ES2104014T3 - Derivados del 1,2,4-oxadiazol para la lucha contra los endoparasitos. - Google Patents
Derivados del 1,2,4-oxadiazol para la lucha contra los endoparasitos.Info
- Publication number
- ES2104014T3 ES2104014T3 ES93114857T ES93114857T ES2104014T3 ES 2104014 T3 ES2104014 T3 ES 2104014T3 ES 93114857 T ES93114857 T ES 93114857T ES 93114857 T ES93114857 T ES 93114857T ES 2104014 T3 ES2104014 T3 ES 2104014T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- hydrogen
- haloalkyl
- hydroxy
- sulfinyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 244000079386 endoparasite Species 0.000 title abstract 2
- 150000005071 1,2,4-oxadiazoles Chemical class 0.000 title 1
- -1 ALCOXY Chemical class 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000005090 alkenylcarbonyl group Chemical group 0.000 abstract 2
- 125000001188 haloalkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000005083 alkoxyalkoxy group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004656 alkyl sulfonylamino group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000000266 alpha-aminoacyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000005135 aryl sulfinyl group Chemical group 0.000 abstract 1
- 125000004391 aryl sulfonyl group Chemical group 0.000 abstract 1
- 125000005110 aryl thio group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 125000004440 haloalkylsulfinyl group Chemical group 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical class [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- 125000005113 hydroxyalkoxy group Chemical group 0.000 abstract 1
- WCPAKWJPBJAGKN-UHFFFAOYSA-N oxadiazole Chemical group C1=CON=N1 WCPAKWJPBJAGKN-UHFFFAOYSA-N 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 abstract 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000005208 trialkylammonium group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/82—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with three ring hetero atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE A LA UTILIZACION DE LOS DERIVADOS DE 1,2,4 -, OXADIAZOL SUSTITUIDOS DE LA FORMULA GENERAL (I) EN DONDE R1 ES HIDROGENO, ALQUILO QUE ES SUSTITUIDO EVENTUALMENTE POR MEDIO DE HALOGENO, ALCOXI, HIDROXI, AMINO, ALQUILAMINO, DIALQUILAMINO, CICLOALQUILAMINO ASI COMO CICLOALQUILO, ARILO EVENTUALMENTE SUSTITUIDO O HETARILO, R2 ES HIDROGENO Y ALQUILO; X ES O,S,SO, SO2 Y N O DIFERENTE DE LA SERIE, HIDROGENO ES HALOGENO, CIANO, NITRO, ISOTIOCIANATO, AMINO, AMINOACILO, ALQUILAMINO, DIALQUILAMINO, HALOGENURO DE TRIALQUILAMONIO, SULFONILAMINO, HIDROXI, MERCAPTO, ALQUILO, ARALQUILO, HALOGENALQUILO, ALCOXI, ARALCOXI, HALOGENALCOXI, ARILO, ARILOXI, ARILTIO, ARILO SULFINILO, ARILSULFONIL, ALQUILTIO, HALOGENALQUILTIO, ALQUILO SULFINIL, HALOGENALQUILO SULFINILO, ALQUILO SULFONILO, HALOGENALQUILO SULFONILO, ALCOXI CARBONILO, ALQUILO CARBONILO, ALQUILO CARBONILOXI, ALCOXIALQUILO, ALCOXIALCOXI, HIDROXI ALCOXI, HETARILMETILENOXI, ES ADECUADO PARA LA LUCHA CONTRA ENDOPARASITOS EN MEDICINA, Y VETERINARIA, ASI COMO NUEVOS COMPUESTOS DE LA FORMULA (I) Y SU ELABORACION.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4232418A DE4232418A1 (de) | 1992-09-28 | 1992-09-28 | Verwendung von substituierten 1,2,4-Oxadiazolderivaten zur Bekämpfung von Endoparasiten, neue substituierte 1,2,4-Oxadiazolderivate und Verfahren zu ihrer Herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2104014T3 true ES2104014T3 (es) | 1997-10-01 |
Family
ID=6468996
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES93114857T Expired - Lifetime ES2104014T3 (es) | 1992-09-28 | 1993-09-15 | Derivados del 1,2,4-oxadiazol para la lucha contra los endoparasitos. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5428047A (es) |
| EP (1) | EP0590415B1 (es) |
| JP (1) | JP3463945B2 (es) |
| KR (1) | KR100295272B1 (es) |
| AT (1) | ATE154015T1 (es) |
| AU (1) | AU662833B2 (es) |
| CA (1) | CA2106897C (es) |
