DK0644778T3 - Technetium-99-mærkede peptider til imagografi - Google Patents
Technetium-99-mærkede peptider til imagografiInfo
- Publication number
- DK0644778T3 DK0644778T3 DK93915221.1T DK93915221T DK0644778T3 DK 0644778 T3 DK0644778 T3 DK 0644778T3 DK 93915221 T DK93915221 T DK 93915221T DK 0644778 T3 DK0644778 T3 DK 0644778T3
- Authority
- DK
- Denmark
- Prior art keywords
- peptides
- technetium
- linker moiety
- binding
- polyvalent linker
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 10
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 9
- GKLVYJBZJHMRIY-OUBTZVSYSA-N Technetium-99 Chemical compound [99Tc] GKLVYJBZJHMRIY-OUBTZVSYSA-N 0.000 title abstract 2
- 238000003384 imaging method Methods 0.000 title 1
- 125000005647 linker group Chemical group 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 3
- 230000009870 specific binding Effects 0.000 abstract 3
- 230000027455 binding Effects 0.000 abstract 2
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 229940056501 technetium 99m Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/082—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being a RGD-containing peptide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/893,981 US5508020A (en) | 1992-06-05 | 1992-06-05 | Technetium-99M labeled peptides for imaging |
| PCT/US1993/005372 WO1993025244A1 (en) | 1992-06-05 | 1993-06-04 | TECHNETIUM-99m LABELED PEPTIDES FOR IMAGING |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0644778T3 true DK0644778T3 (da) | 1997-11-03 |
Family
ID=25402435
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK93915221.1T DK0644778T3 (da) | 1992-06-05 | 1993-06-04 | Technetium-99-mærkede peptider til imagografi |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US5508020A (da) |
| EP (1) | EP0644778B1 (da) |
| JP (1) | JP2954354B2 (da) |
| AT (1) | ATE152918T1 (da) |
| AU (1) | AU688264B2 (da) |
| CA (1) | CA2137009C (da) |
| DE (1) | DE69310733T2 (da) |
| DK (1) | DK0644778T3 (da) |
| ES (1) | ES2105292T3 (da) |
| WO (1) | WO1993025244A1 (da) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5792444A (en) * | 1989-05-09 | 1998-08-11 | The General Hospital Corporation | Labeled chemotactic peptides to image focal sites of infection or inflammation |
| US5700444A (en) * | 1992-02-20 | 1997-12-23 | Rhomed Incorporated | Chemotactic peptide pharmaceutical applications |
| US5759515A (en) * | 1989-08-09 | 1998-06-02 | Rhomed Incorporated | Polyvalent peptide pharmaceutical applications |
| US5443816A (en) * | 1990-08-08 | 1995-08-22 | Rhomed Incorporated | Peptide-metal ion pharmaceutical preparation and method |
| US5443815A (en) * | 1991-11-27 | 1995-08-22 | Diatech, Inc. | Technetium-99m labeled peptides for imaging |
| US5997844A (en) * | 1991-02-08 | 1999-12-07 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
| US5736122A (en) * | 1991-02-08 | 1998-04-07 | Diatide, Inc. | Technetium-99m labeled peptides for thrombus imaging |
| US5552525A (en) * | 1991-02-08 | 1996-09-03 | Diatech Inc. | Technetium-99m labeled peptides for imaging inflammation |
| US5645815A (en) * | 1991-02-08 | 1997-07-08 | Diatide, Inc. | Radiolabled compounds for thrombus imaging |
| US5830856A (en) * | 1991-02-08 | 1998-11-03 | Diatide, Inc. | Radiolabeled compounds for thrombus imaging |
| US6019958A (en) * | 1991-02-08 | 2000-02-01 | Diatide, Inc. | Technetium-99m labeled peptides for imaging inflammation |
| US5965107A (en) * | 1992-03-13 | 1999-10-12 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
| US5849261A (en) * | 1991-02-08 | 1998-12-15 | Diatide, Inc. | Radiolabeled vasoactive intestinal peptides for diagnosis and therapy |
| DE69230525T2 (de) * | 1991-02-08 | 2000-06-21 | Diatide, Inc. | Technetium-99m markierte Polypeptide zur Bildformung |
| US5783170A (en) * | 1991-11-27 | 1998-07-21 | Diatide, Inc. | Peptide-metal chelate conjugates |
