ES2104478T3 - Metodos de identificar linfocitos con fenotipos mutadores. - Google Patents

Metodos de identificar linfocitos con fenotipos mutadores.

Info

Publication number
ES2104478T3
ES2104478T3 ES95907407T ES95907407T ES2104478T3 ES 2104478 T3 ES2104478 T3 ES 2104478T3 ES 95907407 T ES95907407 T ES 95907407T ES 95907407 T ES95907407 T ES 95907407T ES 2104478 T3 ES2104478 T3 ES 2104478T3
Authority
ES
Spain
Prior art keywords
lymphocytes
identifying
mutatory
phenotypes
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95907407T
Other languages
English (en)
Inventor
Richard J Albertini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Vermont
Original Assignee
University of Vermont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Vermont filed Critical University of Vermont
Application granted granted Critical
Publication of ES2104478T3 publication Critical patent/ES2104478T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5094—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for blood cell populations

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Ecology (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

LA INVENCION SUMINISTRA METODOS PARA IDENTIFICAR LINFOCITOS CON UN FENOTIPO MUTAGENO AISLANDO LINFOCITOS QUE SOPORTAN UN MARCADOR SELECCIONABLE; IDENTIFICANDO ENTRE LOS LINFOCITOS UNA POBLACION QUE PERTENECE AL MISMO CONJUNTO CLONALMENTE AMPLIFICADO; Y DETERMINANDO SI LA POBLACION TIENE AL MENOS DOS LINFOCITOS QUE TENGAN, ENTRE ELLOS, DOS MUTACIONES INDEPENDIENTES ENTRE ALELOS DIFERENTES EN EL LUGAR DEL GEN DEL MARCADOR SELECCIONABLE; LA PRESENCIA DE LOS CUALES INDICA UN FENOTIPO MUTAGENO. EN UNA REALIZACION DE LA INVENCION EL MARCADOR SELECCIONABLE ES "HPRT".
ES95907407T 1994-01-14 1995-01-13 Metodos de identificar linfocitos con fenotipos mutadores. Expired - Lifetime ES2104478T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/182,416 US5482837A (en) 1994-01-14 1994-01-14 Methods of identifying lymphocytes with mutator phenotypes

Publications (1)

Publication Number Publication Date
ES2104478T3 true ES2104478T3 (es) 1997-10-01

Family

ID=22668382

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95907407T Expired - Lifetime ES2104478T3 (es) 1994-01-14 1995-01-13 Metodos de identificar linfocitos con fenotipos mutadores.

Country Status (11)

Country Link
US (1) US5482837A (es)
EP (1) EP0739418B1 (es)
JP (1) JP3319602B2 (es)
AT (1) ATE154949T1 (es)
AU (1) AU1564995A (es)
CA (1) CA2179281C (es)
DE (1) DE69500393T2 (es)
DK (1) DK0739418T3 (es)
ES (1) ES2104478T3 (es)
GR (1) GR3023995T3 (es)
WO (1) WO1995019444A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005518779A (ja) * 2001-03-23 2005-06-30 イェダ リサーチ アンド デベロップメント カンパニー リミテッド ガンを発症する危険性を明らかにするための方法およびキット、ガン治療の有効性および投与量を評価するための方法およびキット、ならびにｄｎａ修復酵素の活性とガンとを相関させるための方法およびキット

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4066510A (en) * 1976-05-24 1978-01-03 Massachusetts Institute Of Technology Assay for mutagenesis in diploid human lymphoblasts
US4544632A (en) * 1981-06-12 1985-10-01 Yuichi Yamamura Human T cell lines and method of producing same
US4647535A (en) * 1981-08-12 1987-03-03 Research Corporation Human nonsecretory plasmacytoid cell line
US5112735A (en) * 1987-06-22 1992-05-12 University Of Vermont Detection of lymphocyte amplification
CA1305912C (en) * 1987-06-22 1992-08-04 Richard J. Albertini Detection of lymphocyte amplification

Also Published As

Publication number Publication date
DK0739418T3 (da) 1998-02-02
JP3319602B2 (ja) 2002-09-03
EP0739418B1 (en) 1997-07-02
AU1564995A (en) 1995-08-01
JPH09511132A (ja) 1997-11-11
US5482837A (en) 1996-01-09
ATE154949T1 (de) 1997-07-15
WO1995019444A1 (en) 1995-07-20
GR3023995T3 (en) 1997-10-31
CA2179281C (en) 2001-12-18
DE69500393D1 (de) 1997-08-07
EP0739418A1 (en) 1996-10-30
DE69500393T2 (de) 1997-12-18
CA2179281A1 (en) 1995-07-20

Similar Documents

Publication Publication Date Title
WO1997040462A3 (en) Correlating polymorphic forms with multiple phenotypes
DE60030145D1 (de) Nachweisverfahren für kurze sequenzvarianten
AU1133500A (en) Parallel methods for genomic analysis
IL156002A0 (en) Methods and products for analyzing polymers
IL122808A0 (en) Kit for detecting genetic predisposition for osteoporosis
DK0705903T3 (da) Mutationer i det 17q-koblede bryst- og ovariecancerprædisponeringen
ATE408422T1 (de) Methode zur hemmung immunstimulatorischer mit dna assoziierter antworten
WO2000069896A3 (en) Molecular interactions in haematopoietic cells
AU3321695A (en) Method for diagnosing a predisposition for breast and ovarian cancer
AU1671300A (en) Cancer detection method and reagents
GB9704054D0 (en) Assay
WO2000063441A3 (en) Single nucleotide polymorphisms in mitochondrial genes that segregate with alzheimer's disease
CA2269664A1 (en) Diagnostic assay for breast cancer susceptibility
WO2001009384A3 (en) Serial analysis of genetic alterations
WO1995022612A3 (en) Genes and genetic elements associated with sensitivity to platinum-based drugs
EP1001037A3 (en) Pre-selection and isolation of single nucleotide polymorphisms
ES2104478T3 (es) Metodos de identificar linfocitos con fenotipos mutadores.
AU2215897A (en) Methods and compositions for detecting dihydropyrimidine dehydrogenase splicing mutations
NO953560L (no) Genetiske suppressorelementer assosiert med sensitivitet overfor kjemoterapeutiske medikamenter
AU6030498A (en) An apc mutation associated with familial colorectal cancer in ashkenazi jews
AU7828698A (en) Detection of loss of the wild-type (hu)bub1 gene
WO1999066077A3 (en) Methods for the detection of nucleic acids
ATE275202T1 (de) Acetyl-coa-carboxylase von candida albicans
WO2001038579A3 (en) Method of identifying toxic agents using nsaid-induced differential gene expression in liver
AU2224197A (en) Drug trial assay system

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 739418

Country of ref document: ES