| DE (2) | DE4232418A1 (es) |
| DK (1) | DK0590415T3 (es) |
| ES (1) | ES2104014T3 (es) |
| GR (1) | GR3024272T3 (es) |
| TW (1) | TW308590B (es) |
| ZA (1) | ZA937139B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4401108A1 (de) * | 1994-01-17 | 1995-07-20 | Bayer Ag | 1,2,4-Oxadiazol-Derivate |
| KR101674463B1 (ko) * | 2013-04-03 | 2016-11-10 | 서울대학교산학협력단 | Ｓｔａｔ３ 저해활성을 갖는 화합물 및 이의 용도 |
| LT3483164T (lt) | 2017-03-20 | 2020-05-11 | Forma Therapeutics, Inc. | Pirolpirolo kompozicijos kaip piruvato kinazės (pkr) aktyvatoriai |
| EP3852791B1 (en) | 2018-09-19 | 2024-07-03 | Novo Nordisk Health Care AG | Activating pyruvate kinase r |
| EP3853206B1 (en) | 2018-09-19 | 2024-04-10 | Novo Nordisk Health Care AG | Treating sickle cell disease with a pyruvate kinase r activating compound |
| HRP20251148T1 (hr) | 2019-09-19 | 2025-11-21 | Novo Nordisk Health Care Ag | Pripravci koji aktiviraju piruvat-kinazu r (pkr) |
| US12128035B2 (en) | 2021-03-19 | 2024-10-29 | Novo Nordisk Health Care Ag | Activating pyruvate kinase R |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1620574A1 (de) * | 1966-11-15 | 1970-04-30 | Troponwerke Dinklage & Co | Neue substituierte 1,2,4-Oxadiazolverbindungen und Verfahren zu ihrer Herstellung |
| GB1228142A (es) * | 1967-03-31 | 1971-04-15 | ||
| US3879407A (en) * | 1973-02-09 | 1975-04-22 | Johnson & Son Inc S C | 1,2,4-Oxadiazole and thiadiazole esters and compositions containing same |
| IT1118196B (it) * | 1978-07-13 | 1986-02-24 | Wellcome Found | Procedimento per la produzione di derivati dell'ossadiazolo con attivita'contro i protozoi |
| US4294842A (en) * | 1978-07-13 | 1981-10-13 | Burroughs Wellcome Co. | Anti-protozoal oxadiazole derivatives |
| DE2842284A1 (de) * | 1978-09-28 | 1980-04-17 | Bayer Ag | N-diazolylalkyl-halogenacetanilide, verfahren zu ihrer herstellung sowie ihre verwendung als herbizide |
| JPS57175177A (en) * | 1981-04-21 | 1982-10-28 | Mitsui Toatsu Chem Inc | 3-ethyloxadiazole derivative, its preparation, and herbicide |
| JPS58183688A (ja) * | 1982-04-20 | 1983-10-26 | Nippon Tokushu Noyaku Seizo Kk | オキサジアゾ−ル誘導体、その製法及び除草剤 |
| US4812161A (en) * | 1984-08-08 | 1989-03-14 | Nippon Soda Co., Ltd. | Thia (oxa) diazole derivatives |
| JPS62267274A (ja) * | 1986-05-16 | 1987-11-19 | Aguro Kanesho Kk | １，２，４−オキサジアゾ−ル誘導体 |
| JPS63264584A (ja) * | 1987-04-20 | 1988-11-01 | Aguro Kanesho Kk | 除草剤組成物 |
| GB8712396D0 (en) * | 1987-05-27 | 1987-07-01 | May & Baker Ltd | Composition of matter |
| JPH01249768A (ja) * | 1988-03-30 | 1989-10-05 | Nippon Tokushu Noyaku Seizo Kk | Ｎ−置換フエニル−ヘテロ環式化合物及び除草剤 |
| DE4041474A1 (de) * | 1990-12-22 | 1992-06-25 | Bayer Ag | Verwendung von substituierten 1,2,4-oxadiazolderivaten zur bekaempfung von endoparasiten, neue substituierte 1,2,4-oxadiazolderivate und verfahren zu ihrer herstellung |
-
1992
- 1992-09-28 DE DE4232418A patent/DE4232418A1/de not_active Withdrawn
-
1993
- 1993-08-26 AU AU44929/93A patent/AU662833B2/en not_active Ceased
- 1993-08-31 TW TW082107047A patent/TW308590B/zh active
- 1993-09-15 ES ES93114857T patent/ES2104014T3/es not_active Expired - Lifetime
- 1993-09-15 DK DK93114857.1T patent/DK0590415T3/da active
- 1993-09-15 DE DE59306648T patent/DE59306648D1/de not_active Expired - Lifetime
- 1993-09-15 AT AT93114857T patent/ATE154015T1/de not_active IP Right Cessation
- 1993-09-15 EP EP93114857A patent/EP0590415B1/de not_active Expired - Lifetime
- 1993-09-21 US US08/124,909 patent/US5428047A/en not_active Expired - Lifetime
- 1993-09-22 JP JP25753493A patent/JP3463945B2/ja not_active Expired - Fee Related
- 1993-09-24 KR KR1019930019693A patent/KR100295272B1/ko not_active Expired - Fee Related
- 1993-09-24 CA CA002106897A patent/CA2106897C/en not_active Expired - Fee Related
- 1993-09-27 ZA ZA937139A patent/ZA937139B/xx unknown
-
1997
- 1997-07-30 GR GR970401921T patent/GR3024272T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TW308590B (es) | 1997-06-21 |