| US5556609A (en) * | 1992-02-20 | 1996-09-17 | Rhomed Incorporated | YIGSR peptide radiopharmaceutical applications |
| US5738838A (en) * | 1992-02-20 | 1998-04-14 | Rhomed Incorporated | IKVAV peptide radiopharmaceutical applications |
| WO1993017719A1 (en) * | 1992-03-13 | 1993-09-16 | Diatech, Inc. | TECHNETIUM-99m LABELED PEPTIDES FOR IMAGING INFLAMMATION |
| US5989519A (en) * | 1992-03-13 | 1999-11-23 | Diatide, Inc. | Technetium-99m labeled peptides for imaging inflammation |
| AU709306B2 (en) * | 1992-04-30 | 1999-08-26 | Cis Bio International | Radiolabeled compounds for thrombus imaging |
| US5508020A (en) * | 1992-06-05 | 1996-04-16 | Diatech, Inc. | Technetium-99M labeled peptides for imaging |
| US5968476A (en) * | 1992-05-21 | 1999-10-19 | Diatide, Inc. | Technetium-99m labeled peptides for thrombus imaging |
| US5716596A (en) * | 1992-06-23 | 1998-02-10 | Diatide, Inc. | Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses |
| US5620675A (en) | 1992-06-23 | 1997-04-15 | Diatech, Inc. | Radioactive peptides |
| US6017512A (en) * | 1992-06-23 | 2000-01-25 | Diatide, Inc. | Radiolabeled peptides |
| DE69332203T2 (de) * | 1992-10-02 | 2003-05-28 | Diatide, Inc. | Multimerische mehrzweckwirkstoffe gegen thrombose |
| US6056940A (en) * | 1993-04-08 | 2000-05-02 | Diatide, Inc. | Radiolabeled compounds for thrombus imaging |
| AU698176B2 (en) * | 1993-07-28 | 1998-10-29 | Cis Bio International | Radiolabelled glucans |
| CA2179990A1 (en) * | 1994-01-12 | 1995-07-20 | Gary Robert Bower | Biological targeting agents |
| US5569745A (en) * | 1994-02-25 | 1996-10-29 | Resolution Pharmaceuticals Inc. | Peptide-Chelator conjugates |
| DK0750610T3 (da) * | 1994-03-18 | 2002-03-11 | Diatide Inc | Piperidyl-4-substituerede tyrosinderivater som scintigrafiske billedfrembringende midler til diagnose af thrombose |
| IL113610A0 (en) * | 1994-06-03 | 1995-08-31 | Immunomedics Inc | A method of radiolabeling a protein, radiolabeled proteins prepared thereby and diagnostic kits containing the same |
| US6051206A (en) * | 1994-06-03 | 2000-04-18 | Diatide, Inc | Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses |
| CA2165228A1 (en) * | 1994-12-27 | 1996-06-28 | Yoshitoshi Itaya | Metal chelate forming peptides and use thereof |
| US5891418A (en) * | 1995-06-07 | 1999-04-06 | Rhomed Incorporated | Peptide-metal ion pharmaceutical constructs and applications |
| US6331285B1 (en) | 1996-06-05 | 2001-12-18 | Palatin Technologies, Inc. | Structurally determined cyclic metallo-constructs and applications |
| EP0975374B1 (en) * | 1996-07-12 | 2007-12-05 | Immunomedics, Inc. | Radiometal-binding peptide analogues |
| GB9708265D0 (en) * | 1997-04-24 | 1997-06-18 | Nycomed Imaging As | Contrast agents |
| EP1905357B1 (en) | 1997-04-30 | 2012-11-28 | The Board Of Trustees Of The Leland Stanford Junior University | Method of imaging cell death in vivo |
| US6083480A (en) * | 1997-05-01 | 2000-07-04 | Diatide, Inc. | Calcitonin receptor binding reagents |
| US5886142A (en) * | 1997-05-20 | 1999-03-23 | Thomas Jefferson University | Radiolabeled thrombus imaging agents |
| US6028056A (en) * | 1998-02-06 | 2000-02-22 | Diatide, Inc. | Pharmaceutical compositions for imaging and treating thrombi |
| US6022857A (en) * | 1998-06-19 | 2000-02-08 | Diatide, Inc. | Radiolabeled compounds for thrombus imaging |
| US6254852B1 (en) | 1999-07-16 | 2001-07-03 | Dupont Pharmaceuticals Company | Porous inorganic targeted ultrasound contrast agents |
| US7385025B2 (en) | 2000-12-19 | 2008-06-10 | Palatin Technologies, Inc. | Metallopeptide compounds |
| WO2003033030A1 (en) * | 2001-10-19 | 2003-04-24 | Thomas Jefferson University | Pacap compositions and methods for tumor imaging and therapy |
| AU2003225023A1 (en) * | 2002-04-22 | 2003-11-03 | Thomson Licensing S.A. | A web browser for use with a television display for preventing screen burn |
