ES2105292T3 - Peptidos marcados con tecnecio-99m para obtencion de imagenes. - Google Patents
Peptidos marcados con tecnecio-99m para obtencion de imagenes.Info
- Publication number
- ES2105292T3 ES2105292T3 ES93915221T ES93915221T ES2105292T3 ES 2105292 T3 ES2105292 T3 ES 2105292T3 ES 93915221 T ES93915221 T ES 93915221T ES 93915221 T ES93915221 T ES 93915221T ES 2105292 T3 ES2105292 T3 ES 2105292T3
- Authority
- ES
- Spain
- Prior art keywords
- reagents
- union
- peptides
- specific
- tecnecio
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/082—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being a RGD-containing peptide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
ESTA INVENCION DESCRIBE REACTIVOS RADIOMARCADOS, INCLUYENDO SUS CASOS DE PEPTIDOS DE UNION ESPECIFICA, Y LOS METODOS PARA PRODUCIR Y APLICAR TALES REACTIVOS. ESPECIFICAMENTE, LA INVENCION DESCRIBE LOS REACTIVOS PARA PREPARAR AGENTES DE REPRESENTACION DE IMAGENES ESCINTOGRAFICAS PARA SITIOS DE REPRESENTACION DE IMAGENES EN UN CUERPO DE MAMIFERO. SE DESCRIBEN LOS REACTIVOS, LOS METODOS Y LAS HERRAMIENTAS PARA HACER TALES REACTIVOS, Y LOS METODOS PARA APLICAR TALES REACTIVOS MARCADOS CON TECNECIO-99M (TC-99M) POR PARTES DE UNION DE TC-99M QUE COMPRENDE DICHOS REACTIVOS. EN PARTICULAR, LOS PEPTIDOS DE UNION ESPECIFICA Y LAS PARTES DE UNION DE TC-99M QUE COMPRENDE LOS REACTIVOS DE LA INVENCION ESTAN UNIDOS COVALENTEMENTE A UNA PARTE LIGADORA POLIVALENTE, TAL QUE LA PARTE LIGADORA POLIVALENTE ESTA LIGADA COVALENTEMENTE A UNA MULTIPLICIDAD DE LOS PEPTIDOS DE UNION ESPECIFICA, Y LAS PARTES DE UNION DE TC-99M SON COVALENTEMENTE LIGADAS A UNA PLURALIDAD DE PEPTIDOS DE UNION ESPECIFICA, LA PARTE LIGADORA POLIVALENTE O A AMBOS PEPTIDOS DE UNION ESPECIFICA Y PARTE LIGADORA POLIVALENTE.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/893,981 US5508020A (en) | 1992-06-05 | 1992-06-05 | Technetium-99M labeled peptides for imaging |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2105292T3 true ES2105292T3 (es) | 1997-10-16 |
Family
ID=25402435
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES93915221T Expired - Lifetime ES2105292T3 (es) | 1992-06-05 | 1993-06-04 | Peptidos marcados con tecnecio-99m para obtencion de imagenes. |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US5508020A (es) |
| EP (1) | EP0644778B1 (es) |
| JP (1) | JP2954354B2 (es) |
| AT (1) | ATE152918T1 (es) |
| AU (1) | AU688264B2 (es) |
| CA (1) | CA2137009C (es) |
| DE (1) | DE69310733T2 (es) |
| DK (1) | DK0644778T3 (es) |
| ES (1) | ES2105292T3 (es) |
| WO (1) | WO1993025244A1 (es) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5792444A (en) * | 1989-05-09 | 1998-08-11 | The General Hospital Corporation | Labeled chemotactic peptides to image focal sites of infection or inflammation |
| US5700444A (en) * | 1992-02-20 | 1997-12-23 | Rhomed Incorporated | Chemotactic peptide pharmaceutical applications |
| US5759515A (en) * | 1989-08-09 | 1998-06-02 | Rhomed Incorporated | Polyvalent peptide pharmaceutical applications |
| US5443816A (en) * | 1990-08-08 | 1995-08-22 | Rhomed Incorporated | Peptide-metal ion pharmaceutical preparation and method |
