ES2105292T3 - Peptidos marcados con tecnecio-99m para obtencion de imagenes. - Google Patents
Peptidos marcados con tecnecio-99m para obtencion de imagenes.Info
- Publication number
- ES2105292T3 ES2105292T3 ES93915221T ES93915221T ES2105292T3 ES 2105292 T3 ES2105292 T3 ES 2105292T3 ES 93915221 T ES93915221 T ES 93915221T ES 93915221 T ES93915221 T ES 93915221T ES 2105292 T3 ES2105292 T3 ES 2105292T3
- Authority
- ES
- Spain
- Prior art keywords
- reagents
- union
- peptides
- specific
- tecnecio
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/082—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being a RGD-containing peptide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
ESTA INVENCION DESCRIBE REACTIVOS RADIOMARCADOS, INCLUYENDO SUS CASOS DE PEPTIDOS DE UNION ESPECIFICA, Y LOS METODOS PARA PRODUCIR Y APLICAR TALES REACTIVOS. ESPECIFICAMENTE, LA INVENCION DESCRIBE LOS REACTIVOS PARA PREPARAR AGENTES DE REPRESENTACION DE IMAGENES ESCINTOGRAFICAS PARA SITIOS DE REPRESENTACION DE IMAGENES EN UN CUERPO DE MAMIFERO. SE DESCRIBEN LOS REACTIVOS, LOS METODOS Y LAS HERRAMIENTAS PARA HACER TALES REACTIVOS, Y LOS METODOS PARA APLICAR TALES REACTIVOS MARCADOS CON TECNECIO-99M (TC-99M) POR PARTES DE UNION DE TC-99M QUE COMPRENDE DICHOS REACTIVOS. EN PARTICULAR, LOS PEPTIDOS DE UNION ESPECIFICA Y LAS PARTES DE UNION DE TC-99M QUE COMPRENDE LOS REACTIVOS DE LA INVENCION ESTAN UNIDOS COVALENTEMENTE A UNA PARTE LIGADORA POLIVALENTE, TAL QUE LA PARTE LIGADORA POLIVALENTE ESTA LIGADA COVALENTEMENTE A UNA MULTIPLICIDAD DE LOS PEPTIDOS DE UNION ESPECIFICA, Y LAS PARTES DE UNION DE TC-99M SON COVALENTEMENTE LIGADAS A UNA PLURALIDAD DE PEPTIDOS DE UNION ESPECIFICA, LA PARTE LIGADORA POLIVALENTE O A AMBOS PEPTIDOS DE UNION ESPECIFICA Y PARTE LIGADORA POLIVALENTE.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/893,981 US5508020A (en) | 1992-06-05 | 1992-06-05 | Technetium-99M labeled peptides for imaging |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2105292T3 true ES2105292T3 (es) | 1997-10-16 |
Family
ID=25402435
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES93915221T Expired - Lifetime ES2105292T3 (es) | 1992-06-05 | 1993-06-04 | Peptidos marcados con tecnecio-99m para obtencion de imagenes. |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US5508020A (es) |
| EP (1) | EP0644778B1 (es) |
| JP (1) | JP2954354B2 (es) |
| AT (1) | ATE152918T1 (es) |
| AU (1) | AU688264B2 (es) |
| CA (1) | CA2137009C (es) |
| DE (1) | DE69310733T2 (es) |
| DK (1) | DK0644778T3 (es) |
| ES (1) | ES2105292T3 (es) |
| HK (1) | HK1007685A1 (es) |
| WO (1) | WO1993025244A1 (es) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5792444A (en) * | 1989-05-09 | 1998-08-11 | The General Hospital Corporation | Labeled chemotactic peptides to image focal sites of infection or inflammation |
| US5700444A (en) * | 1992-02-20 | 1997-12-23 | Rhomed Incorporated | Chemotactic peptide pharmaceutical applications |
| US5759515A (en) * | 1989-08-09 | 1998-06-02 | Rhomed Incorporated | Polyvalent peptide pharmaceutical applications |
| US5443816A (en) * | 1990-08-08 | 1995-08-22 | Rhomed Incorporated | Peptide-metal ion pharmaceutical preparation and method |
| US5997844A (en) * | 1991-02-08 | 1999-12-07 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
| US5443815A (en) * | 1991-11-27 | 1995-08-22 | Diatech, Inc. | Technetium-99m labeled peptides for imaging |
| US5965107A (en) * | 1992-03-13 | 1999-10-12 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