| US20060029544A1 (en) * | 2004-08-06 | 2006-02-09 | The Regents Of The University Of California Office Of Technology Transfer | Receptor-binding cyclic peptides and methods of use |
| CN102088991A (zh) | 2008-05-13 | 2011-06-08 | 堪萨斯大学 | 金属提取肽标签和相关方法 |
| JP6243335B2 (ja) | 2011-08-17 | 2017-12-06 | ピラマル イメージング ソシエテ アノニム | 血小板固有の糖タンパク質IIb/IIIaに結合する化合物と血栓造影のためのその使用 |
| US9187735B2 (en) | 2012-06-01 | 2015-11-17 | University Of Kansas | Metal abstraction peptide with superoxide dismutase activity |
| CA2900595A1 (en) | 2013-02-12 | 2014-08-21 | Bayer Pharma Aktiengesellschaft | Metal chelate compounds for binding to the platelet specific glycoprotein iib/iiia |
| DE102013113156A1 (de) * | 2013-11-28 | 2015-05-28 | Freie Universität Berlin | Verbindung und Verfahren zur selektiven Radiomarkierung von Polypeptiden mittels Festphasensynthese |
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|---|---|---|---|---|
| US4427646A (en) * | 1981-04-02 | 1984-01-24 | Research Corporation | Use of radiolabeled peptide derived from crosslinked fibrin to locate thrombi in vivo |
| US4647447A (en) * | 1981-07-24 | 1987-03-03 | Schering Aktiengesellschaft | Diagnostic media |
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| US4673562A (en) * | 1983-08-19 | 1987-06-16 | The Children's Medical Center Corporation | Bisamide bisthiol compounds useful for making technetium radiodiagnostic renal agents |
| ATE66469T1 (de) * | 1985-01-14 | 1991-09-15 | Neorx Corp | Metall-radionuklid markiertes protein fuer diagnose und therapie. |
| US4748022A (en) | 1985-03-25 | 1988-05-31 | Busciglio John A | Topical composition |
| US4746505A (en) * | 1985-04-26 | 1988-05-24 | President And Fellows Of Harvard College | Technetium radiodiagnostic fatty acids derived from bisamide bisthiol ligands |
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| GB8914020D0 (en) * | 1989-06-19 | 1989-08-09 | Antisoma Ltd | Synthetic peptides for use in thrombus detection |
| DK0436005T3 (da) * | 1989-07-20 | 1995-07-03 | Sandoz Ltd | Mærkede polypeptidderivater |
| FR2650672A1 (fr) * | 1989-08-02 | 1991-02-08 | Medgenix Group Sa | Procede de marquage de proteines ou polypeptides au technetium-99m, conjugue obtenu, utilisation a titre d'agent d'imagerie, kit de reconstitution desdits conjugues |
| US4961869A (en) * | 1989-08-03 | 1990-10-09 | E. I. Du Pont De Nemours And Company | Ternary azeotropic compositions of 2,3-dichloro-1,1,1,3,3-pentafluoropropane with trans-1,2-dichloroethylene and methanol |
| US5443816A (en) | 1990-08-08 | 1995-08-22 | Rhomed Incorporated | Peptide-metal ion pharmaceutical preparation and method |
| US5196404B1 (en) * | 1989-08-18 | 1996-09-10 | Biogen Inc | Inhibitors of thrombin |
| IL97459A0 (en) * | 1990-03-09 | 1992-06-21 | Hybritech Inc | Trifunctional antibody-like compounds as a combined diagnostic and therapeutic agent |
| US5273743A (en) * | 1990-03-09 | 1993-12-28 | Hybritech Incorporated | Trifunctional antibody-like compounds as a combined diagnostic and therapeutic agent |
| GB9012995D0 (en) * | 1990-06-11 | 1990-08-01 | Celltech Ltd | Multivalent antigen-binding proteins |
| WO1992005154A1 (en) * | 1990-09-14 | 1992-04-02 | Mallinckrodt Medical, Inc. | Novel nitrogen-sulfur ligands useful in radiographic imaging agents |
| DE69230525T2 (de) * | 1991-02-08 | 2000-06-21 | Diatide, Inc. | Technetium-99m markierte Polypeptide zur Bildformung |
| US5997844A (en) * | 1991-02-08 | 1999-12-07 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
| US5736122A (en) * | 1991-02-08 | 1998-04-07 | Diatide, Inc. | Technetium-99m labeled peptides for thrombus imaging |
| US5830856A (en) * | 1991-02-08 | 1998-11-03 | Diatide, Inc. | Radiolabeled compounds for thrombus imaging |
| US5965107A (en) * | 1992-03-13 | 1999-10-12 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