| US5443815A (en) * | 1991-11-27 | 1995-08-22 | Diatech, Inc. | Technetium-99m labeled peptides for imaging |
| US5997844A (en) * | 1991-02-08 | 1999-12-07 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
| US5736122A (en) * | 1991-02-08 | 1998-04-07 | Diatide, Inc. | Technetium-99m labeled peptides for thrombus imaging |
| US5552525A (en) * | 1991-02-08 | 1996-09-03 | Diatech Inc. | Technetium-99m labeled peptides for imaging inflammation |
| US5645815A (en) * | 1991-02-08 | 1997-07-08 | Diatide, Inc. | Radiolabled compounds for thrombus imaging |
| US5830856A (en) * | 1991-02-08 | 1998-11-03 | Diatide, Inc. | Radiolabeled compounds for thrombus imaging |
| US6019958A (en) * | 1991-02-08 | 2000-02-01 | Diatide, Inc. | Technetium-99m labeled peptides for imaging inflammation |
| US5965107A (en) * | 1992-03-13 | 1999-10-12 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
| US5849261A (en) * | 1991-02-08 | 1998-12-15 | Diatide, Inc. | Radiolabeled vasoactive intestinal peptides for diagnosis and therapy |
| DE69230525T2 (de) * | 1991-02-08 | 2000-06-21 | Diatide, Inc. | Technetium-99m markierte Polypeptide zur Bildformung |
| US5783170A (en) * | 1991-11-27 | 1998-07-21 | Diatide, Inc. | Peptide-metal chelate conjugates |
| US5556609A (en) * | 1992-02-20 | 1996-09-17 | Rhomed Incorporated | YIGSR peptide radiopharmaceutical applications |
| US5738838A (en) * | 1992-02-20 | 1998-04-14 | Rhomed Incorporated | IKVAV peptide radiopharmaceutical applications |
| WO1993017719A1 (en) * | 1992-03-13 | 1993-09-16 | Diatech, Inc. | TECHNETIUM-99m LABELED PEPTIDES FOR IMAGING INFLAMMATION |
| US5989519A (en) * | 1992-03-13 | 1999-11-23 | Diatide, Inc. | Technetium-99m labeled peptides for imaging inflammation |
| AU709306B2 (en) * | 1992-04-30 | 1999-08-26 | Cis Bio International | Radiolabeled compounds for thrombus imaging |
| US5508020A (en) * | 1992-06-05 | 1996-04-16 | Diatech, Inc. | Technetium-99M labeled peptides for imaging |
| US5968476A (en) * | 1992-05-21 | 1999-10-19 | Diatide, Inc. | Technetium-99m labeled peptides for thrombus imaging |
| US5716596A (en) * | 1992-06-23 | 1998-02-10 | Diatide, Inc. | Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses |
| US5620675A (en) | 1992-06-23 | 1997-04-15 | Diatech, Inc. | Radioactive peptides |
| US6017512A (en) * | 1992-06-23 | 2000-01-25 | Diatide, Inc. | Radiolabeled peptides |
| DE69332203T2 (de) * | 1992-10-02 | 2003-05-28 | Diatide, Inc. | Multimerische mehrzweckwirkstoffe gegen thrombose |
| US6056940A (en) * | 1993-04-08 | 2000-05-02 | Diatide, Inc. | Radiolabeled compounds for thrombus imaging |
| AU698176B2 (en) * | 1993-07-28 | 1998-10-29 | Cis Bio International | Radiolabelled glucans |
| CA2179990A1 (en) * | 1994-01-12 | 1995-07-20 | Gary Robert Bower | Biological targeting agents |
| US5569745A (en) * | 1994-02-25 | 1996-10-29 | Resolution Pharmaceuticals Inc. | Peptide-Chelator conjugates |
| DK0750610T3 (da) * | 1994-03-18 | 2002-03-11 | Diatide Inc | Piperidyl-4-substituerede tyrosinderivater som scintigrafiske billedfrembringende midler til diagnose af thrombose |