| US5552525A (en) * | 1991-02-08 | 1996-09-03 | Diatech Inc. | Technetium-99m labeled peptides for imaging inflammation |
| JP2774378B2 (ja) * | 1991-02-08 | 1998-07-09 | ダイアテク,インコーポレイテッド | 映像用テクネチウム−99m標識化ポリペプチド |
| US6019958A (en) * | 1991-02-08 | 2000-02-01 | Diatide, Inc. | Technetium-99m labeled peptides for imaging inflammation |
| US5830856A (en) * | 1991-02-08 | 1998-11-03 | Diatide, Inc. | Radiolabeled compounds for thrombus imaging |
| US5645815A (en) * | 1991-02-08 | 1997-07-08 | Diatide, Inc. | Radiolabled compounds for thrombus imaging |
| US5736122A (en) * | 1991-02-08 | 1998-04-07 | Diatide, Inc. | Technetium-99m labeled peptides for thrombus imaging |
| US5849261A (en) * | 1991-02-08 | 1998-12-15 | Diatide, Inc. | Radiolabeled vasoactive intestinal peptides for diagnosis and therapy |
| US5783170A (en) * | 1991-11-27 | 1998-07-21 | Diatide, Inc. | Peptide-metal chelate conjugates |
| US5556609A (en) * | 1992-02-20 | 1996-09-17 | Rhomed Incorporated | YIGSR peptide radiopharmaceutical applications |
| US5738838A (en) * | 1992-02-20 | 1998-04-14 | Rhomed Incorporated | IKVAV peptide radiopharmaceutical applications |
| DE69332879T2 (de) * | 1992-03-13 | 2004-02-19 | Diatide, Inc. | Technetium-99-markierte peptide zur visualisierung vom entzuendungen |
| US5989519A (en) * | 1992-03-13 | 1999-11-23 | Diatide, Inc. | Technetium-99m labeled peptides for imaging inflammation |
| AU687080B2 (en) * | 1993-04-08 | 1998-02-19 | Cis Bio International | Radiolabeled compounds for thrombus imaging |
| AU709306B2 (en) * | 1992-04-30 | 1999-08-26 | Cis Bio International | Radiolabeled compounds for thrombus imaging |
| US5508020A (en) * | 1992-06-05 | 1996-04-16 | Diatech, Inc. | Technetium-99M labeled peptides for imaging |
| US5968476A (en) * | 1992-05-21 | 1999-10-19 | Diatide, Inc. | Technetium-99m labeled peptides for thrombus imaging |
| US6017512A (en) * | 1992-06-23 | 2000-01-25 | Diatide, Inc. | Radiolabeled peptides |
| US5716596A (en) * | 1992-06-23 | 1998-02-10 | Diatide, Inc. | Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses |
| US5620675A (en) | 1992-06-23 | 1997-04-15 | Diatech, Inc. | Radioactive peptides |
| AU696206B2 (en) * | 1992-10-02 | 1998-09-03 | Cis Bio International | Multimeric polyvalent antithrombotic agents |
| DK0788377T3 (da) * | 1993-07-28 | 2000-12-27 | Diatide Inc | Radiomærkede glucaner |
| CA2179990A1 (en) * | 1994-01-12 | 1995-07-20 | Gary Robert Bower | Biological targeting agents |
| US5569745A (en) * | 1994-02-25 | 1996-10-29 | Resolution Pharmaceuticals Inc. | Peptide-Chelator conjugates |
| WO1995025720A1 (en) * | 1994-03-18 | 1995-09-28 | Diatech, Inc. | Piperidyl-4-substituted thyrosine derivatives as scintigraphic imaging agents for the diagnosis of thrombosis |
| US6051206A (en) * | 1994-06-03 | 2000-04-18 | Diatide, Inc | Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses |
| IL113610A0 (en) * | 1994-06-03 | 1995-08-31 | Immunomedics Inc | A method of radiolabeling a protein, radiolabeled proteins prepared thereby and diagnostic kits containing the same |
| CA2165228A1 (en) * | 1994-12-27 | 1996-06-28 | Yoshitoshi Itaya | Metal chelate forming peptides and use thereof |
| US5891418A (en) * | 1995-06-07 | 1999-04-06 | Rhomed Incorporated | Peptide-metal ion pharmaceutical constructs and applications |
| US6331285B1 (en) | 1996-06-05 | 2001-12-18 | Palatin Technologies, Inc. | Structurally determined cyclic metallo-constructs and applications |
| ATE380038T1 (de) * | 1996-07-12 | 2007-12-15 | Immunomedics Inc | Radiometall-bindende peptide analoge |