| US5443815A (en) * | 1991-11-27 | 1995-08-22 | Diatech, Inc. | Technetium-99m labeled peptides for imaging |
| US5552525A (en) * | 1991-02-08 | 1996-09-03 | Diatech Inc. | Technetium-99m labeled peptides for imaging inflammation |
| US5645815A (en) * | 1991-02-08 | 1997-07-08 | Diatide, Inc. | Radiolabled compounds for thrombus imaging |
| US6019958A (en) * | 1991-02-08 | 2000-02-01 | Diatide, Inc. | Technetium-99m labeled peptides for imaging inflammation |
| US6107459A (en) * | 1991-02-08 | 2000-08-22 | Diatide, Inc. | Technetium-99m labeled peptides for diagnostic imaging |
| US5561220A (en) * | 1991-02-08 | 1996-10-01 | Diatech, Inc. | Technetium-99m labeled peptides for imaging inflammation |
| US5225180A (en) * | 1991-09-10 | 1993-07-06 | Diatech, Inc. | Technetium-99m labeled somatostatin-derived peptides for imaging |
| US5300280A (en) * | 1992-02-14 | 1994-04-05 | Mallinckrodt Medical, Inc. | Stabilized radiopharmaceutical kits |
| US5989519A (en) * | 1992-03-13 | 1999-11-23 | Diatide, Inc. | Technetium-99m labeled peptides for imaging inflammation |
| WO1993017719A1 (en) * | 1992-03-13 | 1993-09-16 | Diatech, Inc. | TECHNETIUM-99m LABELED PEPTIDES FOR IMAGING INFLAMMATION |
| US5326856A (en) * | 1992-04-09 | 1994-07-05 | Cytogen Corporation | Bifunctional isothiocyanate derived thiocarbonyls as ligands for metal binding |
| US5508020A (en) * | 1992-06-05 | 1996-04-16 | Diatech, Inc. | Technetium-99M labeled peptides for imaging |
| EP0641222B1 (en) * | 1992-05-21 | 2000-09-06 | Diatide, Inc. | TECHNETIUM-99m LABELED PEPTIDES FOR THROMBUS IMAGING |
| US5968476A (en) * | 1992-05-21 | 1999-10-19 | Diatide, Inc. | Technetium-99m labeled peptides for thrombus imaging |
| US5620675A (en) * | 1992-06-23 | 1997-04-15 | Diatech, Inc. | Radioactive peptides |
| DE69332203T2 (de) * | 1992-10-02 | 2003-05-28 | Diatide, Inc. | Multimerische mehrzweckwirkstoffe gegen thrombose |
| US6056940A (en) * | 1993-04-08 | 2000-05-02 | Diatide, Inc. | Radiolabeled compounds for thrombus imaging |
| US5951964A (en) * | 1993-06-04 | 1999-09-14 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
| CN1087955C (zh) * | 1994-05-02 | 2002-07-24 | 迪亚太德公司 | 锝-99m标记的成像剂 |
-
1992
- 1992-06-05 US US07/893,981 patent/US5508020A/en not_active Expired - Lifetime
-
1993
- 1993-06-04 AU AU45287/93A patent/AU688264B2/en not_active Ceased
- 1993-06-04 CA CA002137009A patent/CA2137009C/en not_active Expired - Fee Related
- 1993-06-04 ES ES93915221T patent/ES2105292T3/es not_active Expired - Lifetime
- 1993-06-04 DE DE69310733T patent/DE69310733T2/de not_active Expired - Fee Related
- 1993-06-04 DK DK93915221.1T patent/DK0644778T3/da active
- 1993-06-04 EP EP93915221A patent/EP0644778B1/en not_active Revoked
- 1993-06-04 WO PCT/US1993/005372 patent/WO1993025244A1/en not_active Ceased
- 1993-06-04 AT AT93915221T patent/ATE152918T1/de not_active IP Right Cessation
- 1993-06-04 JP JP6501622A patent/JP2954354B2/ja not_active Expired - Lifetime
-
1995
- 1995-06-06 US US08/469,858 patent/US5976494A/en not_active Expired - Fee Related
- 1995-06-06 US US08/467,567 patent/US6113878A/en not_active Expired - Fee Related
-
1997
- 1997-07-08 US US08/889,212 patent/US6667389B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU688264B2 (en) | 1998-03-12 |
| US5976494A (en) | 1999-11-02 |
| DE69310733D1 (de) | 1997-06-19 |
| EP0644778A1 (en) | 1995-03-29 |
| ES2105292T3 (es) | 1997-10-16 |
| JPH07506592A (ja) | 1995-07-20 |
| HK1007685A1 (en) | 1999-04-23 |
| US6113878A (en) | 2000-09-05 |
| CA2137009A1 (en) | 1993-12-23 |
| CA2137009C (en) | 2001-11-27 |
| AU4528793A (en) | 1994-01-04 |
| US5508020A (en) | 1996-04-16 |
| ATE152918T1 (de) | 1997-05-15 |
| DE69310733T2 (de) | 1997-10-30 |
| EP0644778B1 (en) | 1997-05-14 |
| WO1993025244A1 (en) | 1993-12-23 |
| US6667389B1 (en) | 2003-12-23 |
| JP2954354B2 (ja) | 1999-09-27 |
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