| IL113610A0 (en) * | 1994-06-03 | 1995-08-31 | Immunomedics Inc | A method of radiolabeling a protein, radiolabeled proteins prepared thereby and diagnostic kits containing the same |
| US6051206A (en) * | 1994-06-03 | 2000-04-18 | Diatide, Inc | Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses |
| CA2165228A1 (en) * | 1994-12-27 | 1996-06-28 | Yoshitoshi Itaya | Metal chelate forming peptides and use thereof |
| US5891418A (en) * | 1995-06-07 | 1999-04-06 | Rhomed Incorporated | Peptide-metal ion pharmaceutical constructs and applications |
| US6331285B1 (en) | 1996-06-05 | 2001-12-18 | Palatin Technologies, Inc. | Structurally determined cyclic metallo-constructs and applications |
| EP0975374B1 (en) * | 1996-07-12 | 2007-12-05 | Immunomedics, Inc. | Radiometal-binding peptide analogues |
| GB9708265D0 (en) * | 1997-04-24 | 1997-06-18 | Nycomed Imaging As | Contrast agents |
| EP1905357B1 (en) | 1997-04-30 | 2012-11-28 | The Board Of Trustees Of The Leland Stanford Junior University | Method of imaging cell death in vivo |
| US6083480A (en) * | 1997-05-01 | 2000-07-04 | Diatide, Inc. | Calcitonin receptor binding reagents |
| US5886142A (en) * | 1997-05-20 | 1999-03-23 | Thomas Jefferson University | Radiolabeled thrombus imaging agents |
| US6028056A (en) * | 1998-02-06 | 2000-02-22 | Diatide, Inc. | Pharmaceutical compositions for imaging and treating thrombi |
| US6022857A (en) * | 1998-06-19 | 2000-02-08 | Diatide, Inc. | Radiolabeled compounds for thrombus imaging |
| US6254852B1 (en) | 1999-07-16 | 2001-07-03 | Dupont Pharmaceuticals Company | Porous inorganic targeted ultrasound contrast agents |
| US7385025B2 (en) | 2000-12-19 | 2008-06-10 | Palatin Technologies, Inc. | Metallopeptide compounds |
| WO2003033030A1 (en) * | 2001-10-19 | 2003-04-24 | Thomas Jefferson University | Pacap compositions and methods for tumor imaging and therapy |
| AU2003225023A1 (en) * | 2002-04-22 | 2003-11-03 | Thomson Licensing S.A. | A web browser for use with a television display for preventing screen burn |
| US20060029544A1 (en) * | 2004-08-06 | 2006-02-09 | The Regents Of The University Of California Office Of Technology Transfer | Receptor-binding cyclic peptides and methods of use |
| CN102088991A (zh) | 2008-05-13 | 2011-06-08 | 堪萨斯大学 | 金属提取肽标签和相关方法 |
| JP6243335B2 (ja) | 2011-08-17 | 2017-12-06 | ピラマル イメージング ソシエテ アノニム | 血小板固有の糖タンパク質IIb/IIIaに結合する化合物と血栓造影のためのその使用 |
| US9187735B2 (en) | 2012-06-01 | 2015-11-17 | University Of Kansas | Metal abstraction peptide with superoxide dismutase activity |
| CA2900595A1 (en) | 2013-02-12 | 2014-08-21 | Bayer Pharma Aktiengesellschaft | Metal chelate compounds for binding to the platelet specific glycoprotein iib/iiia |
| DE102013113156A1 (de) * | 2013-11-28 | 2015-05-28 | Freie Universität Berlin | Verbindung und Verfahren zur selektiven Radiomarkierung von Polypeptiden mittels Festphasensynthese |
Family Cites Families (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4427646A (en) * | 1981-04-02 | 1984-01-24 | Research Corporation | Use of radiolabeled peptide derived from crosslinked fibrin to locate thrombi in vivo |