| GB9708265D0 (en) * | 1997-04-24 | 1997-06-18 | Nycomed Imaging As | Contrast agents |
| EP1905357B1 (en) | 1997-04-30 | 2012-11-28 | The Board Of Trustees Of The Leland Stanford Junior University | Method of imaging cell death in vivo |
| US6083480A (en) * | 1997-05-01 | 2000-07-04 | Diatide, Inc. | Calcitonin receptor binding reagents |
| US5886142A (en) * | 1997-05-20 | 1999-03-23 | Thomas Jefferson University | Radiolabeled thrombus imaging agents |
| US6028056A (en) * | 1998-02-06 | 2000-02-22 | Diatide, Inc. | Pharmaceutical compositions for imaging and treating thrombi |
| US6022857A (en) * | 1998-06-19 | 2000-02-08 | Diatide, Inc. | Radiolabeled compounds for thrombus imaging |
| US6254852B1 (en) | 1999-07-16 | 2001-07-03 | Dupont Pharmaceuticals Company | Porous inorganic targeted ultrasound contrast agents |
| US7385025B2 (en) | 2000-12-19 | 2008-06-10 | Palatin Technologies, Inc. | Metallopeptide compounds |
| JP2005514335A (ja) * | 2001-10-19 | 2005-05-19 | トマス ジェファソン ユニバーシティ | 腫瘍イメージング及び治療のためのpacap組成物及び方法 |
| JP4516759B2 (ja) * | 2002-04-22 | 2010-08-04 | トムソン ライセンシング | スクリーン焼付けを防止するテレビジョンディスプレイと共に用いるウェブブラウザ |
| WO2006017619A2 (en) * | 2004-08-06 | 2006-02-16 | The Regents Of The University Of California | Receptor-binding cyclic peptides and methods of use |
| AU2009246397B2 (en) | 2008-05-13 | 2013-01-17 | University Of Kansas | Metal abstraction peptide (MAP) tag and associated methods |
| HRP20170464T1 (hr) | 2011-08-17 | 2017-05-19 | Piramal Imaging Sa | Spojevi za vezanje na glikoprotein iib/iiia specifičan za trombocite i njihova upotreba u vizualiziranju ugrušaka |
| WO2013181461A2 (en) | 2012-06-01 | 2013-12-05 | University Of Kansas | Metal abstraction peptide with superoxide dismutase activity |
| EP2956461A1 (en) | 2013-02-12 | 2015-12-23 | Bayer Pharma Aktiengesellschaft | Metal chelate compounds for binding to the platelet specific glycoprotein iib/iiia |
| DE102013113156A1 (de) * | 2013-11-28 | 2015-05-28 | Freie Universität Berlin | Verbindung und Verfahren zur selektiven Radiomarkierung von Polypeptiden mittels Festphasensynthese |
Family Cites Families (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4427646A (en) * | 1981-04-02 | 1984-01-24 | Research Corporation | Use of radiolabeled peptide derived from crosslinked fibrin to locate thrombi in vivo |
| US4647447A (en) * | 1981-07-24 | 1987-03-03 | Schering Aktiengesellschaft | Diagnostic media |
| US4444690A (en) * | 1982-02-25 | 1984-04-24 | University Patents, Inc. | Technetium chelates |
| US4571430A (en) * | 1982-11-08 | 1986-02-18 | Medi-Physics, Inc. | Homocysteine and homocysteinamide derivatives |
| US4434151A (en) * | 1982-11-08 | 1984-02-28 | Medi-Physics, Inc. | Bifunctional chelating agents |
| US4575556A (en) * | 1982-11-08 | 1986-03-11 | Medi-Physics, Inc. | Bifunctional chelating agents |
| US4673562A (en) * | 1983-08-19 | 1987-06-16 | The Children's Medical Center Corporation | Bisamide bisthiol compounds useful for making technetium radiodiagnostic renal agents |
| ATE66469T1 (de) * | 1985-01-14 | 1991-09-15 | Neorx Corp | Metall-radionuklid markiertes protein fuer diagnose und therapie. |
| US4748022A (en) | 1985-03-25 | 1988-05-31 | Busciglio John A | Topical composition |
| US4746505A (en) * | 1985-04-26 | 1988-05-24 | President And Fellows Of Harvard College | Technetium radiodiagnostic fatty acids derived from bisamide bisthiol ligands |
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| WO1989012680A1 (en) * | 1988-06-20 | 1989-12-28 | Washington University | USE OF MODIFIED tPA TO DETECT BLOOD CLOTS |
