEN EL TRATAMIENTO DE DESORDENES MENTALES EN LOS QUE ESTA IMPLICADO UN DEFICIT DOPAMINERGICO.
ES91913695T 1990-07-26 1991-07-15 Piperazinas 1,4-disustituidas. Expired - Lifetime ES2103820T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK178590A DK178590D0 (da) 1990-07-26 1990-07-26 1,4-disubstituerede piperaziner

Publications (1)

Publication Number Publication Date
ES2103820T3 true ES2103820T3 (es) 1997-10-01

Family

ID=8108040

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91913695T Expired - Lifetime ES2103820T3 (es) 1990-07-26 1991-07-15 Piperazinas 1,4-disustituidas.

Country Status (16)

Country Link
EP (1) EP0541617B1 (es)
JP (1) JPH05509311A (es)
AT (1) ATE154018T1 (es)
AU (1) AU665172B2 (es)
CA (1) CA2087855A1 (es)
DE (1) DE69126433T2 (es)
DK (2) DK178590D0 (es)
ES (1) ES2103820T3 (es)
FI (1) FI930296A7 (es)
GR (1) GR3024502T3 (es)
IE (1) IE912492A1 (es)
IL (1) IL98696A (es)
NZ (1) NZ239115A (es)
PT (1) PT98473B (es)
WO (1) WO1992001679A1 (es)
ZA (1) ZA915403B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9200293D0 (en) * 1992-01-08 1992-02-26 Wyeth John & Brother Ltd Piperazine derivatives
US6048859A (en) 1992-06-29 2000-04-11 Merck & Co., Inc. Morpholine and thiomorpholine tachykinin receptor antagonists
US5719147A (en) * 1992-06-29 1998-02-17 Merck & Co., Inc. Morpholine and thiomorpholine tachykinin receptor antagonists
US5637699A (en) * 1992-06-29 1997-06-10 Merck & Co., Inc. Process for preparing morpholine tachykinin receptor antagonists
US5387595A (en) * 1992-08-26 1995-02-07 Merck & Co., Inc. Alicyclic compounds as tachykinin receptor antagonists
US5344830A (en) * 1992-12-10 1994-09-06 Merck & Co., Inc. N,N-diacylpiperazine tachykinin antagonists
US5348955A (en) * 1993-06-22 1994-09-20 Merck & Co., Inc. N,N-diacylpiperazines
IL112778A0 (en) * 1994-03-04 1995-05-26 Merck & Co Inc Substituted heterocycles, their preparation and pharmaceutical compositions containing them
US6103465A (en) * 1995-02-14 2000-08-15 The Perkin-Elmer Corporation Methods and reagents for typing HLA class I genes
FR2815031A1 (fr) * 2000-10-11 2002-04-12 Gilles Fillion Compositions et methodes pour la regulation du systeme nerveux
NL2000351C2 (nl) 2005-12-22 2007-09-11 Pfizer Prod Inc Estrogeen-modulatoren.
NZ601967A (en) 2010-03-12 2015-03-27 Omeros Corp Pde10 inhibitors and related compositions and methods
NZ716494A (en) 2014-04-28 2017-07-28 Omeros Corp Processes and intermediates for the preparation of a pde10 inhibitor
NZ716462A (en) 2014-04-28 2017-11-24 Omeros Corp Optically active pde10 inhibitor
CN107530313A (zh) 2015-04-24 2018-01-02 奥默罗斯公司 Pde10抑制剂以及相关组合物和方法
WO2017079678A1 (en) 2015-11-04 2017-05-11 Omeros Corporation Solid state forms of a pde10 inhibitor

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2988551A (en) * 1954-07-30 1961-06-13 Union Chimique Belge Sa Piperazine derivatives
US3558631A (en) * 1966-01-06 1971-01-26 Smith Kline French Lab Benzhydryloxycyclopropyl heterocyclic amines
FR2276824A1 (fr) * 1974-07-04 1976-01-30 Melon Jean Marie Derives de la piperazine 1,4-disubstituee, leur procede de preparation et leurs applications therapeutiques
FR2310763A1 (fr) * 1975-05-13 1976-12-10 Buzas Andre Derives 1,4-disubstitues de la piperazine, leur procede de preparation et leurs applications
CH634313A5 (en) * 1978-01-01 1983-01-31 Gist Brocades Nv Piperazine derivatives
HU196194B (en) * 1986-04-28 1988-10-28 Richter Gedeon Vegyeszet Process for producing new 1-4 disubstituted piperazines and pharmaceuticals comprising the compounds
FR2601366B1 (fr) * 1986-07-10 1988-11-25 Andre Buzas Derives de la benzhydryloxyethyl-piperazine, procedes d'obtention et de compositions pharmaceutiques les contenant.
DE3726068A1 (de) * 1987-08-06 1989-02-16 Hoechst Ag Diarylalkoxyalkyl-substituierte alkylamine, verfahren zu ihrer herstellung, ihre verwendung sowie sie enthaltende arzneimittel
US4973591A (en) * 1988-10-21 1990-11-27 Syntex Pharmaceuticals, Ltd. Parenteral formulations of 1-diphenylmethyl-4-((2-(4-methylphenyl)-5-methyl-1H-imidazol-4-yl)methyl)piperazine