| US4647447A (en) * | 1981-07-24 | 1987-03-03 | Schering Aktiengesellschaft | Diagnostic media |
| US4444690A (en) * | 1982-02-25 | 1984-04-24 | University Patents, Inc. | Technetium chelates |
| US4434151A (en) * | 1982-11-08 | 1984-02-28 | Medi-Physics, Inc. | Bifunctional chelating agents |
| US4571430A (en) * | 1982-11-08 | 1986-02-18 | Medi-Physics, Inc. | Homocysteine and homocysteinamide derivatives |
| US4575556A (en) * | 1982-11-08 | 1986-03-11 | Medi-Physics, Inc. | Bifunctional chelating agents |
| US4673562A (en) * | 1983-08-19 | 1987-06-16 | The Children's Medical Center Corporation | Bisamide bisthiol compounds useful for making technetium radiodiagnostic renal agents |
| ATE66469T1 (de) * | 1985-01-14 | 1991-09-15 | Neorx Corp | Metall-radionuklid markiertes protein fuer diagnose und therapie. |
| US4748022A (en) | 1985-03-25 | 1988-05-31 | Busciglio John A | Topical composition |
| US4746505A (en) * | 1985-04-26 | 1988-05-24 | President And Fellows Of Harvard College | Technetium radiodiagnostic fatty acids derived from bisamide bisthiol ligands |
| GB8525974D0 (en) * | 1985-10-22 | 1985-11-27 | Nyegaard & Co As | Chemical substance |
| US4861869A (en) * | 1986-05-29 | 1989-08-29 | Mallinckrodt, Inc. | Coupling agents for joining radionuclide metal ions with biologically useful proteins |
| US4965392A (en) * | 1987-03-26 | 1990-10-23 | Neorx Corporation | Chelating compounds for metal-radionuclide labeled proteins |
| AU2258788A (en) * | 1987-07-07 | 1989-01-30 | Cytrx Biopool Ltd. | Fibrin-binding compound and method |
| WO1989002752A1 (en) * | 1987-09-25 | 1989-04-06 | Genentech, Inc. | Method of diagnosing blood clots using fibrin-binding proteins |
| US4871836A (en) * | 1987-10-13 | 1989-10-03 | E. R. Squibb & Sons, Inc. | Boronic acid adducts of rhenium and radioactive isotopes of rhenium dioxime complexes |
| US5648471A (en) * | 1987-12-03 | 1997-07-15 | Centocor, Inc. | One vial method for labeling antibodies with Technetium-99m |
| WO1989005150A1 (en) * | 1987-12-10 | 1989-06-15 | La Jolla Cancer Research Foundation | Conformationally stabilized cell adhesion peptides |
| DE68923274T2 (de) * | 1988-02-09 | 1995-11-09 | Mallinckrodt Inc | Verfahren zur herstellung eines mit metall-radionuklid-markierten proteins. |
| US5061641A (en) * | 1988-04-01 | 1991-10-29 | Immunomedics, Inc. | Method for radiolabeling proteins |
| WO1989010759A1 (en) * | 1988-04-29 | 1989-11-16 | Mallinckrodt, Inc. | Diaminedithiol chelating agents for radiopharmaceuticals |
| EP0413766A4 (en) * | 1988-05-02 | 1991-11-21 | New England Deaconess Hospital Corporation | Synthetic peptides for arterial imaging |
| US5302700A (en) * | 1988-05-23 | 1994-04-12 | Duke University | Radiohalogenation conjugate technology |
| US4988496A (en) * | 1988-05-31 | 1991-01-29 | Neorx Corporation | Metal radionuclide chelating compounds for improved chelation kinetics |
| US5218128A (en) * | 1988-06-15 | 1993-06-08 | Centocor, Inc. | Bifunctional coupling agents and radionuclide labeled compositions prepared therefrom |
| WO1989012680A1 (en) * | 1988-06-20 | 1989-12-28 | Washington University | USE OF MODIFIED tPA TO DETECT BLOOD CLOTS |