| EP0420916B1 (en) | 1988-06-23 | 1993-09-29 | E.I. Du Pont De Nemours And Company | Catalyzed hydrofluorination process |
| WO1990001169A1 (en) * | 1988-07-26 | 1990-02-08 | Szekely Levente | Device for measuring and recording acceleration data |
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| JPH0816656B2 (ja) | 1988-08-03 | 1996-02-21 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 試料の再配向を伴う高分解能核磁気共鳴用プローブ |
| US5169933A (en) * | 1988-08-15 | 1992-12-08 | Neorx Corporation | Covalently-linked complexes and methods for enhanced cytotoxicity and imaging |
| US5180816A (en) * | 1988-08-24 | 1993-01-19 | Centocor | One vial method for labeling protein/linker conjugates with technetium-99M |
| JPH04500805A (ja) * | 1988-10-04 | 1992-02-13 | カンサー・リサーチ・キャンペーン・テクノロジー・リミテッド | 標的剤 |
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| US4986979A (en) * | 1989-03-14 | 1991-01-22 | Neorx Corporation | Imaging tissue sites of inflammation |
| DE69023394T2 (de) * | 1989-06-16 | 1996-07-04 | Merck Frosst Canada Inc | Chelat-Derivate von atrialnatriurethischem Faktor (ANF). |
| GB8914020D0 (en) * | 1989-06-19 | 1989-08-09 | Antisoma Ltd | Synthetic peptides for use in thrombus detection |
| ATE120374T1 (de) * | 1989-07-20 | 1995-04-15 | Sandoz Ag | Markierte polypeptidderivate. |
| FR2650672A1 (fr) * | 1989-08-02 | 1991-02-08 | Medgenix Group Sa | Procede de marquage de proteines ou polypeptides au technetium-99m, conjugue obtenu, utilisation a titre d'agent d'imagerie, kit de reconstitution desdits conjugues |
| US4961869A (en) * | 1989-08-03 | 1990-10-09 | E. I. Du Pont De Nemours And Company | Ternary azeotropic compositions of 2,3-dichloro-1,1,1,3,3-pentafluoropropane with trans-1,2-dichloroethylene and methanol |
| US5443816A (en) | 1990-08-08 | 1995-08-22 | Rhomed Incorporated | Peptide-metal ion pharmaceutical preparation and method |
| US5196404B1 (en) * | 1989-08-18 | 1996-09-10 | Biogen Inc | Inhibitors of thrombin |
| US5273743A (en) * | 1990-03-09 | 1993-12-28 | Hybritech Incorporated | Trifunctional antibody-like compounds as a combined diagnostic and therapeutic agent |
| IL97459A0 (en) * | 1990-03-09 | 1992-06-21 | Hybritech Inc | Trifunctional antibody-like compounds as a combined diagnostic and therapeutic agent |
| GB9012995D0 (en) * | 1990-06-11 | 1990-08-01 | Celltech Ltd | Multivalent antigen-binding proteins |
| AU8721591A (en) * | 1990-09-14 | 1992-04-15 | Mallinckrodt Medical, Inc. | Novel nitrogen-sulfur ligands useful in radiographic imaging agents |
| US5645815A (en) * | 1991-02-08 | 1997-07-08 | Diatide, Inc. | Radiolabled compounds for thrombus imaging |
| US5965107A (en) * | 1992-03-13 | 1999-10-12 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
| US6019958A (en) * | 1991-02-08 | 2000-02-01 | Diatide, Inc. | Technetium-99m labeled peptides for imaging inflammation |
| US5830856A (en) * | 1991-02-08 | 1998-11-03 | Diatide, Inc. | Radiolabeled compounds for thrombus imaging |
| US5561220A (en) * | 1991-02-08 | 1996-10-01 | Diatech, Inc. | Technetium-99m labeled peptides for imaging inflammation |
| US5552525A (en) * | 1991-02-08 | 1996-09-03 | Diatech Inc. | Technetium-99m labeled peptides for imaging inflammation |
| US5997844A (en) * | 1991-02-08 | 1999-12-07 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
| US6107459A (en) * | 1991-02-08 | 2000-08-22 | Diatide, Inc. | Technetium-99m labeled peptides for diagnostic imaging |
| US5443815A (en) * | 1991-11-27 | 1995-08-22 | Diatech, Inc. | Technetium-99m labeled peptides for imaging |