Also Published As

Publication number Publication date
IL98696A0 (en) 1992-07-15
CA2087855A1 (en) 1992-01-27
FI930296L (fi) 1993-01-25
EP0541617A1 (en) 1993-05-19
WO1992001679A1 (en) 1992-02-06
PT98473A (pt) 1992-05-29
JPH05509311A (ja) 1993-12-22
IE912492A1 (en) 1992-01-29
GR3024502T3 (en) 1997-11-28
DE69126433D1 (de) 1997-07-10
ATE154018T1 (de) 1997-06-15
DK0541617T3 (da) 1997-11-03
ZA915403B (en) 1992-04-29
AU665172B2 (en) 1995-12-21
FI930296A0 (fi) 1993-01-25
EP0541617B1 (en) 1997-06-04
PT98473B (pt) 1999-04-30
IL98696A (en) 1995-11-27
FI930296A7 (fi) 1993-01-25
AU8300591A (en) 1992-02-18
DK178590D0 (da) 1990-07-26
DE69126433T2 (de) 1997-12-04
NZ239115A (en) 1993-07-27

Similar Documents

Publication Publication Date Title
DE69100079D1 (de) Naphthalin-derivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen.
DK0565549T3 (da) Anvendelse af 1,3-oxathiolannucleosidanaloger til fremstilling af et præparat til behandling af hepatitis B
ES2109332T3 (es) Ciclopropilamino-1,3,5-triazinas sustituidas.
ES2081187T3 (es) Nuevas naftil-alquil-aminas, su procedimiento de preparacion y composiciones farmaceuticas que las contienen.
CO5320599A1 (es) Inhibidores no peptidilicos de la union a las celulas depen dientes de vla-4 utiles en el tratamiento de enfermedades inflamatorias, autoinmunes y respiratorias
DK0391799T3 (da) Sulfonamider afledt af benzocykliske eller benzoheterocykliske syrer, fremstilling deraf samt anvendelse deraf til terapi
ES8303395A1 (es) "procedimiento de preparar compuestos benzoxepinicos y analogos".
ES2087854T3 (es) Nuevos oxatiolanos y derivados de los mismos, composiciones farmaceuticas que los contienen y el uso de los mismos como medicamentos.
ES2044981T3 (es) Un proceso para la preparacion de nuevos derivados de 4(3h)-quinazolinona.
SE8403801L (sv) Nya bensotiazepiner med kardiovaskuler anvendbarhet, forfarande for framstellning derav och farmaceutiska kompositioner som innehaller dem
ES2148305T3 (es) Derivados de aminoacidos ciclicos que tienen actividad inhibidora de ace y nep.
AR006761A1 (es) Compuestos (2-(1-piperacinil)etoxi)metilo sustituidos, procedimiento para su preparacion, su uso para preparar un compuesto (2-(4-(bis-fenilo sustituido metil)-1-piperacinil)etoxi)metilo sustituido y procedimineto para la preparacion de este ultimo
NO952402L (no) Substituerte 6-azaandrostenoner
PT98473A (pt) Processo de preparacao de piperazinas 1,4-dissubstituidas e de composicoes farmaceuticas
ES2132761T3 (es) Derivados del acido piperidin acetico utiles como antagonistas del fibrinogeno.
ES2061487T3 (es) Compuestos macrolidos.
MX174210B (es) Procedimiento para la preparacion de compuestos arilpiperazinil-alquilenfenil-p-heterociclicos
ES467170A1 (es) Procedimiento para preparar tetrahidro-1,3,5-triazina-2,6- dionas
ES483003A1 (es) Procedimiento de preparacion de derivados de fenil-1-pipera-zina
ES476408A1 (es) Un procedimiento de preparacion de derivados de 2,4-tiazoli-dindiona.
DE3787844D1 (de) Thioester und dessen Verwendung zur Herstellung von pharmazeutischen Zusammensetzungen zur Behandlung von Ischämie und von Reperfusion-Syndromen.
ES2059550T3 (es) Derivados de la bencimidazola, su preparacion y su aplicacion en terapeutica.
GR880100526A (el) Φαρμακευτικα παρασκευασματα δια εξωτερικην χρησιν.
FI861934A0 (fi) Nya isoxazolderivat, foerfarande foer deras framstaellning och dessa innehaollande farmaceutiska preparat.
EP0123146A3 (en) Compounds with antiinflammatory activity, process for preparation thereof and pharmaceutical compositions therefrom

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 541617

Country of ref document: ES