| KR0143906B1 (ko) | 1988-06-23 | 1998-07-15 | 미리암 디 메코너헤이 | 촉매 처리된 불화수소화 방법 |
| WO1990001169A1 (en) * | 1988-07-26 | 1990-02-08 | Szekely Levente | Device for measuring and recording acceleration data |
| US4925648A (en) * | 1988-07-29 | 1990-05-15 | Immunomedics, Inc. | Detection and treatment of infectious and inflammatory lesions |
| ATE172796T1 (de) | 1988-08-03 | 1998-11-15 | Univ California | Sonde für hohe auflösung nmr mit wiederorientierung der muster |
| US5169933A (en) * | 1988-08-15 | 1992-12-08 | Neorx Corporation | Covalently-linked complexes and methods for enhanced cytotoxicity and imaging |
| US5180816A (en) * | 1988-08-24 | 1993-01-19 | Centocor | One vial method for labeling protein/linker conjugates with technetium-99M |
| WO1990003798A2 (en) * | 1988-10-04 | 1990-04-19 | Cancer Research Campaign Technology Limited | Targetting agents |
| US5196510A (en) * | 1988-12-29 | 1993-03-23 | Cytogen Corporation | Molecular recognition units |
| US4986979A (en) * | 1989-03-14 | 1991-01-22 | Neorx Corporation | Imaging tissue sites of inflammation |
| EP0403243B1 (en) * | 1989-06-16 | 1995-11-08 | Merck Frosst Canada Inc. | Chelate derivatives of atrial natriuretic factor (ANF) |
| GB8914020D0 (en) * | 1989-06-19 | 1989-08-09 | Antisoma Ltd | Synthetic peptides for use in thrombus detection |
| DK0436005T3 (da) * | 1989-07-20 | 1995-07-03 | Sandoz Ltd | Mærkede polypeptidderivater |
| FR2650672A1 (fr) * | 1989-08-02 | 1991-02-08 | Medgenix Group Sa | Procede de marquage de proteines ou polypeptides au technetium-99m, conjugue obtenu, utilisation a titre d'agent d'imagerie, kit de reconstitution desdits conjugues |
| US4961869A (en) * | 1989-08-03 | 1990-10-09 | E. I. Du Pont De Nemours And Company | Ternary azeotropic compositions of 2,3-dichloro-1,1,1,3,3-pentafluoropropane with trans-1,2-dichloroethylene and methanol |
| US5443816A (en) | 1990-08-08 | 1995-08-22 | Rhomed Incorporated | Peptide-metal ion pharmaceutical preparation and method |
| US5196404B1 (en) * | 1989-08-18 | 1996-09-10 | Biogen Inc | Inhibitors of thrombin |
| IL97459A0 (en) * | 1990-03-09 | 1992-06-21 | Hybritech Inc | Trifunctional antibody-like compounds as a combined diagnostic and therapeutic agent |
| US5273743A (en) * | 1990-03-09 | 1993-12-28 | Hybritech Incorporated | Trifunctional antibody-like compounds as a combined diagnostic and therapeutic agent |
| GB9012995D0 (en) * | 1990-06-11 | 1990-08-01 | Celltech Ltd | Multivalent antigen-binding proteins |
| WO1992005154A1 (en) * | 1990-09-14 | 1992-04-02 | Mallinckrodt Medical, Inc. | Novel nitrogen-sulfur ligands useful in radiographic imaging agents |
| DE69230525T2 (de) * | 1991-02-08 | 2000-06-21 | Diatide, Inc. | Technetium-99m markierte Polypeptide zur Bildformung |
| US5997844A (en) * | 1991-02-08 | 1999-12-07 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
| US5736122A (en) * | 1991-02-08 | 1998-04-07 | Diatide, Inc. | Technetium-99m labeled peptides for thrombus imaging |
| US5830856A (en) * | 1991-02-08 | 1998-11-03 | Diatide, Inc. | Radiolabeled compounds for thrombus imaging |