| AU4492993A (en) | 1994-04-14 |
| ZA937139B (en) | 1994-03-29 |
| CA2106897C (en) | 2005-01-04 |
| AU662833B2 (en) | 1995-09-14 |
| DE59306648D1 (de) | 1997-07-10 |
| EP0590415A2 (de) | 1994-04-06 |
| JP3463945B2 (ja) | 2003-11-05 |
| GR3024272T3 (en) | 1997-10-31 |
| EP0590415A3 (en) | 1994-06-01 |
| DK0590415T3 (da) | 1997-12-22 |
| JPH06192243A (ja) | 1994-07-12 |
| ATE154015T1 (de) | 1997-06-15 |
| KR940006589A (ko) | 1994-04-25 |
| KR100295272B1 (ko) | 2001-09-17 |
| CA2106897A1 (en) | 1994-03-29 |
| US5428047A (en) | 1995-06-27 |
| EP0590415B1 (de) | 1997-06-04 |
| DE4232418A1 (de) | 1994-03-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20030131A1 (es) | Derivados de 6-fenildihidropirrolpirimidindiona | |
| ES2104014T3 (es) | Derivados del 1,2,4-oxadiazol para la lucha contra los endoparasitos. | |
| ES2155067T3 (es) | Fenilimidazolidinas sustituidas, su aplicacion como medicamentos y las composiciones farmaceuticas que los contienen. | |
| ES2055119T3 (es) | Procedimiento para la preparacion de derivados de la bacatina iii y de la desacetil-10 bacatina iii. | |
| AR023703A1 (es) | N-carboniloximetilesteres de nitroetilendiaminas y nitroguanidinas, proceso para su preparacion, composicion parasiticida, una preparacion en combinacionpara controlar parasitos en animales de sangre caliente, uso de dichos compuestos y compuestos intermediarios para su uso en dicho proceso de prepa | |
| AR247388A1 (es) | Compuestos derivados de la 2-anilino-pirimidina, procedimiento para su obtencion y composiciones agroquimicas que lo contienen | |
| ES2051854T3 (es) | Procedimiento para preparar derivados del acido hidroxamico con propiedades anti-inflamatorias. | |
| AR016551A1 (es) | Derivados de 2-oxindol, composiciones farmaceuticas que los comprenden y el uso de los mismos para la manufactura de medicamentos | |
| AR032428A1 (es) | Compuestos derivados de resorcinol, composicion farmaceutica, uso de los compuestos para preparar medicamentos | |
| ES2063117T3 (es) | Derivados del tieno(2,3-d)acepina, procedimiento para su preparacion y composiciones farmaceuticas que los contienen. | |
| PL285067A1 (en) | Agent for fighting against arthropoda, nematoda, parasites or protozoa | |
| AR247380A1 (es) | Procedimiento para preparar derivados de n-aminobutil n-fenil arilamidas | |
| ES2116467T3 (es) | Derivados de 5h,10h-imidazo(1,2-a)indeno(1,2-e)pirazina-4-ona, su preparacion y los medicamentos que les contienen. | |
| ES2053983T3 (es) | Carboxamidas hetera-alifaticas. | |
| ES2133511T3 (es) | Composicion tintorea que contiene p-fenilendiaminas con azufre, p-fenilendiaminas con azufre y su procedimiento de preparacion. | |
| ES2059903T3 (es) | Procedimiento para la lucha contra las pestes con ayuda de pirimidinas. | |
| ES2055804T3 (es) | Procedimiento de preparacion de nuevas meta-fenilendiaminas sustituidas con trialcoxi. | |
| PE20030346A1 (es) | Proceso para la produccion de quinazolinas | |
| CO5170464A1 (es) | Derivados de 1-trifluorometil-4-hidroxi-7-piperidinil- aminometilcromano | |
| EP0290285A3 (en) | Bicyclic sulfonamide derivatives and their preparation, their use and formulations containing them | |
| NO20005390D0 (no) | Nye forbindelser av 9-(3,5-dimetyloksyfenyl)-5,8,8a,9- tetrahydrofuro[3',4':6,7]nafto[2,3-d]-[1,3]dioksol-6(5aH)-on, fremgangsmÕte ved deres fremstilling og farmasøytiske sammensetninger inneholdende dem | |
| ES2016017A6 (es) | Procedimiento para preparar derivados de acido 1,1-dioxocefem-4-carbotiolico. | |
| CO5290255A1 (es) | Pirazolo(4,3-e)diazepinas sustituidas novedosas, composiciones farmaceuticas que las contienen, su uso como productos medicinales y procesos para prepararlas | |
| ES2059348T3 (es) | Composicion farmaceutica para el tratamiento de cataratas. | |
| DE3877036D1 (de) | Biologisch aktive verbindungen. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
Ref document number: 590415 Country of ref document: ES |