| JP2774378B2 (ja) * | 1991-02-08 | 1998-07-09 | ダイアテク,インコーポレイテッド | 映像用テクネチウム−99m標識化ポリペプチド |
| US5736122A (en) * | 1991-02-08 | 1998-04-07 | Diatide, Inc. | Technetium-99m labeled peptides for thrombus imaging |
| US5225180A (en) * | 1991-09-10 | 1993-07-06 | Diatech, Inc. | Technetium-99m labeled somatostatin-derived peptides for imaging |
| US5300280A (en) * | 1992-02-14 | 1994-04-05 | Mallinckrodt Medical, Inc. | Stabilized radiopharmaceutical kits |
| US5989519A (en) * | 1992-03-13 | 1999-11-23 | Diatide, Inc. | Technetium-99m labeled peptides for imaging inflammation |
| DE69332879T2 (de) * | 1992-03-13 | 2004-02-19 | Diatide, Inc. | Technetium-99-markierte peptide zur visualisierung vom entzuendungen |
| US5326856A (en) * | 1992-04-09 | 1994-07-05 | Cytogen Corporation | Bifunctional isothiocyanate derived thiocarbonyls as ligands for metal binding |
| AU687080B2 (en) * | 1993-04-08 | 1998-02-19 | Cis Bio International | Radiolabeled compounds for thrombus imaging |
| US5508020A (en) * | 1992-06-05 | 1996-04-16 | Diatech, Inc. | Technetium-99M labeled peptides for imaging |
| US5968476A (en) * | 1992-05-21 | 1999-10-19 | Diatide, Inc. | Technetium-99m labeled peptides for thrombus imaging |
| DE69334033D1 (de) * | 1992-05-21 | 2006-07-27 | Diatide Inc | Technetium-99M markierte Peptide zur Bilderzeugung von Thrombus |
| US5620675A (en) * | 1992-06-23 | 1997-04-15 | Diatech, Inc. | Radioactive peptides |
| AU696206B2 (en) * | 1992-10-02 | 1998-09-03 | Cis Bio International | Multimeric polyvalent antithrombotic agents |
| US5951964A (en) * | 1993-06-04 | 1999-09-14 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
| EP0772459B1 (en) * | 1994-05-02 | 2003-03-19 | Diatide, Inc. | TECHNETIUM-99m LABELED IMAGING AGENTS |
-
1992
- 1992-06-05 US US07/893,981 patent/US5508020A/en not_active Expired - Lifetime
-
1993
- 1993-06-04 ES ES93915221T patent/ES2105292T3/es not_active Expired - Lifetime
- 1993-06-04 AU AU45287/93A patent/AU688264B2/en not_active Ceased
- 1993-06-04 EP EP93915221A patent/EP0644778B1/en not_active Revoked
- 1993-06-04 JP JP6501622A patent/JP2954354B2/ja not_active Expired - Lifetime
- 1993-06-04 WO PCT/US1993/005372 patent/WO1993025244A1/en not_active Ceased
- 1993-06-04 DE DE69310733T patent/DE69310733T2/de not_active Expired - Fee Related
- 1993-06-04 CA CA002137009A patent/CA2137009C/en not_active Expired - Fee Related
- 1993-06-04 AT AT93915221T patent/ATE152918T1/de not_active IP Right Cessation
- 1993-06-04 HK HK98106974A patent/HK1007685A1/en not_active IP Right Cessation
- 1993-06-04 DK DK93915221.1T patent/DK0644778T3/da active
-
1995
- 1995-06-06 US US08/467,567 patent/US6113878A/en not_active Expired - Fee Related
- 1995-06-06 US US08/469,858 patent/US5976494A/en not_active Expired - Fee Related
-
1997
- 1997-07-08 US US08/889,212 patent/US6667389B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2137009A1 (en) | 1993-12-23 |
| AU688264B2 (en) | 1998-03-12 |
| EP0644778B1 (en) | 1997-05-14 |
| US6667389B1 (en) | 2003-12-23 |
| US6113878A (en) | 2000-09-05 |
| JPH07506592A (ja) | 1995-07-20 |
| DE69310733D1 (de) | 1997-06-19 |
| JP2954354B2 (ja) | 1999-09-27 |
| WO1993025244A1 (en) | 1993-12-23 |
| DK0644778T3 (da) | 1997-11-03 |
| DE69310733T2 (de) | 1997-10-30 |
| AU4528793A (en) | 1994-01-04 |
| US5976494A (en) | 1999-11-02 |
| HK1007685A1 (en) | 1999-04-23 |
| ATE152918T1 (de) | 1997-05-15 |
| US5508020A (en) | 1996-04-16 |
| EP0644778A1 (en) | 1995-03-29 |
| CA2137009C (en) | 2001-11-27 |
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