| US5965107A (en) * | 1992-03-13 | 1999-10-12 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
| US5443815A (en) * | 1991-11-27 | 1995-08-22 | Diatech, Inc. | Technetium-99m labeled peptides for imaging |
| US5552525A (en) * | 1991-02-08 | 1996-09-03 | Diatech Inc. | Technetium-99m labeled peptides for imaging inflammation |
| US5645815A (en) * | 1991-02-08 | 1997-07-08 | Diatide, Inc. | Radiolabled compounds for thrombus imaging |
| US6019958A (en) * | 1991-02-08 | 2000-02-01 | Diatide, Inc. | Technetium-99m labeled peptides for imaging inflammation |
| US6107459A (en) * | 1991-02-08 | 2000-08-22 | Diatide, Inc. | Technetium-99m labeled peptides for diagnostic imaging |
| US5561220A (en) * | 1991-02-08 | 1996-10-01 | Diatech, Inc. | Technetium-99m labeled peptides for imaging inflammation |
| US5225180A (en) * | 1991-09-10 | 1993-07-06 | Diatech, Inc. | Technetium-99m labeled somatostatin-derived peptides for imaging |
| US5300280A (en) * | 1992-02-14 | 1994-04-05 | Mallinckrodt Medical, Inc. | Stabilized radiopharmaceutical kits |
| US5989519A (en) * | 1992-03-13 | 1999-11-23 | Diatide, Inc. | Technetium-99m labeled peptides for imaging inflammation |
| WO1993017719A1 (en) * | 1992-03-13 | 1993-09-16 | Diatech, Inc. | TECHNETIUM-99m LABELED PEPTIDES FOR IMAGING INFLAMMATION |
| US5326856A (en) * | 1992-04-09 | 1994-07-05 | Cytogen Corporation | Bifunctional isothiocyanate derived thiocarbonyls as ligands for metal binding |
| US5508020A (en) * | 1992-06-05 | 1996-04-16 | Diatech, Inc. | Technetium-99M labeled peptides for imaging |
| EP0641222B1 (en) * | 1992-05-21 | 2000-09-06 | Diatide, Inc. | TECHNETIUM-99m LABELED PEPTIDES FOR THROMBUS IMAGING |
| US5968476A (en) * | 1992-05-21 | 1999-10-19 | Diatide, Inc. | Technetium-99m labeled peptides for thrombus imaging |
| US5620675A (en) * | 1992-06-23 | 1997-04-15 | Diatech, Inc. | Radioactive peptides |
| DE69332203T2 (de) * | 1992-10-02 | 2003-05-28 | Diatide, Inc. | Multimerische mehrzweckwirkstoffe gegen thrombose |
| US6056940A (en) * | 1993-04-08 | 2000-05-02 | Diatide, Inc. | Radiolabeled compounds for thrombus imaging |
| US5951964A (en) * | 1993-06-04 | 1999-09-14 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
| CN1087955C (zh) * | 1994-05-02 | 2002-07-24 | 迪亚太德公司 | 锝-99m标记的成像剂 |
-
1992
- 1992-06-05 US US07/893,981 patent/US5508020A/en not_active Expired - Lifetime
-
1993
- 1993-06-04 AU AU45287/93A patent/AU688264B2/en not_active Ceased
- 1993-06-04 CA CA002137009A patent/CA2137009C/en not_active Expired - Fee Related
- 1993-06-04 ES ES93915221T patent/ES2105292T3/es not_active Expired - Lifetime
- 1993-06-04 DE DE69310733T patent/DE69310733T2/de not_active Expired - Fee Related
- 1993-06-04 DK DK93915221.1T patent/DK0644778T3/da active
- 1993-06-04 EP EP93915221A patent/EP0644778B1/en not_active Revoked
- 1993-06-04 WO PCT/US1993/005372 patent/WO1993025244A1/en not_active Ceased
- 1993-06-04 AT AT93915221T patent/ATE152918T1/de not_active IP Right Cessation
- 1993-06-04 JP JP6501622A patent/JP2954354B2/ja not_active Expired - Lifetime
-
1995
- 1995-06-06 US US08/469,858 patent/US5976494A/en not_active Expired - Fee Related
- 1995-06-06 US US08/467,567 patent/US6113878A/en not_active Expired - Fee Related
-
1997
- 1997-07-08 US US08/889,212 patent/US6667389B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU688264B2 (en) | 1998-03-12 |
| US5976494A (en) | 1999-11-02 |
| DE69310733D1 (de) | 1997-06-19 |
| EP0644778A1 (en) | 1995-03-29 |
| JPH07506592A (ja) | 1995-07-20 |
| HK1007685A1 (en) | 1999-04-23 |
| US6113878A (en) | 2000-09-05 |
| CA2137009A1 (en) | 1993-12-23 |
| CA2137009C (en) | 2001-11-27 |
| AU4528793A (en) | 1994-01-04 |
| US5508020A (en) | 1996-04-16 |
| ATE152918T1 (de) | 1997-05-15 |
| DK0644778T3 (da) | 1997-11-03 |
| DE69310733T2 (de) | 1997-10-30 |
| EP0644778B1 (en) | 1997-05-14 |
| WO1993025244A1 (en) | 1993-12-23 |
| US6667389B1 (en) | 2003-12-23 |
| JP2954354B2 (ja) | 1999-09-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2105292T3 (es) | Peptidos marcados con tecnecio-99m para obtencion de imagenes. | |
| CA2111863A1 (en) | Technetium-99m labeled peptides for imaging | |
| ES2194846T3 (es) | Peptidos marcados con tecnecio-99m para obtencion de imagenes de inflamacion. | |
| DE69329382D1 (de) | Technetium-99m markierte peptide zur bilderzeugung von thrombus | |
| ES2083368T3 (es) | Utilizacion de disolventes de hidrocarburos halogenados como agentes de limpieza. | |
| CA2156390A1 (en) | Technetium-99m labeled peptides for diagnostic imaging | |
| DK0649434T3 (da) | Radioaktivt mærkede somatostatin-afledte peptider til billeddannende og terapeutiske anvendelser | |
| PT762901E (pt) | Peptidos marcados com tecnecio-99m para imagiologia. | |
| ES2091235T3 (es) | Procedimiento de reajuste sobre una trayectoria teorica para un vehiculo, modificando la curvatura de la trayectoria real. | |
| BR9105691A (pt) | Mecanismo sincronizador do tipo de pino para transmissao | |
| DE3854283D1 (de) | Direkt-abbildendes monochromatisches Elektronenmikroskop. | |
| ATA81590A (de) | Wechselschild | |
| DE69220622D1 (de) | Doppelt ausgelöstes Integrationsschema für Elektronenstrahltester | |
| AR018546A1 (es) | Reactivo precursor y composicion farmaceutica que lo comprende | |
| ES2083416T3 (es) | Hexahidro-1h-quino(4,3,2-ef)(1,4)benzoxazepinas y compuestos relacionados, un procedimiento y compuestos intermedios para su preparacion y su uso como medicamentos. | |
| ITRE920004A0 (it) | Bambola con parti anatomiche intercambiabili | |
| IT223673Z2 (it) | Compasso con strumenti da disegno intercambiabili | |
| BR6701836U (pt) | Estojo de ferramentas para chaveiro | |
| IT7964362U1 (it) | Collana con pendaglio intercambiabile | |
| BR7202022U (pt) | Kit enxoval para bonecas | |
| IT1267551B1 (it) | Cassaforma modulare per lo stampaggio di utensili abrasivi per la lavorazione di materiali lapidei | |
| BR9302516A (pt) | Estribo com engate rápido para armação de ferragens utilizado na construção civil | |
| BR7702196U (pt) | Manequim odontológico para uso educacional | |
| GB8318872D0 (en) | Interchangeable jaw pliers | |
| ES1011184Y (es) | Lupa para instrumentos manuales. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
Ref document number: 644778 Country of ref document: ES |